이묘산(二妙散)의 항(抗)류마티즘 효능(效能)에 대한 연구(硏究)

임창경,윤용갑,Lim, Chang-Kyung,Yun, Young-Gab 대한한의학방제학회 2009 대한한의학 방제학회지 Vol.17 No.1

Rheumatoid arthritis is characterized by focal loss of cartilage due to an up-regulation of inflammatory pathways, which produce pro-inflammatory mediators, such as interleukin-1(IL-1), tumour necrosis factor alpha($TNF-\alpha$), prostaglantin, and nitric oxide(NO). We investigated the anti-arthritic effects of water extracts from Pellodendri cortex and Atractylodis rhizoma in vitro and in vivo. Each extract suppressed the production of inflammatory mediators(NO, $IL-1\beta$, $TNF-\alpha$, and prostaglandin $E_2$) and the expression of inducible NO synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated macrophages in a dose-dependent manner. These suppressive effects were synergistically increased by their combination. The same results were also observed in the rat osteoblast sarcoma cell line ROS17/2.8 stimulated with $IL-1\beta$, $IFN-\gamma,$ and $TNF-\alpha$. Moreover, the combination of these water extracts significantly suppressed collagen-induced mouse arthritis. These results suggest that the combination of water-extractable components of Pellodendri cortex and Atractylodis rhizoma may be useful for therapeutic drugs against rheumatoid arthritis, probably by suppressing the production of inflammatory mediators.

東洋醫學的 胎敎에 對한 考察

任昌慶,朴炅 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

Now we can abstract as following after considering the Fetal Education. To conceire a healthy baby, man and wife shall have sexual intercourse when mind and body are sound, weather os fine and shall take position at ease. Pregnant woman should not be overworked on, idle and should take proper exercise and rest. The emotion if pregnant woman shall not be onesided. When the weather changes heavily, pregnant woman had better not go out. Pregnant woman shall avoid sexual intercourse. The mind of fetus will be sound when the pregnant woman keep quiet always by seeing, hearing and speaking good things. Pregnant women had better have simple food and avoid the greasy or hot diet. Pregnant women shall be free from hot on poisonous drugs and blood activating and coagulation removing. Human education is consisted of native and acquired education. Acquired education can be better by the help of native education, therefore Fetal Education had better be done positively as a project of nation.

하이브리드 버켓을 이용한 대규모 집적회로에서의 효율적인 분할 개선 방법

임창경,정정화 대한전자공학회 1998 電子工學會論文誌, C Vol.c35 No.3

In this paper, we present a fast and efficient Iterative Improvement Partitioning(IIP) technique for VLSI circuits and hybrid bucket structures on its implementation. The IIP algorithms are very widely used in VLSI circuit partition due to their time efficiency. As the performance of these algorithms depends on choices of moving cell, various methods have been proposed. Specially, Cluster-Removal algorithm by S. Dutt significantly improved partition quality. We indicate the weakness of previous algorithms wjere they used a uniform method for choice of cells during for choice of cells during the improvement. To solve the problem, we propose a new IIP technique that selects the method for choice of cells according to the improvement status and present hybrid bucket structures for easy implementation. The time complexity of proposed algorithm is the same with FM method and the experimental results on ACM/SIGDA benchmark circuits show improvment up to 33-44%, 45%-50% and 10-12% in cutsize over FM, LA-3 and CLIP respectively. Also with less CUP tiem, it outperforms Paraboli and MELO represented constructive-partition methods by about 12% and 24%, respectively.

