만성호중구성백혈병 2예

김형회,여승민,문건식,이은엽,김순호 대한임상검사정도관리학회 1994 臨床檢査와 精度管理 Vol.16 No.2

게임을 활용한 공감훈련이 초등학생의 친사회적 행동 증진에 미치는 영향

김형회,Kim, Hyung-Hoe 한국초등상담교육학회 2005 초등상담연구 Vol.4 No.1

The purpose of this study was to examine the effect of game-centered empathy training on the prosocial behaviors of elementary schoolers in a bid to suggest how their prosocial behaviors could be boosted. The research questions were posed as below: 1. Does game-based empathy training improve the overall empathy of school children? 2. Does game-based empathy training have a better effect on the cognitive empathy of school children or their emotional empathy? 3. Does game-based empathy training enhance the prosocial behaviors of school children? The subjects in this study were 62 children in their fourth year of D elementary school in Eumseong-gun, north Chungcheong province. They were divided into an experimental group and a control group, and a survey was conducted before and after the experimental group under-went empathy training for about six weeks. The instrument used in this study was David(1980)'s Interpersonal Reactivity Index adopted by Park Sung-hee(1996) to suit school children. Another instrument was Park Sung-hee (1997)'s inventory to assess the prosocial behaviors of children. The collected data were analyzed by SPSS 10.0 for Windows program, and reliability analysis and t-test were employed. The findings of the study were as follows: First, as for the effects of the game-based empathy training on the overall empathy of the elementary school youngsters that included both emotional and cognitive empathy, both groups got lower scores in posttest than in pretest. The experiment produced unexpected results, as the experimental group got significantly lower scores. This fact indicated that the game-based empathy training was ineffective. Second, the game-centered empathy training didn't exercise any influences on their cognitive and emotional empathy. The experiment had a reverse impact on the cognitive and emotional empathy of the experimental group, which implied that the training served as a factor to deteriorate the two types of empathy, and the hypothesis posed in this study was rejected. Therefore, which type of empathy could make a better progress by being exposed to the training couldn't definitely be determined. Third, the game-based empathy training didn't serve to Improve the prosocial behaviors of the elementary schoolers. There was no change in the experimental group, and this fact signified that there's something wrong with the attempt to develop school children's empathy to step up their prosocial behaviors. Based on the above-mentioned findings, the following conclusion was reached: First, the game-centered empathy training had no effects on boosting the overall empathy of the school children. Second, the game-centered empathy training couldn't be said to be effective in improving either cognitive empathy or emotional one. From a viewpoint of relativity, that could be said to affect emotional empathy more than cognitive one. Third, the game-based empathy training wasn't effective in improving prosocial behaviors. Rather, that resulted in interrupting the promotion of prosocial behaviors.

지식경영은 휴먼 터치로부터

김형회,Kim, Hyeong-Hoe 한국IT전문가협회 2003 소프트웨어세계 Vol.6 No.-

만성 C형 간염환자에 있어서 단핵구의 Th1/Th2 사이토카인 생성에 관한 연구

김형회,이은엽,손한철 대한진단검사의학회 2002 Annals of Laboratory Medicine Vol.22 No.4

배경 : C형 간염바이러스(HCV)에 감염되면 환자의 약 50%는 만성간염을 일으키며 이 중 약 반은 간경변 혹은 간암으로 진행한다. HCV 감염환자에서 만성화와 질병의 진행에 따른 면역조절기전을 알아보기 위하여 IFN- , IL-12, IL-2의 Th1 사이토카인과 IL-4의 Th2 사이토카인을 이용하여 면역능을 분석하고자 하였다.방법 : 만성 C형 간질환 환자 31명(만성간염 19예, 간경변증12명)과 대조군의 혈청과 배양된 말초혈 단핵구에서 생성된IFN- , IL-12, IL-2, IL-4 사이토카인을 효소면역법으로 측정하였다. 결과 : 혈청 IFN- 치는 만성간염과 간경변증에서 대조군보다유의하게 높았다(P<0.05). 대조군의 단핵구자연생성 IFN- 치는 모두 검출농도 이하로 낮았지만 만성간염에서는 42%, 간경변증은 75%에서 검출되어 대조군과 유의한 차이가 있었다( P<0.05). PHA로 자극한 단핵구에서 생성된 IFN- 치는 간질환군에서 대조군에 비해 유의하게 낮았다(P<0.05). 혈청 IL-12는 대조군 및 간질환군에서 모두 검출되지 않았고 PHA로 자극한 단핵구 생성 IL-12치는 대조군보다 간염군에서 유의하게 낮았다(P<0.01). IFN- 는 IL-12, 림프구 수, 단핵구 수와 유의한 상관관계를 보였고 다른 사이토카인과 상관성은 없었다.

