백서의 피부 및 뇌혈류에 미치는 고려홍삼 사포닌 및 비사포닌의 영향

김신희(Shin Hee Kim),김국성(Cuk Seong Kim),박진봉(Jin Bong Park),한찬수(Chan Soo Han),김광진(Kwang-Jin Kim),김신혜(Shin Hye Kim),김세훈(Se Hoon Kim),남기열(Ki Yeul Nam),전병화(Byeong Hwa Jeon) 고려인삼학회 2002 Journal of Ginseng Research Vol.26 No.3

본 연구에서는 혈류량의 변화를 실시간으로 측정할 수 있는 레이져 도플러 혈류량측정장치를 이용하여 피부혈류 및 뇌혈류량에 미치는 고려홍삼의 사포닌과 비사포닌의 효능을 연구하고자 고려홍삼의 정맥내 복강내 및 구강내로 주입하고 혈류의 변화를 관찰하여 다음과 같은 결론을 얻었다. 고려 홍삼<br/> 의 사포닌 성분은 피부혈류량에는 영향을 주지 않으나 뇌혈류량을 증가시키는 효능이 있다. 고려 홍삼의 비사포닌 성분은 피부혈류량 및 뇌혈류량에 거의 영향을 주지 않았다. 고려홍삼 사포닌에 의한 뇌혈류량의 증가는 복강내 및 경구로 투여할 경우는 관찰할 수 있으나 정맥내로 직접 투여할 경우는<br/> 관찰되지 않았다.이상의결과를종합해볼때고려홍삼의 사포닌 성분은 뇌혈류량을 증가시키는 혈류개선작용이 있는 것으로 사료된다. To study the effect of Korea red ginseng (KRG) on the skin and cerebral blood flow, we evaluated the change of skin perfusion rate and cerebral perfusion rate after the intravenous, intraperitoneal, and oral administration of crude saponin (CS) and saponin-free fraction (SFF) of KRG in the rats. The change of skin perfusion rate and cerebral perfusion rate was measured laser doppler flowmetry. The intravenous injections of CS or SFF of KRG and intraperitoneal injection of SFF of KRG did not change the relative skin and cerebral blood flow in the rats. When the rats were treated by the<br/> intraperitoneal injection of CS of KRG, relative cerebral blood flow was significantly increased with a time-dependent manner, however, relative skin blood flow was not influenced by the them. Oral administration of CS of KRG slightly increased skin blood flow in the rats. Also, the change of cerebral blood flow by transient bilateral carotid arterial clamp in the CS-treated rats was significantly decreased, compared with control groups. From the above results, it was suggested that Korea red ginseng have a increasing property of cerebral blood flow in the rats.<br/> Key words : Korea Red Ginseng, Cerebral blood flow, Skin blood flow, Laser Doppler flowmeter.

요가 수리야 나마스카라 수련형태에 따른 에너지소비량 및 호흡순환기능 비교

김국성(Kim, Kook-Sung),남상석(Nam, Sang-Seok),박준성(Park, Joon-Sung),노호성(Nho, Ho-Sung) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.6

The purpose of this study was to provide a comprehensive reference base for designing exercise prescription program through a comparative analysis of Ashtanga Surya Namaskar (ASN) and Vini Surya Namaskar (VSN) by physiologically quantifying energy consumption and respiratory circulation response of 12 different postures of each yoga series in yoga instructors. Subjects were female yoga instructors (mean age, 35.5±7.0 years) with an experience of teaching for more than 3 years at least twice per week and 60 minutes per session. Subjects were asked to perform 12 poses of ASN and VSN as a chi-square test and their energy consumption and respiratory circulation response were measured while staying each stationary position for a minute. Based on resting heart rate and oxygen uptake, we minimized the effect of each position on a following position. Differences before and after each yoga pose and in energy consumption and respiratory circulation response between ASN and VSN were tested using two-way repeated m easures ANOV A. Moreover, t he d ata was analyzed u sing d ependent t -test to d etermine differences between the means of yoga practices. According to the results of this study, the mean energy consumption of 12 postures was 1.6 /min in both ASN and VSN. The energy ㎉ consumption of a series of 12 yoga poses was 3.6㎉/min in ASN and 3.2 ㎉/min in VSN. According to the analysis of exercise intensity when performing 12 postures of ASN and VSN, both yoga series required 1.7 METs, and HRmax was 48.2% in A SN and 50% in V SN. In addition, VO2max was measured 19.4% in ASN and 20.1% in VSN. The findings of this study are expected to provide quantitative physiological data necessary in choosing yoga postures and types, energy consumption patterns and exercise intensity appropriate for yoga trainees’ fitness levels.

