전립선 비대증 유발 백서에서 복분자를 주성분으로 한 생약제제 KH-305가 미치는 영향

김세웅,이병희,손동완,조용현,이승민,김세웅 한국생약학회 2008 생약학회지 Vol.39 No.2

Benign prostatic hyperplasia (BPH) is one of the common diseases in elderly men. Recently, the old-aged population has increased, with the interest in the clinical importance of BPH ever growing. This study is designed to investigate the effects of KH-305 on BPH induced rat. The herb formulation KH-305 is consisted of Rubus coreanus, Cornus officinalis and Cuscuta chinensis. An experimental prostatic hyperplasia was induced in male rats by the administration of testosterone propionate, 3 mg/kg SC, for 2 months. The rats were divided into 3 experimental groups: the control, BPH-induced, oral KH- 305 ingestion group. After 2 months, the prostates were removed, and analyzed for their prostatic weight and histological examination. The prostate weights were measured in each group, and found to be 820±38mg, 3140±26mg, 1880±21mg in the control, BPH-induced, and oral KH-305 ingestion group, respectively. The BPH induced group showed statistically significant increases in their prostatic weights compared with control group(p<0.05) but oral KH-305 ingestion group showed more significant decreases than BPH-induced group statically(p<0.05). Histologically injected testosterone lead to prostatic hyperplasia in rats, but oral KH-305 ingestion decreased this change. These results suggest that KH-305 may be effective in treatment of BPH, and complementary medicine of BPH.

자동차 자동 전환 장치를 발명한, 김세웅

김세웅,장명학 사회발전연구소 1987 한국인 Vol.6 No.5

麻醉中 不整脈의 頻度

金世雄,韓永文 최신의학사 1973 最新醫學 Vol.16 No.2

Incidence of arrhythmias during anesthesia increases in their frequency, because of the average sur?gical patients tend to be older than in the past. And cardiovascular surgery was performed more frequently to-day. Prompt recognition, skillful treatment and prevention of the cardiac arrhythmias may determine the successful outcome of the anesthesia and surgery. Out of the total 1370 surgical cases, 256 cases were selected for evaluation of cardiac condition during surgery, because the latter were suspected to have some cardiac problems preoperatively. Of these 256 cases, ECG was checked preoperatively and the incidence of arrhythmias during anes?thesia were observed. The results were as follows; 1. Arrhythmias had been found preoperatively in 84 cases among the 256 cases studied (32.8%). The incidence of arrhythmia for the total 1370 surgical patients was 6.1%. 2. In the above 84 cases, 30 cases developed arrhythmia during anesthesia (35.7%). The remaining 172 cases which had showed normal cardiac rhythm preoperatively, developed arrhythmia in 36 cases (20.8%). Therefore, out of the 256 cases, 66 cases developed arrhythmia during anesthesia (25.8%). 3. Types of arrhythmias found during anesthesia were ventricular premature contraction (40.9%), sinus tachycardia (36.4%), atrial premature contraction (9.1%), sinus bradycardia (7.6%), right bundle branch block (1.5%), left bundle branch block(1.5%), atrial fibrillation(1.5%) and ventricular fibrillation (1.5%). 4. Incidence of arrhythmias concerning about sex was 53.0>% in the male and 47.0% in the female. 5. For the types of the surgery, high incidence of arrhythmia was found in the dental, E. N. T. , and urological surgery. (The majority number of the patients were the geriatric cases.) 6. Incidence of arrhythmias concerning about the anesthesia time were 59.1% within 3 hours of anesthesia and 40.9% over 3 hours of anesthesia. 7. The incidence of arrhythmias during the induction period was 45.5% and during the mrii tenance period was 28.8%. And incidence of arrhythmias through induction period to maintenance period was 25.7%.

