단기간의 Amiodarone 투여 후 발생한 급성 폐독성 1예 -증례 보고-

김정혁,전해리,정진성,유승현,고규한,고영민,김정혁 대한중환자의학회 2011 Acute and Critical Care Vol.26 No.2

Amiodarone is one of the most commonly prescribed antiarrhythmic drug for almost all atrial or ventricular arrythmias. Amiodarone-induced pulmonary toxicity (APT) was first described in 1980 and has potentially serious side effects that are believed to develop in 5% of patients. In general, APT occurs only when high amiodarone doses are used for a long time. However, during short-term therapy of amiodarone, APT is rarely reported. In this report, we describe a case of amiodarone-induced pulmonary toxicity after a short course of amiodarone therapy for atrial fibrillation.

고밀도 플라즈마 반응성 DC 마그네트론 스퍼터링법으로 증착한 TiNx 박막의 특성 연구

김정혁,박지봉,김정곤,김용태,강충길,송풍근 한국소성가공학회 2011 한국소성가공학회 학술대회 논문집 Vol.2011 No.5

유방의 비정형유관사이증식증: 방사선학적 소견과 병리학적 소견의 연관성

김정혁,오유환,Kim, Jeong-Hyeok,O, Yu-Hwan 대한영상의학회 2003 대한영상의학회지 Vol.49 No.4

목적: 비정형 유관상피증식증의 임상소견, 유방촬영술과 유방초음파상의 방사선학적 소견을 분석하고, 방사선학적 소견과 병리학적 소견과의 연관성을 알아보고자 하였다. 대상과 방법: 2000년 3월부터 2003년 3월까지 수술로 확진된 64명 환자들의 64 병소들을 대상으로 하였다. 64예 모두가 유방촬영술을 시행하였고, 30예에서 유방초음파를 시행하였다. 두 명의 유방 방사선과 전문의가 후향적으로 유방촬영술소견과 초음파소견을 분석하여, 병면을 종괴, 미세석회화, 이외의 기타소견(유관변화 등)과, 병면이 보이지 않은 경우 등 4군으로 나누었다. 유발촬영술상종괴의 경우는 모양, 경계, 음영, 석회화 동반 여부 등을 알아보았고, 미세석회화의 경우는 모양과 분포를 관찰하였으며, 유방초음파에서는 종괴의 모양, 경계, 내부와 후방 에코패턴, 석회화 동반 여부, 유관과 연결유무, 피부와 나란한 방향인지 등을 살펴보았다. 비정형 유관상피증식증의 방사선학적 병리학적 연관성을 직접연관(direct), 근접연관(near direct), 연관성 없음(remote correlation) 의 3가지로 분류하였다. 결과: 유방촬영술에서는 미세석회화가 37예(57.8%), 종괴가 14예(21.9%), 기타소견은 2예(3.1%)이었고, 11예(17.2%)에서는 병면이 발견되지 않았다. 미세석회화의 경우, 모양은 원형이 19예(50.0%), 비균질한 다형성이 16예(42.1%)이었고, 분포는 군집형이 29예(76.3%)로 가장 많았다. 유방초음파를 시행한 30예 중 29예가 종괴로 보였고, 타원형이나 원형의 모양이 15예(51.7%), 불규칙한 모야이 14예(48.3%)이었다. 종괴의 경계는 불분명한 경우가 16예(55.2%), 저에코가 19예(62.1%), 주변 유관과의 연결은 22예(75.9%)에서 보였으며, 22예(75.9%)는 종괴의 장축이 피부와 평행하였다. 방사선학적 소견과 병리학적 소견은 직접연관은 44예(68.8%), 근접연관은 13예(20.3%)였고, 나머지 7예(10.9%)는 연관성이 없었다. 임상소견은 64예중 47예(73.4%)에서 증상이 없이 우연히 선별검사에서 병면이 발견되었고 증상을 동반한 17예중 7예(10.9%)는 촉지되는 종괴를, 7예(10.9%)는 유두분비물을, 나머지 3예(4.7%)는 통증을 동반하였다. 결론: 비정형 유관상피증의 가장 흔한 유방촬영술 소견은 군집형 분포를 보이는 원형 또는 비균질한 다형성 모양의 미세석회화이고, 가장 흔한 초음파소견은 불분명한 경계의 원형이나 타원형 또는 불규칙한 모양의 저에코의 종괴로서 피부와 평행하게 위치하며 유관과의 연결을 동반한다. 비정형 유관 상피증식증은 임상적으로 특별한 소견이 없이 방사선학적 검사에서 우연히 발견되는 예가 대부분이며, 이 연구에서 유방촬영술에서 병면이 보이지 않는 17.2%가 유방초음파에서 발견되므로, 유방촬영술과 함께 유방초음파가 보완적인 역할을 할 것으로 기대된다. Purpose: To evaluate the clinical and radiologic findings of atypical ductal hyperplasia (ADH) using mammography and ultrasonography, and to correlate the radiologic and histopathologic findings. Materials and Methods: Sixty-four pathologically proven lesions in 64 patients who were examined between March 2000 and March 2003 were the subject