요가 아사나(Yoga Asana)가 고관절,골반의 불균형에 따른 하지변형 교정

김국성 ( Kook Sung Kim ) 국제통합대체의학협회 2011 국제통합대체의학회지 Vol.7 No.2

The goal of this study is to develop the healing program of recovering the body imbalance by means of yoga asana as well as to provide a fundamental data in domestic yoga therapeutics development, after revealing the effects of it. The subjects of this research were selected within the women members in their twenties to forties in Seoul M-yoga academy institute after conducting the survey in advance. The experiment was done 2 times a week for 8 weeks, and the vini healing yoga program(VHYP) was practiced distinguishing long legs, short legs, and O-shaped legs in accordance with physical traits, applying the principle of 2 to 1. X-ray photographing was done before the experiment began and after the experiment, in order to verify the effects which yoga asana had on the change in the iliac length(AS/PI), one in the iliac width(IN/EX), hip joint angle(internal rotation / external rotation), the change of the lower part of a leg, and the change of a pelvis circumference and that of the vini healing yoga program. In the O-shaped leg vini healing yoga program, there appeared some noticeable changes in the iliac width(L), in a hip joint angle(L), in the lower part of a leg(L), in a pelvis circumference in the second verification. In the O-shaped leg vini healing yoga program produced a more effectively. But there weren`t any noticeable changes in the pelvis length, in the pelvis width, and in the length of the lower part of the leg.

요가 수리야-나마스카라 수련형태에 따른 자율신경계 변화 비교

김국성(Kim, Kook-Sung),남상석(Nam, Sang-Seok) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.3

The purpose of this study is to compare the effects of ashtanga surya-namaskar(ASN) emphasizing motion types on the autonomic nervous system during repeated execution of vini surya-namaskar(VSN) that emphasize mental movements. This study was conducted on 20 yoga instructors. Experiments were performed with all subjects repeatedly performing ASN and VSN at intervals of one week. Autonomic nervous system tests were performed before and after 12 consecutive runs of 12 ASN and VSN, respectively. Autonomic variables used heart rate variability. Heart rate variability variables were sandard deviation of the normal to normal interval(SDNN), the square root of the mean squared differences of successive NN intervals(RMSSD), very low frequency(VLF), low frequency(LF), high frequency(HF), ratio of LF per HF(LF/HF), and total power(TP). Statistical analysis was performed using repeated ANOVA, independent t-test, and dependent t-test. Statistical significant level was at .05. As a result, after 12 consecutive sessions, LF / HF increased ASN and decreased VSN, indicating that VSN is effective for parasympathetic activation.

음성정보 기반 건강 자가진단 시스템의 개발

김국성(Cuk-Seong Kim),조동욱(Dong-Uk Cho),박현종(Hyun-Jong Park),박전규(Jeon-Gu Park) 한국통신학회 2018 한국통신학회 학술대회논문집 Vol.2018 No.1

적응적 탬플릿 마스킹과 패턴 벡터 기법을 이용한 일본 차량 번호판 인식

김미진(Mi-Jin Kim),김국성(Kook-Sung Kim),이응주(Eung-Joo Lee) 한국멀티미디어학회 2003 한국멀티미디어학회 학술발표논문집 Vol.2003 No.1