Dimension RxL Max HM기기에서 NT-proBNP 검사평

김형회,이은엽,손한철 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23

Background: N-terminal pro-brain type natriuretic peptide (NT-proBNP) has been identified as a promising biochemical marker for congestive heart failure (CHF). Recently, the NT-proBNP assay using electrochemiluminescence method has been developed. We evaluated performance of the NT-proBNP assay and its relationship with Triage BNP assay. Methods : NT-proBNP(DADE BEHRING, Germany) was evaluated for within-run precision, within-day precision, between-days precision, and linearity. With 96 patients samples, NT-proBNP were compared with Triage BNP assay. For reference interval, we tested 120 healthy adult sample under 75years old. Results : The coefficients of variation(CVs) of within-run precision, within-day precision and between-days precision were less than 10%, mostly 6%. The lower reportable limit was 10.1 pg/mL and upper limit was 30,000 pg/mL. The comparison study indicated good agreement between Triage BNP positive results and NT-proBNP, but correlation was not excellent. The reference interval were 85.1 pg/mL for man and 120 pg/mL for woman. Conclusions : NT-proBNP(DADE BEHRING, Germany) showed a good precision and good agreement with Triage BNP positive results, but correlation was not excellent. 배경: 혈장 BNP 측정은 울혈성 심부전의 진단과 평가에 이용되며 또한 급성관상동맥질환 환자의 위험도 평가 및 호흡곤란을 보이는 환자의 감별진단에 이용될 수 있다. 본 연구에서는 자동화학 장비인 Dimension RxL-Max(DADE BEHRING, Germa) 이용하여 NT-proBNP(PBNP) 검사의 정밀도와 일간 변동, 기존의 Triage BNP assay (Biosite Inc., San Diego, USA) 와 상관성 등의 수행능력을 비교하고 한국인의 참고범위를 설정하고자 하였다. 방법 : 3가지 농도의 상품화된 정도관리 물질을 이용하여 검사일내 정밀도, 검사일간 정밀도와를 직선성 평가를 실시하고 상관성평가는 96명의 환자검체를 이용하여 Triage BNP assay와 비교하였고, 참고범위는 75세미만의 건강성인 120 명 을 대상으로 설정하였다. 결과: 정밀도 분석은 검사 간 변이계수 (between-run coefficient of variation), 일간변이계수 (b etween-day coefficient of variation) 빛 총변이계수(total coefficient of variation) 모두 10%이하이고 대부분 6%이하의 우수한 결과를 보였고, NT-proBNP 검사의 보고가능 범위는 하한치가 10.1pg/mL, 상한치가 30,000 pg/mL 이었다. Triage BNP와 비교에서 불일치율이 11.4%였고 Triage BNP에서 cut-off이상을 보인 환자의 일치율은 98.1%로 상당히 좋았다. 75세 미만의 건강성인에서 97.5th percentile 을 기준으로 참고범위의 설정은 남자는 85.1 pg/mL, 여자는 120 pg/mL 이었다. 결론 : NT-proBNP는 우수한 정밀도와 직선성을 보여주었고 기존의 검사와 비교에서 검사결과의 일치율은 높았지만 상관관계는 낮았다.

