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한국산 겨우살이 (Viscum album coloratum)로부터 정제된 렉틴 성분 KML-IIU의 예비 독성 및 일반 약리 시험
강태봉(Tae Bong Kang),윤택준(Taek Joon Yoon),김종배(Jong Bae Kim),송사유(Seong Kyu Song),이관희(Kwan Hee Lee),곽진환(Jin Hwan Kwak) 大韓藥學會 2001 약학회지 Vol.45 No.3
The study was carried out to evaluate the preliminary toxicity and general pharmacology of KML-IIU, a purified lectin com Korean Mistletoe (Visum album coloratum). KML-IIU was administered intravenously to ICR mice and Spargue-Dawley rats to investigate the acute toxicity. LD5O values in mice and rats were above 30mcg/kg. KML-IIU had no effects on the general behaviors, acetic acid induced writh- ing syndrome, pentobarbial induced sleeping time, pentylenetetrazole induced convulsion and the change of body temperature. In addition, KML-IIU did not show any effects on digestive system and blood coagulation system.
강태봉 ( Tae Bong Kang ),윤택준 ( Taek Joon Yoon ) 한국식품영양학회 2011 韓國食品營養學會誌 Vol.24 No.4
These studies were conducted to investigate the effects an herbal extract composition(MHE) containing Hovenia dulcis T., Artemisa capillaris T., Pueraria thunbergiana B., Polygonatum falcatum A., Agastache rugosa O., Silybum marianum L. and Glycyrrhiza uralensis F. in alcohol administered mice. Prophylactic administration of different doses of MHE(20~100 ㎎/㎏) had beneficial actions toward alcohol degradation in acute alcohol treated mice. In addition, intraperitoneal administration of the MHE showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. MHE also reduced the concentrations of nitric oxide(NO) and tumor necrosis factor(TNF)-α in macrophages that were activated by LPS. These results demonstrate that MHE possesses the potential to stimulate alcohol degradation and inhibit inflammatory effects in mice.
Macrophages로부터 IL-1β 분비 및 전사에 있어서 한국산 겨우살이 추출물 M11C (non-lectin components)의 효과
장성호,전명하,강태봉,문세환,이준호,성낙술,이성태,김종배,허억,Chang, Sung Ho,Jun, Myung Ha,Kang, Tae Bong,Mun, Se Hwan,Lee, Jun Ho,Seong, Nak Sul,Lee, Sung Tae,Kim, Jong Bae,Her, Erk 대한면역학회 2001 Immune Network Vol.1 No.2
Background: Korean mistletoe (Viscum album) extract has been found to posses immunostimulatory activity. In this study, Korean mistletoe extract, M11C (non-lectin components), was used to know whether this extract might activate mouse peritoneal macrophages to produce interleukin $1{\beta}$ (IL-$1{\beta}$). Methods: Hemagglutination assay was carried out to examine whether M11C contained a lectin or not. To know the effect of M11C on the production of IL-$1{\beta}$, the macrophages were treated by the M11C, and then collected the supernatant (M11C stimulated macrophages-conditioned media; MMCM). MMCM was analyzed for the IL-$1{\beta}$ quantification and mRNA expression by means of ELISA and RT-PCR, respectively. Results: Maximum effective dose and time of M11C on IL-$1{\beta}$ production from macrophages were $20{\mu}g/m{\ell}$ and 8 hours, respectively. This ELISA data was reconfirmed by immunoblotting assay. indicating that M11C is a good candidate for an immunomodulator. The dose and time dependent effects of M11C on the expression of IL-$1{\beta}$ mRNA from macrophages was also shown in expression of mRNA detected by RT-PCR. Treatment dose and time for the maximum expression of IL-$1{\beta}$ mRNA were $20{\mu}g/m{\ell}$ and 4 hours, respectively. Maximum gene expression of IL-$1{\beta}$ was much earlier than maximum production of it. Conclusion: As results, Korean mistletoe extract, M11C, may be used for an immunomodulator. This will be able to make up for and solve the problems caused by existent immunoagent with many adverse effects through many other studies in future including one molecule extraction.
