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Song Seung Ha,Lee Hyunju,Lee Hoan Jong,송은송,Ahn Jong Gyun,박수은,Lee Taekjin,Cho Hye-Kyung,Lee Jina,Kim Yae-Jean,조대선,김종현,강현미,이준기,김천수,김동현,김황민,최재홍,은병욱,김남희,Cho Eun Young,Kim Yun-Kyung,Oh Chi Eun,김경효,Ma Sang 대한의학회 2023 Journal of Korean medical science Vol.38 No.16
Background: The coronavirus disease-2019 (COVID-19) pandemic has contributed to the change in the epidemiology of many infectious diseases. This study aimed to establish the pre-pandemic epidemiology of pediatric invasive bacterial infection (IBI). Methods: A retrospective multicenter-based surveillance for pediatric IBIs has been maintained from 1996 to 2020 in Korea. IBIs caused by eight bacteria (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pyogenes, Listeria monocytogenes, and Salmonella species) in immunocompetent children > 3 months of age were collected at 29 centers. The annual trend in the proportion of IBIs by each pathogen was analyzed. Results: A total of 2,195 episodes were identified during the 25-year period between 1996 and 2020. S. pneumoniae (42.4%), S. aureus (22.1%), and Salmonella species (21.0%) were common in children 3 to 59 months of age. In children ≥ 5 years of age, S. aureus (58.1%), followed by Salmonella species (14.8%) and S. pneumoniae (12.2%) were common. Excluding the year 2020, there was a trend toward a decrease in the relative proportions of S. pneumoniae (rs = −0.430, P = 0.036), H. influenzae (rs = −0.922, P < 0.001), while trend toward an increase in the relative proportion of S. aureus (rs = 0.850, P < 0.001), S. agalactiae (rs = 0.615, P = 0.001), and S. pyogenes (rs = 0.554, P = 0.005). Conclusion: In the proportion of IBIs over a 24-year period between 1996 and 2019, we observed a decreasing trend for S. pneumoniae and H. influenzae and an increasing trend for S. aureus, S. agalactiae, and S. pyogenes in children > 3 months of age. These findings can be used as the baseline data to navigate the trend in the epidemiology of pediatric IBI in the post COVID-19 era.
이경태(Kyung Tae Lee),손일철(Il Cheol Sohn),공은아(Eun Ah Kong),김동현(Dong Hyun Kim),최승기(Seung Ki Choi),최종원(Jong Won Choi),박희준(Hee Juhn Park) 대한약학회 1999 약학회지 Vol.43 No.6
Antioxidative and cytoprotective effects of tectorigenin and glycitein isolated from the Pueraria thunbergiana and its derivative, genistein, were determined. Among these three compounds, tectorigenin and glycitein bearing 6-methoxyl groups in both isoflavones showed significant free radical scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generating superoxide anion radical. Tectorigenin only showed a slight inhibitory effect on XOD. We further studied the inhibitory effects of these isoflavones on the lipid peroxidation in rat liver microsomes induced by enzymatic and non-enzymatic methods. Each of them exhibited inhibitory effect on both ascorbic acid/Fe2+- and ADP/NADPH/Fe+3-induced lipid peroxidation. Moreover, tectorigenin exhibited the highest protection of hydrogen peroxide damage on HepG2 and Vero cells among the three isoflavones, in the cytoprotective assay. It was suggested that the pattern of antioxidative and cytoprotective effect of isoflavones could by crucially changed by the aromatic substitution of oxygen-containing groups.
정은아(Eun Ah Jung),김윤경(Yun Kyung Kim),김남재(Nam Jae Kim),김동현(Dong Hyun Kim),이상인(Sang In Lee) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.2
Gamigwaruhaebaekwhanggum-Tang (GGHWT) have been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by Triton WR-1339, corn oil and high cholesterol-diet. Especially, GGHWT is formulated with Trichosanthis Fructus, Pinelliae Tuber, Aurantii Immaturus Fructus, Magnoliae Cortex, Allii Macrostemi Bulbus, Cinnamomi Ramulus and Scutellariae Radix. Oral administration of GGHWT at 500 mg/kg/day for 3 days significantly inhibited the increase of serum triglyceride and LDL-cholesterol, liver triglyceride in hyperlipidemic rats induced by Triton WR-1339. And, GGHWT significantly inhibited the increase of serum triglyceride in hyperlipidemic rats induced by corn oil. Also, administration of GGHWT (500 mg/kg, once daily for 1 week, p.o.) prevented the increase of serum total cholesterol, triglyceride, LDL-cholesterol, liver total cholesterol and triglyceride in 1 % cholesterol-diet fed mice. These results suggest that GGHWT is effective for the treatment of hyperlipidemia.
내시경적 절제술로 치료된 바터팽대부의 동시 발현된 신경절세포부신경절종과 이소성 췌장 1예
강균은 ( Gyoun-eun Kang ),김현수 ( Hyunsoo Kim ),이재광 ( Jae Kwang Lee ),김동현 ( Dong Hyun Kim ),정비나 ( Bi-na Jeong ),장지훈 ( Ji-hun Jang ),여상명 ( Sang-myung Yeo ),손경락 ( Kyung-rak Sohn ) 대한췌담도학회 2016 대한췌담도학회지 Vol.21 No.4
저자들은 상복부 불편감으로 발견된 바터팽대부 점막하종양의 진단과 치료를 위해 시행한 내시경적 절제술상 신경절세포 부신경절종과 이소성 췌장이 동시 발현된 증례를 경험하여 문헌고찰과 함께 보고하는 바이다. Gangliocytic paraganglioma is an uncommon tumor of digestive system that is usually found in the second portion of duodenum. It is generally considered benign tumor, although few reports of local recurrences and regional lymph node metastases have been made. Gangliocytic paraganglioma is characterized by its histologic pattern including ganglion cells, spindle cells and epithelioid cells. Heterotopic pancreas, also known as ectopic pancreas, is a pancreatic tissue appeared outside of its normal location lacking anatomic or vascular connection with the pancreas. In duodenum, it is a relatively unusual lesion that may be found incidentally during surgery or endoscopy. We present a case of 39-year-old woman with gangliocytic paraganglioma combined with heterotopic pancreas in the ampulla of Vater successfully treated by endoscopic resection.
한방약물로부터 항고지혈증 치료약물개발(3) -In vitro에서 가미과루해백황금탕 및 구성약물의 항고지혈증 활성-
정은아,김윤경,김동현,이상인,김남재,Jung, Eun-Ah,Kim, Yun-Kyung,Kim, Dong-Hyun,Lee, Sang-In,Kim, Nam-Jae 한국생약학회 2001 생약학회지 Vol.32 No.1
80% extract of Gamigwaruhaebaekbaekju-Tang (GGHBT), Gagamgwaruhaebaekbaekju-Tang (GGGHBT) and Gamigwaruhaebaekwhanggum-Tang (GGHWT) remarkably showed inhibitory effects on HMG-CoA reductase, lipid peroxidation of rat liver and LDL oxidation, and DPPH free radical scavenging effect in a dose-dependent manner. Especially, GGHWT which is formulated with Trichosanthis Fructus, Pinelliae Tuber, Aurantii Immatures Fructus, Magnoliae Cortex, Allii Macrostemi Bulbus, Cinnamomi Ramulus and Scutellariae Radix on the basis of Gwaruhaebaekbaekiu-Tang listed on the traditional medicinal references showed more effective hypocholesterolemic activities in vitro bioassay than the other prescriptions.