장기 운송 후 수송배지에 따른 임균 검출능 및 타 성 매개 병원균과의 동시 감염률 평가

구현민,서영희,이양순,이혁민,용동은,정석훈,이경원 대한임상미생물학회 2014 Annals of clinical microbiology Vol.17 No.4

Background: Neisseria gonorrhoeae infection remains prevalent, and the emergence of antimicrobial resistance has made the treatment and control of gonorrhea more difficult. Therefore, it is important to compare isolation methods and transport media to overcome gonorrhea via epidemiologic understanding and to determine co-infection rates with other sexually transmitted diseases among primary-care hospitals. In this study, we determine the recovery rate of transferred specimens according to type of transport media and co-infection rate using PCR. Methods: Genital specimens were collected at three primary-care hospitals from January 2010 to November 2012 using transgrow media and commercial BD transport media. Culture and multiplex PCR were conducted to isolate N. gonorrhoeae. Results: Among 162 specimens, 57 (35.2%) isolates were recovered, and 146 (90.1%) specimens were positive for multiplex PCR. The recovery rate was 29.9% (78/261) using transgrow media and 19.2% (50/261) using BD transport media. The most common co-infected bacteria with N. gonorrhoeae was Chlamydia trachomatis (15.8%), followed by Mycoplasma hominis (6.2%) and M. genitalium (3.4%). Conclusion: Under general transport conditions, the rate of recovery of N. gonorrhoeae was as low as 19.2-29.9% depending on the type of transport media, suggesting that molecular diagnostic methods are required to detect the remaining 70% of gonorrhea-infected patients. Co-infection with other sexually transmitted diseases was not rare, and other tests for accurate additional antimicrobial regimens should also be considered. (Ann Clin Microbiol 2014; 17:-114)

Gait analysis on the condition of arm swing in healthy young adults

구현민,이수영 물리치료재활과학회 2016 Physical therapy rehabilitation science Vol.5 No.3

Objective: The arm swing is associated with gait ability in healthy young adults. The purpose of this study was to examine the effects of arm swing during gait in healthy young adults. Design: Cross-sectional study. Methods: Forty-five subjects without any orthopedic or neurological injuries participated in this study. All subjects performed all three conditions according to the arm swing type as follows: first procedure (condition 1), walking as usual without arm swing constraint; second procedure (condition 2), constraint of dominant arm swing walking as usual; third procedure (condition 3), constraint of both arm swing walking as usual. Gait parameters such as gait velocity, stride length, cadence, step time, single limb support, and double limb support were measured in all arm swing conditions performed randomly, with the mean value obtained from three measurements. A rest period of 5 minutes was given to prevent repetition of each condition and learning effect. All data was analyzed using repeated measures ANOVA to notice the changes between arm swing conditions. Results: Within walking conditions, significant difference of gait velocity, stride length, cadence, and double limb support was noticed (p<0.05), except step time and single limb support. Gait velocity and stride length were significant reduced, and in cadence and double limb support were increased (p<0.05). Condition 3 had the most significant decrease of gait ability compared with condition 1 (p<0.05). Conclusions: These finding suggested that constraint arm swing conditions reduced gait ability in healthy young adults. Also, these findings can be utilized as a reference to future studies that not only pelvic, knee and ankle, but also upper limb affect to gait ability.

Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion

구현민,이상국,김정호 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.2

Sodium and potassium intake was assessed on the basis of its respective excretion levels in 24 hr urine samples. However, owing to the inconvenience of collection, we evaluated random spot urine for alternative sodium and potassium excretion markers. We included 250 patients who submitted 24 hr- and spot urine for clinical tests. However, 22 patients who showed 24 hr urine creatinine excretion levels <500 mg/day were excluded, because these samples possibly resulted from incomplete urine collection. Moreover, 24 patients were excluded because of their use of diuretics during the urine collection period. We observed significant correlations between 24 hr urine sodium excretion and both the sodium/creatinine (r=0.34, P<0.0001) and the sodium/specific gravity unit (SGU) ratios (r=0.19, P=0.007) in random urine samples. Similarly, 24 hr urine potassium excretion and both the spot urine potassium/creatinine (r=0.47, P<0.0001) and potassium/SGU ratios (r=0.28, P<0.0001) were significantly correlated. Although the estimated sodium/creatinine and potassium/creatinine ratios showed a significant correlation with 24 hr urine sodium and potassium excretion, respectively, further studies are required to develop a spot urine test for individualized monitoring of sodium and potassium excretion.

