한국인 소아에서 분리한 Helicobacter pylori 균주의 항균제 내성률

김유미,이연주,오석희,성흥섭,김미나,김경모,Kim, Yoo-Mi,Lee, Yeoun-Joo,Oh, Seak-Hee,Sung, Heung-Sup,Kim, Mi-Na,Kim, Kyung-Mo 대한소아소화기영양학회 2011 Pediatric gastroenterology, hepatology & nutrition Vol.14 No.1

목 적: Helicobacter pylori (H. pylori) 제균 치료의 적절한 항균제 선택의 기반이 되기 위해 소아에서 H. pylori 항균제 내성률을 알아보고자 하였다. 방 법: 2003년 7월부터 2009년 4월까지 상복부 통증으로 본원을 방문한 환자 중 위 문부 생검 조직 배양에서 H. pylori 가 동정된 균주를 대상으로 항균제 감수성 검사를 시행하였다. 감수성 검사는 clarithromycin과 amoxicillin은 디스크 확산법으로, tetracycline과 metronidazole은 E-test를 시행하였다. 치료 원칙은 감수성 결과가 확인 된 환자는 감수성 결과에 따라 항균제를 선택 하였고, BAM (bismuth subsalicylate, amoxicillin, metronidazole) 또는 OAC (omeprazole, amoxicillin, clarithromycin)를 바탕으로 한 경험적 삼제요법을 택하였다. 치료 실패 시에는 bismuth (또는 bismuth subsalicylate)를 포함한 사제요법을 선택하였다. 결 과: 33명의 환자가 배양검사 양성을 보였고 28명의 환자에서 감수성 검사를 시행하였다. 이 중 항균제 내성을 보인 환아는 9명(32.1%)으로 그 중 7명(25%)이 clarithromycin 내성 균주를 보였고 5명(17.8%)이 metronidazole 내성 균주를 보였다. 대상이 적어 통계적인 분석을 하지 못하였으나 Clarithromycin과 metronidazole의 내성률이 시기적으로 감소하는 추세를 보였다. 결 론: 본 연구는 단일 병원에서 소수의 환아를 대상으로 이루어진 연구로 한계가 있으나, 간접적으로 국내소아 환아에서 분리된 H. pylori의 균주에서도 높은 항균제 내성과 시기적으로 내성률이 변하는 것을 알 수있었다. 따라서 소아 환자에서 적절한 항균제 선택을 제시하기 위한 보다 광범위한 연구가 필요한 것으로 생각한다. Purpose: The antimicrobial resistance of Helicobacter pylori is one of the critical factors in failure of eradication therapy. The purpose of this study was to evaluate antimicrobial resistance of H. pylori in Korean children. Methods: Gastric mucosal specimens for H. pylori were obtained from children with dyspepsia who were cared for at Asan Medical Center Children's Hospital in Seoul, Korea between 2003 and 2009. Antimicrobial resistance tests were performed using the disk diffusion method for clarithromycin and amoxicillin and the E-test for metronidazole and tetracycline. Most children with H. pylori infections were treated using triple therapies. Results: Thirty-three children had positive H. pylori cultures, although a resistance test was only performed in 28 patients. Resistant strains were found in 9 children (32.1%). The resistance rates to clarithromycin and metronidazole were 25% and 17.8%, respectively. There was no resistance to amoxicillin or tetracycline. The resistance rates decreased from 44.4% (2003~2006) to 26.3% (2006~2009) during the study period. Conclusion: Korean children demonstrated relatively high antimicrobial resistance to H. pylori in this study. However, there was a temporarily decreasing trend during the study period. A larger multi-regional study may be needed to determine the optimal antimicrobial treatment for pediatric patients infected with H. pylori.

대전, 충청 지역에서 판매되는 즉석식품의 트랜스지방 및 조지방 함량 모니터링

김유미,허옥순,이기택,Kim, Yu-Mi,Heo, Oak-Sun,Lee, Ki-Taek 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.8

