혈관 평활근에서 Protein Kinase C와 Norepinephrine 수축에 대한 Ketamine의 효과

김지응 대한정맥마취학회 2000 정맥마취 Vol.4 No.2

서론: Ketamine은 해리성 마취제로 평활근에서 고농도 KCI과 수용체 agonist carbachol histamine과 endotheline에 의한 수축을 억제시키는 효과가 있다. 이런 작용은 평활근에서 Ca^2+의 세포내 이동을 억제시킴으로써 나타난다. 하지만 이런 ketamine의 작용은 잘 알려져 잇지 않고 있다. 본 연구에서는 흰쥐의 대동맥 평활근에서 protein kinase C (PKC)와 norepinephrine (NE)의 수축에 미치는 ketamine의 효과에 대해 알아보고자 하였다. 방법: 대동맥 혈관 평활근을 생리적 식염수에 처리 후 칼슘이온 제거 생리적 식염수에 처리하여 PKC 활성제인 12-Deoxyphorbol 13-isobutyrate (DPB)로 수축을 일으킨 후 ketamine에 의한 효과를 살펴보고, 또 PKC 유무에 따른 ketamine의 효과를 알아보기 위해 phorbol 12-myristate 13-acetate (PMA) 처리군과 비처리군에서 ketamine의 효과를 관찰하였다. 그리고 NE 처리한 후 ketamine을 투여하여 세포내 Ca^2+ 농도 변화를 알아보았다. 결과: Ca^2+ 제거 식염수에서 혈관 평활근을 DPB로 수축을 일으킨 후 ketamine을 처리시 수축이 억제되었다. 또한 PKC 유무에 따른 ketamine의 효과는 KCI 수축시는 PMA 처리군에서 ketamine의 효과가 강하게 나타났으나 endothelin-1에 의한 수축에서는 동일하게 발생하였다. 그리고 NE에 의한 처리 후 ketamine 투여시 세포내 Ca^2+ 이온 농도가 감소되었다. 결론: Ketamine은 혈관 평활근의수축을 억제하며 이완기전으로는 Ca^2+ 이온 통로 및 세포내 Ca^2+ 이온 증가억제와 Ca^2+ 이온에 의존하지 않는 수축도 억제하는 것을 알 수 있었다. Background: It is well known that ketamine, a dissociative anesthetics, inhibits smooth muscle contraction induced by high KCI and receptor agonists such as carbachol, histamine and endothelin. It has been reported that the inhibitory effect was mediated by decrease of Ca^2+ influx through plasma membrane in smooth muscle. However the mechanism for action of ketamine is not fully understood. In the present study, the effect of ketamine on protein kinase C (PKC) and norepinephrine (NE) contraction were investigated in rat aortic muscle. Methods: Aortic smooth muscle strips from Sprague-Dawley rat were mounted in organ bath with physiological salt solution (PSS). When 12-deoxyphorbol 13-isobutyrate (DPB), PKC stimulator induced contraction stead level in Ca^2+-free PSS, KCI or endothelin-1 induced contraction with or without PKC, or NE induced contraction in PSS, ketamine was added cumulatively, the changes in tension and cytosolic Ca^2+ level ([Ca^2+]_i) of the muscle strips were measured. Results: DPB increased muscle contraction in Ca^2+-free PSS and the contraction was inhibited by the treatment with ketamine. And contractile response to KCI was more attenuated with phorbol 12-myristate 13-acetate (PMA) than without PMA by ketamine, then similarly ketamine decreased the contraction by endothelin-1 in abscence or presence of PMA. The phasic contraction produced by NE, increased intracellular calcium, was also inhibited by ketamine. Conclusions: These results suggest that ketamine inhibits PKC contraction in vascular smooth muscle by Ca^2+-independent contraction mechanisms and ketamine incompletely relaxes NE contracted rat aorta by decreasing calcium entry.

