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한국산 담자균류의 항암성분에 관한 연구 - 만년 버섯의 균사 배양 및 항암 성분 -
강창율,심미자,최응칠,이영남,김병각 ( Chang Yul Kang,Mi Ja Shim,Eung Chil Choi,Young Nam Lee,Byong Kak Kim ) 생화학분자생물학회 1981 BMB Reports Vol.14 No.2
To find antineoplastic components from Korean higher fungi, the mycelium of Ganoderma lucidum (Fr.) Karsten was grown in shake culture and a protein-bound polysaccharide was isolated. This component suppressed tumor growth of sarcoma 180 grafted in A-strain mice. The component was administered intraperitoneally to the mice at a dose of 50 ㎎/㎏ daily for five days. Ten days later, the mice were immunized with 1×10^7 sheep red blood cells. The number of plaque-forming cells in their spleen was significantly greater than that of control mice. Three monosaccharides and sixteen amino acids were identified from the protein-bound polysaccharide.
한국산 담자균류의 항암성분에 관한 연구 -만년 버섯의 균사 배양 및 항암 성분-
강창율,심미자,최응칠,이영남,김병각,Kang, Chang-Yul,Shim, Mi-Ja,Choi, Eung-Chil,Lee, Young-Nam,Kim, Byong-Kak 생화학분자생물학회 1981 한국생화학회지 Vol.14 No.2
To find antineoplastic components from Korean higher fungi, the mycelium of Ganoderma lucidum (Fr.) Karsten was grown in shake culture and a protein-bound polysaccharide was isolated. This component suppressed tumor growth of sarcoma 180 grafted in A-strain mice. The component was administered intraperitoneally to the mice at a dose of 50 mg/kg daily for five days. Ten days later, the mice were immunized with $1{\times}10^7$ sheep red blood cells. The number of plaque-forming cells in their spleen was significantly greater than that of control mice. Three monosaccharides and sixteen amino acids were identified from the protein-bound polysaccharide. 한국산 고등 균류 중에서 항암성분을 탐색할 목적으로 담자균류의 하나인 만년 버섯, Ganoderma lucidum (Fr.) Karsten의 균사를 진탕 배양하여 얻은 균사체와 그 배양여액으로부터 단백다당류를 추출 분리하였으며 종양 억제작용 및 면역에 미치는 영향을 검토하였다. Sarcoma 180 세포를 흰 쥐에 이식한 후 이 단백다당류를 주사하였을 때 60% 이상의 저지율을 나타내었다. 또한 흰 쥐에 이 단백다당류를 5일간 복강내에 주사하여 10일이 지난뒤에 $1{\times}10^7$개의 면양 적혈구를 주사했을 때 용혈반을 만드는 비장세포의 수가 현저히 증가함을 관찰하였다. 이 단백다당류를 산으로 가수분해하여 3종의 단당류과 16종의 아미노산을 확인하였다.
김병각,김기호,최응칠,강창율 한국균학회 1976 韓國菌學會誌 Vol.4 No.1
The carpophores of Daedaleopsis tricolor(Fr.) Bond. et Sing. which grows wildly in Korea were collected in the Gyeong Gi Province and extacted with chloroform and methanol. Four compounds were isolated from the extract and two of these compounds were identified as ergosterol and stigmasterol by T.L.C., G.L.C. and chemical tests.