피부화상에 의한 피부 및 간의 조직학적 변화에 관한 연구

김한수,김상수,김용권,Kim, Han-Soo,Kim, Sang-Soo,Kim, Yong-Kwon 대한물리치료과학회 2001 대한물리치료과학회지 Vol.8 No.1

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total body surface area 30%) except for inhalated injury. At 5 and 24 h after scald bum, biochemical assay and morphological changes in skin tissue, serum and liver tissue were examined. The effects of bum injury on the levels of glutathione, lipid peroxide and on the activities of oxygen free radical generating and scavenging enzymes have been determined in association with observing of histologic and ultrastructural changes, measuring the protein concentration in plasma, and counting the number of intravascular polymorphonuclear leukocytes. The activity of xanthine oxidase, an enzyme of oxygen free radical generating system. was elevated (p<0.01) in serum, but not in skin and in liver tissue. Futhermore, thermal injury decreased not only the protein concentration in plasma but also the number of leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

몰로키아 분말을 첨가한 밀·보리 혼합 식빵의 제조 및 생리활성 평가

김한수,김영호,김애정,Kim, Han soo,Kim, Young Ho,Kim, Ae Jung 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.4

This study was performed to produce WBM (wheat and barley mixture) bread containing molokhia powder with quality characteristics and antioxidant activities. Analysis of the chromaticity of WBM prepared with molokhia powder showed that; the lightness and redness were decreased, but yellowness was increased. In mechanical properties, hardness, gumminess, and chewiness were significantly increased as the amount of molokhia powder was increased. However, cohesiveness was significantly decreased. In sensory evaluation, WBM bread containing 1.5% of molokhia powder (MB1.5) showed an overall high preference level. The total polyphenol content of molokhia powder EtOH extract and MB1.5 were 29.19 and 58.18 mg TAE/g, respectively. The total flavonoid contents of molokhia powder EtOH extract and MB1.5 were 20.62 mg and 33.25 mg RE/g, respectively. The radical scavenging ability ($IC_{50}$) of DPPH ($IC_{50}$) for molokhia powder EtOH extract and MB1.5 was 31.04 and $58.18{\mu}g/mL$, respectively while that of ABTS was 33.25 and $54.15{\mu}g/mL$, respectively. The ${\alpha}-glucosidase$ inhibitory effects of molokhia powder EtOH extract and MB1.5 were 494.88 and $814.88{\mu}g/mL$, respectively. MB bread containing 1.5% molokhia powder showed antioxidative effects and ${\alpha}-glucosidase$ inhibitory activity, meaning that not only molokhia but also MB1.5 bread has the potential to prevent chronic degenerative diseases such as diabetes.

위식도접합부선암의 임상병리학적 특성

김한수,정오,박영규,김동의,류성엽,김영진,Kim, Han-Su,Jeong, Oh,Park, Young-Kyu,Kim, Dong-Yi,Ryu, Seong-Yeop,Kim, Young-Jin 대한위암학회 2008 대한위암학회지 Vol.8 No.4

목적: 위식도접합부선암의 임상병리학적 특성은 서구와 아시아 간의 많은 차이를 보인다고 알려져 있다. 그러나, 한국의 경우 위식도접합부선암의 유병율이 매우 낮고 이에 대한 연구 또한 부족하다. 따라서 저자들은 우식도접합부선암의 Siewert 분류에 따른 임상병리학적 특성을 조사하여 서구와 다른 국내 위식도접합부선암의 특성을 연구하고자 하였다. 대상 및 방법: 2004년 5월부터 2008년 2월까지 본원에서 위암으로 수술을 시행 받은 환자들을 대상으로 수술소견 및 병리 사진을 토대로 Siewert 분류법에 따라 위식도접합부선암을 분류하고, 의무기록을 바탕으로 환자들의 임상병리학적 특성들을 조사하였다. 결과: 위식도접합부선암은 전체 1,778예 중 70예(3.9%)였다. Siewert 1형은 3예(4.3%)로 매우 드물었으며, 2형과 3형이 각각 30예(42.8%) 37예(52.8%)였다. 2형이 3형에 비하여 평균연령이 높았으나(64세 vs 59세, P=0.049), 남녀비에는 차이가 없었다. 2형과 3형간에 Barrett 식도의 발현 정도나 Lauren 분류의 차이는 없었으나, 저분화암의 빈도는 3형에서 유의하게 높았다(P=0.045). 68예(97.1%)에서 근치적 절제가 시행되었으며, 각 아형간에 TNM 병기의 차이는 없었다. 결론: 국내의 위식도접합부선암은 매우 드물며 특히 1형의 유병율이 매우 낮다. 본 연구에서 서구의 보고와 부분적으로 일치하지 않는 병리학적 특성을 보였다. 향후 보다 많은 환자들을 대상으로 한국인의 위식도접합부선암의 특성을 연구할 필요가 있다. Purpose: Siewert's classification of adenocarcinoma of the esophagogastric junction (AEG) has been widely adopted, but there is a wide discrepancy of the clinicopathological features of AEG of the Asian patients as compared to that of the Western patients. The aim of this study was to investigate the clinicopathological characteristics of AEG according to the Siewert classification. Materials and Methods: Among the patients who underwent surgery for gastric carcinoma in our institution between May 2004 and February 2008, the AEG patients were selected based on their operation records and the photographs according to Siewert's classification. Results: There were 70 AEG patients (3.9%) among the total of 1,778 patients. There were 3 patients (4.3%) with type I, 30 patients (42.8%) with type II and 37 patients (52.8%) with type III. Curative resection (R0) was achieved in 68 cases (97.1%). No significant differences in gender, stage, Barrett's esophagus and the proximal margin were found between the patients with type II and type III AEG. The patients with type III were younger than the patients with type II (59 vs 64 years, respectively, P=0.049). Well differentiated histology (P=0.045) and the intestinal type (P=0.055) were significantly more frequent in the patients with type II as compared with that in the patients with type III. Conclusion: There was a striking difference of the Asian patients from the Western patients for the incidence of AEG (and especially type I). Some of the differences between type II and type III patients were similar to those of the previous Western studies. A large study is needed to investigate whether these features are typical in the Korean population.