산학연 협업 활성화를 위한 R&D 네트워크 연결 예측 연구

박미연(Mi-yeon Park),이상헌(Sangheon Lee),김국성(Guocheng Jin),심홍매(Hongme Shen),김우주(Wooju Kim) 한국지능정보시스템학회 2015 지능정보연구 Vol.21 No.3

The recent global trends display expansion and growing solidity in both cooperative collaboration between industry, education, and research and R&D network systems. A greater support for the network and cooperative research sector would open greater possibilities for the evolution of new scholar and industrial fields and the development of new theories evoked from synergized educational research. Similarly, the national need for a strategy that can most efficiently and effectively support R&D network that are established through the government’s R&D project research is on the rise. Despite the growing urgency, due to the habitual dependency on simple individual personal information data regarding R&D industry participants and generalized statistical data references, the policies concerning network system are disappointing and inadequate. Accordingly, analyses of the relationships involved for each subject who is participating in the R&D industry was conducted and on the foundation of an educational-industrial-research network system, possible changes within and of the network that may arise were predicted. To predict the R&D network transitions, Common Neighbor and Jaccard’s Coefficient models were designated as the basic foundational models, upon which a new prediction model was proposed to address the limitations of the two aforementioned former models and to increase the accuracy of Link Prediction, with which a comparative analysis was made between the two models. Through the effective predictions regarding R&D network changes and transitions, such study result serves as a stepping-stone for an establishment of a prospective strategy that supports a desirable educational-industrial-research network and proposes a measure to promote the national policy to one that can effectively and efficiently sponsor integrated R&D industries. Though both weighted applications of Common Neighbor and Jaccard’s Coefficient models provided positive outcomes, improved accuracy was comparatively more prevalent in the weighted Common Neighbor. An un-weighted Common Neighbor model predicted 650 out of 4,136 whereas a weighted Common Neighbor model predicted 50 more results at a total of 700 predictions. While the Jaccard’s model demonstrated slight performance improvements in numeric terms, the differences were found to be insignificant.

Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향

김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.

고혈압백서 대동맥에서 Ca에 의한 수축에 미치는 Na/Ca교환기전의 영향

전병화,김국성,박경숙,김주석,김세훈,장석종 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

We investigated the contraction by sodium-calcium(Na-Ca) exchanges in the aortic strips of spontaneously hypertensive rats(SHR) and Wistar-Kyoto (WKY) rats. Resting tension of aortic strips in SHR was decreased by the removal of extracellular Ca and those were recovered by the addition of Ca. However, resting tone of aortic strips in WKY was not changed by Ca removal or Ca addition. Ca-induced contraction after exposure to Ca-free solution was suppressed by verapamil 10^-6M to 90% or more. In the presence of verapamil 10^-5M, phentolamine 10^-6M, caffeine 5mM and atropine 10^-6M, the reduction of extracellular sodium concentration([Na]o) from normal(158 mM) to 0 mM(replaced by choline chloride) caused the contraction(Ca entry by Na-Ca exchange). The amplitude of contraction was more greater in SHR than in WKY rats. In the presence of verapamil 10^-5M, phentolamine 10^-6M, caffeine 5mM and atropine 10^-6M, aortic strips were not contracted by Naand Ca-free solution, but was contracted by the addition of Ca. In the presence of verapamil 10^-5M and phentolamine 10^-6M and ouabain 10^-5M, Ca did not induce contraction after exposure to Ca-free Tyrode ' s solution, but in the presence of verapamil 10^-5M and phentolamine 10^-6M and monensin 10^-5M a sodium ionophore, Ca induced a little contraction in the aortic strips of SHR. These observations suggest that Na-Ca exchange does not contribute the development of Ca-induced contraction after exposure to Ca-free Tyrode ' s Solution in the presence of normal extracellular Na concentration. However, Na/Ca exchange in vascular smooth muscle is increased in SHR and may be involved in the mechanism for hypertension in SHR.

고혈압 백서에서 운동 후 혈압강하 현상

전병화,이재웅,김국성,박진봉,김일곤,김세훈,전종귀 대한스포츠의학회 2001 대한스포츠의학회지 Vol.19 No.2