This study was designed to determine the trans fatty acid (tF A) contents of 41 take-out food items in Daejeon and Chungcheong Province. Total fatty acid composition and tFA contents of samples were determined by gas chromatography (GC) after fat extraction (Folch method). Maximum fat content among the observed samples was obtained from theater popcorn (13.74${/cdot}$38.09%) while minimum content was observed from the glutinous rice doughnut. 31${/cdot}$5.44%). The contents of tFA (g/100 g food) in toasts, glutinous rice doughnut and ggwabaegi (twisted doughnut sold in streets) ranged from 0.02 to 0.56 g while those in fried sweet potatostick (from highway resting place), fried squid and theater popcorn ranged from 0.05 to 3.08 g/100 g. As a result, most samples showed the tFA content as less than 1 g (g/100 g food) except one sample from theater popcorn which contained 3.08 g (g/100 g food) as tFA content. 대전 및 충청 지역에서 판매되고 있는 즉석식품의 조지방 및 트랜스지방산의 함량을 조사하고자 찹쌀도넛과 꽈배기 각각 6종, 고구마 스틱 2종, 토스트 9종, 그리고 멀티플렉스 극장 팝콘 11종 등 총 41종을 수거하여 분석하였다. 조지방 함량은 멀티플렉스 극장 팝콘 13.74${\sim}$38.09%로 가장 높았으며, 고구마 스틱 20.82${\sim}$20.88%, 오징어 튀긴 9.37${\sim}$25.53%등의 순이었다. 수거한 시료는 유탕처리 식품이었으며, 멀티플렉스 팝콘은 전자렌지용 팝콘과 달리 트랜스지방산 함량이 매우 적게 분석된 것으로 보아 식물성 부분 경화 유지를 상요하지 않은 것으로 보인다. 트랜스지방산 함량은 대부분 1 g(g/100 g food) 미만으로 낮았으나, 멀티플렉스 극장 팝콘 중 한 시료만이 3.08 g(g/100 g food)으로 높게 나타났다.

침술 후 발생한 표재 비골 신경 및 심 비골 신경의 손상(1예 보고)

김유미,Kim, Yu-Mi 대한족부족관절학회 2011 대한족부족관절학회지 Vol.15 No.3

Acupuncture has been widely used to treat a variety of disease and symptoms. But various complications have been reported. Among them, peripheral nerve injuries have been reported less frequently than other complications. The purpose of this report is to describe what we believe to be the first case of delayed superficial and deep peroneal nerve compressive neuropathy caused by fibrotic mass formed by neglected broken acupuncture needle.

저온 다결정 실리콘 박막 트랜지스터의 비정상적인 Hump 현상 분석

김유미,정광석,윤호진,양승동,이상율,이희덕,이가원,Kim, Yu-Mi,Jeong, Kwang-Seok,Yun, Ho-Jin,Yang, Seung-Dong,Lee, Sang-Youl,Lee, Hi-Deok,Lee, Ga-Won 한국전기전자재료학회 2011 전기전자재료학회논문지 Vol.24 No.11

In this paper, we investigated an anomalous hump phenomenon under the positive bias stress in p-type LTPS TFTs. The devices with inferior electrical performance also show larger hump phenomenon. which can be explained by the sub-channel induced from trapped electrons under thinner gate oxide region. We can confirm that the devices with larger hump have larger interface trap density ($D_{it}$) and grain boundary trap density ($N_{trap}$) extracted by low-high frequency capacitance method and Levinson-Proano method, respectively. From the C-V with I-V transfer characteristics, the trapped electrons causing hump seem to be generated particularly from the S/D and gate overlapped region. Based on these analysis, the major cause of an anomalous hump phenomenon under the positive bias stress in p-type poly-Si TFTs is explained by the GIDL occurring in the S/D and gate overlapped region and the traps existing in the channel edge region where the gate oxide becomes thinner, which can be inferred by the fact that the magnitude of the hump is dependent on the average trap densities.

유방에서 선근상피세포종의 유방촬영술 및 초음파 소견: 증례 보고

김유미,Kim, Yu-Mi 대한영상의학회 2003 대한영상의학회지 Vol.49 No.6

유방의 선근상피세포종은 매우 드문 질환으로 이의 희귀성 때문에 방사선학적인 소견도 잘알려져 있지 않아 진단이나 치료에 대한 정보도 드물다.저자는 유방 종괴를 주소로 내원하여 조직 검사와 면역조직화학검사에서 각각 양성과 악성 선근상피세포종으로 진단된 2예를 보고 하고자 한다. Adenomyoepithelioma is very rare. Because of its rarity, adeonomyoepithelioma may present a diagnostic challenge to the radiologists and there is a little information on the diagnosis and treatment of this condition. I report on two patients with benign and malignant adenomyoepitheliomas which represent breast masses on mammograms and ultrasonograms. The diagnosis was confirmed by immunohistochemical study of the resected specimens