of this study. Mammography was performed in all 64 cases, and ultrasonography in 30. Two radiologists retrospectively evaluated the radiologic findings, classifying them as one of four types: mass, microcalcification, other finding, and no detected lesion. At mammography, masses were classified according to their shape, margin, and density and microcalcifications according to their shape and distribution. At ultrasonography, masses were evaluated in terms of their shape, margin, internal and posterior echotexture, ductal extension, and parallelism to skin. Geographic correlation between the radiologic and histopathologic findings was classified as direct, near direct, or remote correlation. Results: Mammography demonstrated 37 cases of microcalcification (57.8%), 14 in which masses were present (21.9%), two in which there were other findings (3.1%), and 11 in which lesions were not detected (17.2%). The "other finding" was ductectasia. Microcalcifications were round in 19 cases, pleomorphic heterogeneous in 16, and branching linear in one. The most common distribution of microcalcification was clustered (29 cases; 78.4%). Masses were oval or round in nine cases and irregular in three, and in seven cases their margin was ill-defined. In 13 cases, the density of the masses was equal to that of breast tissue. Ultrasonography showed that the masses were round or oval in 15 cases and irregular in 14, and that the margin was ill-defined in 16 cases and circumscribed in ten. In 19 cases, the echotexture of the masses was low, and in 20 cases, heterogeneous. Parallel orientation was seen in 25 cases, and ductal extension in 22. Category 4 was the most common final assessed BI-RADS category, found in 75% of cases. Radiologic-histopathologic correlation was direct in 44 cases, near direct in 13, and remote in seven. Clinically, self or clinical examination of the breast revealed no abnormality in 47 cases, a palpable mass in seven, nipple discharge in seven, and breast pain in three. Conclusion: At mammography, the most common finding of ADH was clustered round or pleomorphic heterogeneous microcalcifications, and at ultrasonography, illdefined, round or oval, or irregular-shaped, hypoechoic masses with parallel orientation and ductal extension. Clinically, most ADH was incidentally discovered at radiologic examination. In this study, 17.2% of ADH cases were not demonstrated by mammography but were detected at ultrasonography, and for the detection of ADH, the use of this latter modality, alongside mammography, is thus feasible.

Correlation between dynamic left ventricular outflow tract obstruction and false positive treadmill test in exercise stress echocardiography (초)

