로타바이러스 백신

고홍,Koh, Hong 대한소아소화기영양학회 2009 Pediatric gastroenterology, hepatology & nutrition Vol.12 No.suppl1

Rotavirus infection is the leading cause of severe diarrhea disease in infants and young children worldwide. Rotavirus infects every child at least once by her/his $5^{th}$ birthday. It has been known that single episode of rotavirus infection can protect or alleviate subsequent illness caused by both homotypic and heterotypic rotaviruses. There are two currently licensed rotavirus vaccines. One is human-bovine rotavirus reassortant pentavalent vaccine ($RotaTeq^{TM}$), which contains five reassortant rotavirus (expressing protein G1, G2, G3, G4 and P[8]) and was licensed in Korea for use among infants in 2007. Another is live-attenuated human rotavirus vaccine ($Rotarix^{TM}$) derived from 89-12 strain which represents the most common of the human rotavirus VP7(G1) and VP4(P[8]) antigens. $Rotarix^{TM}$ was licensed in Korea in 2008. Both live oral rotavirus vaccines are efficacious in preventing severe rotavirus gastroenteritis.

분변미생물이식의 임상적 활용

고홍 ( Hong Koh ) 대한간학회 2019 임상연구방법론워크숍 Vol.2019 No.1

고령가구의 혼인상태변화에 따른 주거만족도에 관한 연구

고홍(Koh, Hong),유선종(Yoo, Seon Jong) 한국주거환경학회 2017 주거환경(한국주거환경학회논문집) Vol.15 No.2

The purpose of this study is to analyze the effect of housing characteristics on the satisfaction of the elderly households over the age of 50, According to the analysis of gender, region, housing type, housing area and housing satisfaction according to marital status change, gender showed significant residence satisfaction when the divorce. There were no differences in residential satisfaction in residential areas in Seoul and metropolitan cities but there were differences in residential satisfaction in urban areas. In the housing type, the apartments had the highest residential satisfaction, followed by the single - family house, and the lowest in the allied and multi -family houses. The housing area was 110m2~130m2 in the satisfaction group and 65m2~90m2 in the unsatisfactory group. As population aging increases the likelihood of divorce and bereavement, it is necessary to supplement the characteristics of the elderly households according to their characteristic

서울지역 시중은행지점의 매출과 점포입지 특성에 관한 연구

고홍(Hong Koh),유선종(Seon-Jong Yoo) 건국대학교 부동산도시연구원 2014 부동산 도시연구 Vol.6 No.2

금융위기 이후 경기침체로 세계는 통화팽창, 저금리 등의 금융정책을 내놓고 있다. 국내에서도 시중은행들이 대출금리 인하, 각종 수수료 면제 등으로 수익이 급감되어 비용절감을 통해 이를 극복하려고 은행점포의 면적을 다운사이징 등을 진행 중이다. 은행은 인터넷뱅킹 등의 전자서비스를 적극 활용하는 전략을 통해 점포를 찾는 고객수가 점점 줄어들어 점포의 업무처리 부담도 낮아져 점포 근무인원을 절감효과가 있었다. 하지만 점포운영의 고비용, 저수익 구조로 인해 비용절감 효과의 한계가 있으며, 비용관점에서는 전자서비스의 효과가 있지만, 수익측면에서는 고객과 은행직원과의 대면접촉의 감소로 인해 장기적으로 대출, 보험 등 다양한 금융상품을 통한 새로운 수익창출의 어려움이 예상되어 구매와 수익을 위한 점포의 중요성이 부각되고 있다. 본 연구에서는 은행점포 개점 후 총수신평잔, 총대출평잔에 영향을 주는 광역입지변수 및 점포특성 변수와의 관계를 서울지역과 서울시 25개 구별로 영향정도를 실증적으로 분석함으로써 은행점포 입지특성을 이해하기를 기대한다. After the financial crisis cut lending rates by commercial banks, various fee waiver is a sharp drop in profits as cost-cutting efforts are. Nature, such as stores, banks and device industry has. Bank of the opening of the store after the initial sales of a large width is difficult to expect an increase in sales over the years that have properties. Target stores, a bank in Seoul operating period, the working personnel, handling financial and business local variables receive store sales and total average balance, average balance of total loans in the multiple regression analysis was found to be significant variables. Only received a total average balance of population density, the number of businesses registered with the population average balance of total loans is the only significant variables. In addition, two other properties located in Seoul, 25 distinct store sales for the multiple regression analysis, the variable number of working nine to affect almost 25 gave the following instruction to the operating period and have affected the financial variables in order. In this study, the bank opened a store in-store sales and store wide characteristic variables that affect the relationship between Seoul and Seoul, with 25 distinct reasoning of the independent variables and changes in location empirical analysis of the impact of stores opened by the presence the purpose is to understand the characteristics.

