집합주택단지 생활가로 조성 사례의 활용과 계획적 의미 분석

김진성,이현진,양우현,Kim, Jin-Sung,Lee, Hyun-Jin,Yang, Woo-Hyun 한국주거학회 2007 한국주거학회 논문집 Vol.18 No.6

In Korea, open spaces of urban housing do not serve residents as "regular living areas". We carried out research on the "streets" of urban housings in that the meaning of traditional "streets", playing roles which are not only means of passage but also boundary of life, cannot include present meaning of "streets" of the urban housing. This research is to propose the direction of planning Community Streets for the recovery of the public- and communal urban housing's streets, researching the present employment condition of Community Streets that were prepared recently. Working with 3 complexes which have been completed since 2000, We studied the present employment condition and planned signification, according to the conditions of their surroundings, the physical conditions of Community Streets, and the relationship among main apartment buildings, open spaces, and facilities. From this study, We came up with several suggestions that can present the planning line of Community Streets. Therefore this research is to create the Community Streets for the activity of the streets, the recovery of the community, and improvement of ambulatory environment.

Design and fabrication of the MMIC frequency doubler for 29 GHz local oscillator application

김진성,이성대,이복형,김성찬,설우석,임병옥,김삼동,박현창,박형무,이진구,Kim, Jin-Sung,Lee, Seong-Dae,Lee, Bok-Hyoung,Kim, Sung-Chan,Sul, Woo-Suk,Lim, Byeong-Ok,Kim, Sam-Dong,Park, Hyun-Chang,Park, Hyung-Moo,Rhee, Jin-Koo The Institute of Electronics and Information Engin 2001 電子工學會論文誌-TC (Telecommunications) Vol.38 No.11

밀리미터파 대역에서 안정적이고 경제적인 local oscillator (LO) 신호를 생성하기 위한 주파수 체배기를 설계 및 제작하였다. 주파수 체배기는 14.5 GHz를 입력받아 29 GHz를 생성하도록 설계되었으며, 측정 결과 14.5 GHz에서 S11이 -9.2 dB, 29 GHz에서 S22가 -18.6 dB 로 입력 측은 14.5 GHz에, 출력 측은 29GHz에 매칭이 되었다. 변환손실의 경우 14.5 GHz에서 입력전력 6 dBm일 때 최소 값인 18.2 dB를 보였으며, 출력 단에서의 주파수 스펙트럼 특성은 14.5 GHz에서 15.2dB의 값을 나타내었다. 또한 입력신호의 isolation특성은 10.5 GHz에서 18.5GHz까지 주파수 범위에서 30 dB이상의 값을 보였다. 제작된 MMIC(Microwave monolithic integrated circuits) 주파수 체배기의 칩 사이즈는 $1.5{\times}2.2\;mm^2$이다. We demonstrate the MMIC (monolithic microwave integrated circuit) frequency doublers generating stable and low-cost 29 GHz local oscillator signals from 14.5 GHz input signals. These devices were designed and fabricated by using the M MIC integration process of $0.1\;{\mu}m$ gate-length PHEMTs (pseudomorphic high electron mobility transistors) and passive components. The measurements showed S11 or -9.2 dB at 145 GHz, S22 of -18.6 dG at 29 GHz and a minimum conversion loss of 18.2 dB at 14.5 GHz with an input power or 6 dBm. Fundamental signal of 14.5 GHz were suppressed below 15.2 dBe compared to the second harmonic signal at the output port, and the isolation characteristics of fundamental signal between the input and the output port were maintained above :i0 dB in the frequency range 10.5 GHz to 18.5 GHz. The chip size of the fabricated MMIC frequency doubler is $1.5{\times}2.2\;mm^2$.

