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β-Fluoro-α-phenylpyrrole 유도체의 합성에 관한 연구
郭炅喆,吳賢哲,鄭悳商,李英行,白承和,金鍾洙,蔡奎允 濟州大學校 基礎科學硏究所 2001 基礎科學硏究 Vol.14 No.2
플루오르가 선택적으로 치환된 유기화합물은 모체 화합물 보다 향상된 생리활성을 지니는 경우가 많이 보고 된바 있다. 이는 할로젠족 원소인 플루오르의 큰 전기음성도 때문에 비교적 강한 탄소플루오르 결합 형성 및 증가된 리피드 용해도 때문이다. Pyrrole과 그의 유도체들은 폴리머, 의약품 그리고 염료 등에 광범위하게 사용되어 왔고 오래 전부터 잘 알려진 화합물이다. 최근 자연계에서 산출되거나 합성 가능한 플루오르가 선택적으로 치환된 fluoropyrrole 유도체들은 진통제, 소염제 및 살균제 등으로 다양하게 이용될 수 있음이 알려져 있기 때문에 fluoropyrrole 유도체의 합성에 대한 연구가 활발히 진행되고 있다. 일반적으로 플루오르는 반응성이 매우 커서 유기화합물에 대한 선택적인 플루오르기의 도입이 극히 제한적이다.
Carboxyethylgermanium sesquioxide(Ge-132)가 항암제의 세포독성에 미치는 영향
표명윤,민순홍,곽영희 숙명여자대학교 약학연구소 1998 약학논문집-숙명여자대학교 Vol.14 No.-
The cytotoxicity of carboxyethylgermanium sesquioxide(Ge-132) and anticancer drugs (cisplatin, mitomycin C, 5-fluorouracil) against tumor cell lines(L1210, SK-HepG-1) and mouse splenocytes was examined by MTT assay. Ge-132(8.5 x 10²㎕/ml, 1.7 X 10³㎕/ml, 3.4 x 10³㎕/ml) showed dose-dependent cytotoxicity against the tumor cell lines, on the contrary, increased cell proliferation against the normal mouse splenocytes. Combination of Ge- 132 with cisplatin(1.5㎕/ml, 15㎕/ml), mitomycin C(0.5㎕/ml, 1.0㎕/ml) or 5-fluorouracil (0.31㎕/ml, 1.25㎕/ml) showed additional cytotoxicity against L1210 and SK-HepG-1 cell lines, however, reduced clearly the anticancer drugs-induced cytotoxicity against the normal mouse splenocytes.
鐵道騷音에 의한 影響과 實態에 關한 硏究 : 湖南線을 中心으로
이병윤,윤해동,곽광수,장영휴,김재수 順天靑巖大學 1998 論文集-順天靑巖大學 Vol.22 No.2
Rail noise and vibration is one of the major problem for the residents living nearby railway tracks. The rail noise may inflict a considerable damage to physiological, spiritual, mental and discomfort to neighboring peoples. Therefore, residents living nearby railway were appeal many troubles. Nevertheless, in our country, adequate guidelines for the rail noise are not yet established because of the lack of basic data and insufficient research works. In this point, this study attempts to surveys the influence of rail noise in urban area using questionnaire. This study also present a basic data in establishing effective plans for rail noise in the future.
만성 활동성 간염에 있어서 Ursodeoxycholic acid의 치료효과
김성록,안병철,윤영미,탁원영,곽규식,최용환,정준모 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.4
The purpose of this study is to evaluate the clinical and biochemical effects of SGD-F^(R)(UDCA, Vitamin B_1, Vitamin B_2 complex) in chronic active hepatitis. Observed cases were given orally after each meal(three times a day) for 4 weeks. The results were as follows: 1. Among subjective symptoms, improvement rate showed in easy fatigability 86.7%, anorexia 68.0%, indigestion 80.0%, nausea and vomiting 72.7%, RUQ pain 83.3%. 2. Biochemical parameters such as SGOT, SGPT, showed to be improved significantly after the 4 weeks treatment.(p<0.01) 3. There was no specific side effect during the study period in all cases. In conclusion, SGD-F^(R) capsule may be safe and effective for chronic active hepatitis.