호흡기 염증성 가성종양(Pulmonary Inflammatory Pseudotumor) 1례

고홍 ( Hong Koh ),채현욱 ( Hyun Wook Chae ),이수진 ( Su Jin Lee ),윤봉식 ( Bong Shik Yoon ),장광천 ( Gwang Cheon Jang ),강경훈 ( Kyung Hoon Kang ),기정혜 ( Jeong Hae Kie ) 대한소아알레르기호흡기학회 2006 소아알레르기 및 호흡기학회지 Vol.16 No.3

Inflammatory pseudotumor of the lung is considered to be a rare, benign, neoplastic lesion, consisting mainly of spindle mesenchymal cells, sometimes in such a way that its histological appearance mimics that of a spindle cell sarcoma, fibrous histiocytoma or fibrosarcoma. A case of inflammatory pseudotumor of the lung occurring in a 13-year-old boy is reported with pathologic findings, including its ultrastructure. The patient had had no symptoms and accidentally discovered his condition after a chest X-ray examination at a regular school physical check up. The mass was located in the suprahilar area of the left lung. Exploratory thoracotomy revealed a large mass that was removed, together with the left upper lobe of the lung. Microscopically, the mass was composed of numerous interstitial inflammatory cells, mainly lymphoplasma cells. Ultrastructurally, the spindle-shaped mesenchymal cells were arranged haphazadly and the normal pulmonary structure was nearly totally destroyed. Emphasis is given to complete resection of the tumor for both diagnostic and therapeutic purposes. [Pediatr Allergy Respir Dis(Korea) 2006;16:248-252]

간관 폐쇄증이 동반된 알라질 증후군 (Alagille Syndrome) 1예

김효선,고홍,정기섭,오정탁,박영년,김명준,Kim, Hyo-Sun,Koh, Hong,Chung, Ki-Sup,Oh, Jung-Tak,Park, Young-Nyun,Kim, Myeung-Jun 대한소아소화기영양학회 2008 Pediatric gastroenterology, hepatology & nutrition Vol.11 No.1

A two-month-old baby had acholic stool, neonatal hyperbilirubinemia and congenital heart disease. Atresia of the hepatic duct was confirmed by open cholangiography, which showed a non-opacified intrahepatic bile duct. Liver biopsy and the Kasai operation were performed. Because the liver biopsy pathology revealed a paucity of intrahepatic bile ducts, the patient was diagnosed with the Alagille syndrome. We report the case of an infant diagnosed with the Alagille syndrome with atresia of the hepatic duct. 담도 폐쇄증은 수술적 치료가 필요하며 알라질 증후군은 대증적 치료가 가능하기 때문에 이를 감별하는 것이 중요하다. 저자들은 신생아기에 선천성 심장질환과 함께 담즙 정체 소견이 있는 환아에게서 원인 질환을 진단하는 과정에서 수술적 담관조영술 통해 제2형 담도 폐쇄증인 간관 폐쇄를 동반한 알라질 증후군 1예를 경험하였기에 보고하는 바이다.

소아에서 상부 위장관내시경 검사 시 Midazolam 투여에 따른 생명활력징후의 변화 및 진정 효과

백승연,고홍,정기섭,Baek, Seoung Yon,Koh, Hong,Chung, Ki Sup 대한소아소화기영양학회 2006 Pediatric gastroenterology, hepatology & nutrition Vol.9 No.2

