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김용규,신재공,박종원,홍경수,이승연,오홍석,이용석,곽용태,장재승,이유상,Kim, Yong-Kyu,Shin, Jae-Kong,Park, Chong-Won,Hong, Kyung Sue,Lee, Seung-Yeoun,Oh, Hong-Seok,Lee, Yong-Suk,Kwak, Yong-Tae,Chang, Jae Seung,Lee, Yu-Sang 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2
Objectives:EEG coherence could imply the connectivity between two different areas of the brain, which is known to be important in the pathophysiology of bipolar I disorder(BPD I) and schizophrenia. The authors investigated EEG coherence in patients with BPD I and schizophrenia to examine the connectivity of the neural circuit. Methods:EEGs were recorded in 15 schizophrenia and 14 bipolar disorder patients, and 14 age-matched normal control subjects from 16 electrodes with linked-ear reference. Spectral parameters and coherence were calculated for the alpha bandwidth(8-13Hz) by a multi-channel autoregressive model using 20 artifact-free 2-seconds epochs and the differences were compared among three groups by two different statistical methods;F-test and Kruskal-Wallis test. Furthermore, when there were significant differences among three groups, Scheffe's multiple comparison tests were provided and Jonckheere-Terpstra tests for the ordered alternative were given. Results:In the intra-hemispheric comparison, left frontal coherence was increased in order of control, BPD I and schizophrenia. In the inter-hemispheric comparison, 1) inter-prefrontal coherence in BPD I was signifi- cantly higher than in normal controls, and 2) inter-prefrontal coherence in schizophrenia was significantly lower than in controls. Conclusion:These results suggest that 1) both schizophrenia and BPD I are diseases having the abnormality of neural circuit connectivity in both frontal and prefrontal lobes, and 2) the abnormality is more severe in schizophrenia than in BPD I. Furthermore, the data support that a common pathogenetic process may reside in both schizophrenia and BPD I.
김용규,최성락,Yong-Kyu Kim,Sung-Nak Choi Korean Chemical Society 1986 대한화학회지 Vol.30 No.5
$Ni^{2+}$와 D-penicillamine사이의 착물형성반응에 대한 반응속도 및 평형에 관한 수용액중에서 실시하였다. 속도론적 실험은 압력-급변법을 사용하여 pH8~9범위에서 실시하였다. D-Penicillamine은 질소와 유황원자를 주게로 하여 pH>9.2조건에서 $Ni^{2+}$이온에 배위하나 pH값 8.25∼9.07범위에서 총괄 안정도 상수값이 급격히 감소하며 비해리된 mercapto기가 결합에 참여하지 않는 것으로 밝혀졌다. 또한 이 착물 형성반응에 있어 율속단계는 $Ni^{2+}$이온의 내부 배위권으로 부터 물분자가 유리되는 과정임이 밝혀졌다. Rates and equilibriurn of complex formation between $Ni^{2+}$ and D-penicillamine have been investigated in aqueous solutions. Kinetic study on the complex formation were performed in the pH range of 8∼9 by the use of pressure-jump technique. D-Penicillamine coordinates to the nickel(II) ion utilizing sulfur and nitrogen as donor atoms in the high pH condition (pH 9.2). However, in the pH range of 8.25∼9.07, the stepwise stability constant becomes drastically reduced and the undissociated mercapto group does not participate in bonding. The rate-determining step of the complexation reaction is found to be the release of a water molecule from the inner-coordination sphere of $Ni^{2+}$ ion.