2003년도 해양스포츠 체험활동을 통한 소아건강교실 사례 발표
김현준,이상엽,이가영,곽현,이남수,김혜선,김윤진,김인주,김용기,대한비만학회 부산분과학회 일동 대한비만학회 2003 The Korean journal of obesity Vol.13 No.4
부산에 소재한 3개 초등학교 청소년단체 소속의 초등하교 3학년부터 6학년까지 구성된 172명을 대상으로 청소년단체 지도자, 초등학교교사, 자원봉사자, 의사와 영양사가 1박 2일간의 해양스포츠 체험활동 을 통한 건강교실을 시행하였다. 대상자의 체질량지수, 체지방량을 측정하여 비만정도를 평가하였으며, 칼로리 섭취에 대한 강의를 시행하였고, 설문지 조사를 통해 대상자의 식이 섭취 습관에 대한 조사를 시행하였고, 본 건강교실에 대한 만족도를 측정하였다. 대상자중 남자에서는 40%, 여자에서는 25.69%에서 비만 경향을 보였다. 대상자의 대부분에서 시행된 건강교실에 긍정적 반응을 보였으며, 향후 체계적인 구성과 철저한 사전계획이 병행되어 본 증례 보고와 같은 건강교실을 시행한다면, 비만아동에서 거부감 없이 비만에 대한 교육을 실시할 수 있으며, 정상 체중 아동군에서도 비만에 대한 예방교육을 시행할 수 있는 프로그램이 될 것이다. 172 elementary school students involved this health program. This subjects were learened about obesity that affect health problem, ideal eating habits, calories that contained in the children's favorite foods by doctors and nutritionist. And this stubjects were checked heights, weight, body fat percent. Obesity is 40% in the boys and 25.69% in the girls. Most subjects were satisfactory with this health program. So we will effectively educate obese children without resistance and prevent normal weight children from obesity through structured and well-designed health program that similar to this program.
응급실 내원 환자의 만족도 평가 및 관련 요인에 대한 연구
서강석,감신,박정배,이정헌,김종근,윤영국,곽경숙,이원기,우석정 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4
Background: To examine the influencing factors on patients' satisfaction in the emergency department(ED) for quality assurance. Methods: Patients who visited to the ED were prospectively investigated from November 1 to December 31, 1997. Authors developed questionnaire to investigate influencing factors on patients' satisfaction. A Chi-square test and LISREL 7.0 were applied for statistical analysis. Results: Patients' satisfaction was significantly related to physical environment variables, accessibility variables, kindness of hospital personnel variables, and patient's trust for doctors variables. In path analysis, willingness for revisit was influenced by patients' satisfation, accessibility, physical environment, patients' trust for doctors in order, and willingness for recommendation was influenced by accessibility, patients' satisfaction, and kindness of hospital personnel in order. Conclusions: The influencing factors on patients' satisfaction are physical environment, accessibility, kindness of hospital personnel, and patient's trust for doctors. Willingness for revisit and willingness for recommendation are influenced by patients' satisfation. In spite of some limitations, the results of this study can be used as a baseline information for exploring the influencing factors on patients' satisfaction. Further comprehensive research efforts should be made on the study of patients' satisfactoin in the ED.
Chemotherapy Use and Associated Factors among Cancer Patients near the End of Life
Yun, Young Ho,Kwak, Miyoung,Park, Sang Min,Kim, Samyong,Choi, Jong Soo,Lim, Ho-Yeong,Lee, Chang Geol,Choi, Youn Seon,Hong, Young Seon,Kim, Si-Young,Heo, Dae Seog S. Karger AG 2008 Oncology Vol.72 No.3
<P><I>Objectives:</I> We investigated the frequency of chemotherapy use and its associated factors in patients in all age groups in the last year of life. <I>Methods:</I> We identified cancer patients who died in 2004 in any of 17 hospitals. We used demographic and treatment characteristics by computerized hospital information systems and by linking the identification numbers to the 2004 death registry. <I>Results:</I> 48.7% of patients in the last 6 months of life, 43.9% in the last 3 months, and 30.9% in the last month of life received chemotherapy. The frequency of chemotherapy use was lower for older patients. In those ≥65 years old, there was no difference between women and men in the proportion that received chemotherapy. For patients <65 years of age, a larger proportion of women than men received chemotherapy, and chemotherapy use was significantly less frequent for patients with refractory disease than for those with responsive disease. Patients dying at a relatively small hospital without a hospice inpatient unit were significantly more likely to receive chemotherapy. <I>Conclusions:</I> Despite the fact that most cancer patients are resistant to chemotherapy at the end of life, it was administered often to all age groups.</P><P>Copyright © 2007 S. Karger AG, Basel</P>