목 적: 상부위장관 내시경은 위장관계 질환을 검사하는 데 매우 유용한 검사이나, 소아에서는 검사에 따른 불안과 불편감으로 시행에 어려움이 많다. 최근에 midazolam 등의 진정제 투여로 이런 것들을 상당부분 개선하고 있다. 저자들은 midazolam 투여시 소아의 활력징후 변화를 측정하여 약제투여의 안전성과 진정 효과를 확인하고자 하였다. 방 법: 2003년 8월부터 2005년 7월까지 연세대학교 의과대학 소아과에 내원하여 상부위장관 내시경 검사를 받은 244명의 소아를 대상으로 midazolam 투여군과 비투여군에서 검사 전과 검사 도중의 산소포화도, 심박동수, 의식상태의 변화 등을 측정하여 그 결과를 조사 분석하였다. 결 과: midazolam 투여군과 비투여군 사이에 생명 활력 징후는 임상적으로 유의한 차이가 없었다. 내시경검사 시 투여된 midazolam의 용량과 의식상태 및 산소포화도 변화사이에 유의한 상관관계는 없었다. 산소포화도는 비투여 및 투여군 양 군에서 검사 전보다 검사 도중에 유의하게 감소하였으나(p<0.01), 양 군 모두에서 산소포화도는 95% 이상으로 유지되어 임상적 의미는 없었다. 심박동수는 비투여 및 투여군 모두에서 검사 전보다 검사 도중이 유의하게 증가되었으나(p<0.01), 양 군 간의 심박동수 증가는 통계학적으로 유의한 차이는 없었다. 투여 용량의 증량에도 진정효과가 더 잘 유도되지 못했으며 대부분의 환아가(76.1%) alert한 의식상태를 유지하여 진정효과가 충분하지 못하였다. 결 론: 본 연구에서 저용량 midazolam을 투여하였을 때 생명활력징후의 안전성은 확인하였으나, 충분한 진정효과 및 기억 상실 효과를 얻기에는 다소 미흡하였다. Purpose: Esophagogastroduodenoscopy (EGD) is a very useful procedure in diagnosing gastrointestinal diseases. However, there can be some difficulty in performing this procedure in children due to the associated discomfort. Recently, sedative agents such as midazolam have been introduced to alleviate this problem quite successfully. In our study, we attempted to confirm the safety and efficacy of midazolam use by monitoring the vital signs of children undergoing endoscopy. Methods: We analyzed data on 244 children who received EGD in the department of pediatrics at Severance Hospital, Yonsei University between August 2003 and July 2005. We evaluated $O_2$ saturation, heart rate and change of mental status before and during the procedure and analyzed the results using the SPSS 12.0 package (Chi-square test, cross table method, etc.). Results: There was no significant difference in vital signs measured before and during EGD between midazolam treated and non treated children. There was no significant relationship between the amount of midazolam given and $O_2$ saturation or a change of mental status. Regarding the $O_2$ saturation, it was decreased during EGD in both groups with p<0.01 though no difference was noted between the groups; the $O_2$ level was maintained above 95% in all patients. The heart rate was also increased during EGD in both groups with a p<0.01; however, no significant difference was noted between the groups. Conclusion: We confirmed the safety of low dose midazolam by evaluating the vital signs of children during endoscopies. However, the doses used were not sufficient for sedation or to obtain an amnestic effect.

소아 베체트 병에서 발생된 복부 천공 1예

최금옥,고홍,정기섭,Choi, Kum-Ok,Koh, Hong,Chung, Ki-Sup 대한소아소화기영양학회 2008 Pediatric gastroenterology, hepatology & nutrition Vol.11 No.1

소아 베체트병은 상당히 드문 질환으로 전체 베체트병의 약 2~3%에 해당한다. 이 중 장 점막과 관련된 경우는 2~50%까지 다양하게 보고되나, 대부분이 40~50대 성인에서 보고되는 내용이며 소아 베체트병 환자에서 장 천공이 보고된 증례는 극히 드물다. 본 증례는 4년 9개월된 남아로, 베체트병을 진단받은 후 약물 치료하며 추적 관찰 중, 지속되는 복통이 있어 시행한 대장 내시경상에 다발성 장점막 궤양이 관찰되었고, 이후 스테로이드 용량 감량하며 경과 관찰하던 중 장 천공이 발생하여 수술한 1예를 경험하였기에 보고하는 바이다. Behcet's disease (BD) is a multisystem inflammatory disorder dominated clinically by recurrent oral and genital ulceration, uveitis and erythema nodosum. BD is very rare in children, especially those less than 10 years of age, who account for only an estimated 5% of all cases. Gastrointestinal ulcers, in patients with Behcet's disease with intestinal involvement are rare and have been reported in only 1-2% of all cases. The intestinal ulcers of Behcet's disease are usually multiple and scattered and tend to cause perforations associated with significant morbidity. Patients with BD and abdominal symptoms must be evaluated thoroughly for potential perforation of the gastrointestinal tract. Here we report the case of a 4 year 9 month old child with multiple perforations of the gastrointestinal tract associated with BD.