가변적인 연결도 임계치 설정에 의한 대규모 집적회로 설계에서의 안정적인 다단 분할 방법

임창경,정정화 대한전자공학회 1998 電子工學會論文誌, C Vol.c35 No.10

본 논문에서는 대규모 집적회로 설계에 있어 효율적이고 안정된 분할을 위한 새로운 다단 분할 방법을 제안한다. 대규모 회로의 설계에 반복적인 분할 개선 방법을 적용함에 있어 성능의 한계를 극복하기 위해 제안된 다단 분할 방법은 분할 계층구조의 형성 방식에 의해 그 성능이 결정되었다. 기존에 제안된 대부분의 다단 분할 방법은 계층구조를 형성하는 과정에서 실험에 의한 인위적인 제한 조건을 설정하여 분할 결과의 안정성이 저하되는 문제가 있었다. 이러한 안정성의 결여는 반복 수행시의 분할 결과 편차가 매우 커지는 상황을 초래한다. 본 논문에서는 이러한 인위적인 제한 조건의 설정을 최소화하고 계층구조 형성 과정에서 현재 회로 연결 상태를 고려하여 자율적인 제한조건에 의해 클러스터링을 수행하는 새로운 계층구조 형성 방식을 제안한다. 제안된 방법에 의해 형성된 분할 계층구조는 HYIP/sup 11/의 하이브리드 버켓을 이용한 분할 개선방법을 반복적으로 적용하여 분할 결과를 얻는다. 본 다단 분할 방법은 ACM/SIGDA에서 제공한 벤치마크회로를 대상으로 실험한 결과 기존 분할 방식/sup [3] [4] [5] [8] [9]/에 비해 약 10-40% 가량의 최소 cutsize 감소 효과가 있었고 기존의 다단 분할 방법 중에 가장 효율적인 방법으로 평가되는 ML/sup [10]/에 비해 제안된 방법이 최소 cutsize에 있어서는 약 5%, 평균 outsize에 있어서는 평균 20%이상의 성능 향상을 가져 왔다. 더욱이 제안된 방법을 10회 수행한 결과가 ML 방법을 100회 수행한 결과 보다 앞서는 성능을 보였다. This paper presents a new efficient and stable multilevel partitioning algorithm for VLSI circuit design. The performance of multilevel partitioning algorithms that are proposed to enhance the performance of previous iterative-improvement partitioning algorithms for large scale circuits, depend on choice of construction methods for partition hierarchy. As the most of previous multilevel partitioning algorithms forces experimental constraints on the process of hierarchy construction, the stability of their performances goes down. The lack of stability causes the large variation of partition results during multiple runs. In this paper, we minimize the use of experimental constraints and propose a new method for constructing partition hierarchy. The proposed method clusters the cells with the connection status of the circuit. After constructing the partition hierarchy, a partition improvement algorithm, HYIP$^{[11]}$ using hybrid bucket structure, unclusters the hierachy to get partition results. The experimental results on ACM/SIGDA benchmark circuits show improvement up to 10-40% in minimum outsize over the previous algorithm $^{[3] [4] [5] [8] [10]}$. Also our technique outperforms ML$^{[10]}$ represented multilevel partition method by about 5% and 20% for minimum and average custsize, respectively. In addition, the results of our algorithm with 10 runs are better than ML algorithm with 100 runs.

동의보감(東醫寶鑑)에 수록된 홍화(紅花)가 배오(配伍)된 처방(處方)에 대한 방제학적(方劑學的) 고찰(考察)

임창경,윤용갑,Im Chang-Gyeong,Yun Yong-Gap 대한한의학방제학회 2000 대한한의학 방제학회지 Vol.8 No.1

항 백혈병작용에 관련된 천연물의 자료조사

배현옥,임창경,장선일,한동민,안원근,윤유식,전병훈,김원신,윤용갑 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3