한 농촌 지역 일반 성인의 휴지기 심전도 상 ST 분절 하강과 관련 요인

김유미,김미경,신진호,임헌길,백도명,최보율,Kim, Yu-Mi,Kim, Mi-Kyung,Shin, Jin-Ho,Lim, Heon-Kil,Paek, Do-Myung,Choi, Bo-Youl 대한예방의학회 2006 예방의학회지 Vol.39 No.6

Objectives : To measure the distribution of electrocardiographic ST segment depression, and evaluate its relationships with cardiovascular risk factors based on the cross-sectional studies within a rural Korean community Methods : This study analyzed 1,343 persons, over 40 years old, who participated in a baseline survey during 2002-2005; the exclusion criteria included: a past history of myocardial infarction and angina pectoris, and specific conduction abnormalities. A Standard 12 leads ECG was recorded using an FCP-2101 (Fukuda Denshi Co.). The ST segment depression was retrospectively measured by a physician, according to the Minnesota code classification. Results : ST segment depression was found in 3.6 and 6.4% of male and female participants, respectively. After adjusting for age, gender, smoking, physical activity and obesity differences, high blood pressure showed significant relations with ST depression in females (male ORs=2.67, 95% CI=0.85-8.50; female ORs=2.62, 95% CI=1.29-5.32) Conclusions : As an ischemic ECG sign, ST depression was related to hypertension in female participants. This relationship remained significant, even after cases with left ventricular hypertrophy were removed.

A neonate with hyperornithinemia-hyperammonemia-homocitrullinuria syndrome from a consanguineous Pakistani family

김유미,임한혁,Mi Hyeon Gang,Yong Wook Lee,Sook Za Kim,Gu-Hwan Kim,Han-Wook Yoo,Jung-Min Ko,Meayoung Chang 대한의학유전학회 2019 대한의학유전학회지 Vol.16 No.2

Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a rare autosomal recessive urea cycle disorder. HHH is caused by a deficiency of the mitochondrial ornithine transporter protein, which is encoded by the solute carrier family 25, member 15 (SLC25A15) gene. Recently, government supported Korean newborn screening has been expanded to include a tandem mass spectrometry (MS/MS) measurement of ornithine level. We report a case of a neonate with HHH syn-drome showing a normal MS/MS measurement of ornithine level. A female newborn was admitted to neonatal intensive unit due to familial history of HHH syndrome. Her parents were consanguineous Parkistani couple. The subject’s older sister was diagnosed with HHH syndrome at age of 30 months based on altered mental status and liver dysfunction. Even though the subject displayed normal ammonia and ornithine levels based on MS/MS analysis, a molecular test conἀrmed the diagnosis of HHH syndrome. At 1 month of age, amino acid analysis of blood and urine showed high levels of ornithine and homoc-itrulline. After 11 months of follow up, she showed normal growth and development, whereas affected sister showed progres-sive cognitive impairment despite no further hyperammonemia after protein restriction and standard therapy. Our report is in agreement with a previous Canadian study, which showed that neonatal samples from HHH syndrome patients demonstrate normal ornithine levels despite having known mutations. Considering the delayed rise of ornithine in affected patients, ge-netic testing, and repetitive metabolic testing is needed to prevent patient loss in high risk patients.

대전, 충천 지역 제빵류의 조지방 및 트랜스 지방산 함량 조사

김유미,허옥순,이기택,Kim, Yu-Mi,Heo, Oak-Sun,Lee, Ki-Teak 동아시아식생활학회 2007 동아시아식생활학회지 Vol.17 No.4