남자 핸드볼 골키퍼 방어율 분석 : 2020 도쿄올림픽 대회 기록을 중심으로

김지응,문광현 한국체육무용과학회 2021 Journal of Sport and Dance Science Vol.1 No.2

배깅과 부스팅 알고리즘을 이용한 핸드볼 결과 예측 비교

김지응,박종철,김태규,이희화,안지환,Kim, Ji-eung,Park, Jong-chul,Kim, Tae-gyu,Lee, Hee-hwa,Ahn, Jee-Hwan 한국융합학회 2021 한국융합학회논문지 Vol.12 No.8

The purpose of this study is to compare the predictive power of the Bagging and Boosting algorithm of ensemble method based on the motion information that occurs in woman handball matches and to analyze the availability of motion information. To this end, this study analyzed the predictive power of the result of 15 practice matches based on inertial motion by analyzing the predictive power of Random Forest and Adaboost algorithms. The results of the study are as follows. First, the prediction rate of the Random Forest algorithm was 66.9 ± 0.1%, and the prediction rate of the Adaboost algorithm was 65.6 ± 1.6%. Second, Random Forest predicted all of the winning results, but none of the losing results. On the other hand, the Adaboost algorithm shows 91.4% prediction of winning and 10.4% prediction of losing. Third, in the verification of the suitability of the algorithm, the Random Forest had no overfitting error, but Adaboost showed an overfitting error. Based on the results of this study, the availability of motion information is high when predicting sports events, and it was confirmed that the Random Forest algorithm was superior to the Adaboost algorithm.

필드하키 종목 연도별 연구동향 분석: 국내연구를 중심으로

김지응,문광현,송인욱 한국체육무용과학회 2024 Journal of Sport and Dance Science Vol.4 No.4

본 연구는 국내 필드하키 연구동향을 분석하여 연구 성과를 점검하고 현재 상태를 파악하여, 향후 연구방향을 제시하는데 목적이 있다. 이를 위해 학술연구정보서비스(RISS) 데이터베이스를 사용하여 국내에서 발행된 학술논문들을 검색하였으며 총 92편의 연구와 376개의 키워드를 수집하였다. 수집된 연구들을 연도, 연구분야, 연구대상, 연구방법별로 나누어 연구 빈도를 확인하였으며, 키워드를 바탕으로 TF-IDF값을 산출하였다. 연구동향 분석에 따른 결과는 다음과 같다. 첫째, 연도별 연구동향은 2019년에 가장 많았으며, 5년단위 빈도에서도 점점 늘어나고 있다. 둘째, 연구분야별 연구동향은 운동생리학, 경기분석, 운동역학, 스포츠사회학, 스포츠심리학 순으로 연구가 많이 수행되었다. 셋째, 연구대상별 연구동향은 성인선수 위주로 연구가 많이 진행되었다. 넷째, 연구방법별 연구동향은 실험연구, 질적연구, 양적연구, 혼합연구 순으로 진행되었다. 마지막으로 키워드 분석에서는 필드하키, 경기력, GPS, 하키선수, 페널티코너 순으로 진행되었다. 본 연구를 바탕으로 국내에서 필드하키 연구의 흐름을 확인할 수 있었다. Objectives This study is to analyze domestic field hockey research trends to check the research results, identify the current status, and suggest future research directions. Methods To achieve this research purpose, academic papers published in Korea were searched using the Research Information Service (RISS) database, and a total of 92 studies and 376 keywords were collected. The collected studies were divided by year, research field, research subject, and research method to check the frequency of the study, and the TF-IDF value was calculated based on the keywords. Results The results of the analysis of research trends are as follows. First, research trends by year were the most in 2019, and they are increasing in the frequency of 5year units. Second, as for research trends by research field, many studies were conducted in the order of exercise physiology, game analysis, kinematics, sports sociology, and sports psychology. Third, many studies were conducted mainly on adult players. Fourth, research trends by research method were conducted in the order of experimental research, qualitative research, quantitative research, and mixed research. Finally, in the keyword analysis, field hockey, performance, GPS, hockey player, and penalty corner were conducted in that order. Conclusions Based on this study, the flow of field hockey research in Korea could be confirmed.

Arm 펌웨어 프레임워크 명세 기계화 가능성

김지응 한국ITS학회 2024 한국ITS학회 학술대회 Vol.2024 No.4

국제경기에서 나타난 럭비 7’s 경기시간 특성 분석

김지응,정회덕 한국체육과학회 2022 한국체육과학회지 Vol.31 No.2

The purpose of this study is to identify the characteristics of APT (Actual Playing time) and DOP (Duration of Out of Play) that occur in rugby 7s man international games and to confirm the difference from competitors. In order to achieve the purpose of the study, data were collected in LA rugby 6 matches and Tokyo Olympics 5 matches in 2021. The collected data was t-tested using SPSS 25.0 to confirm the difference between the Republic of Korea and the other country. As a result, first, the average ACT of the Korean national team at the LA competition was 2 minutes 10 seconds ± 30.2 seconds, the average 4 minutes 02 seconds ± 34.7 seconds, and the average 2 minutes 51 seconds ± 1 minute 17 seconds for South Korea at the Tokyo Olympics, and the average 4 minutes 3 seconds ± 42.6 seconds for the opposing team. Second, at the LA competition, the average DOP of the Korean national team was 2 minutes 11 seconds ± 1 minute 13.4 seconds, the average of the opposing team was 6 minutes 41 seconds ± 1 minute 19.6 seconds, the average of South Korea was 3 minutes 8 seconds ± 53 seconds, and the opposing team was 6 minutes 21 seconds ± 54 seconds. Finally, in the two groups, there was a significant difference in time after the conversion kick. Based on these results, it is expected to be used as useful information when planning tactical training programs.