人蔘, 虎杖根, 常山 등에서 분리한 성분들이 HL60, HL-60, Jurkat, Molt-4에 대한 억제작용이 있는 것으로 조사되었고, 益母草의 Leonunrine, 大靑葉의 Indirubin, 天門冬의 Aspargus polysaccharide A.B.C.D, 百合의 Colchicnamile, 益母草의 Leonunrine, 山豆根, 紫草根 추출물이 여러유형의 백혈병 환자에 대한 백혈병 억제효과가 있는 것으로 조사되었으며, mouse의 P388, L1210, L615, L120, S-180 등에 항 백혈병 효과가 있는 것으로는 莞花, 노회, 遠志, 吳茱萸, 巴豆, 雷公藤, 石蒜, 白朮, 丹蔘, 山藥, 牧丹皮, 靑黛, 甘草, 當歸에서 분리한 성분들이 있으며 白屈菜, 馬錢子, 가시오가피, ??草 축출물들이 동물실험에서 항암작용이 있는 것으로 조사되었다. 또 천연물에서 분리한 성분이 항백혈병 작용이 있는것으로는 ginsenoside Ro, ginsenoside Rh2, Emodin, Yuanhuacine, Aleemodin, phorbocdiester, Triptolide, Homolycorine, Atractylol, Colchicnamile, Paeonol, 당귀다당체, Aspargus, polysaccharideABCD, Indirubin, Leonunrine, Acinosohic acid, Trichosanthin, Ge 132, Schizandrin, allicin, Indirubin, cmdiumlactone chuanxiongol, 18A glycyrrhetic acid, Kansuiphorin A, 13 oxyingenol Kansuiphorin B 등이 조사되었고 추출물이 항 백혈병 작용이 있는 것으로는 遠志, 吳茱萸, 白屈菜, 大黃, 山豆根, 馬錢子, 가시오가피, 천초 등이 조사되었다. According to the Leukemia and Lymphoma Society, leukemia is a malignant disease (cancer) that originates in a cell in the marrow. It is characterized by the uncontrolled growth of developing marrow cells. These are two major classifications of leukemia: myelogenous or lymphocytic, which can each be acute or chronic. The terms myelogenous or lymphocytic denote the cell type involved. Thus, four major types of leukemia are: acute or chronic myelogenous leukemia and acute or chronic lymphocytic leukemia. Leukemia, lymphoma and myeloma are considered to be related cancers because they involve the uncontrolled growth of cells with similar function and origins. The diseases result from an acquired (not inherited) genetic injury to the DNA of a single cell, which becomes abnormal (malignant) and multiplies continuously. In the United States, about 2,000 children and 27,000 adults are diagnosed each year with leukemia. Treatment for cancer may include one or more of the following: chemotherapy, radiation therapy, biological therapy, surgery and bone marrow transplantation. The most effective treatment for leukemia is chemotherapy, which may involve one or a combination of anticancer drugs that destroy cancer cells. Specific types of leukemia are sometimes treated with radiation therapy or biological therapy. Common side effects of most chemotherapy drugs include hair loss, nausea and vomiting, decreased blood counts and infections. Each type of leukemia is sensitive to different combinations of chemotherapy. Medications and length of treatment vary from person to person. Treatment time is usually from one to two years. During this time, your care is managed on an outpatient basis at M. D. Anderson Cancer Center or through your local doctor. Once your protocol is determined, you will receive more specific information about the drug(s) that will be used to treat your leukemia. There are many factors that will determine the course of treatment, including age, general health, the specific type of leukemia, and also whether there has been previous treatment, there is considerable interest among basic and clinical researchers in novel drugs with activity against leukemia, the vast history of experience of traditional oriental medicine with medicinal plants may facilitate the identification of novel anti leukemic compounds. In the present investigation, we studied 31 kinds of anti leukemic medicinal plants, which its pharmacological action was already reported through many experimental articles and oriental medical book: 「pharmacological action and application of anticancer traditional chinese medicine」 In summary : Used leukemia cellline are HL60, HL-60, Jurkat, Molt-4 of human, and P388, L-1210, L615, L-210, EL-4 of mouse. 31 kinds of anti leukemic medicinal plants are Panax ginseng C.A Mey; Polygonum cuspidatum Sieb, et Zucc; Daphne genkwa Sieb, et Zucc; Aloe ferox Mill; Phorboc diester; Tripterygium wilfordii Hook .f.; Lycoris radiata(L Her)Herb; Atractylodes macrocephala Koidz; Lilium brownii F.E. Brown Var; Paeonia suffruticosa Andr; Angelica sinensis (Oliv.) Diels; Asparagus cochinensis (Lour.)Merr; Isatia tinctoria L; Leonurus heterophyllus Sweet; Phytolacca Roxb; Trichosanthes kirilowii Maxim; Dioscorea opposita Thumb; Schisandra chinensis (Rurcz.)Baill; Auium Sativum L; Isatis tinctoria, L; Ligustisum Chvanxiong Hort;Glycyrrhiza uralensis Fisch; Euphorbia Kansui Liou; Polygala tenuifolia Wild; Evodia rutaecarpa (Juss.) Benth; Chelidonium majus L; Rumax madaeo Mak; Sophora Subprostmousea Chunet T.ehen; Strychnos mux-vomical; Acanthopanax senticosus (Rupr.et Maxim.)Harms; Rubia cordifolia L. Anti leukemic compounds, which were isolated from medicinal plants are ginsenoside Ro, ginsenoside Rh2, Emodin, Yuanhuacine, Aleemodin, phorbocdiester, Triptolide, Homolycorine, Atractylol, Colchicnamile, Paeonol, Aspargus polysaccharide A.B.C.D, Indirubin Leonunrine, Acinosohic acid, Trichosanthin, Ge 132, Schizandrin, allicin, Indirubin, cmdiumlactone chuanxiongol, 18A glycyrrhetic acid, Kansuiphorin A 13 oxyingenol Kansuiphorin B. These investigation suggest that it may be very useful for developing more effective anti leukemic new dregs from medicinal plants.