수종 한약제의 위암세포에 대한 항암작용 효능 검색 및 약리작용에 관한 분자생물학적 연구

김진성,이지향,류봉하,박재훈,지성길,유진화,Kim, Jin-Seong,Lee, Ji-Whyang,Ryu, Bong-Ha,Park, Jae-Hoon,Ji, Sung-Gil,Yoo, Jin-Hwa 대한암한의학회 1999 大韓癌韓醫學會誌 Vol.5 No.1

Traditional oriental medicines have been used for treatment of various kinds of human cancers for long times and some of them proven to be effective clinically. However, the pharmacological actions and mechanisms related to cancer treatment are generally unknown. In an effort to clarify the action mechanisms of several oriental medicines used for cancer treatments, we planned this experimental procedures. We selected Cordyceps sinensis (冬蟲下草), Punellae Herba (夏枯草), Rehmanniae Radix (熟地黃), Paeoniae Radix (白芍藥), Oldenlandiae Herba (白花蛇舌草), Partulaceae Herba (馬齒? ), Scdopendra subspinipes mutilans (蜈蚣), Mylabris Phalerara (班蟄), Phellinus igniarius(桑黃), Ganodermae Lignum(靈芝) for evaluation, which have been used for patients of gastric cancers. The twenty grams of medicines were boiled in 100ml of water for 1 hour and filtered with $0.2\;{\mu}m$ pore-sized filter unit to remove insoluble particles. Initially we evaluated the effects oriental medicines on growth inhibition in stomach cancer cells. The gastric cancer cell line, AGS, was cultured in RPMI 1640 supplemented with l0% heat-inactivated fetal bovine serum and treated with $10{\mu}l$ oriental medicines per 1ml of medium up to 48 hours. The specimens were subjected to MTT assay for evaluation of growth inhibition. We found mat Mylabris phalerata (班蟄) markedly suppressed the growth of cancer cells as shown in results. Next, we checked the effects of oriental medicines on cancer on cell cycles and apptosis. Mylabrls phalerata (班蟄) inhibited cell cycle progression of cancer cells a compared with control cells and cells treated with other medicines. In addition, Mylabri phalerata (班蟄) induced apoptosis in 30-40% of stomch cancer cells within 24 hours. Other oriental medicines used for this experiments did not show apoptosis-inducing effects on cancer cells. Finally, we determined the expression levels of genes associated with cell cycle and apoptosis. The expressions of Bcl-2 and bcl-XL were downregulated by the treatment of Mylabris phalerata (班蟄). However, the expression levels of genes related to cell cycles were not altered significantly. In conclusion, we found that Mylabris phalerata (班蟄) has in vivo gowth-inhibiting and apptosis-inducing effects on stomach cancer cells. However, we think that at least animal experiments are necessay for evduations.

만성 B형 간질환 환자의 정신사회적 측면

김진성,Kim, Jin-Sung 한국정신신체의학회 2000 정신신체의학 Vol.8 No.1

연구목적 : 저자는 만성 B형 간질환 환자의 정신과학적 측면과 사회학적 측면을 관찰해 보고자 본 연구를 실시하였다. 방법 : 저자는 1966년부터 1999년까지의 Medline database에 등록된 B형 간질환에 관한 모든 문헌들을 고찰하였다. 결과 : 만성 B형 간질환 환자와 관계되는 정신과학적 측면은 섬망, 전반적인 의학적 상태에 기인하는 정신병(특히 조증), 불안, 우울, 적응장애, 알코올 남용과 의존, 및 약물남용과 의존 등이다. 만성 B형 간질환 환자와 관계되는 사회학적 측면은 간염보균자로서의 낙인문제, 감염과 연관된 죄책감, 증가된 가족들의 부담에 대한 죄책감, 대인관계의 소외와 철수, 성장애, 직업상실 및 의료진의 치료 거부등이다. 결론 : 만성 경과를 거치는 B형 간염환자의 여러 가지 정신과학적 사회학적 문제로 볼 때, 적절한 조기의 교육적 상담 개업이 필요하다고 하겠다. 적절한 교육적 상담 개입은 간염으로부터 간경화 간암으로의 진행과정에 B형 간염환자의 치료의 순응도를 높이고 나아가 악화의 과정을 예방할 수 있다. Objectives : The author wanted to summarize the psychiatric and social aspects of the patients with hepatitis B virus infection. Methods : The author reviewed all pertinent citations in the Medline database from 1966 to 1999. Results : Psychiatric problems in this population include delirium, psychotic disorder due to general medical condition(especially mania), anxiety, depression, adjustment disorder, alcohol abuse/dependence, and drug abuse/dependence. Social aspects of the patients with hepatitis B viral infection relate to the stigma of being a carrier, guilty feeling about infection, guilty feeling about increased family burden, impacts of having hepatitis on interpersonal relations, sexual difficulties, and job loss with increased financial burden, and health care worker's refusal. Conclusions : Appropriate early educational counseling interventions regarding the expected course and psychosocial intervention should be tailored to the sociocultural needs of special populations. Those interventions will increase compliance of treatment and prevent progression to hepatocellalar carcinoma from hepatitis.

