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The Role of DNA Binding Domain in hHSF1 through Redox State
김솔,황윤정,김희은,여명,김안드레,문지영,강호성,박장수,Kim, Sol,Hwang, Yun-Jeong,Kim, Hee-Eun,Lu, Ming,Kim, An-D-Re,Moon, Ji-Young,Kang, Ho-Sung,Park, Jang-Su Korean Society of Life Science 2006 생명과학회지 Vol.16 No.6
다양한 종류의 박테리아에서부터 사람의 세포에 이르기까지 환경적인 스트레스나 병에 의한 스트레스 혹은 스트레스가 없는 상황에서도 열충격반응(heat shock response) 유도되어진다. 열충격반응에 노출된 세포에서는 모든 단백질의 발현이 정지되는 반면, 열충격단백질(heat shock proteins: HSPs)은 발현되어 스트레스로부터 세포를 보호한다. HSF1(heat shock factor 1)이라는 HSPs 유도단백질은 열충격반응시 단량체형태에서 삼중체의 형태로 구조변화를 일으켜 heat shock element(HSE)라고 불리우는 HSP gene의 발현 promoter에 특이적으로 결합하게 되어 HSPs를 발현시킨다. Human HSF1(hHSF1)은 다섯 개의 시스테인 잔기를 가지고 있는데 이 시스테인의 thiol(-SH)기는 강한 친전자성을 띔으로 급격히 산화되거나 질산화된다. 이러한 고찰은 시스테인 잔기가 산화 환원 의존적인 황산기/이황화결합 전환을 통해 구조적인 변화를 가져온다는 사실을 의미하고 있다. 따라서 본 연구에서는 여러 가지 산화환원제를 이용하여 HSF1에 존재하는 다섯 개의 시스테인 잔기의 역할과 삼량체 형성에 관여하는 잔기에 대하여 알아보고자 하였다. 또한 이황화결합을 통한 삼량체형성의 구조적변화의 관점에서 HSF1의 구조 변화와 DNA 결합력과의 상관관계에 관하여도 알아보고자 하였다. 본 연구결과로 HSF1의 DNA binding domain은 삼량체를 형성하는 구조적인 변화를 통해서 DNA에 대한 결합력이 증가되는 것을 알 수 있었는데 이것은 삼량체가 됨으로서 HSF1의 내부에 위치해 있던 DNA binding domain이 외부로 노출 되어져 DNA에 쉽게 결합할 수 있게 된다는 사실을 시사한다. The heat shock response is induced by environmental stress, pathophysiological state and non-stress conditions and wide spread from bacteria to human. Although translations of most proteins are stopped under a heat shock response, heat shock proteins (HSPs) are produced to protect cell from stress. When heat shock response is induced, conformation of HSF1 was changed from monomer to trimer and HSF1 specifically binds to DNA, which was called a heat shock element(HSE) within the promoter of the heat shock genes. Human HSF1(hHSFl) contains five cysteine(Cys) residues. A thiol group(R-SH) of Cys is a strong nucleophile, the most readily oxidized and nitrosylated in amino acid chain. This consideration suggests that Cys residues may regulate the change of conformation and the activity of hHSF1 through a redox-dependent thiol/disulfide exchange reaction. We want to construct role of five Cys residues of hHSF by redox reagents. According to two studies, Cys residues are related to trimer formation of hHSF1. In this study, we want to demonstrate the correlation between structural change and DNA-binding activity of HSF1 through forming disulfide bond and trimerization. In this results, we could deduce that DNA binding activity of DNA binding domain wasn't affected by redox for always expose outside to easily bind to DNA. DNA binding activity of wild-type HSF's DNA binding domain was affected by conformational change, as conformational structure change (trimerization) caused DNA binding domain.
편측성 구순구개열 환자의 상악측절치 결손과 재건에 대한 연구
김솔아(Sol-a Kim),황대석(Dae-seok Hwang) 대한구순구개열학회 2022 대한구순구개열학회지 Vol.25 No.1
Cleft lip and palate is one of the most prevalent congenital craniofacial anomalies, and it commonly has greater incidence of dental abnormalities in number, size, shape, and eruption of teeth. Maxillary lateral incisor is the most frequently affected. The aim of this study is to analyze the prevalence of congenital missing of lateral incisor in cleft side and non-cleft side in unilateral cleft patients who were treated in Pusan national university dental hospital. Radiographs and records were reviewed to find the relationship of missing tooth and cleft side, maintenance of maxillary lateral incisor, rehabilitation method. The ratio of congenital missing was 50% in cleft side and 18.75% in non-cleft side. The ratio of extraction after bone graft was 62.6% in cleft side and 31.25% in non-cleft side. The result suggested that since the ratio of maintenance of maxillary lateral incisor is low, early extraction can be considered in some cases.
