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종합병원 환자에서 분리된 호기성 그람음성 간균의 Cefepime에 대한 감수성
정윤섭,이경원,권오현 대한감염학회 1995 감염 Vol.27 No.5
목 적 : 소수의 우리나라 균주를 대상으로한 한천희석법 시험에서 cefepime은 여러 그람음성간균에 대한 항균력이 강함이 보고된 바 있다. 이 연구에서는 다수의 균주를 대상으로 감수성을 검토하고자 하였다. 방 법 : 종합병원 환자에서 1993년에 분리한 4797주의 Enterobacteriaceae, Aeromonas, P. aeruginosa, A. baumannii 및 X. maltophilia의 감수성을 디스크 확산법으로 시험하였다. 결 과 : Enterobacteriaceae의 내성율은 ampicillin에 대해 82%, gentamicin에 24%, ofloxacin에 10%, cephalothin에 71%, cefotaxime에 15%, cefoperazone/sulbactam에 7%, cefepime에 1%이었다. P. aeruginosa의 내성율은 cefepime과 cefoperazone/sulbactam에 대해서 가장 낮아서 24%이었다. Cefotaxime 내성 균주의 cefepime 감수성율은 C. freundii 77%, E. cloacae 61% 그리고 S. marcescens 53%이었다. 결 론 : 제3세대 cephalosporin에 내성인 원내감염균을 포함한 호기성 그람음성 간균의 cefepime에 대한 내성율은 비교된 모든 항균제에 대해서 보다 낮다. Background : Previous agar dilution test showed that cefepime is very active against various gram-negative bacilli including the third generation cephalosporin-resistant Enterobacter, Serratia and Citrobacter. The aim of this study was to test the susceptibility of large number of recent clinical isolates of gram-negative bacilli to cefepime. Methods : A total of 4797 isolates of Enterobacteriaceae, Aeromonas, Pseudomonas aeruginosa, Acinetobacter baumannii and Xanthomonas maltophilia isolated from a tertiary-care general hospital patients, were tested by the NCCLS disk diffusion test and the results were analyzed using a WHONET Ⅲ program. Results : Resistance rates of Enterobacteriaceae were 82% to ampicillin, 71% to cephalothin, 24% to gentamicin, 10% to ofloxacin, 15% to cefotaxime, 7% to cefoperazone/sulbactam and 1% to cefepime. P. aeruginosa showed the lowest resistance rate of 24% to both cefepime and ceftazidime. The cefepime susceptible rates of cefotaxime-resistant isolates were C. freundii 77%, E. cloacae 61% and S. marcescens 53%. Conclusion : Resistance rates of the recent clinical isolates of aerobic gram-negative bacilli, including the third generation cephalosporin-resistant nosocomial pathogens, are lower to cefepime than to the other antimicrobial agents compared.
Group B Streptococcus 배양성적을 통해 본 감염의 현황
정윤섭,남정현,이경원,권오현 대한감염학회 1994 감염 Vol.26 No.1
Clinical significance of Streptococcus agalactiae (group B streptococci, GBS) infection was recognized only in the 1970s. GBS causes serious neonatal infections as well as various diseases in adults with underlying diseases. Increased GBS infection was reported increasingly in other countries, but in Korea, out knowledge on the infection is very limited. To determine the current situation of GBS infection, we retrospectively analysed the cultural results of β-hemolytic streptococci from various clinical materials during the years 1986-1990 at Severance hospital and the significance on the GBS infection. GBS was the second most frequently isolated group of β-hemolytic streptococci and the proportion was increased. It was more frequently isolated from 30-39 year-old women and genitourinary specimens. It was relatively frequently isolated from neonates and adults with underlying diseases. It is concluded that rapid and accurate microbiological diagnosis is very important for the proper treatment of GBS-infected patients, as GBS infections in neonates is often serious and those in adults with underlying disease results in relatively high mortalilty, and as some isolates are resistant to antimicrobial agents.