Knowledge Conversion between Conceptual Graph Model and Resource Description Framework

김진성,Kim, Jin-Sung Korean Institute of Intelligent Systems 2007 한국지능시스템학회논문지 Vol.17 No.1

On the Semantic Web, the content of the documents must be explicitly represented through metadata in order to enable contents-based inference. In this study, we propose a mechanism to convert the Conceptual Graph (CG) into Resource Description Framework (RDF). Quite a large number or representation languages for representing knowledge on the Web have been established over the last decade. Most of these researches are focused on design of independent knowledge description. On the Semantic Web, however, a knowledge conversion mechanism will be needed to exchange the knowledge used in independent devices. In this study, the CG could give an entire conceptual view of knowledge and RDF can represent that knowledge on the Semantic Web. Then the CG-based object oriented PROLOG could support the natural inference based on that knowledge. Therefore, our proposed knowledge conversion mechanism will be used in the designing of Semantic Web-based knowledge representation and inference systems.

보두(寶豆)의 수치법(修治法)에 따른 독성(毒性) 및 소화기계(消化器系)에 미치는 영향(影響)

김진성,윤상협,류봉하,류기원,조유경,Kim, Jin-Sung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Cho, Yu-Kyung 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.1

Objective : These experiments were designed to investigate the effects of Strychni Ignatii Semen on the gastrointestinal system and declining of toxicity. About experiments of acute toxicity, I investigated the quantity of Strychni $(C_{21}H_{22}N_2O_2)\;and\;LD_{50}$. In order to study the effects on gastrointestinal tract, I investigated the changes of gastric juice, discharging level of pepsin, inhibiting effects of ulceration, and transporting of intestine. Methods : Sample I : No making Strychni Ignatii Semen Sample II : Depositing for three days in water and then dry it. Sample III : Depositing for one hour in sesame oil and bum it. The results were as follows : 1. The average values of Strychnine decreased in Sample III. 2. The levels of $LD_{50}$ increased in Sample Ⅲ by about 70%. 3. In Sample III, inhibiting effects of ulceration and discharging level of pepsin were great. 4. In the level of gastric juice decreased in Sample I.II.III. 5. The transporting ability of large intestine elevated in Sample I.II.III. According to the results, making Strychni Ignatii Semen, especially Sample 3, toxicity decreased and has good effects on the gastrointestinal system.

반모가 수종의 인체 암세포에 미치는 영향

김진성,윤상협,류봉하,류기원,정명채,Kim, Jin-Sung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Jung, Myung-Chai 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

Object : Objective: This study was conducted to investigate the anti-cancer effects of Mylabris phalerata (반모) in some kinds of cancer cells. Materials and Methods: Some kinds of cancer cells lines were treated. We used nine kinds of cancer cell lines, such as stomach cancer cells (Kato), lung cancer cells (Calu-1, NCI-H 1395), urinary bladder cancer cells (HS789T), bone cancer cells (Saos-2), brain cancer cells (SK-N-MC), liver cancer cells (Hep-G2), skin cancer cells (Mo-1) and prostate cancer cells (PC-3) with the water decoction of Mylabris phalerata. The histological changes of all cell lines in the media (RPMI-1640) containing the decoction of Mylabris phalerata were observed and we examined cell death assay by trypan blue exclusion testing was examined. Finally, the change of mitochondrial membrane potential was measurd and the inhibitory effect of Mylabris phalerata on cell increase was examined by analyzing the cell cycle. Results: In histologic change all cancer cell lines showed withdrawn and floating appearance that is typical in cellular impairment. Most of the cell lines showed over 50% death rate after 24 hours in trypan blue exclusion tests. Especially the stomach, urinary bladder. brain and liver cell lines showed over 30% death rate after 12 hours. All cell lines treated with Mylabris phalerata were less stained than the control group and the mitochondrial membrane potential in the Mylabris phalerata treated cell lines was markedly lower than that in the control group. The measurement of DNA quantity in all cell lines showed the disappearance of the peak and the thickened left axis, which suggests that all cellular DNA degraded. Conclusion: Mylabris phalerata had cytotoxicity on various kinds of cancer cell lines and the mechanism of that was the impairment of mitochondria by the breakdown of the mitochondrial cell membrane. We propose that this is in part attributable to the destruction of DNA in cancer cells.

