http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
강기운,김옥순,진정연,김원호,박상현,최유정,신종호,정경태,임도선,이성규 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.4
Background: Obesity is well-known as a risk factor for heart failure, including diastolic dysfunction. However, this mechanism in high-fat diet (HFD)-induced obese rats remain controversial. The purpose of this study was to investigate whether cardiac dysfunction develops when rats are fed with a HFD for 10 weeks; additionally, we sought to investigate the association between mitochondrial abnormalities, adenosine triphosphate (ATP) levels and cardiac dysfunction. Methods: We examined myocardia in Wistar rats after 10 weeks of HFD (45 kcal% fat, n=6) or standard diet (SD, n=6). Echocardiography, histomorphologic analysis, and electron microscopy were performed. The expression levels of mitochondrial oxidative phosphorylation (OXPHOS) subunit genes, peroxisome-proliferator-activated receptor γ co-activator-1α (PGC1α) and anti-oxidant enzymes were assessed. Markers of oxidative stress damage, mitochondrial DNA copy number and myocardial ATP level were also examined. Results: After 10 weeks, the body weight of the HFD group (349.6±22.7 g) was significantly higher than that of the SD group (286.8±14.9 g), and the perigonadal and epicardial fat weights of the HFD group were significantly higher than that of the SD group. Histomorphologic and electron microscopic images were similar between the two groups. However, in the myocardium of the HFD group, the expression levels of OXPHOS subunit NDUFB5 in complex I and PGC1α, and the mitochondrial DNA copy number were decreased and the oxidative stress damage marker 8-hydroxydeoxyguanosine was increased, accompanied by reduced ATP levels. Conclusion: Diastolic dysfunction was accompanied by the mitochondrial abnormality and reduced ATP levels in the myocardium of 10 weeks-HFD-induced rats.
강기운,이성규,윤현수,진정연,명진철,김원호,박상현,최유정,정경태,정명호 대한비만학회 2013 The Korean journal of obesity Vol.22 No.4
Background: Previous reports have demonstrated that obese patients may have better clinical outcomes after percutaneous coronary intervention (PCI) than non-obesepatients; however this “obesity paradox” remains still unknown in young patients. Therefore, we investigated the influence of obesity on the outcomes of young patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: A total of 541 young patients (≤ 45 year old) with acute STEMI undergoing urgent PCI were enrolled in the Korea Acute Myocardial Infarction Registry betweenJanuary 2008 and Aug 2011. These patients were categorized according to their body mass index (BMI, kg/m2) as non-obese (BMI < 27.5, N = 73), obese (27.5 ≤ BMI < 32.5,N = 183) and morbidly obese (BMI ≥ 32.5, N = 285). At follow-up, the major adverse cardiac events (MACE; defined as death, myocardial infarction, and target vesselrevascularization) were compared among the three groups. Results: The mean duration of follow-up was 384 ± 82 days. Among the three groups, age, sex, cardiovascular risk factors and left ventricular ejection fraction were similar andnumber of infarct-related artery or stenotic coronary artery was also similar. The length of stay in the coronary care unit was shorter among the obese and morbidly obese group compared with that of the non-obese group. In-hospital death and clinical outcomes among the three groups were not significantly different. At follow-up, the one-year MACE-free survival rate of those groups was not significantly different (93% in non-obese, 94% in obese and 95% in morbidly obese). Conclusion: In young patients with STEMI undergoing urgent PCI, influence of obesity on clinical outcomes was not observed as significant in the young Korean patients.
Leptin as a Key Between Obesity and Cardiovascular Disease
강기운,옥민호,이성규 대한비만학회 2020 The Korean journal of obesity Vol.29 No.4
Obesity increases the risk of cardiovascular disease through various influencing factors. Leptin, which is predominantly secreted by adipose tissue, regulates satiety homeostasis and energy balance, and influences cardiovascular functions directly and indirectly. Leptin appears to play a role in heart protection in leptin-deficient and leptin-receptor-deficient rodent model experiments. Hyperleptinemia or leptin resistance in human obesity influences the vascular endothelium, cardiovascular structure and functions, inflammation, and sympathetic activity, which may lead to cardiovascular disease. Leptin is involved in many processes, including signal transduction, vascular endothelial function, and cardiac structural remodeling. However, the dual (positive and negative) regulator effect of leptin and its receptor on cardiovascular disease has not been completely understood. The protective role of leptin signaling in cardiovascular disease could be a promising target for cardiovascular disease prevention in obese patients.