괴화(槐花) 에탄올 추출물이 RBL-2H3 비만세포에서 Ca<SUP>++</SUP> Ionophore에 의한 알레르기 반응 조절에 미치는 효과
손효(Sun Xiao),강군(Jun Jiang),심도완(Do-Wan Shim),김태권(Tae-Kweon Kim),강태봉(Tae-Bong Kang),이광호(Kwang-Ho Lee) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.3
세포내 Ca<SUP>++</SUP>의 증가는 비만세포에서 수용체 활성을 거치지 않고 탈과립을 유도한다. 괴화는 천연 염색 재료로 사용되고 있으며, 또한 항염증 작용과 FcεRI와 IgE 가교에 의한 항알레르기 효능도 보고되었다. 이번 연구에서 비만세포에서 Ca<SUP>++</SUP> 유입에 의해 생산되는 알레르기 매개물에 대한 괴화추출물의 조절 기능을 보고한다. 괴화 추출물은 A23187에 의해 유도되는 IL-4와 TNF-α의 생산과 탈과립을 저해하였다. 또한 괴화 추출물은 DNFB로 유도한 알레르기 피부염의 동물 모델에서 알레르기 반응을 억제하였다. 괴화추출물 50 mg/kg을 경구투여 또는 도말을 한 경우, DNFB를 단독으로 처리한 군보다 IL-4, TNF 그리고 IFN-γ와 같은 염증성 사이토카인의 생산량이 감소하였다. 또한 괴화 추출물을 처리한 경우 혈청 내 IgE의 함량이 DNFB를 단독으로 처리한 군보다 감소하였다. 괴화 추출물을 처리한 군에서의 비장과 림프절의 무게도 DNFB를 단독으로 처리한 군보다 감소하였다. 이러한 결과를 토대로 괴화는 비만세포에서 FcεRI 자극뿐만 아니라 Ca<SUP>++</SUP>의 유입에 의한 항알레르기 효능이 있다는 것을 보고한다. Elevation of intracellular calcium (Ca<SUP>++</SUP>) triggers degranulation of mast cells by bypassing receptor activation. Flos Sophora japonica L. has been used as a natural dying source and has been reported to have biological activities such as anti-inflammatory and anti-allergic effects through FcεRI and IgE crosslinking. In the present investigation, we report the regulatory effect of ethanolic extract of Flos Sophora japonica L. (S.F) on allergic mediators produced by Ca<SUP>++</SUP> ionophore activation in mast cells. S.F significantly inhibited calcium ionophore (A23187)-induced interleukin (IL)-4 and tumor necrosis factor (TNF)-α production as well as mast cell degranulation. Furthermore, administration of S.F suppressed allergic reactions in a 2,4-dinitrofluorobenzene (DNFB)-induced allergic dermatitis mouse model. Both oral administration and ear painting using 50 mg/kg of S.F significantly reduced levels of cytokines such as IL-4, TNF, and interferon-γ in ear tissues compared to the DNFB alone-treated group. Serum IgE level in the S.F-treated group also decreased compared to the DNFB alone-treated group. Weights of spleens and lymph nodes in the S.F-treated groups also decreased compared to the control group. Considering the data, we conclude that S.F mediates its anti-allergic effects not only through FcεRI stimulation but also Ca<SUP>++</SUP> influx in mast cells.
한국산 겨우살이 유산균 발효 추출물의 독성 및 면역증강 효과
윤택준(Taek Joon Yoon),양웅석(Woong Suk Yang),박성민(Sung Min Park),정회윤(Hoe Yune Jung),이안나(An Na Lee),정진혁(Jin Hyuk Jung),강태봉(Tae Bong Kang),유영춘(Yung Choon Yoo),김종배(Jong Bae Kim) 한국식품과학회 2009 한국식품과학회지 Vol.41 No.5
Lactobacillus casei KCTC 2180 및 Lact. plantarum KCTC 3103으로 발효된 한국산 겨우살이 추출물인 FKM-110의 렉틴 성분의 함량 변화, 독성 및 면역증강 효과를 검토하여 다음과 같은 결과를 얻었다. 두 가지 유산균을 이용하여 KM-110을 1-3일간 발효시킨 결과, 렉틴 성분은 발효 전에 비하여 53-71% 정도의 함량을 나타냄으로서 감소되는 경향을 보였다. 마우스에 대한 시료의 독성시험을 위하여 각 시료를 피하 주사하고 LDsub{50} 값을 측정한 결과, KM-110은 50-100 mg/kg인 반면 유산균으로 발효된 겨우살이 추출물인 FKM-110은 150-200 mg/kg인 결과를 보임으로 발효에 의하여 in vivo 독성효과는 감소하는 경향을 보였다. 각 시료를 macrphage에 직접 자극하여 염증성 cytokine인 IL-1β 및 TNF-α의 생산능력을 조사한 결과, FKM-110이 KM-110에 비하여 낮은 cytokine의 생산양식을 나타냈다. 그러나 FKM-110의 항원 KLH에 대한 면역증가 효과를 항체 생산능으로 조사한 결과, KM-110과 차이 없이 항원 단독 투여군에 비하여 높은 역가의 항체가 생산되었다. 따라서 겨우살이 추출물을 유산균으로 발효시킨 결과, in vivo 독성은 감소하였으나 면역증강 활성은 KM-110과 동일하게 유지되는 결과를 얻었다. 따라서 겨우살이의 면역증강 활성에 관여하는 성분으로 렉틴 이외에 물질이 관여할 수 있음을 강하게 시사하였다. In this study, Korean mistletoe extract (KM-110) was fermented with two strains of Lactobacillus (FKM-110) and then toxicity, lectin content, and immune activities were investigated. The lectin content of FKM-110 was about 53- 71% lower than that of KM-110. When mice were subcutaneously administered with KM-110 and FKM-110, the LDsub{50} obtained for KM-110 treatment was 50-100 mg/kg as compared to 150-200 mg/mL for FKM-110. Each preparation stimulated macrophages directly and enhanced productivity of inflammatory cytokines such as TNF-α and IL-1β. FKM-110 treatment resulted in lower cytokine production compared to KM-110. When mice were immunized with Keyhol limpet hemocyanin (KLH) antigen along with KM-110 or FKM-110 administration, higher antibody titers to KLH were observed in the KM-110 or FKM-110 groups compared to mice immunized with KLH alone, thereby showing no difference between KM-110 and FKM-110. Therefore, fermentation of Korean mistletoe extract with these Lactobacillus strains decreased toxicity in vivo while the enhancement of immune activity by KM-110 and FKM-110 was similar. These data suggest that KM-110 fermentation tended to decrease lectin content and in vivo toxicity. In addition, other components in the fermented mistletoe extract appear to stimulate immuno-adjuvant activity instead of lectin.