김정혁,이미래,손관협,변경민,한혜진,오세훈,최이령,최진오,박승우 대한내과학회 2008 대한내과학회지 Vol.75 No.1S

원자력 구조물 합성바닥판 적용에 관한 구조적 연구

김정혁,조문희,김강식,김우범,이광수,신성우 한국구조물진단유지관리학회 2000 한국구조물진단학회 학술발표회논문집 Vol.- No.-

SPSA에 근거한 Tylor 모델 근사화와 전력계통 안정화 시스템에 적용

김정혁,김호찬 제주대학교 공과대학 첨단기술연구소 2004 尖端技術硏究所論文集 Vol.15 No.2

This paper presents a Taylor model approach for a closed-loop system identification using input and output data and its application to design a power system stabilizer (PSS). The Taylor model concept is introduced as an alternative intelligent system technique to design a controller for an unknown system with input and output data only, and without the detailed knowledge of mathematical model for the system. In the Taylor model, the data used has incremental forms using backward difference operators. The parameters of the Taylor model can be obtained by the simultaneous perturbation stochastic approximation (SPSA) method. The feasibility of the proposed method is demonstrated in a one-machine infinite-bus power system. The linear quadratic regulator (LQR) method is applied to the Taylor model to design a PSS for the system, and compared with the conventional PSS in different loading conditions and system failures such as the outage of a major transmission line or a three phase to ground fault which causes the change of the system structure

공급사슬망 설계를 위한 수리모형 수립 및 응용

김정혁,김대기 한국경영과학회 2004 經營 科學 Vol.21 No.2

Great effort has been exerted to redesign the supply chain network as a means to improve corporate competitiveness. In this study, we present a mathematical model and a solution system to help redesign corporate logistics networks. The objective of the model is to minimize total logistics costs. We applied the solution system to real problem cases. We use the model and the concept to develop decision support system that is based on C++ with the use of CPLEX callable library as a solution engine. We tested and verified the DSS for redesigning the network of a large Korean electronics company. Through various scenario analyses, we recommend to redesign their supply chain network that demonstrates the possibility of substantial logistics cost savings.

방사선옥소의 정맥주사가 갑상선에 미치는 영향에 관한 연구

김정혁 대한영상의학회 1977 대한영상의학회지 Vol.13 No.1

The thyroid uptake study of 131I that has been most commonly used in the diagnosis of the thyroid disease, is usually performed by giving oral administration in fasting state. Therefore, the patients with thyroid disease have to visit the hospital in fasting state and on two sucessive days for this uptake study of the thyroid gland. This study was included the total number of 87 cases: Of these, radioiodine was orally administered to 8 healthy individuals, 46 cases that were euthyroid received it intravenously, and 33 patients with hyperthyroidism, it was also administered intravenously. All of the cases uptake rates by thyroid gland were measured at the time of 15min, 30min, 1, 2, 6 and 24 hours after administration of 131I. In an attempt to minimize such an inconvenience for the patients as well as shorten the time of examination, the authors have made an observation on early uptake rates by thyroid gland and changes of thyroid function as related to the meals. The result btained are summerized as follow: 1. In both cases of oral and I.V. administration, there were found higher tendencies of uptake rate in non-fasting state than in fasting state, oral administration stastically showed definite significance of increasing uptake rate in non-fasting state after 6 hours while I.V. administration showed this after one hour. 2. When 131Iwas administered intravenously the early thyroid uptake rate showed higer tendencies than oral administration, that is, if the values of uptake rate surpass 20% after one hour measurement, hyperthyroidism could be highly suspected and if exceeds 40% of 6 hour uptake rate, hyperthyroidism may certainly be predicted to exist. 3. The uptake rate of non-fasting state I somewhat higher than in fasting state, however, since the differences exist only with the negligerble boundary, the test of non-fasting state is considered to have a good validity. 4. Finally it was felt that euthyroidism and hyperthyrodism could be differentiate within 6 hours after intravenous injection in an usual non-fasting state, and results not only in an increase in rapidity of the diagnosis but also more convenience with a great saving in time.

DC 반응성 스퍼터링법으로 알루미늄 기판에 증착된 2차 연료 전지용 분리판을 위한 TiN, TiCN 박막의 특성 연구

김정혁,강충길,송풍근 한국표면공학회 2011 한국표면공학회 학술발표회 초록집 Vol.2011 No.11

포스터 전시 발표 순서 : 순환기 ; 대동맥궁 혈전 Aortic arch thrombus (초)

김정혁,변경민,손관협,한혜진,이미래,김은영,최진오,박승우 대한내과학회 2008 대한내과학회지 Vol.75 No.1S