테타니가 발생한 윌슨병 1예

라채익,김상용,고홍,Ra, Chae-Ik,Kim, Sang-Yong,Koh, Hong 대한소아소화기영양학회 2011 Pediatric gastroenterology, hepatology & nutrition Vol.14 No.1

구리를 운반하는 P형 ATPase 단백을 합성하는 ATP7B 유전자의 돌연변이로 인하여 간, 뇌, 각막, 신장 및 적혈구 등 여러 조직에 구리가 축적되어 발병하는 상염색체 열성 유전 질환인 윌슨병은 간 증상과 신경증상이 주요 증상이지만 이외에도 용혈성 빈혈, 심장, 신장 및 내분비 이상 증상을 초래할 수 있다. 저자들은 윌슨병으로 진단되어 치료 받던 중 부갑상샘의 구리 침착에 의한 것으로 추측되는 부갑상샘저하증, 여러 복합요인에 의한 비타민 D 결핍 그리고 원인이 불명확한 저마그네슘혈증으로 인하여 발생한 테타니를 칼슘, 마그네슘 및 비타민 D 투여로 치료하였던 1예를 경험하였기에 보고하는 바이다. Wilson's disease is an autosomal recessive disorder of copper metabolism consequence of which leads to accumulation of copper in the liver, brain, cornea and other tissues. The manifestations are more likely to be hepatic in the early childhood and neurological in the adolescents. In addition, the abnormalities that develop during disease progression may result in other manifestations such as hematologic, endocrine, or renal findings. We report a thirteen year-old girl who manifested tetany shortly after the initial diagnosis of Wilson's disease. Despite aggressive calcium, magnesium and vitamin D replacement, the hypocalcemia and hypomagnesemia did not respond to the therapy promptly. It took more than three weeks for blood levels of the minerals to be normal. We concluded that tetany occurred in our patient because of hypoparathyroidism as a rare complication of Wilson disease, vitamin D deficiency resulting from various conditions, and inconclusive hypomagnesemia.

유전자 검사로 진단된 제2형 Crigler-Najjar 증후군 1예

김상이,이수현,고홍,이승태,기창석,김종원,정기섭,Kim, Sang-Yee,Lee, Soo-Hyun,Koh, Hong,Lee, Seung-Tae,Ki, Chang-Seok,Kim, Jong-Won,Chung, Ki-Sup 대한소아소화기영양학회 2008 Pediatric gastroenterology, hepatology & nutrition Vol.11 No.2

저자들은 4개월간 지속된 황달을 주소로 내원한 13년 6개월 남아에서 유전자 검사로 UGT1A1 유전자의 5번째 exon에서 1456번째 염기 치환(1456T>G)으로 인한 486번째 아미노산인 tyrosine이 aspartate로 치환된 변이(Y486D)를 확인하고 제2형 Crigler-Najjar 증후군으로 진단한 증례를 경험하였기에 보고한다. Crigler-Najjar syndrome is a rare inherited disease associated with unconjugated hyperbilirubinemia. It is inherited via an autosomal recessive pattern and is caused by mutation in one of the five exons of the bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) gene. The synthesis of inactive isoforms of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (B-UGT) results in unconjugated hyperbilirubinemia. A 13-year-old boy with jaundice for 4 months was admitted to our hospital. He had unconjugated hyperbilirubinemia with no evidence of infection, hemolysis, or structural abnormalities on abdominal ultrasonography or 99mTc-DISIDA scan. The authors identified a missense mutation of Tyr486Asp in the fifth exon of the UGT1A1 gene and diagnosed the patient with Crigler-Najjar syndrome type II. This is the first reported case of Crigler-Najjar syndrome in a Korean child, and it is also the first reported case of a genetic mutation leading to Crigler-Najjar syndrome in Korea.