Sub-Block과 밝기 분포의 가중치를 이용한 센서스 변환 기반 스테레오 매칭

이종철,임창경,홍현기 사단법인 인문사회과학기술융합학회 2016 예술인문사회융합멀티미디어논문지 Vol.6 No.1

Census transform, one of representative stereo matching algorithms, has a merit that is robust to the radial distortion and brightness changes between stereo views. In general, census transform compares an intensity value of central pixel in a matching window with relative intensity distribution of neighbors. So this method is sensitive to image noise. More specifically, performance of the census transform is deteriorated as an intensity value of the central pixel is degraded by noise. This paper presents a novel census transform that performs 5 levels decision instead of binary decision in neighbors intensity comparison. Conventional census transform is based on central pixel only, but the proposed method divides a matching window into several sub-windows and employs their average values in intensity comparison process. When the intensity values of neighbors in the matching window are similar to the average values, the census transform is difficult to obtain precise stereo matching result. The proposed method examines a variance of intensity distribution in sub-window and computes relative weight values. Experimental results showed that the proposed method can achieve better performance than previous census transform. 스테레오 매칭 알고리즘으로 널리 사용되는 센서스 변환(census transform)은 이미지의 방사 왜곡과 밝기 변화에 강한 장점이 있다. 그러나 중심 화소의 밝기 값을 기준으로 전체 마스크 영역에서의 높고 낮음을 비교하기 때문에 잡음에 민감한 단점이 있다. 즉, 중심 화소의 밝기 값이 잡음 등의 영향을 받는 경우 주변 화소의 밝기 값들과의 센서스 변환 결과를 신뢰하기 어렵다. 이를 해결하기 위해 본 논문에서는 주변 영역 내 화소 밝기 분포에 따라 5 단계로 결정하는 강건한 센서스 변환 방법이 제안된다. 중심 화소의 밝기 값만을 기준으로 하는 기존 센서스 변환과는 다르게, 정합 창을 여러 개의 보조 창으로 나누고 각 보조 창의 평균값을 이용하는 새로운 센서스 변환 방법이 제안된다. 평균값에 유사한 밝기 값을 가지는 화소들은 그렇지 않은 경우에 비해 센서스 변환 과정에서 오 정합이 발생할 확률이 높다. 따라서 주변 화소의 밝기 값의 차이를 계산하고, 차이가 클수록 센서스 변환된 값들에 대해서는 가중치를 상대적으로 크게 부여한다. 실험 결과로부터 제안된 방법의 개선된 스테레오 매칭 성능을 확인하였다.

