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김창덕 ( Chang Duk Kim ),김창욱 ( Chang Ook Kim ),김병천 ( Byung Chun Kim ),이규석 ( Kyu Suk Lee ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7
N/A Background : Many studies focused on the distribution of skin tumors in Korea, but none of them included whole data refered from deparments other than dermatology and primary physicians. Objective : This study was to investigate the incidence and distribution of skin tumors among Korean people. Methods : A study was made on 1448 cases of skin tumors which were obtained mainly from surgical pathology specimen during the period of 10 years from 1992 to 2001 at Department of Dermatology in Keimyung University Dongsan Medical center. Results : 1. Of the 1448 cases of skin tumors, 1171 cases(80.9%) were benign tumor, 277 cases (19.1%) were malignant tumor and male to female ratio was 1:1.1. 2. Among the 1171 cases of benign tumors, 174 cases of melanocytic nevi, 173 cases of epidermal cyst, 109 cases of seborrheic keratosis, 62 cases of granuloma pyogenicum were noted. 3. Among 277 cases of malignant tumors, 107 cases of basal cell carcinoma, 58 cases of squamous cell carcinoma, 27 cases of metastatic cutaneous carcinoma, 24 cases of Bowen disease were noted. 4. The predilection sites of Intradermal nevi were face(38.4%), trunk(17.4%), scalp(16.3%), and those of epidermal cyst were face(41.0%), trunk(29.5%), neck(8.1%), The predilection site of basal cell carcinoma, squamous cell carcinoma was face(80.4%, 58.6%). Conclusion : The 1448 cases of skin tumors, which were confirmed histologically from surgical pathology specimen at Department of Dermatology in the Keimyung University Dongsan Medical Center during the period of 10 years from 1992 to 2001, were reviewed.
허혈양상화, adenosine 및 pinacidil이 허혈 및 재관류후 흰쥐 넙다리곧은근에서 나타나는 세포자멸의 발현에 미치는 영향
김병천(Byung Chun Kim),백두진(Doo Jin Paik),안동춘(Dong Choon Ahn),조원길(Won Gil Cho),이관형(Kwan Hyung Lee),황규성(Kyu Sung Hwang),정호삼(Ho Sam Chung) 대한체질인류학회 1998 대한체질인류학회지 Vol.11 No.2
본 실험에서는 뼈대근육에서 2시간 허혈 및 재관류시, 허혈양상화후, adenosine 수용체 자극 후 및 KATP 통로 개구 후 2시간 허혈 및 재관류시 나타나는 세포자멸의 반도를 비교 관찰하여 허혈양상화의 효과와 그 기전을 규명하고자 하였다. 실험동물로는 200~250g의 건강한 Sprague -Dawley계 웅성흰쥐를 사용하였으며, pentobarbital(50mg/kg)을 복강 내 투여하여 마취시킨 다음 하복부를 절개하고 왼쪽 온엉덩동맥을 혈관집게로 2시간 차단하여 허혈 시켰고, 2시간 허혈직후와 재관류 1시간, 2시간, 6시간, 12시간 및 24시간 경과 후 왼쪽 넙다리곧은근의 중간 표면부위를 적출하였다. 허혈양상화처치는 2시간 허혈 전에 5분간 허혈과 5분간 재관류를 3회 반복하였고, adenosine(50μg/kg) 혹은 pinacidil(50 mg/kg)은 허혈개시직전 정맥 주사로 투여한 다음 2시간 허혈 시키고 재관류시켰다. 적출한 왼쪽 넙다리곧은근을 적출하여 24시간 내에 파라핀 블록을 제작하고 6μm의 절편을 획득한 다음 세포자멸강지 kit를 이용하여 세포자멸의 발현을 관찰하여 다음과 같은 결과를 얻었다. 1 허혈양상화시와 adenosine 혹은 pinacidil 투여 시 넙다리곧은근에서 세포자멸의 반응은 음성 혹은 미약하게 나타났다. 2 2시간 허혈 및 재관류 시 세포자멸의 반응은 증가하였다. 허혈양상화후와 pinacidil 투여 후 2시간 허혈 및 재관류 시에는 세포자멸의 반응이 음성 혹은 미약하게 나타났다. 3 Adenosine 투여 후 허혈 및 재관류 시에는 넙다리곧은근에서 세포자멸의 반응이 강하게 나타났다. 이상의 결과에서 허혈양상화로 흰쥐의 넙다리곧은근에서 허혈 및 재관류 후 나타나는 세포자멸의 반응이 감소하였으며, 이러한 효과는 KATP통로의 개구와 연관이 있는 것으로 결론지을 수 있다.
김병천(Byung Chun Kim),이규석(Kyu Suk Lee),송준영(Joon Young Song) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.4
We present a case of lymphangioma circumscriptum in a 17 year-old girl according to tihe clinical and histopathological findings. This case is unusual in that lesions developed on the vulva and thigh without preceding lymphedema. Our patient had a plaque of grouped vesicle-like papules resembling frog's apawn on The both labia majora of vulva and several scattered, skin tag like soft papules on the right upper thigh of theree years duration. Histopathologic findings showed variable sized, dilatated lymphatic channels lined by single layer of normal endothelial cells confined to the only upper dermis.
피부병변을 동반한 Sinus Histiocytosis with Massive Lymphadenopathy
김병천(Byung Chun Kim),이규석(Kyu Suk Lee),송준영(Joon Young Song),이상숙(Sang Sook Lee),장은숙(Eun Sook Chang) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.6
Sinus histiocytosis with massive lymphadenopathy(SHML) is a benign, generally selflimited pseudolymphomatous disease that typically appears with cervical massive lymphaclenopathy. Extranodal involvement including skin occurs in the 28% of the cases. We report a case af SHML in 51 year-old male who had several, prominent firm masses ranging from 1-10cm in the cervical, axillary, inguinal areas and multiple, plum colored nodules and plaques in the face, trunk for about 10 years. The histopathological findings of cervical lymph node, facial nodule showed dense heavy infiltration of large histiocytes with abundant pale eosinophilic cytoplasm in the subcapsular and medullary sinuses of lymph node and dermis of skin. No atypical cells suggesting malignancy is seen in the infiltrates. The patient had been treated with combination of prednisolone and vinblasstine, but he expired 1 month later.