http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
3차 의료기관을 방문한 천식 환자에서 아토피 유병률의 변화
박흥우(Heung Woo Park),김상헌(Sang Heon Kim),김상훈(Sang Hoon Kim),장윤혜(Yoon Hae Chang),정희(Hee Chung),이병재(Byung Jae Lee),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.1
N/A Background: The prevalence of atopy and atopy-related disease has been known to increase during the past decade. Objective : This study was desinged to evaluate the changes of atopy prevalence among asthmatic patients and the causative allergens. Method : A total of 698 asthmatic patients visiting Seoul National University Hospital in 1983, 1990 and 1997 was recruited. Skin prick test with common inhalant allergens was carried out and interpreted as positive when the mean wheal size formed by allergen was larger than 3 mm. Atopy was defined when skin reaction to one or more allegens was positive. Result. The prevalence of atopy among asthmatic patients was 54% in 1983, 48.8% in 1990 and 58% in 1997, respectively. The prevalence of atopy decreased as the age of patients in- creased. Recently, old asthmatic patients ( >55 years) showed a higher tendency to visit the tertiary referral hospital. When the data were analyzed according to age, the prevalence of atopy significantly increased among asthmatic patients aged 15-35 years, in whom the prevalence was 60.4% in 1988 and 81.3% in 1997 (p< 0.05). The positive rate of skin test to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen were significantly higher in 1997 than in 1983 (p < 0.05). Conclusion : The prevalence of atopy among asthmatic patients aged 15-85 years showed significant increase in 1997 compared to 1983. The changes of skin response to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen contributed to the increase of atopy.
스테로이드 의존성 천식 환자에서 스테로이드와 β2-아드레날린 수용체 mRNA의 발현양상
반준우 ( Joon Woo Bahn ),오선영 ( Sun Young Oh ),김세훈 ( Sae Hoon Kim ),장윤석 ( Yoon Seok Chang ),김우경 ( Woo Kyung Kim ),김상훈 ( Sang Hoon Kim ),김윤근 ( Yoon Keun Kim ),조상헌 ( Sang Heon Cho ),민경업 ( Kyung Up Min ),김유영 대한천식알레르기학회 2003 천식 및 알레르기 Vol.23 No.2
Background:Steroid-dependency is one of phenotypes of severe asthma. Because steroid- dependent asthmatics require long-term systemic steroids to control their symptoms, they have potentially increased risks to experience serious adverse events caused by
급성 천식발작 환자에서 치료 전후의 혈청 Eosinophil Cationic Protein 농도
김윤근(Yun Keun Kim),이상록(Sang Rok Lee),손지웅(Jee Wong Son),김우경(Woo Kyung Kim),박재경(Jae Kyung Park),지영구(Young Ku Jee),송숙희(Sook Hee Song),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.3
N/A Objectives: To prevent progression to fatal asthma it is essential to assess the severity of asthma and treat adequetely. But there was no objective index to evaluate the severity of airway inflammation in asthmatic patients, So we evaluated that serum ECP concentration is a objective parameter of airway inflammation in patients with acute severe asthmatic attack. Methods: We measured the parameters of asthamtic severtity(clinical parameter, FEV1, arterial blood gas, peripheral blood eosinophil counts, and serum ECP levels) before and after antiasthmatic treatment in 9patients with acute severe asthmatic attack, And we compared serum ECP concentrations of severe asthmatic patients with those of control patients with mild to moderate severity. Results: 1) The serum ECP levels in patients with acute asthmatic attacks compared to patients with mild to moderate, asthmatic severity were significantly increased. 2) The serum ECP levels and pheriperal blood eosinophil counts 2hours after antiasthmatic treatment were significantly lower than the value before treatment, but the total scores of clinical parameter, FEV1, and scores of arterial blood gases were not significantly different from the basal values, Conclusion: It is suggested that the serum ECP level is a objective parameter as a response to antiasthmatic treatment as well as a severity of airway inflammation in patients with acute asthmatic attack.
