CFD 해석을 이용한 누설 포집 시스템 해석 방법 수립 및 평가

최대경,박원만,어동진,권태순,최청열 한국유체기계학회 2023 한국유체기계학회 논문집 Vol.26 No.5

Suppose a small amount of leakage exceeds the limit of the operating conditions of a nuclear power plant. In that case, losses due to the nuclear power plant shutdown may occur, or accidents due to leakage may occur. Consequently, there has been a need to develop a system capable of quickly detecting even small amounts of leakage, and research has been conducted to address this need. To develop such a system, it is necessary to understand the thermal-hydraulic characteristics of the system. This study established a CFD-based evaluation process for evaluating leak detection systems. A numerical analysis model was used to simulate leakage, and a two-step CFD analysis was performed to assess its applicability. In the first step, a study of the leakage behavior in the insulation material was conducted, and the effect of the gap between the pipe insulation material and the outer cover was evaluated. In the second step, the collection loop was analyzed using the results of the leakage behavior analysis in the insulation as an input condition. The results of this study were used to construct the collection loop experimental device and will help in understanding the heat flow characteristics in the collection loop.

實驗的結核症 및 癩病의 化學療法에 관한 硏究 : 第1報

崔大卿,徐丙世 대한나학회 1963 대한나학회지 Vol.2 No.1

抗體의 構造 및 그 産生過程

崔大卿 대한의학협회 1973 대한의학협회지 Vol.16 No.1

癩菌의 實驗的 硏究

崔大卿 세계평화교수협의회 1976 廣場 Vol.33 No.-

結核患者에서 分離된 非定型抗酸菌의 微生物學的 硏究

崔大卿,張明雄,朴鼎圭 충남대학교 의과대학 지역사회의학연구소 1980 충남의대잡지 Vol.7 No.2

Attentions have been devoted to the biological and chemotherapeutical studies on the acid fast bacilli isolated from 220 patients who were admitted to the National Kongju Hospital from March to June in 1980. The results were summerized as follows: 1. The sex distribution of 220 patients were 152 males and 68 females. 2. Seventy (31.8%) strains of acid fast bacilli were isolated from 220 patients sputa. 3. Culture were considerablely more sensitive than direct smear in detecting the presence of mycobacteria. 78.6 percent of all culture positive were positive in the direct smear. 4. When the 70 isolated strains classified by Runyon groups, 6 strains (8.5%) were belong to the rapid growers and the rest 64 strains (91.5%) were belong to the M. tuberculosis. 5. In drug sensistivity test, drug resistant strains were found 16. 6 percent of isoniazid(1㎍/ml), 37.0 percent of streptomycin (10㎍/ml) and 40.3 percent of ethambutol (2㎍/ml). From the above results, it was suggested that the majorities of tuberculosis patients were caused by the infection of M. tuberculosis, that strains were resistant to the anti-tuberculosis drugs. It is mainly caused by the increasing occurrence of resistant bacilli which is attributable to inadequate drug medication. The correct chemotherapy based on reliable sensitivity test. It prevents the occurence of resistant bacilli, relapses and stops the progress of the diseases.