화학으로 이해하는 대기환경의 문제들

김세웅 한국기상학회 2014 한국기상학회 학술대회 논문집 Vol.2014 No.4

급성 단순하부요로감염증 치료에서 노르플록사신과 루플록사신의 임상효과 및 안전성

김세웅,이지열,이승주,조용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 루플록사신은 긴 반감기와 넓은 항균력을 가진 퀴놀론계 항생물질이다. 급성 단순하부요로감염 치료에 있어서의 루플록사신의 효과와 안전성을 평가하기 위하여 기존의 퀴놀론계 항생물질인 노르플록사신과 비교임상시험을 실시하였다. 방법 : 본 임상시험은 전향적, 무작위 방법으로 진행하였으며 1997년 8월부터 1999년 3월까지 가톨릭대학교 의과대학 부속 성모병원 비뇨기과에 내원한 급성 단순하부요로감염 환자 72명을 대상으로 하였다. 연속적 무작위 배정방법을 통하여 루플록사신군 36명과 노르플록사신군 36명이 루플록사신 400㎎을 단회 경구투여 받거나 노르플록사신 400㎎을 12시간 간격으로 3일간 6회 경구투여 받았다. 임상효과, 미생물학적 평가 및 부작용을 비교 관찰하였다. 결과 : 총 64명의 환자가 시험을 완료하여 평가가 가능하였고, 이 중 루플록사신군은 32명이었고, 노르플록사신군은 32명이었다. 증상의 치료 및 개선을 임상적 유효성이 있는 경우로 하였을 때, 루플록사신투여군은 32례중 32예(100%)에서, 노르플록사신투여군은 32례 중 31례(96.9%)에서 만족할 만한 결과를 얻었다. 미생물학적 평가에서 루플록사신투여군은 32례 중 29례(90.6%)에서, 노르플록사신투여군은 32례 중 28례(87.5%)에서 미생물학적 소실을 보였다. 미생물학적 재발은 루플록사신군과 노르플록사신군에서 각각 1례(3.1%)과 2례(6.3%)가 나타났고, 재감염은 각각 2례(6.3%)와 1례(3.1%)가 나타났다. 임상효과와 미생물학적 평가에서는 두 약제간의 통계학적 차이는 없었다. 약물역동학적 검사상 루플록사신은 노르플록사신에 비해 높은 MIC를 갖고 있지만 긴 반감기를 통해 소변내에서 높은 농도와 요 살균력을 유지함을 알 수 있었다. 부작용은 루플록사신투여군 34례 중 5례(14/7%)에서, 노르플록사신투여군 35례 중 1례(2.9%)에서 나타났으며, 대부분의 소화기계통의 이상반응 이었으며, 모두 경증으로 24시간 이내에 소실되었다. 루플록사신투여군 중 2례에서는 경증의 중추신경계의 이상반응이 관찰되었다. 결론 : 결론적으로 루플록사신은 급성 단순하부요로감염에 대하여 1회 투여만으로도 노르플록사신의 3일 투여법과 동등한 효과를 나타내는 유용한 약제라고 생각된다. Background : Rufloxacin is a broad-spectrum quinolone that exhibits a prolonged elimination half-life. The purpose of this study is to evaluate the efficacy and safety of a single dose of rufloxacin, campared with those of a norfloxacin standard treatment. Methods : This was a open. randomized. parallel-group, phase 11 clinical trial. A total of 72 women with acute lower urinary tract infections were included and randomly assigned to one of the treatment regimens: rufloxacin 400㎎ single dose, or norfloxacin 400㎎ b.i.d. for 3 days. Clinical and bacteriological assessments were performed twice at the third day and the seventh or tenth day after inclusion. Results : A total of 64 patients(32 and 32 patients in the rufloxacin and norfloxacin groups, respectively) were considered clinically and bacteriologically evaluable. Overall, a clinical response(recovery and improvement) was observed in 32 (100%) of 32 patients treated with rufloxacin and in 31 (96.95) of 32 patients with norfloxacin. The corresponding eradication rates of the primary pathogens were 90.6%(29/32) and 87.5%(28/32), respectively. The microbiological relapses between the seventh and tenth day were recorded in 1 patient(3.1%) and 2 patients(6.3%) in the rufloxacin and norfloxacin groups, respectively. The superinfections occurred in 2(6.3%) and 1(3.1%) patients, respectively. No statistically significant differences in the clinical or bacteriological outcome were observed between the treatment groups. The pharmacodynamic evaluation showed similar median urine bactericidal titers(UBT) for both treatment groups against initial isolates, despite a higher MIC of rufloxacin than that of norfloxacin. Five patients (14.7%) in the rufloxacin group and 2 patients (5.7%) in the norfloxacin group reported 9 and 4 adverse events, respectively, almost all of them being mild and lasting <24 h. Overall, gastrointestinal reactions were the most frequent adverse events reported. However, 2 patients treated with rufloxacin reported 3 central nervous system adverse events. Conclusion : This study suggests that single dose of rufloxacin treatment is effective and well tolerated as norfloxacin 3-day standard treatment in acute uncomplicated lower urinary tract infections.