반모가 대장암세포에 미치는 영향

김진성,윤상협,류봉하,류기원,김현일,Kim, Jin-Sung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Kim, Hyeon-Yil 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

The study examines the anti-cancer effects of the hot water extract of Mylabris phalerata(MP) using SNU-C5 cell lines. Microscopic analysis showed that 12 hours after MP treatment, the number of dead cells increased prominently. Significant cell death was observed 12, 24, and 48 hours after MP treatment through trypan blue exclusion testing. This suggests that MP is time-dependently cytotoxic. Mitotracker Red CMXRos staining and flowcytometry revealed that MP decreased mitochondrial membrane potentials. The absence of peaks on PI staining showed that DNA damage occurred in MP treated cells. Taken together, measurements suggest that MP has a strong anti-cancer effect on SNU-5 cell lines, and that this is likely to be due to the destruction of mitochondria and DNA damage.

영상유도 양성자치료를 위한 콘빔 CT 재구성 알고리즘: 기하학적 보정방법에 관한 연구

김진성,조민국,조영빈,윤한빈,김호경,윤명근,신동호,이세병,이레나,박성용,조관호,Kim, Jin-Sung,Cho, Min-Kook,Cho, Young-Bin,Youn, Han-Bean,Kim, Ho-Kyung,Yoon, Myoung-Geun,Shin, Dong-Ho,Lee, Se-Byeung,Lee, Re-Na,Park, Sung-Yong,Cho, Kwan- 한국의학물리학회 2008 의학물리 Vol.19 No.4