척수손상 수준에 따른 외상성 척수손상환자의 합병증 발생양상

김한수,이용덕,박윤기,서태수,허춘복,Kim, Han-Su,Lee, Yong-Deok,Park, Yun-Gi,Seo, Tae-Su,Heo, Chun-Bok 대한물리치료사협회 1992 대한물리치료사협회지 Vol.13 No.2

CM at Risk 제도 도입에 따른 현안 진단과 발전 방향

김한수,Kim, Han-Su 한국건설관리학회 2010 건설관리 : 한국건설관리학회 학회지 Vol.11 No.3

근위 상완골 골종양에서 골수강내 금속정과 골시멘트를 이용한 사지 구제술

김한수,오주한,남우동,이태연,정진영,이한구,이상훈,Kim, Han-Soo,Oh, Joo-Han,Nam, Woo-Dong,Rhie, Tae-Yon,Jeong, Jin-Young,Lee, Han-Koo,Lee, Sang-Hoon 대한근골격종양학회 2000 대한골관절종양학회지 Vol.6 No.2

목적 : 상완골 근위부의 악성 골종양에 대한 골수강내 금속정과 골시멘트를 이용한 사지 구제술을 시행한 환자에서 수술 후 기능적 결과 및 종양학적 추시 결과를 분석하고자 하였다. 대상 및 방법 : 본 연구는 1992년 8월부터 1998년 4월까지 상완골 근위부의 악성 골종양으로 수술을 받은 18례를 대상으로 하였다. 골육종이 7례, 연골육종이 3례, 재발성 거대세포종이 3례, 전이성 악성 골종양이 3례, 다발성 골수종이 1례, 악성 섬유성 조직구증이 1례였다. 평균 연령은 38세이며, 추시 기간은 평균 26개월이었고, 수술은 병소 절제후 상완골두 모양으로 성형한 골시멘트와 골수강내 정을 이용하여 관절 성형술을 시행하였다. 술후 환자의 기능 평가는 국제 사지 보존 회의(ISOLS)의 기능 평가 방법을 이용하였으며, 또한 국소 재발, 원격 전이, 합병증 및 생존 기간 등을 분석하였다. 결과 : 기능 평가 점수는 평균 21.1(70.3%)이었다. 3례에서 국소 재발이 있었고, 5례에서 원격 전이가 발생하였다. 합병증으로 1례에서는 견관절 불안정성, 1례에서는 심부 조직의 감염이 발생하였다. 현재 지속적 무병 상태 7례, 유병 생존 상태 7례이며, 4례는 원격 전이 등으로 사망하였다. 결론 : 상완골 근위부 악성 골종양에 대하여 골수강내 정과 골시멘트를 이용한 사지 구제술을 시행하여 비교적 만족할 만한 기능적 결과를 얻었다. 이 술식은 선택된 경우에 있어서 상완골 근위부 종양 치료에서 재건 방법의 하나로 고려될 수 있을 것으로 보인다. Purpose : The purpose of the current study is to evaluate the functional and oncologic results of the limb salvage surgery with intramedullary nailing and cementization in malignant bone tumors of the proximal humerus. Materials and Methods : We reviewed 18 cases of limb salvage surgery of resection and reconstruction with an intramedullary nail and cement-molded humeral head for the malignant bone tumors of the proximal humerus, which performed between August, 1992 through the April, 1998. The diagnoses included the osteosarcoma in 7 patients, chondrosarcoma in 3, the recurrent giant cell tumor in 3, metastatic tumor in 3, multiple myeloma in one patient and the one patient with malignant fibrous histiocytoma. The mean age at the time of surgery was 38 years(range, 15-73 years). The mean follow-up period was 26 months(range, 6-67 months). Results : Average functional score by ISOLS evaluation system was 21.1(70.3%). There were 3 local recurrences and 5 distant metastases. There were one case of shoulder instability and one case of deep infection. The seven patients are continuously disease free state and seven patients are alive with disease. Four patients died from the disease. Conclusion : The limb salvage surgery with intramedullary nailing and cementization in the bone tumors of the proximal humerus may be considered an option for the malignant bone tumors of the proximal humerus in selected patients.