국제 경기기록 활용한 남자 휠체어농구 승패요인 탐색 : 2018~2019 국제대회를 중심으로

김지응,이용국,이승훈 한국체육과학회 2022 한국체육과학회지 Vol.31 No.2

The purpose of this study is to explore the factors of winning or losing and the determinants of the upper and lower countries using game records. For the purpose of the study, the study was conducted on official records provided in 95 games in 2018 and 2019. The analysis variables were based on 9 shooting variables and 7 technical variables, and independent sample t-test and decision tree analysis were performed to confirm the difference between the winning and losing games and the difference between the upper and lower countries. According to the research, the first 2point shot success and the attack rebound were the biggest differences in the winning game and the losing game. Second, the biggest difference between the upper and lower countries was the difference in 2point and 3point shots, assist and turnover. Third, the winning and losing factors in the decision-making factor were 2point shots and attack rebounds, while the upper and lower countries were assists and turnovers. In conclusion, in order to win the Paralympics, a two-point shooting success and rebound success rate must be prepared.

엘리트 여자하키 국제대회 경기 내용 분석 : 2017~2022년 국제대회를 중심으로

김지응,문광현 한국체육무용과학회 2022 Journal of Sport and Dance Science Vol.2 No.2

2018, 2022년 월드컵 경기기록을 분석한 한국축구 경기력 비교

김지응,문광현 한국체육무용과학회 2023 Journal of Sport and Dance Science Vol.3 No.2

엘리트 3x3 농구 승패결정요인 : 2020 도쿄올림픽을 중심으로

김지응,문광현 한국체육무용과학회 2024 Journal of Sport and Dance Science Vol.4 No.1

Objectives This study was to identify the factors that influence the outcome of the game in 3x3 basketball games. Methods To achieve this research purpose, 3x3 basketball game data for the 2020 Tokyo Olympics was collected by gender on the website, and 13 factors were selected as research variables. The corresponding sample t-test and decision tree analysis method were used using SPSS 25.0 to confirm the difference in game results and the winning or losing factors. Results First, men's game showed a total of points, the number of successful two-point shots, and the number of free throws, and the women's game showed big differences in total points, 1-point shooting success rate, free throw success rate, and rebound number. Second, in the result of classification by decision tree analysis, the total score factor for men's games and the total number of points and rebounds for women's games were identified as factors that classify the game results. Conclusions This study was able to find important factors in the winning game using statistical techniques, and based on the results presented in the future, it is expected that the national team leaders will be useful information for setting intensity and developing training programs to improve players' performance. 본 연구의 목적은 3x3 농구경기에서 경기결과에 영향을 미치는 요인을 확인하는 것이다. 연구의 목적을 위하여 웹사이트에서 2020 도쿄올림픽 3x3농구 전체 기록을 성별에 따라 수집하였으며, 13개의 요인을 연구변인으로 선정하였다. 경기결과에 대한 차이와 승패요인을 확인하기 위하여 SPSS 25.0을 이용하여 대응표본 t검정과 의사결정나무 분석 방법을 활용하였다. 연구결과에 따르면 첫 번째, 남자경기에서 전체득점과 2점슛 성공횟수, 자유투 성공 횟수로 나타났으며, 여자경기에서는 전체득점, 1점슛 성공률, 자유투 성공률, 리바운드 횟수에서 큰 차이가 나타났다. 두 번째, 의사결정나무 분석으로 분류한 결과에서는 남자경기는 전체득점 요인, 여자경기는 전체득점과 리바운드 횟수가 경기결과를 분류하는 요인으로 확인되었다. 본 연구는 통계기법을 활용하여 승리경기에 중요한 요인을 찾을 수 있었으며, 앞으로 제시된 결과를 바탕으로 국가대표 지도자들이 선수들의 경기력향상을 위한 강도설정 및 훈련 프로그램 개발에 유익한 정보가 되기를 기대해본다.