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Cytologic Features of Endometrial Papillary Serous Carcinoma
공구,홍은경,이중달,Kong, Gu,Hong, Eun-Kyung,Lee, Jung-Dal The Korean Society for Cytopathology 1990 대한세포병리학회지 Vol.1 No.2
자궁내막의 유두상 장액성 암종은 자궁 내막에서 발생하는 매우 희귀한 선암종의 한 형태로, 동명의 난소 암종과 조직학적으로 동일하며, 매우 불량한 예후를 나타낸다. 대개 이 종양은 말기에 진단되며, 같은 조직학적 소견을 보이는 전이성 난소암종과 혼돈되기 쉽다. 최근, 저자들은 자궁경부-질 도말 표본에서 2예의 유두상 장액성 암종을 진단 하였는데, 그 세포학적 소견은 종양 세포의 유두상 구조가 풍부하게 도말되었고, 종양 세포들은 거대한 핵소체를 가지고 있었다. 도말배경은 괴사성 및 혈성으로 종양소인을 잘 반영하고 있었다. 이 세포학적 진단은 자궁 절제 표본의 조직학적 검사로 확인 되었다. Endometrial papillary serous carcinoma (EPSC) is a distinct variant of endometrial adenocarcinoma that histologically resembles ovarian serous papillary adenocarcinoma and has an aggressive clinical course. Usually, the tumor is diagnosed at the advanced stage. The tumor has well confused with metastatic ovarian tumor of identical histology. Dignosis of EPSC should be considered when the cervico-vaginal smear reveals nomerous papillary clusters of tumor cells with macronucleoli and psammoma bodies. Recently, we have experienced two cases of EPSC diagnosed on cervico-vaginal smears, which revealed characteristic cytologic features including numerous papillary clusters of tumor cells with macronucleoli. The cytologic diagnoses were confirmed on histologic sections.
공구,김은경,홍은경,이중달,Kong, Gu,Kim, Eun-Kyung,Hong, Eun-Kyung,Lee, Jung-Dal 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.1
Glassy cell carcinoma is an unusual neoplasm of the uterine cervix with highly aggressive clinical behavior. On cervico-vaginal smear examination, the tumor has well confused of atypical repair ceil of the endocervix. Recently, we have experienced two cases of glassy cell carcinoma of the uterine cervix, diagnosed on cervico-vaginal smears and confirmed on fellowing histologic sections. The cervico-vaginal smears revealed abundant clusters with well defined boarders. The cell clusters were composed of large tumor cells. The tumor cells had distinct granular cytoplasm and eosinophilic macronucleoli, Characteristic cytologic features of this tumor were discussed in view of differential diagnosis.
공구,장세진,이중달,Kong, Gu,Jang, Se-Jin,Lee, Jung-Dal 대한세포병리학회 1990 대한세포병리학회지 Vol.1 No.1
The fluoroscopy-guided fine needle aspiration biopsy has been gaining widespread acceptance as a rapid and effective method to make a pre-operative diagnosis of mediastinal tumors including thymoma, malignant lymphoma, and metastatic carcinoma. Although thymoma is a most common tumor of the superior mediastinum, most cytopathologists are not experted in cytologic diagnosis of this tumor because of limited experience. In order to define the diagnostic cytologic features of thymoma, we have retrospectively reviewed imprinting smears and corresponding tissue sections from four cases of this tumor. All cases revealed an apparent biphasic pattern of epithelial cell clusters and lymphocytes with occasional branching capillary fronds extending from three dimensional epithelial cell clusters. Epithelial cell clusters predominated in one case and lymphocytes in two cases. Mixed epithelial cell and lymphocyte type represented in one of four cases. In the lymphocyte predominant type, the presence of epithelial cell clusters and small mature lymphocytes are helpful features to differentiate from a malignant lymphoma.
흉선 유암종의 세침 천자 세포학적 소견 - 1 예 보고-
공구,이중달,Kong, Gu,Lee, Jung-Dal 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.2
Diagnosis of a thymic carcinoid was made on transthoracic fine needle aspiration in a 36-year old woman who had an anterior mediastinal mass on chest X-ray and CT scan. The aspiration smears showed numerous anastomosing ribbons and cords of small round tumor cells. The tumor cells had slightly eccentric nuclei and some granular cytoplasm. The small and uniform nuclei of the tumor cells had finely granular chromatin and thin nuclear membrane. The cytologic diagnosis of a carcinoid was confirmed on histopathologic, immunohistochemical, and electromicroscopic examination of surgical specimen.
공구,이중달 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.2
Congenital cystic diseases of the lung include lobar overinflation (LOI), cystic adenomatoid malformation (CAM), pulmonary lobar sequestration (PLS), and congenital bronchogenic syst (CBC). Their pathologic changes vary and pathogenesis are complicated. In order to make the correlation between the pathologic changes of the congenital cystic lung diseases and bronchopulmonary foregut development the author reviesed development of the bronchopulmonary bud in the early period of embryogenesis. Also reviewed were pathologic materials (gross and imcroscopic slides) and clinical histories of LOI (one case), CAM (three), PLS (six) and CBC(four cases). LOI was manifested in the neonatal or infantile period with dyspnea and funnel chest. Overdistention of the alveoli and bronchioles was pathologic characteristics. Faulty formation of cartilage in the bronchial wall was the fundamental defect led to the overdistention of alveoli. CAM was presented in the infancy with cough and dyspnea and involved an entire lobe of the lung. Three distinct types of CAM according to the size of cysts were classified. In type I, large cyst type, a single or a few huge cysts replaced the entire lobe of the lung parenchyma. The cyst walls were made up of the tissue similar to immature bronchial structures. Type Ⅱ consisted of many large and small cysts which were lined by simple bronchiolar epithelium. Type Ⅲ, solid type, was made up of tiny cystic spaces reminiscent of immature alveolar structures. Of six cases with PLS intralobar (ILS, five cases) and extralobar pulmonary sequestration (ELS, one case) were distinguished. ELS appeared in the neonatal period with dyspnea and ILS was presented in the wide range of ages with cough, fever and signs of secondary infection of the lung. PLS, in general, revealed large and small cysts similar to those of cam, type Ⅱ. CBC appeared through many decades of ages. Intrapulmonary cyst was manifested as cough with sputum, and extrapulmonary (mediastinal of neck) cysts appeared as a mass. The cyst wall had the structure similar to bronchial wall of the fetal stage. These four congenital cystic lesions of the lung share similar clinical and embryologic characteristics. The pathologic features of the lesions are thought to be the manifestation of bronchopulmonary developmental anomalies in various stages of embruogenesis.