2018 대한부정맥학회 비판막성 심방세동 환자의 동율동 조절 약제 지침
강기운,심재민,안진희,이대인,김준,정보영,최기준 대한내과학회 2018 대한내과학회지 Vol.93 No.2
Rhythm control therapy is the main strategy for restoring and maintaining sinus rhythm in patients with non-valvular atrial fibrillation (NVAF). Sinus rhythm is better restored and maintained with antiarrhythmic drugs than with placebo treatment. In addition, catheter ablation or combination therapy is more effective than antiarrhythmic drugs for treating NVAF. However, in most clinical trials to date, rhythm control therapy has resulted in neutral clinical outcomes compared with rate control therapy. The decision to undergo rhythm control therapy should be based on age, atrial fibrillation (AF)-related symptoms, type of AF, structural heart disease, and underlying comorbidities. For now, rhythm control therapy is indicated to improve symptoms in patients with NVAF who have refractory symptoms after adequate rate control therapy. The Korean Heart Rhythm Society organized the Korean AF Management Guideline Committee and analyzed all available data, including South Korean patients with NVAF. This review article provides general principles and detailed methodology for rhythm control therapy in South Korean patients with NVAF.
강기운,Kim Wonho 고신대학교(의대) 고신대학교 의과대학 학술지 2023 고신대학교 의과대학 학술지 Vol.38 No.3
Scrub typhus is known as one of the most common seasonal infections in endemic rural areas, but life-threatening cardiac complications in cases of scrub typhus are very infrequent. In addition, scrub typhus infection has been rarely reported among workers assembling pallets using manufactured wood in metropolitan areas. Herein, we present two cases involving myocarditis and cardiac tamponade as complications of scrub typhus. One patient died and the other patient survived. These cases indicate that scrub typhus infection could be an environmental hazard in metropolitan areas, especially in locations with poor hygiene, and highlight the need for timely diagnosis and proper management of severe scrub typhus infections. Therefore, we present these two informative fatal cases of scrub typhus infection presenting with myocarditis and cardiac tamponade as an environmental hazard in metropolitan areas.
증례 : 순환기 ; 한약에 의한 급성 신부전 후 동시 발병한 급성 심근경색과 위궤양 출혈
강기운 ( Ki Woon Kang ),이경진 ( Kyung Jin Lee ),윤현수 ( Hyeon Soo Yoon ),조용수 ( Yong Soo Cho ),김시범 ( Si Bum Kim ),이상 ( Sahng Lee ),정성희 ( Sung Hee Jung ) 대한내과학회 2010 대한내과학회지 Vol.78 No.3
급성 신부전, 급성 심근경색과 위궤양 출혈은 특히 고령의 환자에게 높은 이환율, 사망률과 관련이 되는 질환이다. 이 세 질환 중에 어느 한 질환의 발병으로 인해 나머지 다른 질환이 발병될 수 있다고 보고가 되어 있지만 세 질환이 동시에 발병하는 경우는 드물다. 저자들은 한약인 감초와 알로에가 포함된 건강식품만을 10일간 복용한 후에 발생한 전신 허약으로 입원한 92세 남자 환자를 보고하였다. 입원 후에 환자는 6시간 차이로 급성 심근경색과 위궤양 출혈이 Acute renal failure, acute myocardial infarction (AMI), and gastric ulcer bleeding (GUB) are associated with high rates of morbidity and mortality, especially in older patients. The development of each of these conditions can be followed by the development
강기운 ( Ki Woon Kang ),이재우 ( Jae Woo Yi ),이봉재 ( Bong Jae Lee ) 경희대학교 경희의료원 2015 慶熙醫學 Vol.30 No.1
Hypersensitivity reactions remain a major problem in the perioperative period. These reactions are rapid onset and start within seconds to minutes of exposure to the allergen. Symptoms progress rapidly and can affect most organ systems. Anesthesiologists use a variety of drugs during provision of an anesthetic and may be involved in risk of hyperseneitivity reactions. We report a case of anaphylaxis which is developed in discectomy during general anesthesia. Anaphylaxis is a potentially life-threating reaction the requires immediate treatment including epinephrine as a first choice vasopressor.