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산업용 모터 구동을 위한 고내압 저전력 Power MOSFET 최적화 설계에 관한 연구
김범준,정헌석,김성종,정은식,강이구,Kim, Bum-June,Chung, Hun-Suk,Kim, Seong-Jong,Jung, Eun-Sik,Kang, Ey-Goo 한국전기전자재료학회 2012 전기전자재료학회논문지 Vol.25 No.3
Power MOSFET is develop in power savings, high efficiency, small size, high reliability, fast switching, low noise. Power MOSFET can be used high-speed switching transistors devices. Recently attention to the motor and the application of various technologies. Power MOSFET is devices the voltage-driven approach switching devices are design to handle on large power, power supplies, converters, motor controllers. In this paper, design the 600 V Planar type, and design the trench type for realization of low on-resistance. For both structures, by comparing and analyzing the results of the simulation and characterization.
김범준,장기육,오용석,승기배,백상홍,신우승,임상현,김재형,홍순조,최규보 대한심장학회 2005 Korean Circulation Journal Vol.35 No.2
Background and Objectives :Matrix metalloproteinase-9 (MMP-9) plays an important role in the genesis of atherosclerotic plaque rupture and acute coronary syndrome (ACS), including an acute myocardial infarction (AMI). A single nucleotide polymorphism (SNP) in the MMP-9 promoter (- 1562C>T) has recently been identified. This study investigated whether the SNP of the MMP-9 promoter is a significant risk factor for an AMI due to plaque rupture and if SNPs afect the transcription of the gene that elevates the MMP-9 expresion level. Subjects and Methods :A polymerase chain reaction, followed by a restriction fragment length poly-morphism analysis, was performed in 173 control participants and 206 AMI patients. The serum levels of MMP-9 in the groups with or without the SNP were measured, using ELISA, and compared. Results:There was a significantly higher incidence of the -1562C> (27.6% vs. 17.9%, p=0.04). A multiple logistic regresion analysis of the risk factors for coronary artery disease and the MMP-9 polymorphism showed the MMP-9 polymorphism to be an important factor in the prediction of an AMI (odds ratio 1.67, 95% confidence interval 1.02-2.67, p=0.04). Conclusion :The -1562C>T polymorphism in the MMP-9 promoter is a definite risk factor for an AMI, and is associated with elevated MMP-9 expression. These results sugest that a SNP in the MMP-9 promoter is strongly associated with an Acute Myocardial Infarction.
구강 세척액으로서의 저농도 차아염소산의 안전성 및 구강내 세균에 대한 항균효과
김범준,김영효,장태영 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.6
Background and Objectives The authors aimed to evaluate the safety of low concentration hypochlorous acid as an oral gargle solution. To do this, we carried out in vitro and in vivo experiments and evaluated its efficacy by compared with normal saline and chlorhexidine gargle using throat culture before and after gargling. Materials and Method The authors treated oral mucosal epithelial cell with 3.5 ppm hypochlorous acid and evaluated cytotoxicity. For evaluation of morphological change, oral mucosa specimens were obtained during surgery before 30 minutes and 2 hours after treatment with hypochlorous acid. The specimens were evaluated with light microscopy. For evaluation of efficacy, we performed oral gargle with normal saline, chlorhexidine and hypochlorous acid in 10 healthy volunteers. The throat cultures were performed before and after each gargling. Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Klebsiella pneumoniae, Aspergillus fumigatus, Rhizopus oryzae were evaluated semi-quantitatively (Grade 0 to 4). Results There was no cellular toxicity in MTT assay and the morphological changes were not observed. Both chlorhexidine and hypochlorous acid showed significant decrease of microbes (chlorhexidine: p=0.036, hypochlorous acid: p=0.031). There was no significant differences between them (p=0.217). Conclusion Low concentration hypochlorous acid is safe for the oral mucosal epithelium and has antimicrobial efficacy similar to that of chlorhexidine.
전문의 고시에서 표준화 환자를 이용한 진료 수행 시험의 경험: 3개 연도 신경과 전문의 시험 결과 분석을 바탕으로
김범준,성정준,박훈기,서대원,정진상,윤병우 한국의학교육학회 2011 Korean journal of medical education Vol.23 No.2
Purpose: Evaluation of clinical skills and attitude including development of dynamic patient-doctor relationship is important in board examination (BE). Korean Neurological Association (KNA) has introduced clinical performance examination (CPX) utilizing standardized patients (SP) to BE in 2007. In this study, the authors describe the 3-year experience of CPX in BE through 2009. Methods: To implement CPX session in BE, KNA developed CPX workshop for BE attendees and members of grading committee. CPX sessions in BE consisted of two model scenarios mimicking neurological patients in clinical practice. The total score and itemized scores of CPX sessions were compared with other areas of BE, and scores from each year were also compared. Results: Scores from CPX sessions were significantly correlated with BE step II. Among the itemized scores of CPX sessions, clinical items including history taking and physical examination were significantly correlated with scores from other areas of BE. However,scores from global assessment from SP were strongly associated with patient-doctor relationship, history taking, and patient education. Conclusion: Our experiences suggest that CPX utilizing SP is a useful tool to assess the clinical skills in BE. In order to produce clinically well qualified neurologists, more efforts should be made to develop cases and to improve assessment tools for CPX.