Cefepime의 Enterobacter cloacae, Serratia marcescens 및 Pseudomonas aeruginosa 등 호기성 그람음성 간균에 대한 항균력
이경원,권오현,정윤섭 대한감염학회 1992 감염 Vol.24 No.1
Infections due to such resistant bacteria as Citrobacter freundii, Enterobacter cloacae, Serratia marcescens and Pseudomonas aeruginosa became increasingly serious treatment problem at large medical centers, in Korea. Cefepime was reported to be more active than other cephalosporins against these problem organisms. The activity of cefepime aginst the bacteria isolated mostly from inpatients at a hospital in Seoul, in 1991, were tested by the agar dilution method. Among the antimicrobial agents tested, cefepime showed the lowest ?? against C. freundii and E. cloacae, 0.12 ㎍/㎖ and 8 ㎍/㎖, respectively. ?? of cefepime and amikacin, 8 ㎍/㎖, was the lowest against S. marcescens. ?? of cefepime, ceftazidime and doxycycline, 32 ㎍/㎖, were the lowest against Acinetobacter anitratus. Against P. aeruginosa, the ?? was relatively high, 32 ㎍/㎖, but still the lowest. Among the cefotaxime-resistant to ceftazidime, ceftizoxime and cefuzonam, respectively. Again, only 6% of gentamicin-resistant isolates were resistant to cefepime, compared to 91%, 72%, 69% and 63% to ceftazidime, ceftizoxime, cefuzonam and cefotaxime, respectively. The highly active in vitro test result should indicate the usefulness of cefepime for the treatment of various gram-negative bacilli infections including nosocomial ones.
임상검체에서 분리된 세균의 항균제 감수성 : 1988-1992년 결과
이경원,정윤섭,권오현,박홍석,김준명 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2
Desite of availability of many antimicrobial agents, selection of drugs for treatment become very difficult, because of ever increasing resistant bacteria. As the resistance rates to drugs may vary greatly, depending on the species and the country of the isolation. It is important to know the current trend of resistance for the empiric therapy of patients. We analyzed the routine disk susceptibility test results at the Severance Hospital, during the years 1988-1992. During the period, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa remained to be the most frequently isolated species, while Acinetobacter baumannii, Enterobacter cloacae and Klebsiella pneumoniae were also prevalent. Increased isolation of Enterococcus was remarkable. These tendencies were considered to rellect increased resistance of these species. Methicillin-resistetant S.aureus, ampicillin-resistant Enterococcus and penicillin G-resistant Streptococcus pneumoniae were increased significantly. Increased resistance was also noted in E.coli, Citrobacter freundii, E.cloacae and A. baumannii, Although the resistance rates in our data may be relatively high, because the strains were mostly Isolated from inpatients, it is certain that resistant strains are more prevalent in Korea. In conclusion, this trend indicates that some drugs can be empirically selected with good predictable effect, while others with unpredictable effect. For durgs with unpredictable effect, susceptibility testing is required to guide selection of still effective old agents as much as possible to preserve the activity of newer agents the future.
여러 질환에서의 Antinuclear Antibody(ANA) Test 에 관한 연구
조준구,김현숙,홍천수,조철호,권오현,김현만,이수곤,허갑범,전상일 대한내과학회 1987 대한내과학회지 Vol.32 No.2
Antinuclear antibodies are autoantibodies that are usually detected by indirect immunofluorescence and are directed against components of human and other mammalian cell nuclei. Between January 1982 and December 1984, we retrospectively reviewed the records of 238 patients with a positive ANA test. The following results were obtained from this review. 1) Among 238 ANA positive specimens, 98 (41.2%) were connective tissue disorders, 43 (18.0%) immune disorders and 97 (40.8%) other disorders. 2) Among 238 ANA positive specimens, 135 (57%) were low, 26 (11%) intermediate and 77 (32%) high titers. Sixty three of 98 (64.2%) sera from patients with connective tissue disorders and 44 of 53 (83%) sera from patients with SLE had ANA titers of 1:80 or more. Thirty two of 42 (74.4%) sera from patients with immune disorders and 68 of 97 (70.1%) sera from patients with other disorders had ANA titers of 1: 20. 3) Among 238 ANA positive specimens, immunofluorescent patterns showed that 105 (44%) were homogeneous, 102 (43%) speckled, 13 (5.5%) mixed, 12 (5%) peripheral and 6(2.5%) nucleolar pattern. 4) In 53 SLE patients, 41 (77%) were high titers in ANA test and homogeneous and speckled patterns were 26 (55.5%) and 20 (37.7%) respectively. Thirty of 37 (81%) SLE patients had positive anti-DNA test and 16cases (43%) were high titers. 5) Nineteen patients (13.6%) of 140 nonrheumatic disorders showed high ANA titers. Among nine patients with idipathic thrombocytopenic purpura, three patients showed high ANA titers (1:160 1). In conclusion ANA test was useful to diagnose various rheumatic disease. Some nonrheumatic patients also revealed positive ANA test. ANA titers were high in rheumatic disorders, but some non-rheumatic patients with high ANA titers should be followed to look for evolving rheumatic disorders.