모바일 게임을 위한 개선된 무손실 이미지 압축

김세웅,조병호 한국정보처리학회 2006 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.13 No.3

본 논문에서는 모바일 게임의 전체 용량 중 상당 부분을 차지하는 이미지를 무손실로 압축하기 위한 방법을 제안하였다. 이미지의 압축률을 높이기 위해 실제로 압축을 수행하기 전에 전처리 과정에서 이미지를 재구성 한 후 RFC-1951에 정의된 Deflate 알고리즘으로 압축하였다. 전처리 과정에서는 이미지의 정보를 바탕으로 사전 기반 부호화의 특징인 사전의 크기를 얻고, 픽셀 패킹과 DPCM 예측 기법을 사용하여 이미지를 재구성하는 방법을 사용하여 일반적인 방법으로 압축할 때 보다 압축률을 향상시켰다. 제안된 압축 방법을 다양한 모바일 게임 이미지에 적용하여 압축률을 실험한 결과 기존 모바일 이미지 포맷에 비해 약 9.7%의 압축률이 향상됨을 보였다. In this paper, the method to make lossless image compression that holds considerable part of total volume of mobile game has been proposed. To increase the compression rate, we compress the image by Deflate algorithm defined in RFC 1951 after reorganize it at preprocessing stage before conducting actual compression. At the stage of preprocessing, we obtained the size of a dictionary based on the information of image which is the feature of Dictionary-Based Coding, and increased the better compression rate than compressing in a general manner using in a way of restructuring image by pixel packing method and DPCM prediction technique. It has shown that the method increased 9.7% of compression rate compare with existing mobile image format, after conducting the test of compression rate applying the suggested compression method into various mobile games.

한국판 WEMWBS의 타당화 연구

김세웅,정한용,나경세,이소영,김신겸,이아름,조준택 대한신경정신의학회 2014 신경정신의학 Vol.53 No.4

Objectives The aim of this study was to develop the Korean version of the Warwick-Edinburgh Mental Well-being Scale (K-WEMWBS) and to examine its factorial structure, reliability, and convergent/discriminant validity. Methods In this study, the Warwick-Edinburgh Mental Well-being Scale (WEMWBS), a self-rating measure for assessment of mental well-being, was translated into Korean. It was completed by 222 respondents, including 117 healthy subjects and 105 psychiatric patients from both inpatient and outpatient clinics at Soonchunhyang University Hospitals in Bucheon, Cheonan, and Seoul. Results The K-WEMWBS showed good content validity. Confirmatory factor analysis supported a single factor structure. The Cronbach’s alpha value for the K-WEMWBS was 0.944, which demonstrated good internal consistency. Test-retest reliability at 2–8 weeks was high (0.789). The K-WEMWBS showed high correlations with mental health, positive affect, and quality of life scales. Moderate negative correlation was observed between the K-WEMWBS and the negative affect scale. Discriminant validity was partially identified. Statistically significant differences in scores were observed between the psychiatric patient group and the control group. Conclusion The results of this study indicate that the K-WEMWBS is a reliable and valid instrument for assessment of mental well-being, particularly the positive aspects of mental health.

크랭크축 각속도의 변동을 이용한 기관 이상 진단 방법 비교

김세웅,배상수,김응서,Kim, Se-Ung,Bae, Sang-Su,Kim, Eung-Seo 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.6

^In this paper, diagnostic technique for detecting the engine faults, especially misfire, are introduced and compared with each other under the same conditions. With all of them the instantaneous angular velocitys, measured at the flywheel, were analyzed. The techniques include the frequency analysis, auto-correlation function, velocity index, acceleration index, maximum acceleration index, and integrated torque index. Since the main driving components for the angular velocity fluctuation are both the pressure and the inertia torque, the component of the inertia torque in it must be excluded to extract the information of the combustion from the angular velocity. To do this, it is required to consider only the first half of the combustion period in the angular velocity fluctuations, which has never been proposed in the existing methods. On the basis of this fact, the results show that the most effective diagnostic technique is maximum acceleration index.

