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      • [KCERN 56차 포럼 보고서] 기후변화의 전령사 미세먼지 목차

        김영우,박노언,이민화,김다해,주강진,김애선,윤예지,김예지,황동규 KCERN 2019 포럼보고서 Vol.- No.56

        1. 세계경제포럼(WEF)을 비롯한 주요 미래 연구 기관들은 인류 최대 위협으로 ‘기후변화’를 지목하고 있으나 기후 변화의 주범인 에너지 소비는 줄지 않고 있으며 시민들의 참여는 저조한 상황이었음 2. 기후변화와 미세먼지는 탄소경제라는 동일한 원인의 다른 결과로써 미세먼지 해결을 위한 노력은 기후변화의 대책이기도 하므로, 미세먼지는 인류를 기후변화 위협를 알리는 전화위복의 전령사가 될 수 있음 3. 미세먼지 문제 해결을 위해서는 우선 미세먼지 평균이 아닌 최근 3년간 증가한 고농도 초미세먼지 경보에 초점을 맞추어 문제를 단순화해야 함 4. 미세먼지 원인으로 중국 발 미세먼지의 계절적 영향, 국내 디젤 차량의 증가, 기후온난화로 인한 대기정체, 원자력 감축에 따른 석탄 발전 증가 등이 지목되고 있으나 고농도 초미세먼지의 최근 급증 현상에 대한 근본 원인은 될 수 없음 5. ‘겨울 · 봄철’ 고농도 PM2.5 초미세먼지 3년내 경보 급증에 대하여 양쯔강 기단의 활성화에 따른 서풍의 영향이 계절성을 설명하고, 최근 3년 사이 중국 동해안 일대에 100기 이상의 석탄 발전소와 90기의 쓰레기 소각장 건설과 중국 물류 이동 입항 선박들의 미세먼지 증가가 3년 내 경보 급증을 설명함 6. 이에 따라 한국의 미세먼지 저감 대책을 다음과 같이 제시함 ① 첫 번째, 「단기 국내대책」 GIS기반 미세먼지 실 · 내외 맵을 구축하고, 에어컨 헤파필터를 활용한 실내 미세먼지 저감 효과 검증과 실외 대책으로 택시미세먼지 간이 측정기(인공지능을 활용하여 표준측정기에 연동한 계절 · 기타요인 보정 가능)로 도시 미세먼지 맵을 바탕으로 차량 헤파필터 등의 대안의 효과를 검증하며, 1 단계 조치는 100억원 대 예산 투입의 가성비 높은 대책이 될 것임 ② 두 번째, 「중기 해외대책」 중국과의 공조를 통해 중국 동부 연안의 산업 미세먼지 측정과 개선을 유도하고 이에 대한 인센티브 제공 대안을 제시 ③ 세 번째, 「장기 대책」 미세먼지에 대한 스마트 트랜스폼 상관관계 모델링 작업을 통하여 종합적 미세먼지 대안 제시

      • KCI등재

        다산과 대진의 『맹자』 해석 비교 연구

        김영우 서울대학교 규장각한국학연구원 2008 한국문화 Vol.43 No.-

        This article compares two interpretations on Mencius, one by Dai Zhen, the representative bibliographical scholar from Qing dynasty, and the onther by Dasan Chong Yag-yong, the most notable scholar of Practical Learning School from Chosun dynasty. What two scholars shared in common was that they strongly opposed the interpretation through NeoConfucian notions and propagated the historical and bibliographical research in interpreting the classical literature. On the other hand, the two scholars differ sharply in their aim and problematik as they opposed Zhu Xi’s interpretation on Mencius. That is, while Dai Zhen criticized the socio-cultural oppression caused by conceptualized morality that is detached from real-life desire, Dasan, through his theory of ‘nature as moral appetite’, attempted to uncover the fact that determining moral subjectivity is nothing but free-will of humankind, and that humans hold the key to moral responsibility and practice. In short, Dai Zhen stressed the capacity of mind that discerns the principle (li), and Dasan emphasized the mind’s autonomous making of moral decision to follow the human nature. This article compares two interpretations on Mencius, one by Dai Zhen, the representative bibliographical scholar from Qing dynasty, and the onther by Dasan Chong Yag-yong, the most notable scholar of Practical Learning School from Chosun dynasty. What two scholars shared in common was that they strongly opposed the interpretation through NeoConfucian notions and propagated the historical and bibliographical research in interpreting the classical literature. On the other hand, the two scholars differ sharply in their aim and problematik as they opposed Zhu Xi’s interpretation on Mencius. That is, while Dai Zhen criticized the socio-cultural oppression caused by conceptualized morality that is detached from real-life desire, Dasan, through his theory of ‘nature as moral appetite’, attempted to uncover the fact that determining moral subjectivity is nothing but free-will of humankind, and that humans hold the key to moral responsibility and practice. In short, Dai Zhen stressed the capacity of mind that discerns the principle (li), and Dasan emphasized the mind’s autonomous making of moral decision to follow the human nature.