네트워크 사회에 성공하려면

김형회,Kim, Hyeong-Hoe 한국IT전문가협회 2001 소프트웨어세계 Vol.5 No.-

Laccaria laccata B.의 Phytohemoagglutinin에 關한 硏究

金亨會 고려대학교 의과대학 1973 고려대학교 의과대학 잡지 Vol.10 No.3

혈장분획제제에서 사람면역 철핍바이러스(HIV) 청량검사법 검토

김형회,이은엽,손한철 부산대학교 병원 암연구소 2007 부산대병원학술지 Vol.- No.21

Purpose : The FDA approved that the commercial PCR reagents (Cobas amplicor and CHIRON TMA HIV-lIHCV Assay) for HIV detection could be used only for human serum. We tried to evaluate the usefulness of the commercial PCR reagents for the serum of 4kinds of plasma derivative products. Subjects and Method : The known concentration of HIV virus was added in 4 kinds of plasma derivative products, and the HIV detections were performed by the commercial PCR reagents. We analyzed the precision and specificity levels, and the availability of tests. Results : 1. The specificity level of the test for HIV detection which was performed by Cobas amplicor for 4 kinds of plasma derivative products was 100%. 2. The total CV value for 4 kinds of plasma derivative products was 31.9%, and the CV values for albumin, antithrombin III, and greenmono were relatively low as 26.04%, 18.29%, 13.55% respectively. Only the CV values of IV globulin S was relatively high as 54.48%. The CV value of day-to-day was 5.0%-35.9%. 3. Recovery rate for albumin product using Cobas Amplicor was 17.5% , it could be inhibitory effect during PCR. Conclusions : The results of test performed with both Cobas amplico Assay revealed that the commercial PCR reagents have reliable result not only for human serum, but also for the plasma derivative products. With the result of our experiment, firstly , we confirmed the suitability of using the commercial PCR reagent for HIV detection in the 4 kinds of plasma derivative products. 목적 : 혈장분획 제제에서 COBASAMPLICOR HIV-1 MONITORTM TEST, VERSION 1.5 (Roche Diagnostics Systems, Meylan, France: Cobas AM) 핵산증폭 검사법 가능 여부를 검사의 특이도, 정밀도 분석과, 회수율시험을 통하여 확인하고 평가하고자하였다. 대상 및 방법 : 검체가 사람 혈장이 아닌 혈장 분획 제제에서 핵산증폭검사법으로 검사 시 저해작용 없이 검출이 가능함을 확인하기 위해 4종류의 혈장분획 제제를 대상으로 검사특이도 (specificity), 검사정 밀도 (Sensitivity) 를 분석 하였고 혈장 및 혈장분획 제제에 동일한 농도의 HIV를 첨가하여 결과 검토 후 검사가능 여부를 분석하여 혈장분획에서의 상용화된 검사의 특성을 평가한다. 결과 :1. 모든 혈장분획 제제는 HIV Cobasamplicor 정량검사 특이도가 100%였다. 2. 혈장의 총 변이계수 (CV) 31.90%, 알부민, 항트롬빈 III, 그린로모는 각각 26.04% ,18.29%, 13.55%로 낮은 안정적인 결과를 보였고 IVIG는 54 .48%로 비교적 높은 변이계수를 보였고, 일간변이 계수는 5.0-35.9%였다. 3. Cobas Amplicor를 이용한 HIV정량검사 회수율은 알부민제제가 17.5% 의 낮은 회수율을 보여 알부민제제를 이용한 정량검사에서는 일부 저해요인이 있는 것으로 생각되었다. 결론 : 혈장분획제제를 대상으로 상품화된 HIV 정량검사인 Cobas Amplicor를 이용한 검사는 특이도, 정밀도는 혈청과 유사하였으며 정량검사는 알부민제제는 일부저해요인 있었지만 다른 혈장 분획제제에서는 정량검사가 가능하였다.

'투명한 것은 쫀쫀한 것이다?'

김형회,Kim, Hyeong-Hoe 한국IT전문가협회 2003 소프트웨어세계 Vol.6 No.-

Laccaria laccata B.의 Phytohemoagglutinin에 關한 硏究

金亨會,文國鎭 고려대학교 의과대학 1973 고려대 의대 잡지 Vol.10 No.3

The author screened twenty three kinds of mushroom native to Korea on its hemoagglutination activity to human red blood cell (RBC) and found out a new Phytohelnoagglutinin (PHA) in the saline extract of Laccaria laccata B. (LLB). Its hemoagglutination titer, absorption test with human saliva and sugars, heat stability test, salt fractionation by anmonium sulfate, sperm agglutination activity and elution test were studied. The results could be summarized as follows : 1) Anti A-lectin was found in LLB. 2) Anti A-lectin in LLB was absorbed by same group's RBC and saliva of secretor. 3) The agglutination titer of anti A-lectin in LLB were 1:8 with type A RBC and 1:4 with type AB RBC, and its optimal temperature of agglutination was 37℃. 4) The anti A-lectin was found in precipitates of LLB treated by 40% saturated amiuonium sulfate solution. 5) The agglutinating activity of anti A-fraction in LLB was inhibited by various sugars except dextrose. 6) The human sperms were not agglutinated by PHA in LLB. 7) It was possible to detect blood type A RBC in the blood stains and various humoral stains by elution test with anti A-lectin in LLB.