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다낭성 난포증후군 환자에서 총 경동맥의 혈관내막 두께 측정을 통한 인슐린 저항성과 잠재성 동맥경화의 관계분석
김정연(Jeong Yeon Kim),박기현(Ki Hyun Park),정경아(Kyung Ah Jeong),강경숙(Gyoung Sook Kang),안철우(Chul Woo Ahn),배상욱(Sang Wook Bai),조동제(Dong Jae Cho),송찬호(Chan Ho Song) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
N/A Objectives: The purpose of this study was to determine whether women with PCOS have greater subclinical atherosclerosis and evaluate the relationship to risk factors for atherosclerosis. Methods: Women with PCOS(n=24) and age and body mass index(BMI)-matched cycling women(n=16) as control group underwent carotid scanning for the measurement of the IMT. We compared IMT and plaque between cases and controls, assessed some risk factors for atherosclerosis, and analyzed factors affecting IMT. Results: There was no difference between the groups in waist-hip ratio(WHR) and in the levels of total cholesterol, triglyceride(TG), LDL, Lp(a), fibrinogen, homocystein, plasminogen activator inhibitor 1. However, HDL was significantly lower, and systolic and diastolic blood pressure, fasting blood sugar or insulin concentration and IMT was significantly higher in PCOS group than control group (51.1±11.6 vs 60.4±10.0mg/dl, 119.4±12.5 vs 109.0±11.6mmHg, 79.1±11.1 vs 68.9±7.8mmHg, 93.6±11.1 vs 85.0±5.9 mg/dl, 8.9±5.2 vs 5.0±3.3pU/ml, 0.57±0.12 vs 0.49±0.11mm respectively, all p<0.05). In the analysis of correlation between the IMT and clinical characteristics, PCOS status, BMI, systolic and diastolic blood pressure, fasting blood sugar or insulin concentration, TG, HDL, fibrinogen were significantly independent variables (Coefficients of correlation were 0.358, 0.461, 0.452, 0.349, 0.405, 0.466, 0.478, -0.433, 0.349 respectively, all p<0.05). The factors affecting IMT by multivariate regression were PCOS status and fasting insulin concentration. Conclusions: We concluded that women with PCOS might have an increased risk of subclinical atherosclerosis and insulin resistance was assumed to be the main risk factor of atherosclerosis.
Sertoli - Leydig Cell Tumor 1 예
한상원 ( Sang Won Han ),김태윤 ( Tae Yoon Kim ),권혜경 ( Hye Kyung Kwon ),강경숙 ( Gyoung Sook Kang ),연혜정 ( Hye Jeong Yeon ),기정혜 ( Jung Hye Kie ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
The Sertoli-Leydig cell tumor is a rare sex cord stromal tumor of the ovary, accounting for less than 0.5% of all primary ovarian neoplasm. This tumor is the most common type of all virilizing ovarian tumors. However, only one-third of patients develop virilization. Recently, we experienced a case of intermediately differentiated Sertoli-Leydig cell tumor with amenorrhea and so we present it with brief review of literature.
임신중기에 47 , XYY 핵형으로 산전 진단된 태아의 만삭분만 1 예
김영한,박기현,이창희,양영호,조재성,김세광,강경숙 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
47,XYY is a rare sex chromosomal disorder. Approximately 1.45 per 1,000 live births have on XYY chromosome pattern. The extra Y chromosome is paternal in origin and results from nondisjunction in the second meiotic division. Although the phenotype is normal on the newborn, an increased incidence of minor anomalies has been reported. Recently, a 37-year-old primigravid woman received amniocentesis at 17 weeks gestation at a private clinic and was diagnosed as having a fetus with 47,XYY. We performed amniocentesis again at 20 weeks of pregnancy and confirmed fetal karyotype to be 47,XYY using the conventional cytogenetics and fluorescence in situ hybridization (FISH) techniques. As she did not want to terminate her pregnancy, she was put under antenatal care but ended up in vaginal delivery in 40 weeks. As a result of physical examination, the neonate showed a normal phenotype except for a mild hypospadia and a simian crease.