성인에서 기관지과민성과 폐기능의 지표로서 High-Sensitivity C-Reactive Protein의 의미
김민혜 ( Min Hye Kim ),김세훈 ( Sae Hoon Kim ),강혜련 ( Hye Ryun Kang ),박흥우 ( Heung Woo Park ),장윤석 ( Yoon Seok Chang ),김동희 ( Dong Hee Kim ),조상헌 ( Sang Heon Cho ),민경업 ( Kyung Up Min ),김유영 ( You Young Kim ),김선신 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.2
Background: Bronchial hyperresponsiveness is a characteristic feature of asthma and closely related with airway inflammation in part. Serum high-sensitivity C-reactive protein (hs-CRP) is a very sensitive marker for systemic inflammation, and several studies has reported the association between hs-CRP and bronchial hyperresponsiveness. Objective: The objectives of this study are to evaluate the association between hs-CRP and bronchial hyperresponsiveness or lung function in healthy Korean subjects. Method: A total of 7,709 subjects underwent methacholine bronchial provocation tests in Seoul National University Hospital health care Gangnam center from October 2003 to January 2009. Among them, 508 subjects were positive for the methacholine bronchial provocationtest. Another 508 subjects negative for the test were enrolled as control, who were matched for age, sex and body mass index. We reviewed the medical records and compared serum hs-CRP levels and the results of the methacholine bronchial provocation test and pulmonary function tests. Result: Bronchial hyperresponsiveness was more frequently observed in subjects with higher hs-CRP levels (group IV). (24.6% vs. 14.8%) than in subjects with lower hs-CRP levels (group I). There was a negative correlation with hs-CRP levels and FEV1, FVC or FEV1/FVC. Conclusion: There was a negative association between serum hs-CRP levels and bronchial hyperresponsiveness or lung function. (Korean J Asthma Allergy Clin Immunol 2009;29:112-116)
집먼지진드기에 감작된 비염환자에서 메타콜린에 대한 기관지과민성의 증가
김우경,반준우,이병재,김윤근,조상헌,민경업,김유영 (Woo Kyung Kim,Jun Woo Bahn,Byung Jae Lee,Yoon Keun Kim,Sang Heon Cho,Kyung Up Min,You Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.2
Background: Allergic rhinitis is often associated with bronchial asthma, and intranasal treatment with topical corticosteroids reduces bronchial responsiveness. Objective '. In this study, it was evaluated that the bronchial responsiveness to methacholine increased in non-asthmatic adults with house dust mites (HDM)-sensitive allergic rhinitis compared to those without, chronic nasal symptoms. Subjects and methods .' A questionnaire, skin prick t,est to common inhalant allergens, and methacholine bronchial provocation test (MBPT) were performed in a total of 216 subjects, who were composed of 40 non-asthmatic subjects with HDM-sensitive allergic rhinitis (HAR), 63 HDM-sensitive subjects without nasal symptoms (HS), and 113 non-atopic subjects without nasal symptoms (NHS). The bronchial responsiveness was evaluated by positive rate of MBPT (PC,-methacholine200mg/ml), provocative concentration of methacholine at which FEV, decline to 15% compared to baseline value (PC,-methacholine), and slope of dose-response curve (%fall of FEV, / log[last concentrat,ion of methacholine, mg/ml]). Results '. Positive rate of MBPT was significantly increased in HAR than in HS and NHS, and there was no difference between HS and NHS (77.9% vs. 50.7% vs. 38.0%). Log PC[5- methacholine was lower in HAR than in HS and NHS, and lower in HS than in NHS (mean+ SE, 1.568+0.126 vs. 2.05+0.085 vs. 2.277+0.047). Slope of dose-response curve was higher in HAR than in HS and NHS, and there was no difference bet,ween HS and NHS (mean+SE, 22.7 + 11.3 vs. 7.3+ 1.2 vs. 4.9+ 0.5%/mg/ml); Conclusion .' In non-asthmatic adults with HDM-sensitive allergic rhinitis, the bronchial responsiveness to methacholine increased compared to those without chronic rhinitis.
건강한 성인에서 폐기능과 혈청 Carcinoembryonic Antigen (CEA) 수치와의 연관성
정재우 ( Jae-Woo Jung ),최승호 ( Seung Ho Choi ),김세훈 ( Sae Hoon Kim ),강혜련 ( Hye Ryun Kang ),박흥우 ( Heung Woo Park ),장윤석 ( Yoon Seok Chang ),김선신 ( Sun Sin Kim ),조상헌 ( Sang Heon Cho ),민경업 ( Kyung Up Min ),김유영 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.1
Background: Carcinoembryonic antigen (CEA), a serological marker of malignant tumors, may show a modest increase under some nonmalignant conditions, such as aging and cigarette smoking. Objective: We analyzed clinical characteristics according to smoking status and determined whether serum CEA levels are associated with pulmonary function. Method: The cross-sectional data from 2,691 subjects who participated in health screening programs were analyzed. The subjects were divided into 3 categories according to smoking status: never-smokers, former smokers and current smokers. A systematic method to derive an optimal cutoff point of CEA which indicates the difference in FEV1% was used. Result: Smoking status was associated with increased serum CEA levels, WBC counts and neutrophil counts and decreased FEV1% in never-smokers, former smokers and current smokers with increasing correlation. Logistic regression analysis adjusted for age and sex showed no differences in FEV1%, WBC counts and neutrophil counts between never-smokers and former smokers. Logistic regression analysis adjusted for age, sex, BMI and smoking amount in former and current smokers showed significant differences in FEV1, WBC counts and neutrophil counts between those with a CEA level of <2.0 and those with a CEA level of ≥2.0. Conclusion: Our results suggest that smoking cessation may affect recovery of systemic inflammation and decreased lung function. A slight elevation in serum CEA in former or current smokers may be associated with systemic inflammation and decreased pulmonary function. (Korean J Asthma Allergy Clin Immunol 2010;30:30-35)