바이오에탄올 산업화 현황 및 전략

구현민 ( Gu Hyeon-min ) 한국농공학회 2010 韓國農工學會誌 : 전원과 자원 Vol.52 No.3

희귀 의약품의 현재 상황과 발전 방향

손영배,구현민,진동규,Son, Yeong-Bae,Gu, Hyeon-Min,Jin, Dong-Gyu 대한유전성대사질환학회 2013 대한유전성대사질환학회지 Vol.13 No.1

우리나라의 경우 희귀질환은 국내 유병인구가 2만명 이하로 드물게 나타나는 질환으로 적절한치료 방법과 대체의약품이 개발되지 않은 병을 말한다. 희귀의약품은 대상 환자 수가 적어 연구개발이 어렵고 시장에서 수익성을 기대하기 어려워 제약기업이 쉽게 개발할 동기를 갖기 어렵기 때문에 선진국에서는 희귀의약품의 개발을 촉진하기 위한 제도를 운영하고 있다. 국내에서도 희귀질환자들에게 치료기회를 확대 제공하기 위한 일환으로, 1999년 정부의 적극적인 지원하에 한국희귀의약품센터가 설립되었다. 한국희귀의약품센터는 적용대상이 드물고 대체의약품이 없어 긴급한 도입이 요구되는 의약품 및 희귀질환자 치료용 약품의 구입공급과 제반 정보의 수집 및 제공을 함으로써 국민의 건강증진에 기여하고 있다. 한국희귀의약품센터의 주요 역할은 희귀의약품 및 희귀질환에 대한 최신정보를 수집 분류 데이터베이스화하여 이를 희귀의약품의 수요자 및 공급자 등 필요로 하는 자에게 제공하고 있으며, 특히 적용 대상이 드물고 대체의약품이 없어 긴급하게 도입할 필요가 있는 의약품 및 희귀질환자 치료용 의약품에 대하여 자가 치료용 의약품의 수입추천 안내 및 수입대행, 희귀의약품의 지정추천업무 등을 수행하고 있다. 희귀의약품 지정에 관한 규정은 1998년 4월 16일에 식품의약품 안전처에서 고시하였으며 2013년 2월에 식약처에서 고시 제 2013-8호로 개정하였다. 개정 이유는 지속적인 투자, 연구 개발이 필요한 희귀의 약품의 개발을 활성화하고 지정 한도액을 상향하는 등 희귀의약품 지정제도 개선하고자 하는 것이다. 이번 개정의 주요 내용은 개발 초기부터 '개발단계 희귀의약품' 지정하고 지정 갱신을 위해 별도 생산(수입)실적 보고를 폐지하며, 위탁제조판매업자의 희귀의약품 지정 신청을 가능하게 하고, 유병인구 500명 이하인 경우 지정한도 금액 상향 등이다. 이번 개정을 통해 희귀의약품에 대한 연구 개발이 더욱 확대 될 것으로 기대하며, 앞으로도 희귀질환 환자들에게 원활하게 희귀의약품이 공급되도록 지원 정책이 추진되어야 할 것이다.