김솔이 ( Kim Sol-yi ),차수정 ( Cha Su-jung ) 한국무용교육학회 2021 韓國舞踊敎育學會誌 Vol.32 No.2
The study aims to comparatively analyze the works of convergence dance using technology. In this study, among the converged dance works using technology, two domestic cases and three overseas cases, which are permitted to disclose the data, were selected to carry out a comparative analysis of the characteristics of convergence technology using technology, and conducted interviews with the choreographers of organizations in Korea. The results of this study are as follows: 《Beyond Black, 2020》 by the Korea National Contemporary Dance Company shows a new choreography method using AI. HOWHYOU’s 《GODOT, 2018》 is aims to automate dance performances, using technologies that were not used in the existing dance performances such as Black 2.0 and Gyrosens AΦE’s 《0AR, 2018》 used AR to allow the audience to focus more, and showed various aspects by changing the graphic appearance of the dancer 《Celestial Motion II, 2019》 by Alexander Whitley Dance Company uses VR and AR motion capture to increase immersion in the work by giving the audience the feeling of being involved in the work together. 《Celestial Motion: Virtual Dance Experience, 2019》 recorded 《Celestial Motion II, 2019》 on a 360-degree camera, complementing the shortcomings of seeing only the flat surface of the work in conventional video. This result will be an important approach to planning dance performances by expanding the changes in time and society ahead of the advent of the 4th Industrial Revolution and expanding the field of view of the audience with higher standards.
전문상담교사의 동료 슈퍼비전 경험에 관한 합의적 질적 연구
김솔아(Kim, Sol-A),박은경(Park, Eun-Kyung),선혜연(Seon, Hye-Yon) 경인교육대학교 교육연구원 2022 교육논총 Vol.42 No.1
본 연구에서는 전문상담교사를 대상으로 동료 슈퍼비전 경험과 그 영향을 살펴보고자 하였다. 이를 위해 동료 슈퍼비전 경험이 있는 전문상담교사 9명을 대상으로 심층 면담을 진행하였다. 심층 면담을 통해 수집된 자료는 합의적 질적 연구방법의 자료 분석과정을 통해 분석하였고 자료 분석과정에는 3명의 평정팀과 1명의 감수자로 구성된 연구팀이 참여하였다. 자료 분석 결과, 3개의 영역, 13개의 범주, 36개의 하위범주가 도출되었다. 전문상담교사들은 상담교사 업무에 대한 어려움으로 인해 상대적으로 부담감이 적은 동료 슈퍼비전을 시작하고 있었다. 참여자들은 동료 슈퍼비전 과정을 통해 상담 업무 및 역할에 대한 이해뿐만 아니라 정서적지지, 지역네트워크를 형성하고 있었으며 동료 슈퍼비전 후 사례에 대한 전문성 향상, 정체성 및 연대감을 형성하고 성장 동기를 다지게 되는 변화를 경험하였다. 이러한 결과를 토대로 논의를 하였으며 학교 상담자 교육에 대한 실제적 의의와 동료 슈퍼비전 연구에 대한 학문적 의의 및 제한점을 제시하였다. This study examined the peer supervision experience of school counselors by understanding the beginning, the process, and the subsequent change of peer supervision experience. In-depth interviews were conducted with nine school counselors experienced in peer supervision. The data collected through in-depth interviews were analyzed through the consensus qualitative research method, and a research team composed of three evaluation teams and one auditor participated in the data analysis process. Next, 3 areas, 13 categories, and 36 sub-categories were derived. While counselors use supervision as a general method to counsel students, the supervision method may be difficult to process and use because of the counselors’ workload. Therefore, the school counselors in this study used the peer supervision experience method as it was more efficient and was able to relieve the burden that the school counselors faced. Participants connected emotionally, formed local networks, and understood counseling tasks and roles through the peer supervision process. Following the peer supervision method, I experienced changes such as improved expertise and sense of identity and solidarity and increased motivation. Based on these results, discussions were conducted, and the practical significance of school counselor education, academic significance, and limitations of peer supervision research were presented.