「위대한 신브라운」(The Great God Brown) : 신의 부재

김세웅,최진근 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(A)

Eugene O'Neill's object of self-exploration is to achieve a better understanding of man's inner life. He searches for "something" which oppresses and controls the psychological realities of human life. O'Neill defines "something" as "the Force behind- Fate, God, our biological past creating our present, whatever one calls it- Mystery certainly." the very mysterious, inscrutable Forces behind human life make O'Neill express himself in art. The characters in the middle play, The Great God Brown, positively struggle against the Force to overcome it. They try to achieve self-realization through the pursuit of a new god to give meaning to human existence and to comfort the fear of death. O'Neill suggests that man's blind pursuit of a material life in a capitalist society makes him dehumanized. Man is alienated by the god of science and materialism made by himself. His blind pursuit of the material life results in his spiritual corruption. O'Neill severely criticizes the established religions and a capitalist society, and seeks for his new god within man's inner self and purity.

최근 5년간 요로감염의 원인균 및 항생제 감수성

김세웅,임필빈,정웅교,이승주,이지열,조용현,윤문수 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.3

배경 : 최근 요로감염 원인균에 대한 내성 증가로 항생제 감수성에 변화를 가져와 요로감염 환자에게 경험적 1차 치료를 위한 항생제 선택에 어려움을 주고 있다. 단순 및 복잡성 요로감염으로 진단 받은 환자들을 대상으로 원인균과 그에 따른 항생제의 감수성을 살펴봄으로써 향후 단순 및 복잡성 요로감염에 대한 항생제의 선택에 도움을 받고자 한다. 대상 및 방법 : 1996년 6월부터 2001년 5월까지 요배양 검사상 요로 감염균이 10^5cfu/ml 이상의 집락이 형성된 200명을 대상으로 해부학적 또는 구조적인 장애 유무에 따라 단순 요로감염 및 복잡성 요로 감염으로 나누어 각각의 원인균과 그에 따른 항생제의 감수성을 후향적으로 분석하였다. 결과 : 복잡성 요로감염의 가장 흔한 원인질환은 신경인성 방광이었다. 단순 요로감염의 가장 흔한 원인균은 E. coli (61.35%)였고 복잡성 요로감염에서는 E. coli 이외의 균이 E. coli 보다 더 흔한 원인균이었다(58.9%). 단순 및 복잡성 오료감염 중 그람 양성균에서는 vancomycin, penicillin 이 높은 감수성을 보인 반면 ciprofloxacin, imipenem이 낮은 감수성을 보였고 그람음성균에서는 amikacin, imipenem이 높은 감수성을 보인 반면 ampicillin, bactrim이 낮은 감수성을 보였다. 결론 : 단순 및 복잡성 요로 감염의 주 원인균으로 그람 음성균주 특히, Ecoli에 의한 감염이 많은 비중을 차지하고 있으나 빈도가 점차적으로 감소하는 추세이다. 또한 병원성 감염 및 도뇨관의 장기 유치에 따른 교대균의 증가, 비병원성 세균의 출현 등으로 인한 E. coli 이외의 기타 그람음성균 및 그람양성균의 증가하는 추세이다. 향후 임상에서 요로감염의 일치 치료제로 많이 사용되고 있는 ampicillin과 bactrim 등의 항생제의 감수성이 낮으므로 사용시 필요하다고 사료된다. Backround : The increasing frequency of failure of urinary tract infections (UTIs) may be due to emerging resistance to commonly prescribed antimicrobials. We studied the causative microorganisms and their antibiotic sensitivities in uncomplicated and complicated UTIs. Methods : We analyzed 219 microorganisms and their antibiotic sensitivities of 200 outpatients who had more than 10^5cfu/ml on urine from June 1996 to May 2001 retrospectively. The patients weredivided into 2 groups, uncomplicated UTI group and commplicated UTI group according to with or without underlying disease. Results : The most common underlying disease of complicated UTI was neurogenic bladder. The most common pathogenic microorganism was Escherichia coli (E. coli) (61.35%) in uncomplicated UTI group but in complicated UTI, non-E, coli(58.9%) was more common than E. coli. In uncomplicated and complicated UTI, vancomycin, penicillin showed relatively higher sensitivity of gram positive organisms, while ciprofloxacin, imipenem showed relatively lower sensitivity, and imipenem, amikacin showed relatively higher sensitivity of gram negative organisms, while bactrim, amipicillin showed relatively lower sensitivity. Conclusion : We consider that gram negative microorgansisms, especially E. coli, is the main cause of UTI. But, we should concern about the increase of gram positive organsms and other gram negative organisms besides E. coli. Bactrim, amipicllin which were prescribed empirically in UTIs, showed relatively lower sensitivity. Regarding tom the choice of adequate drug in the treatment of UTI, it is necessary to consider the change of pathologic microorganisms.