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조희근(Hee-Keun Cho),서정기(Jung-Ki Seo),김병중(Byoung-Jung Kim),장태성(Tae-Seung Jang),차원호(Won-Ho Cha),이대길(Dai Gil Lee),명로훈(Noh-Hoon Myung) 한국항공우주학회 2010 韓國航空宇宙學會誌 Vol.38 No.7
과학기술위성 3호는 국내 최초의 전구조 복합재 위성이다. 이전에 개발된 위성은 대부분 태양전지판 등 부분적인 복합재 구조로 된 것도 있으나 전 구조 복합재 위성은 개발된 적이 없었다. 본 연구는 소형 복합재 위성의 버스 구조체 개발을 위한 복합재 응용 설계 및 제작 기술의 적용과 그 활용에 중점을 두고 있다. 특히 과학기술위성 3호의 버스 구조체는 이전에 개발된 위성의 구조체 와는 전혀 다른 형태로 개발되었다. A satellite that has an all-composite structure, STSAT-3(science and technology satellite), was initially developed in Korea. Partially use of advanced composites in space applications such as solar panel is well developed, however the application of an all-composite satellite bus has never been achieved in Korea. This study emphasizes the application of composite technology to the design and fabrication of an all-composite spacecraft bus for small-class satellite STSAT-3. Moreover its structure design concept is totally different from the one that was used in the previous satellites developed in Korea.
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Verapamil 과 Bupivacaine 의 단독 및 혼합용액이 쥐의 좌골신경표본에서 신경전도에 미치는 영향
이성우,윤영준,길호영,김병중,최현,이병상 대한마취과학회 1994 Korean Journal of Anesthesiology Vol.27 No.11
Racemic verapamil has been shown to have local anesthetic activity, and fast sodium channel blockade is responsible for its inhibitory effect on nerve conduction. This study de- scribes the dose response inhibition of nerve conduction hy verapamil and bupivacaine alone as well as in combination of both on an isolated rat sciatic nerve preparation. In addition, it describes the effect of caleium ion concentration on this in vitro nerve preparation. Sciat- ic nerve preparation from rats were placed in mammarian ringer solution(MRS) adjusted to pH 7.4 at 22℃. Each nerve was mounted in a nerve conduction chamber containing MRS in the presence of verapamil(10^(-5)M-2×10^(-3) M), bupivacaine(10^(-6)M-10^(-3)M) or a combination of both. Each nerve was stimulated with a square wave pulse at twice threshold potential(4 -7V), 0.02msec of duration, 10Hz of frequency. Compound action potentials(CAP) were photographed and measured on a Tektronix oscilloscope. The nerve was first equilibrated in the nerve conduction chamber in MRS, H 7.4, 22℃ for 30min) and CAP was recorded for control(100% recovery). Then, the nerve was exposed to increasing concentrations of verapamil and bupivacaine for 12 minutes and a CAP was measured after each exposure. All CAP were compared to the control CAP and the results were expressed as a % of control CAP. We got dose response curve of verapamil, bupivacaine and combination of both. Also, we determined EC 25%, 50%, 75% from these data(EC % : Effective concentra- tions of drug for % CAP inhibition). Each of the experiments was performed on at least 4 nerves and differences between groups were analyzed using ANOVA test. Verapamil is shown to inhibit nerve conduction with an EC 25% = 2.2×10^(-4)M, EC 50%=3.8×10-4M, EC 75% =6.3×10^(-4)M and EC 50% for bupivacaine was 5.0×10^(-5) M. When verapamil dose response curves were performed in the presence of a wide range of CaCl2 containing MRS solutions, there was no significant differences in the response curve(P$gt;0.05). in conclusion, racemic verapamil was shown to have dependent local anesthetic activity with a relative potency of 1/8 of bupivacaine. When combined with bupivaeaine, local anesthetic activity inereased in an additive manner. This suggests that these two drugs act on the nerve membrane in a similar fashion. Various CaCl₂ concentrations have no effect on nerve conduction inhibition of verapamil. This implicates sodium channel blockade as the mechanism of local anesthetic activity of verapamil.
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