이종골 이식을 이용한 양성 골 종양 치료

김한수,Kim, Han-Soo 대한근골격종양학회 1995 대한골관절종양학회지 Vol.1 No.2

The authors reviewed 49 cases(48 patients) of benign bone tumor who had surgical treatment with xenograft at department of orthopedic surgery, Seoul National University Hospital from May, 1980 to May, 1994. Materials consist of 21 males and 27 females. The mean age at operation was 20.1 years(range : 4 -55 years) and the mean follow up period was 25.4 months(range : 7 - 85 months). We did xenograft only in 34 cases and xenograft mixed with autograft in 15 cases(14 cases, from ilium, 1 case from femur). The used materials for xenograft were $Lubboc^{(R)}$ in 29 cases, $Surgibone^{(R)}$ in 17 cases and $Pyrost^{(R)}$ in 3 cases. The average durations when bony union was achieved in radiograph were 13.8 weeks in whole cases, 12.5 weeks(range : 8 - 24 weeks) in $Lubboc^{(R)}$ graft cases and 15.7 weeks(range : 6 - 24 weeks) in $Surgibone^{(R)}$ graft cases. The tumor recurred in 4 cases, 1 case was recurred giant cell tumor at distal femur treated with mixed auto and $Lubboc^{(R)}$ graft and 2 cases were large cystic lesions at the proximal humerus diagnosed as simple bone cyst and at distal tibia diagnosed as fibrous dysplasia treated with $Surgibone^{(R)}$ graft and 1 case was aneurysmal bone cyst of the proximal tibia treated with $Lubboc^{(R)}$ graft. Wound infection occurred in 1 case. More transfusion was done in the cases that the lesion was larger than 5cm, the lesions were in the ilium or femur and the cases that were treated with mixed with autograft. This study implies that benign bone tumor is successfully treqated with curettage and xenograft or xenograft mixed with autograft. And also this method will reduce morbidity of donor site, intraoperative bleeding and post-transfusion complications. 저자들은 1980년 5월부터 1994년 5월까지 양성골 종양으로 서울대학교 병원 정형외과에서 수술적 치료를 시행한 49례를 분석하여 다음과 같은 결론을 얻었다. 1. 양성 골종양을, 소파술과 화학적 처리한 이종골 및 이종골과 자가 해면질골을 혼합 이식하여 만족한 결과를 얻었다. 2. 화학적 처리한 이종골 이식은 자가골 이식시보다 수술 시간, 수술중 출혈 및 수혈양을 줄여 수술 및 수혈 합병증을 감소시킨 것으로 사료된다. 3. 이종골 이식은 자가골 이식시 발생할 수 있는 문제를 염두에 둘 때 고려할 만한 골 이식 대치물로 사료된다.

최근 물정보화 동향과 MyWater 기술 SW 커뮤니티 운영

김한수,Kim, Han-Su 한국수자원학회 2016 물과 미래(한국수자원학회지) Vol.49 No.9

2014년~2015년 가뭄의 평가

김한수,김현식,전근일,강신욱,Kim, Han-Su,Kim, Hyeon-Sik,Jeon, Geun-Il,Gang, Sin-Uk 한국수자원학회 2016 물과 미래(한국수자원학회지) Vol.49 No.7

흉강내 식도재건시 늑간동맥을 이용한 유리 공장 전이술

김한수,최상묵,정찬민,서인석,Kim, Han-Soo,Choi, Sang-Mook,Chung, Chan-Min,Suh, In-Seock 대한미세수술학회 1996 Archives of reconstructive microsurgery Vol.5 No.1

The reconstruction of esophageal defect after ablative surgery have more difficult than other digestive tract tumor because the restoration of anatomical and physiologic function is difficult, the risk of tumor invasion into the adjacent tissue is large. The reconstruction of cervical esophus was depended on the degree of resection of the esophagus, various reconstruction method was developed to minimize functional deficiency and deformity of cervical region. Recently, the free jejunal transfer or free radial forearm flap was commonly utilized for esophageal reconstruction due to development of technique of the microvascular anastomosis. After the esophageal reconstruction used by free jejunal transfer was reported by Seidenberg in 1951, jejunum is most commonly used for reconstruction of esophgus. Becaue of, it have been tubed anatomical similarity with muscular layer, relative small risk of complication, possible of oral intake within 10 days after operation, and early rehabilitaion. Authors have been treated esophageal defect with free jejunal transfer in 7 patients after resection of lesion in 6 eshageal cancer and 1 esophageal stricture from December 1994 to January 1996. We were transferred jejunum used by intercostal artery as recipient artery in 3 cases, it was satisfied with results. If intercostal artery was utilized as recipient artery for free jejunal transfer, we believe that any site of intrathoracic or intraabdominal esophageal defect is possible to recontruction.