김용규,남상열,Kim, Yong Kyu,Nam, Sang Yul The Korean Society for Integrative Biology 1969 동물학회지 Vol.12 No.2
붕어, 비둘기, 흰쥐의 肝組織內의 蛋白質含量과 蛋白質代謝에 관하여는 GDH, GOT 및 GPT의 活性과 比較活性, 그리고 GDH 同位酵素를 測定하였다. 1. 蛋白質含量은 흰쥐, 비둘기가 各各 22.0$\pm$0.01mg/ml 및 22.0$\pm$0.16으로서 거의 같은 量의 蛋白質含量으로 組成되었으나 붕어의 肝臟組織內 蛋白質含量은 約 60%에 該當하는 13.0$\pm$0.09이었다(p < 0.01). 2. Glutamic transaminase는 흰쥐, 비둘기, 붕어의 순위로 그 活性度가 낮았다. 卽 GPT의 比較活性은 各各 3.77$\pm$0.18 unit/mg, 1.93$\pm$0.01 및 0.71$\pm$0.07 이었으며 GOT는 8.23$\pm$0.06 unit/mg, 3.95$\pm$0.09 및 0.92$\pm$0.01이었다(p < 0.01). 3. GOT/GDT 比는 흰쥐, 비둘기, 붕어에서 各各 0.20$\pm$0.004, 0.22$\pm$0.005 및 0.20$\pm$0.002로서 별 차이 없었다. 4. GDH 比較活性은 비둘기가 가장 높은 35.7$\pm$0.81 unit/mg이고 붕어는 9.6$\pm$0.16, 흰쥐는 20.5$\pm$0.81이었다. 5. Glutamic transaminase 와 GDH 比較活性이 動物의 種類에 따라 병행하였으며 特히 進化過程과 一致되는 것으로 思料된다. 6. GDH 同位酵素의 樣相은 種特異性이 뚜렷하였다. 흰쥐에서는 음극이 遲延性易動度區劃의 活性이 가장 높았으나, 비둘기에서는 兩極性區劃의 活性이 가장 높았다. 特히 魚類에서는 陰極性區劃이 全然 發見되지 않았으나 兩極性에 4個의 區劃을 볼수 있었다. The present investigation involves a comparative study of enzymatic activities in various animals. The levels of the liver protein of rat (22.0$\pm$0.01mg/ml and pigeon (22.0$\pm$ 0.16) are twice as high as that of crucian carp (13.0$\pm$ 0.09)(p < 0.01). Generally, the specific acitivity (3.77 $\pm$0.18 unit/mg) of rat glutamic pyruvic transaminase (GPT) is highest, pigeon intermediate (1.93 $\pm$0.01), and crucian carp lowest (0.71$\pm$0.07). On the other hand, the specific activity (8.23$\pm$0.09 unit/mg)of rat glutamic oxaloacetic transaminase (GOT) is highest, pigeon intermediate (3.95$\pm$0.09), and crucian carp lowest (0.92$\pm$0.01) (p < 0.01). Ratios of GOT activity to GPT activity appear no remarkable difference from the levels of various animals. Specific activity of glutamic dehydrogenase(GDH) in pigeon tissue exceeds those of rat and crucian carp. In liver, rat GOT specific activity is greater than crucian carp and pigeon. On the other hand, pigeon GDH specific activity is greater than those of rat and crucian carp. This wouls seem to be in accord with protein metabolic intensity. The patterns for GDH isozyme were remarkably appeared in various animals. Glutamic dehydrogenase isozymes gave different electrophoretic mobilities in various animals. It is interesting that crucian carp, pigeon, and rat would show this difference, which may be indicative of an evolutional pattern. The fact that livers in various animals show quite different enzyme activities would suggest the existence of such a general phylogenetic relationship.