선천성 사지 기형 발생기전연구(Ⅰ) : Hox 유전자 발현에 관한 연구 Studies on the expression of Hox gene

김형식,한순영,구현민,박기숙,김규봉,오세동,박희정,이이다,장성재,김명희,박귀례 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-

The Hot genes, a family of developmental regulatory genes, are known to be involved in anteroposterior axial pattern formation during early eTnbryogenesis in both vertebrates and inverts-brates. Among the several fox genes (Hoxa-1, HoBa-2, Hoxb-6, Hoxa-7, and Hoxa-8) involved in thedevelopmental morphogenesis, Hoxa-T gene is highly expressed i:n the aeural tube, neuraB crest, thoracicvertebra, aRd developing limb buds. Thus, the aim of the present study was to investigate the pattern ofretinoic acid (RA ) or cyclophosphamide (CP) on enlbryonic day T.0 of ICa mice. In morphological examinations of fetus, RA (100mg/kg) induced severe shorteniug of the forelimb and tail on day 18 of gesta.tion. CP also markedly induced the anomalies of extremities (syndactylia and polydactflia) in both for☞limb and hindlimb. By northern hybridization, Hoxa-7 gene was strongly expressed in the hindlimb dur.ing early fftbryogenesis. On day 12 of gestation, the eTpressioll of Hoxa-7 gene in the forelimb was'slightly inhibited by CP (20mg/kg). In contrast, Hoxa-7 gene expression was not influenced by R.t -(100mg/0g). These data sugfest that Hoxa-7 may play aB important role in the pattern formation andraorphological changes of developing limb.

상급종합병원과 희귀난치성질환 전문병원의 희귀의약품 사용현황

최경숙,정영미,김유정,김윤희,구현민,이병구,이은숙,이정연 한국임상약학회 2016 한국임상약학회지 Vol.26 No.2

Objective: Until now, there is minimal number of research for overall domestic status of orphan drug use in Korea. The purpose of this study is to identify the list of orphan drugs available in Korea and to understand the status of orphan drug usage in tertiary Hospitals and rare incurable disease Hospital. Methods: We made domestic orphan drug lists based on available orphan drugs in Korea. Based on this lists, we conducted e-mail survey from August, 2014 to September, 2014 to identify domestic status of orphan drug usage including the availability and management of orphan drugs. Results: There are three hundred and eighteen orphan drugs (184 ingredients) registered in Ministry of Food and Drug Safety. Among the three hundred and eighteen orphan drugs, Two hundred and twenty-eight drugs (102 ingredients) were selected. Information on each item was collected and documented with generic and brand names, manufacturers, wholesalers, indications, FDA approval status and insurance coverage. Forty-three tertiary hospitals and thirty-two rare incurable hospitals responded to the survey questionnaire (57.3%). According to the survey result, the antineoplastics and immunomodulating agents group has the highest percentage (40%) usage in the hospital. Of fortythree tertiary hospitals, thirteen hospitals manage orphan drugs separately (30.2%). Based on the reply, most of the healthcare professionals commented the drug information related to efficacy and safety including medication counseling of orphan drugs is insufficient. Conclusion: Through this study we anticipate providing an understanding of orphan drug usage status in Korea. We found the limited resources to the information on orphan drugs and this information requires updating on a regular basis. This can be the basis for further studies about preparing drug information, educational resources for rare disease patients.

중환자실내 호흡기 감염 감소 전략

강경우,이주석,이미화,이명주,구현민,조동우 한국의료QA학회 2005 가을학술대회 Vol.2005 No.2

A case of Cefotetan induced autoimmune hemolytic anemia

이혜경,김선경,김병국,구현민 대한내과학회 2019 대한내과학회 추계학술발표논문집 Vol.2019 No.1

경골 천장부에 발생한 골연골 병변 -1예 보고-

황필성,김도영,박용욱,이상수,구현민,Hwang, Pil-Sung,Kim, Do-Young,Park, Yong-Wook,Lee, Sang-Soo,Koo, Hyun-Min 대한족부족관절학회 2005 대한족부족관절학회지 Vol.9 No.2

Osteochondral lesion usually occurs in the elbow, knee and ankle joints. Many articles about osteochondral lesion of the talus in the ankle joint have been reported. We experienced a rare case of partially detached osteochondral lesion of the tibial plafond treated with excision and multiple drilling.