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김재준(Jae-Jun Kim),김경(Kyung Kim),신선혜(Sun-Hye Shin),유창호(Chang-Ho Yu),정구영(Gu-Young Jeong),오승용(Seung-Yong Oh),권대규(Tae-Kyu Kwon) Korean Society for Precision Engineering 2011 한국정밀공학회지 Vol.28 No.12
In this paper, we assessed muscular activities of lower limbs and foot pressure for car and bus drivers according to operating three electronic pedals that we developed. To analyze drivers’ physical exhaustion, muscular fatigue of lower limbs was evaluated. Eleven car drivers and six urban bus drivers were participated in this experiment. The virtual driving system was used for the real driving environment. The virtual driving system was comprised of a spring seat, a steering wheel, pedals (clutch, excel and brake pedals), a manual transmission and a virtual driving simulation. For the real vibration like situation on the road, six degree of freedom motion base system was used. Measured muscles were rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA) and gastrocnemius (Gn) muscles. For the quantitative muscular activities, integrated electromyography (IEMG) was analyzed. Muscular fatigues also were analyzed through the analysis of the median frequency. In addition, foot pressures were analyzed and compared through the peak and averaged pressure during the operating three developed electronic pedals. The experiments are conducted with total 17 drivers, 11 general public and 6 drivers. As a result of the analysis, electromyogram and fatigue analysis through intermediate frequency reduction for pedal-1 more efficient than other pedals. And foot pressure also was decreased. Consequently, we suggested the most efficient pedal and method to minimize the amount of cumulative fatigue.
한국인 태아 및 성인에서 유당분해효소 mRNA 의 발현양상
김재준(Jae Jun Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.5
N/A Objective: The specific activity of lactase-phlorizin hydrolase (LPH) is very high at birth and sharply declines after weaning, producing lactose intolerance. The prevalence of lactose intolerance is up to 85% in Korean adults. Molecular basis of the regulatory mechanisms responsible for the decline of LPH specific activity is still unknown. In order to elucidate the molecular mechanisms regulating the LPH expression during development, LPH specific activity and mI4NA level of Korean fetal and adult intestines were compared. Methods: 20 fetal small intestines (16-27 weeks) were obtained during therapeutic abortion and were divided into 3 equal length. 20 adult jejunal tissues were obtained from patients without small intestinal disease during laparotomy. Mucosal homogenates were prepared for dissacharidases specific activities measurement and total RNA was extracted for northern and slot hvbridization. LPH mRNA level was measured by laser densitometer. Results: LPH specific activities of proximal, middle and distal portion of fetal intestines (n=20) were 36.2±22.5, 38.6±23.2 and 23.2±19.9 mu/mg protein, respectively. LPH specific activity of adult jejunum (n=8) was 5.9±1.8 mu/mg protein and significantly (p<0.05) lower than those of fetal intestines. However, there was no significant difference in sucrase and trehalase specific activities between fetal intestines and adult jejunum. Although LPH specific activity of adult jejunum was lower than those of fetal intestines, LPH mBNA level of adult jejunum was as high as those of fetal intestines. Conclusion: These results show that LPH specific activity and mRNA level do not parallel, indicating the posttranscriptional control of fetal development of LPH expression.
김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),김태호(Tae Ho Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
N/A Objectives: The effect of continued supplementation of diet with 10gp sucrose, lactose or glucose solution on rat intestinal disaccharidase specific activity was investigated. Methods: Adult rats were fed a diet with 10% sucrose, lactose or glucose solution supplementation. After 6 weeks, small intestines were removed and disaccharidase specific activities and sucrose mRNA levels were measured. Results: Adult rats when fed a diet with 10% sucrose, lactose or glucose solution supplementation for 6 weeks showed increased intestinal sucrose sperific activity. However, there was no increase of lactase specific activity. Slot blot analysis with radiolabeled rat intestinal sucrase cDNA revealed that mRNA levels of sucrase increased after 10% sucrose, lactose or glucose solution supplementation, and these changes in mRNA levels correlated with the corresponding enzyme specific activity (r=0.36, p<0.05). Conclusion: The results demonstrate that the induction of sucrase activity is directly associated with an increase in sucrase mRNA levels. In conclusion, substrate feeding induces an increase of transcription of rat intestinal sucrase gene.
Trinitrobenzene Sulfonic Acid에 의해 유발된 백서의 대장염에서 항염증제제의 치료효과
김재준(Jae Jun Kim),류지곤(Ji Kon Ryu),이동호(Dong Ho Lee),송인성(In Sung Song),김정룡(Chung Yong Kim),김용일(Yong Il Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2
N/A Background/Aims: The causes and pathogenesis of inflammatory bowel disease remain unknown and no definite therapy exists until now. In order to clarify the effect of Artemisia capillaris, colitis was induced by trinitrobenzene sulfonic acid(TNBS) in rats, and the effect of anti-inflammatory drugs and Artemisia capillaris was compared. Methods: Wel]-grown Sprague-Dawley rats were divided into 7 groups and colitis was induced by TNBS except the control group. Each group was treated with 1% methyl ce]lulose, prednisolone l mg/kg, sulfasalazine 100 mg/kg, prednisolone and sulfasalazine, A.capillaris 1 mg/kg and 10 mg/kg per oral route from the next day. After 2 weeks, rats were sacrificed and gross morphologic features of colons were examined. Resullts: Ulceration, adhesion, thickening and dilatation were noticed in the colonic mucosa after TNHS insti]lation. Adhesion, thickening and di]atation were significantly improved in all the treated groups, but the ulceration was significantly improved only in groups treated by prednisolone and A.capillaris 10mg/kg. Conclusions: The colitis induced by TNBS is sirnilar to the human inflammatory bowel disease and the prednisolone and A.capillaris have a healing effect on rat colitis induced by TNBS. (Korean J Gastroenterol 1996; 2S:224 - 231)