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염산, 무기질 및 DHA를 보충한 식이가 흰쥐의 출산능력과 어린 쥐의 학습능력에 미치는 영향
김승조 ( Seong Jo Kim ),하태열 ( Tae Yel Ha ),한찬규 ( Chan Kyu Han ),김나영 ( Na Young Kim ),안홍석 ( Hong Seok Ahn ),신현경 ( Hyeon Kyeong Shin ),신승주 ( Seong Ju Shin ),장성운 ( Sung Woon Chang ),이정노 ( Jung Noh Lee ),임준규 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.9
Objective : Malnutrition and nutritional disorder may cause problem of fertility and therefore adequate nutrition is very important during pregnancy. In this study, we investigated effects of supplemental diet contained folic acid, zinc, calcium, Iron, DHA and taurine on fertility outcome in the female rats and learning ability of their offsprings. Methods : The female rats at 4 week were fed by two group divided control (AIN-76 diet) and supplement diet. The male rats were taken pellet type diet. After 3weeks, female rats and male rats were mated. Then, at 3 weeks after mating, parturition was begun. After paturition, sex and birth weight of offsprings were examined for their offsprings. When the offsprings were 3 weeks of age, position reversional test in a water maze was done for 4 weeks. After female rats were fed experimental diet for 4 weeks, their follicle, corpus luteum, corpus albicans, progesterone, estradiol and ovary weight were measured. Results : 22 rats of 30 in supplemental diet group succeeded on parturition, and 11 rats of 30 in control group succeeded. Pregnancy outcome was fine in both group. There was no significant difference in weight of major bowels and femur length of their offspring. The position reversional test of offspreings in a water maze showed a significant difference between control group and supplement group. Elapsed time and erromeous response to reach the escape platform were significantly lowered in supplemental group than control group. Conclusion : This result suggest that supplementation contained folic acid, multivitamins, DHA and taurine may increase fertility rate in the maternal rats and also learning ability in offsprings.
${\beta}$-시클로덱스트린과의 포접에의한 디플로페낙나트륨의 용해도 및 생체흡수율 증가
이경태,김종환,김주일,김승조,서희경,서성훈,Lee, Kyung-Tae,Kim, Jong-Hwan,Kim, Joo-Il,Kim, Seung-Jo,Seo, Hee-Kyoung,Seo, Seong-Hoon 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.3
Inclusion complexes of diclofenac sodium with ${\beta}-cyclodextrin$ were prepared in aqueous solution, alkaline solution and solid phase. The interaction of diclofenac sodium with ${\beta}-cyclodextrin$ in pH 9.0 alkaline solution was evaluated by the solubility method and the instrumental analysis such as thermal analysis, infrared spectroscopy, X-ray diffractometry. The solubility of diclofenac sodium was increased linearly with the increase in the concentration of ${\beta}-cyclodextrin$up to 0.15 mol and showed that the aqueous solubility rate of diclofenac sodium was significantly increased by complex with ${\beta}-cyclodextrin$. The optimum composition of this complex was one molecule of ${\beta}-cyclodextrin$ included 1.59 molecular weight of diclofenac sodium as a guest molecule. The pharmacokinetic parameters of the diclofenac sodium and the complex with ${\beta}-cyclodextrin$ were studied in rats by oral route. $T_{max}$ between drug alone and inclusion complex showed significant difference to be 120 minute and 20 minute respectively. Both of $C_{max}$ and AUC of inclusion complex was about 40% higher than drug alone. It is estimated from the data in this study that complexation of diclofenac sodium with ${\beta}-cyclodextrin$ increased the absorption rate and improved the bioavalability of the diclofenac sodium by the formation of a water-soluble complexes.
디클로페낙나트륨 디클로페낙나트륨과 β - 시클로덱스트린 포접물의 흰쥐 위 점막 손상 비교
박재훈,김종환,김주일,김승조,서성훈,이경태 ( Jae Hoon Park,Jong Hwan Kim,Joo Il Kim,Seung Jo Kim,Seong Hoon Seo,Kyung Tae Lee ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A This laboratory has recently reported the solubility and in vivo absorption enhancement of diclofenac sodium by β-cyclodextrin complexation. The acute gastroduodenal mucosa injury provoked by administration of 34 ㎎/㎏ and 68 ㎎/㎏ of a diclofenac sodium (DS) and equivalent dose of new formulation [diclofenac sodium-beta-cyclodextrin complexation(DS-β-CD)] was evaluated and compared. Microscopic examinations, performed after 18-hrs treatment, demonstrated that DS-β-CD was less gastrolesive than DS. The drop in gastrophy after a single dose of the assigned drug was considerably greater for DS than for DS-β-CD, which registered similar values to control. Since gastrophy is an expression of the anatomy-functional integrity of the gastric barrier, the results indicate that DS-β-CD exerts less direct acute damage on the gastric mucosa. Therefore, when administered short-term, DS-β-CD appears to be less gastrolesive than the standard DS formulation.
자궁경부암 치료에서 p53 종양억제유전자의 플라스미드와 아데노바이러스를 이용한 유전자 치료법의 개발
이준모(Jun Mo Lee),김승조(Seung Jo Kim),남궁성은(Sung Eun NamKoong),조성대(Sung Dae Cho),황성진(Seong Jin Hwang),박현라(Hyun Ra Park),한유진(You Jin Han),김상태(Sang Tae Kim),이헌영(Hun Young Lee),김동재(Dong Jae Kim),박용석(Yong Serk 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
Background: The basic treatment of malignant tumors is surgery, radiotherapy, chemotherapy. Even though, the object of these treatments is to kill cancer cells, they have limitations. So, in future studies of treatment of cancer, we should look into increasing human immune response using gene therapy in order to induce damage to tumor cells. Objective: The cell growth inhibitory effect of cervical cancer cells was investigated by direct transfection using liposome(pRcCMVp53/lipofectin). and by indirect transfection using Adenovirus(AdCMVp53). Methods: The cervical cancer cell lines we used in this study were HPV16 positive, having inhibitory gene, wild p53 gene, CaSki, SiHa, HPV18 positive HeLa, HeLaS3 and HPV negative C33A, HT3, LacZ gene was used as the marker gene for the transfection efficacy. Direct transfection was done by using lipofectin (pRcCMVp53/lipofectin) and indirect transfection was done by using virus, AdCMVp53. The effect of tumor cell growth inhibition was measured by cell counting assay. Result: Inhibition of growth of cervical cancer cells in cell counts of direct transfection was CaSki(88.5%), SiHa(59.1%), HeLa(86.0%), HeLaS3(78.0%), C33A(91.3%) and HT3(74.0%). Inhibition of growth of cervical cancer cells in cell counts of indirect transfection was CaSki(97.4%), SiHa(91.6%), HeLa(95.8%), HeLaS3(99.7%), C33A(97.3%) and HT3(87.4%). Conclusion : The inhibition of cell growth of cervical cancer cells by direct and indirect transfection was significantly reduced, and showed little differences depending on the type of cells. These results will have a great meaning in treating cervical cancer patients using gene therapy by direct or indirect transfection