수포각막병증에서 각막문신술과 양막이식술 동시 시행 7예
김용규,한영근,위원량,이진학,권지원,Yong Kyu Kim,Young Keun Han,Won Ryang Wee,Jin Hak Lee,Ji Won Kwon 대한안과학회 2008 대한안과학회지 Vol.49 No.3
`Purpose: We report on the clinical efficacy of the combined operation of corneal tattooing and amniotic membrane transplantation on the treatment of bullous keratopathy in patients with poor visual potentials. Case summary: We performed corneal tattooing and amniotic membrane transplantation in 7 eyes with bullous keratopathy. Postoperatively, we assessed the status of corneal reepithelialization, postoperative pain, and cosmetic effects. In all cases but one, corneal reepithelialization was successful without pain, and the corneal tattooing persisted throughout the follow-up period. In one case, a corneal epithelial defect developed, so we performed an additional amniotic membrane transplantation. After 2 weeks, the corneal epithelial defect healed and caused no further pain. Conclusions: The combined operation of corneal tattooing and amniotic membrane transplantation is a good choice for the treatment of bullous keratopathy with regard to cosmetic problems, pain, and poor visual potential.`
김용규(KIM Yong-Kyu),백종현(BAEK Jong-Hyun),최경일(CHOI Kyoung-Il),류근수(YOO Keun-Su) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
Surge proof equipment is an installation to make surge flow on the ground promptly so as to reduce surge-related damage on infrastructure, not to prevent surge from falling down on infrastructure directly. Compared with classical line individual earth, High speed line common earth has higher surge characteristic and plays a significant role to prevent infrastructure damage and injuries from surge, or short circuit accident between 25kV catenary and rail. In this paper, we analyzed the case of accident that caused communication/signaling system impaired while a tractor crossing level crossing at Honam line; in addition, we examined the accident reduction measures to minimize injury and property damage from cutting accidents with respect to common earth network.
12주간 필라테스운동이 비만여성의 Retinol-binding protein 4, 체지방률 및 HOMA 지수에 미치는 영향
김용규 ( Kim Yong-kyu ),이정윤 ( Lee Jeoung-yun ),이서형 ( Lee Seo-hyung ) 한국무용과학회 2017 한국무용과학회지 Vol.34 No.2
본 연구의 목적은 필라테스 운동이 중년 비만여성의 RBP-4 와 HOMA 지수에 미치는 영향을 알아보는데 있다. 연구대상으로는 체지방률 30%이상 되는 비만여성 26명을 무선표집하여 운동집단 13명, 통제집단 13명으로 나누어 필라테스 운동을 12주 동안 실시하였다. 분석변인으로는 RBP-4, 체지방률, 인슐린, 글루코스 및 HOMA 지수를 분석하였으며 모든 데이터는 SPSS23.0을 이용하여 평균과 표준편차를 구하였으며 반복측정에 의한 이원분산 분석(two-way ANOVA repeated measures), independent t-test를 이용하여 통계처리 하였다. 그 결과 다음과 같은 결론을 얻었다. 첫째 RBP-4는 운동 군에서 유의한 감소를 보였으나 통제군 에서는 유의한 변화가 없었다. 둘째 체지방률은 운동 군에서 유의한 감소를 보였으나 통제 군에서는 유의한 변화가 없었다. 셋째 인슐린, 글루코스 및 HOMA 지수는 운동 군에서 유의한 감소를 보였으나 통제 군에서는 유의한 변화를 보이지 않았다. 본 연구결과 필라테스 운동은 체지방감소를 통한 RBP-4, 인슐린저항성에 긍정적인 영향을 미친 것으로 보인다. The purpose of this study was to evaluate the effects of pilates exercise on Retinol-binding protein 4, %body fat and HOMA index in obese middle-aged women. In this study, 26 subjects were divided into 2 groups, exercise(n=13) and control group(n=13), participated in this study for 12 weeks. The untrained obese women in I city voluteered to participate in this study. RBP-4, , %body fat, insulin, glucose and HOMA index were analyzed before and after 12-weeks exercise intervention.. All data were expressed as mean±sd by using SPSS package program(win 23.0). The results of this study were as follows : RBP-4(P<.01), %body fat(P<.01) were significantly decreased in the exercise group. Insulin(P<.01), glucose(P<.01) and HOMA index(P<.01) were significantly reduced in the exercise group. It was concluded that pilates exercise favorably affects the RBP-4, %body fat and insulin resistance. Therefore, 12weeks pilates exercise may be beneficial to prevent and improve obesity and circulatory disease in obese subjects.