IMRT, 양성자 치료와 같이 방사선 치료 기술이 발전할수록 치료 시 환자의 위치를 확인하고 그 정확성을 평가하는 기술의 중요성이 강조되고 있다. 현재 국립암센터 양성자치료센터에 설치되어 있는 양성자 치료기의 단순 X-선 영상시스템을 이용하여 콘빔 CT (cone-beam CT) 3차원 영상을 획득, 영상유도 방사선 치료의 가능성을 확인하고자 하였다. 양성자 치료기에 설치되어있는 X-선 영상시스템(SDD: 2,108 mm, SOD: 1,511 mm, Varian a277 x-ray tube & Varian Paxscan 4030: a-Si+DRZ screen)을 이용하여 양성자 갠트리를 $2^{\circ}$씩 회전시켜가면서 기하학적인 오차 측정을 위한 팬톰과 인체 팬톰 (Humanoid phantom, Rando, CA, USA)의 투사영상을 획득하였다. 현재 시스템적으로 연속적인 회전과 영상획득이 지원되지 않아서 영상획득 후 갠트리를 회전하는 방법으로 투사영상을 획득하였다. 기하학적 오차측정을 위한 팬텀과 두경부 팬텀에 대해서 $360^{\circ}$를 회전하며 180장의 투사영상($2,304{\times}3,200$, 14 bit with 127${\mu}m$ pixel pitch)을 관전압 85 kVp, 관전류 80 mA, 조사시간 0.5 s의 조건으로 촬영하였다. 콘빔 CT 영상재구성을 위해 Ram-Lak filter를 적용한 Feldkamp cone-beam 알고리즘을 사용하였으며, 획득한 180장의 투사영상을 사용하여 $0.4{\times}0.4{\times}0.4mm^3$의 voxel size를 가진 $512{\times}512{\times}512$ CT영상을 재구성하였다. 기하학적인 오차 측정방법을 통해 X-선 선원, 검출기와 갠트리의 기하학적 정보를 측정하였다. 측정된 결과에 의하면 검출기가 $0.25^{\circ}$ 회전된 오차를 보이는 것을 발견하였다. 기하학적 교정으로 재구성된 콘빔 CT 영상을 multi-planar view (axial, sagittal and coronal view) 및 3차원 영상으로 재구성하여 비교 평가 하였다. 현재 양성자치료기에 설치되어있는 단순 X-선 영상 시스템에서 기하학적 오차 측정을 위한 볼 팬텀을 이용하여 시스템의 오차를 측정하였다. 측정한 오차를 바탕으로 기하학적 교정을 통해서 두경부 및 복부 팬텀에 대한 3차원 영상인 콘빔 CT 영상들을 재구성하였다. 추후 연속적인 회전을 통한 영상획득이 가능하게 된다면, 보다 정확하고 신속한 영상재구성이 가능 하며 콘빔 CT가 영상유도 양성자 치료에 매우 유용할 것으로 사려된다. According to improved radiation therapy technology such as IMRT and proton therapy, the accuracy of patient alignment system is more emphasized and IGRT is dominated research field in radiation oncology. We proposed to study the feasibility of cone-beam CT system using simple x-ray imaging systems for image guided proton therapy at National Cancer Center. 180 projection views ($2,304{\times}3,200$, 14 bit with 127 ${\mu}m$ pixel pitch) for the geometrical calibration phantom and humanoid phantoms (skull, abdomen) were acquired with $2^{\circ}$ step angle using x-ray imaging system of proton therapy gantry room ($360^{\circ}$ for 1 rotation). The geometrical calibration was performed for misalignments between the x-ray source and the flat-panel detector, such as distances and slanted angle using available algorithm. With the geometrically calibrated projection view, Feldkamp cone-beam algorithm using Ram-Lak filter was implemented for CBCT reconstruction images for skull and abdomen phantom. The distance from x-ray source to the gantry isocenter, the distance from the flat panel to the isocenter were calculated as 1,517.5 mm, 591.12 mm and the rotated angle of flat panel detector around x-ray beam axis was considered as $0.25^{\circ}$. It was observed that the blurring artifacts, originated from the rotation of the detector, in the reconstructed toomographs were significantly reduced after the geometrical calibration. The demonstrated CBCT images for the skull and abdomen phantoms are very promising. We performed the geometrical calibration of the large gantry rotation system with simple x-ray imaging devices for CBCT reconstruction. The CBCT system for proton therapy will be used as a main patient alignment system for image guided proton therapy.

분심기음의 항암작용 및 면역기능에 관한 연구

김진성,윤상협,류봉하,류기원,여대원,Kim Jin-Sung,Yoon Sang-Hyub,Ryu Bong-Ha,Ryu Ki-Won,Yeo Dae-Won 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2

This study was performed to investigate the effect of Bunsimgieum on antitumor effect after sarcoma-180 cells transplantation into peritoneal cavity or left groin and immune responses on the depressed immunity induced by methotrexate in mice. The Bunsimgieum extract of 10mg/kg was orally administered 14 days for antitumor effects and 21 days for immune responses. 50% inhibitory concentration($IC_{50}$) of SUN-1, SUN-C4, and SUN-396 cancer cell, mean sunvival days and body weight of tumor bearing mice, and growth of tumor mass for antitumor effect; delayed type hypersentivity, hemagglutinin titer, hemolysis titer, rosette forming cells, natured killer cell activity, lymphocyte transformation, productivity of interleukin-2, and phagocytic activity for their immune responses were measured in ICR mice. Significance in antitumor effect is noted in the enlongation of mean life days and inhibition of tumor growth(p<0.01, respectively). Significance of immune responses is also noted in hemolysis titer, lymphocyte transfumotion, IL-2 productivity, phagocytic activity, and natural killer cell activity at E/T ratio 100:1(p<0.01, respectively). Significant in rosette cell formation was seen at dosage of 20mg/kg(p<0.01). However, Difference of body weight as antitumor effect, delayed type hypersensitivity, and hemagglutinin titer were not shown significantly. According to the above results, it could be suggested that Bunsimgieum has prominent antitumor and immunity enhancing effect.