      • KCI등재

        Clinical implications of proliferation activity in T1 or T2 male gastric cancer patients

        김영우,엄방울,Myeong-Cherl Kook,김한성,김미경,Hai-Li Hwang,Vishal Chandra,Shiv Poojan,송유라,고재수,배창대,노정실,홍경만 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-

        Proliferation activity has already been established as a prognostic marker or as a marker for anticancer drug sensitivity. In gastric cancer, however, the prognostic significance of proliferation activity is still being debated. Several studies evaluating proliferation activity using Ki-67 have shown controversial results in terms of the relationship between proliferation activity and overall survival (OS) or drug sensitivity in gastric cancer patients. Because cytoskeleton-associated protein 2 (CKAP2) staining has recently been introduced as a marker of proliferation activity, we analyzed 437 gastric cancer tissues through CKAP2 immunohistochemistry, and we evaluated the chromatin CKAP2-positive cell count (CPCC) for proliferation activity. Although the CPCC did not show any significant correlation with OS in the male, female or total number of cases, it did show a significant correlation in the T1 or T2 male patient subgroup, according to log-rank tests (P=0.001) and univariate analysis (P=0.045). Additionally, multivariate analysis with the Cox proportional hazard regression model showed a significant correlation between the CPCC and OS (P=0.039) for the co-variables of age, gender, T stage, N stage, histology, tumor location, tumor size and adjuvant chemotherapy. In male gastric cancer cell lines, faster-growing cancer cells showed higher sensitivity to cisplatin than slow-growing cells. Thus our study indicates that CPCC-measured proliferation activity demonstrates a significantly worse prognosis in T1 or T2 male gastric cancer patients. The CPCC will help to more precisely classify gastric cancer patients and to select excellent candidates for adjuvant chemotherapy, which in turn will facilitate further clinical chemotherapeutic trials.

      • KCI등재

        헬리코박터 파일로리 제균 치료에서 PCR 기반 7일 치료의 유용성

        김영우,강희준,문상곤,김보형,이혜연,임철현,오정환 대한상부위장관ㆍ헬리코박터학회 2023 Korean Journal of Helicobacter Upper Gastrointesti Vol.23 No.2

        Background/Aims: Standard triple therapy (STT; proton pump inhibitor [PPI]+clarithromycin+amoxicillin) used for Helicobacter pylori (H. pylori) eradication has shown low treatment success rates in recent years, which is most likely attributable to increased clarithromycin resistance. In this study, we compared treatment success rates of tailored therapy (TT) using real-time polymerase chain reaction (RT-PCR) and empirical STT.Methods: This retrospective study included 650 patients with H. pylori infection, who visited Eunpyeong St. Mary’s Hospital in Korea; 343 patients received TT based on RT-PCR assays, and 307 patients received STT. Eradication success was defined as a negative 13C-urea breath test result 4~8 weeks after treatment completion. Patients who failed first-line therapy and those with clarithromycin resistance received bismuth-containing quadruple therapy (BQT; PPI+bismuth+metronidazole+tetracycline).Results: Intention-to-treat analysis showed that H. pylori eradication rates were higher in patients who received RT-PCR–based TT than in those who were treated using empirical STT (80.5% [190/236] vs. 70.4% [216/307], P=0.069). Per-protocol (PP) analysis showed similar results (84.4% [190/225] vs. 74.7% [216/289], P=0.007). PP analysis showed that 7-day TT treatment was associated with a higher eradication rate than that observed with 10- to 14-day STT (85.2% [178/209] vs. 73.8% [59/80], P=0.029). The clarithromycin resistance rate was 27.9% (87/312). The eradication success rate was 89.2% (74/83) in patients with clarithromycin resistance, who received BQT as first-line therapy.Conclusions: The treatment success rate was higher in patients who received 7-day RT-PCR–based TT than in those who were administered 10- to 14-day empirical treatment.

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