GIS를 활용한 광선로 운용관리 시스템 개발 ( Development of GIS-based Fiber-optic Network Management System )

이승민,김종서,임창경,김영환 대한전자공학회 1998 대한전자공학회 학술대회 Vol.1998 No.01

호두仁 에탄올 抽出物의 四鹽化炭素 유도 肝纖維化 억제 효과

장선일(Seon Il Jang),임창경(Chang Kyung Lim),유진덕(Jin Duk Ryu),김희수(Hui Soo Kim),윤용갑(Yong Gab Yun) 한의병리학회 2003 동의생리병리학회지 Vol.17 No.5

특성화고등학교 여학생의 정서적 요인과 신체화 증상의 관계에서 인지적 요인의 매개효과

이미정(Lee mi Jung),임창경(Lim Chang Kyung),유정이(Ryu Jeong Yii) 학습자중심교과교육학회 2014 학습자중심교과교육연구 Vol.14 No.12

본 연구에서는 여자고등학생의 정서적 요인(우울, 불안, 감정표현 불능증, 스트레스)이 신체화 증상에 미치는 영향에서 인지적 요인(신체감각 증폭지각, 신체적 귀인)의 매개효과를 검증하고자 하였다. 자료는 경기도 소재 특성화고등학교 4개교에 재학 중인 2학년 여학생을 대상으로 설문하여 수집했다. 총 1,178부의 설문지를 수거하여 분석하였다. 연구대상의 일반적인 특성을 알아보기 위해 빈도와 백분율을 산출하였고, 각 변인이 신체화 증상에 미치는 영향을 알아보기 위하여 단순회귀분석을 실시하였으며, 정서적 요인(우울, 불안, 감정표현 불능증, 스트레스)이 신체화 증상에 미치는 영향에서 인지적 요인(신체감각증폭지각, 신체적 귀인)의 매개효과를 알아보기 위하여 Baron과 Kenny(1986)가 제안한 매개효과 검증 절차를 사용하였다. 연구결과, 특성화고 여고생의 우울이 신체화 증상에 미치는 영향력은 유의한 것으로 나타났으나, 신체감각 증폭지각과 신체적 귀인 모두 매개효과가 유의하지 않았다. 둘째, 불안이 신체화 증상에 미치는 영향력이 유의하며, 신체감각 증폭지각과 신 체적 귀인 모두 부분 매개효과를 가지는 것으로 나타났다. 셋째, 감정표현 불능증이 신체화 증상에 미치는 영향력이 유의하며, 신체감각 증폭지각과 신체적 귀인 모두부분 매개효과를 가지는 것으로 나타났다. 넷째, 스트레스가 신체화 증상에 미치는 영향력이 유의하며, 신체적 귀인 모두 부분 매개효과를 가지는 것으로 나타났다. The purpose of this study was to investigate the mediating effects of cognitive factors(somato-sensory amplification, somatic attribution) on the relationships between specialized vocational high school student s affective factors(depression, anxiety, alexithymia and stress) and somatization symptom. The subjects of this study were 1,178 students in the 2nd grade in high schools located in Kyunggi-Do. They were assessed by K-CSI(Korean Children s somatization Inventory), CDI( Children s Depression Inventory), BAI(Beck Anxiety Inventory), TAS-20(Toronto 20 item Alexithymia Scale), Stress Inventory, KSAS(Korean Versions of Somatosensory Amplification Scale) and SIQ(Symptom Interpretation Questionnaire). The data were analyzed using frequency analysis and regression analysis by SPSS 18.0 statistics program. In addition, Baron and Kenny s(1986) model was used to verify mediational effects. The results were as follows: First, student s affective factors had a significant on total score of somatization sympom. Second, cognitive facts, which were somato-sensory amplification, somatic attribution, had significant effects on somatization symptom. Third, somato-sensory amplification partially mediated the relationships between student s affective factor(anxiety, Alexithymia, stress) and somatization symptom. Fourth, somatic attribution parlially mediated the associiations between student s affective factor(anxiety, Alexithymia, stress) and somatIzatIon symptom. The results from the findings suggested that it was encouraged to consider cognitive facts in order to understand the relationship between student s affective factor and somatization symptom more comprehensively. Particularly, this study confirmed that somato-sensory amplification and somatic attribution were proved to have the mediating effects between student s affective factor(anxiety, Alexithymia, stress) and somatization symptom.