대전, 충청(청주, 천안)지역의 제과점에서 수거한 제빵류 42개의 시료에서 조지방을 추출하고 이것을 Gas Chromatography(GC)를 이용하여 트랜스 지방의 함량을 분석하였다. 수거한 시료는 생크림 케이크 9개, 페이스츄리 9개, 슈크림 7개, 크로켓 9개, 찹쌀 도넛 8개였다. 추출한 시료의 조지방 함량은 페이스츄리 10.67$\sim$34.26%로 가장 높은 조지방 함량을 보였으며, 찹쌀 도넛은 1.44$\sim$4.34%로 가장 낮은 조지방 함량을 보였다. 트랜스 지방의 함량은 생크림 케이크 0.03$\sim$1.31 g/100 g of food, 페이스츄리가 0.21$\sim$2.69 g/100 g of food, 슈크림 0.09$\sim$0.43 g/100 g of food, 크로켓 0.22$\sim$1.99g/100 g of food, 찹쌀 도넛 0.02$\sim$0.38 g/100 g of food로 페이스츄리가 시료들 중에서 가장 높은 함량을 나타내었으며, 분석한 시료들 중에서 트랜스지방의 함량이 2 g/100g of food를 초과하는 시료가 모두 페이스츄리에서 검출되었다. Bakery food items distributed in Chung-cheong province Daejeon, Cheonan, and Cheongju) were studied to determine their contents of total crude fat and trans fatty acids (TFA). After fat extraction by the Folch method, methylation was carried out to analyze the fatty acid compositions by GC, using a SP-2560 column and flame ionization detector. The total fat contents of the foods were in the approximate range of 2$\sim$34%. The total fat contents of the items were as follows: whipping cream cake : 0.03$\sim$1.31 (g/100 g food), pastries = 0.21$\sim$2.64 (g/100 g food), cream puff = 0.09$\sim$0.43 (g/100 g food), croquette = 0.22$\sim$1.99 (g/100 g food), and glutinous rice doughnut = 0.03$\sim$0.38 (g/100 g food).

인터넷 정보조사를 통한 국내 환자용 식품의 판매가격과 영양 함량 평가

김유미,서유리,김미현,최미경,Kim, Yu-Mi,Seo, Yu-Lee,Kim, Mi-Hyun,Choi, Mi-Kyeong 한국식품영양학회 2021 韓國食品營養學會誌 Vol.34 No.1

The purpose of this study was to examine the relationship between the regular selling price and nutrient contents of foods used for special medical purposes in Korea. This study investigated the regular selling price and nutritional composition of 114 enteral nutrition (EN) foods on the manufacturer's internet homepage. The average price of the total products was 1,156.0 won/100 mL. The price of foods used for calorie and nutrient supplementation (CNS) was significantly higher compared to that of the other EN food types (p<0.01). With respect to the nutritional content per 100 mL of the product, EN foods for CNS had significantly higher contents of energy, protein, 5 minerals, and 7 vitamins than the other EN food types. On comparing the nutritional contents of foods according to the price, the balanced nutrition foods showed significantly higher contents of energy, carbohydrate, protein, 3 minerals, and 7 vitamins in high-priced products than in low-priced foods. Summarizing these results, foods for CNS were approximately twice as expensive as the other EN foods, and the energy, protein, mineral, and vitamin contents were also high. Balanced nutrition foods had higher nutrient contents in high-priced products, which showed the relationship between the product price and nutrient content.

전파 분석 알고리즘 및 전파 간섭 분석 기준 연구를 통한 전파 관리 시스템 기능 강화 방안 도출

김유미,이일근,배석희,Kim, Yu-Mi,Rhee, Ill-Keun,Bae, Suk-Hee 한국전기전자학회 2003 전기전자학회논문지 Vol.7 No.2

본 연구에서는 전파관리시스템(RFMS)의 효율적 운용을 위하여 전파전파 분석 기능 개선 방안을 도출하였다. 즉, ITU-R에서 권고하는 파라미터별 전파전파 알고리즘, 간섭분석 알고리즘 및 공유기준들에 대한 체계적인 분석을 수행한 후, 사용자가 원하는 환경 및 조건에 적합한 전파간섭 분석 알고리즘과 보호기준을 자동으로 선택해 낼 수 있는 모델 선정 기준안을 도출하였다. 이 결과를 이용하여 RFMS에서 최적의 전파 간섭 분석 알고리즘을 자동 선택하여 효율적으로 분석을 수행하도록 해주는 프로그램 및 그 활용 예를 제시하였다. This paper proposed an improvement scheme for effective usage of radio-frequency management system(RFMS), which has been operated to facilitate national spectrum management and monitoring in Korea. Based on the wave propagation models, interference analysis algorithms, and sharing criteria recommended by ITU-R, we derived criteria for the automated selection of the channel interference analysis algorithms and sharing conditions adequate to the environment to be analysed. Then using the obtained criteria, computer and program has been made and shown to select the most appropriate propagation models, interference analysis algorithms, and sharing criteria from the ones provided in RFMS, with the illustrative example.