결핵균 단세포군항체에 의한 항산균항원의 면역화학적 분석에 관한 연구

최대경,백태현,박정규,김화중 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-

β-antigen is one of the major protein of Mycobacterium tuberculosis. We purified reference β-antigen from the unheated culture filtrate of Mycobacterium tuberculosis by serial ammonium sulfate precipitation, gel filtration on Sephacryl S-200 column and preparative polyacryamide gel electrophoresis. Nine monoclonal antibodies against β-antigen were produced by hybridoma technique. The nine monoclonal antibodies were divided into two groups according to their reaction patterns on Western blots. Four monoclonal antibodies(group Ⅰ) reacted with two major bands of 83 and 52 kDa, and two minor bands of 110 and 56 kDa molecules while the other five monoclonal antibodies(group Ⅱ) reacted with a major band of 83 kDa and a minor and of 110 kDa molecule. The interspecies reactivities of nine monoclonal antibodies on the sonicated antigens from 21 species of mycobacteria were also examined by dot blots. Two monoclonal antibodies, designated 4G5E10(group Ⅰ) and 5F3F2(group Ⅱ), showed a specificity restricted to Mycobacterium tuberculosis complex. β-antigien from the cell extract of Mycobacterium tuberculosis was purified by affinity chromatography with 5F3F2 monoclonal antibody and checked its molecular characterization. Affinity purified β-antigen showed two distinct bands of 83 and 52 kDa molecules on SDS-PAGE. These results indicating that β-antigen is a associated protein with molecular weights of 83 and 52 kDa, and contains at least two different specific epitopes for Mycobacterium tuberculosis complex on β- antigen molecules. Affinity purified and reference β- antigens were applied for its potential diagnostic utility for determination of LgG antibody in the cerebrospinal fluids and sera of tuberculosis patients by ELISA. The mean ELISA values of IgG antibody activities to affinity purified β-antigen at the CSF dilution of 1 : 5 were 0.866±0.607 in 12 patients with tuberculous meningitis and 0.058±0.040 in 24 controls(P<0.001). The mean ELISA values of IgG antibody activities to reference β-antigen at the serum dilution of 1 : 100 were 0.861±0.350 in 97 patients with minimal tuberculosis, 1.052±0.443 in 51 patients with moderately advanced, 1.381±0.396 in 49 patients with far advanced and 0.454±0.248 in 138 controls(P<0.01). An indirect sandwich ELISA using specific biotinylated 5F3F2 monoclonal antibody as tracer was designed to detect β-antigen in the culture filtrate of Mycobacterium tuberculosis and sputum samples from patients with pulmonary tuberculosis. The detection limit of indirect sandwich ELISA was 0.1㎍ culture filtrate/㎖. The mean ELISA values of β-antigen reactivities in sputum samples from 52 patients with pulmonary tuberculosis and 25 controls were 0.766±0.404 and 0.453±0.133(not significant).

抗生物質 : 化學療法과 微生物學的 問題點

崔大卿 中央醫學社 1974 中央醫學 Vol.26 No.2

다분절 척추 유합술의 유합 분절 범위가 요추에 미치는 생체역학적 영향

최대경,김경수,김윤혁 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.4-4

나환자의 의학적 관리 실태조사와 그 대책에 관한 연구

백석현,최대경 忠南大學校 環境問題硏究所 1985 環境硏究 Vol.3 No.1

In the hope of solving the problems of medical control of leprosy, all the patints registered in Chungnam province were investigated in the aspects of personal histories, chinical features, bacteriological findings and treatment. etc. In this studies, all the clinical records of 1,240 leprosy patients were analyzed during the period from 1983 to 1984. The results were summarized as follows: 1. Number of patients presenting upper extremity anesthesia were 867 (69.9%) on the left side and 784 (63.2%) on the right side. 2. Number of patients presenting lower extremity anesthesia were 759 (61.2%) on the left and 734 (59.2%) on the right side, and number of patients presenting trophic ulcer were 204 (19.4%) in total. 3. 683 patients (55.1%) were lepromatous type and 416 (33.6%) were tuberculoid type. 4. 169 patients (13.6%) were active, 970 (78.2%) were inactive with treatment and 101 (8.1%)were inactive under surveillance. 5. Bacteriogical examination showed that 144 patients (21.1%) were positive in lepromatous type, 4(19.1%) in boderline type and remaining patients in other types were negative. 6. Out of 1,240 patients, 978(78.9%) were treated with standard DDS only and 241(19.4%) were treated with DDS and rifampicin. 7. Out of 1,240 patients, 68(5.5%) were taking anti- leprosy drugs irregularly and 71 (5.7%) were out-of-control cases. 8. Out of 111 patients in reaction, 91(82.0%) were active patients and 20(18.0%) were inactive patients. 9. The major symptoms and signs of leprosy patients with other clinical manifestation were trophic ulcer, indigestion, headache and corneal injection. 10. The major cause of out-of-leprosy controls were medical rejection, substiute, missing, immobilization and disease denial.

제56차 추계학술대회 및 총회 : 일반연제 1 ; 피부생물학 1 : 피부 기관 배양을 이용한 방사선 피부염의 연구

최대경,이영숙,남용희,김창덕,서영준,이증훈,박장규,조문준 대한피부과학회 2004 초록집 Vol.42 No.20