인슐린비의존형 당뇨병 환자에서 Lipoprotein(a)농도와 혈관합병증

김지연,이태희,박재홍,정민영,양승원,정동진,김명수,김정민,이정훈 대한당뇨병학회 1998 Diabetes and Metabolism Journal Vol.22 No.1

연구배경: 당뇨병 환자에서 동맥경화증의 발생위험이 정상잉인에 비해 높은 원인의 하나로써 혈액응고와 섬유소용해작용의 이상을 초래하는 Lipoprotein(a) [Lp(a)]가 논의되고 있다. 당뇨병 환자의 동맥경화증과 당뇨병성 합병증 발생위험 증가에 Lp(a)가 어느 정도 관여하는지에 대해서도 아직 확실히 알려져 있지 않다. 저자등은 인슐린비의존형 당뇨병 환자의 혈관합병증(대혈관 및 미세혈관합병증) 발생과 Lp(a)농도와의 관계 및 혈관합병증을 일으키는 다른 위험인자와 Lp(a)농도와의 관련성에 대하여 알아보고자 본 연구를 시행하였다. 방법: 인슐린비의존형 당뇨병 환자 152명(여자:남자=72:80)을 대상으로 공복상태에서 혈중 Lp(a), ApoA1, ApoB, 총 콜레스테롤, 중성지방, 고밀도지단백질-콜레스테롤 등을 측정하였다. 대혈관합병증(허혈성 심질환, 뇌혈관질환, 말초혈관폐쇄성 동맥경화증)의 진단을 위해 증상이 있는 환자들에서 심전도, 관상동맥조영술, 뇌전산호단층촬영, Doppler velocimetry, 말초혈관조영술 등을 시행하였고, 미세혈관합병증은 안저활영, 신경전달속도, BBV(beat to beat variation), VPT(vibration perception threshold), 24시간 요단백량 등을 측정하여 확인하였다. 결과: 허혈성 심질환, 뇌혈관질환등 대혈관질환 및 당뇨병성 망막증 등 미세혈관질환을 갖는 환자에서 Lp(a)농도가 대조군보다 통계적으로 유의하게 증가되어 있었다. Lp(a)농도가 30㎎/dL이상인 군에서 ApoB/ApoA1 및 저밀도지단백질-콜레스테롤이 Lp(a)농도가 30㎎/dL 이하인 군보다 높았으며, 혈관질환을 갖는 군에서 Lp(a)는 높은 ApoB/ApoA1와 저밀도지단백질-콜레스테롤과 통계적으로 의의있는 양의 상관관계를 보였다. 결론: Lp(a)는 인슐린비의존형 당뇨병 환자의 대혈관합병증과 미세혈관합병증(특히 당뇨병성 망막증)에 관련이 있는 것으로 보이며, 특히 저밀도지단백질-콜레스테롤 및 ApoB/ApoA1이 높게 나타난 인슐린비의존형 당뇨병 환자에서 Lp(a)농도 측정이 필요하리라 생각된다.

강원도 원주지역 초·중·고등학생의 식습관 및 섭식행동에 관한 단면연구

허혜경,박소미,김기연,김춘배,안정숙,송희영,김기경 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

Purpose : The purpose of this study was to investigate the dietary habits of students in order to identify risk groups according to their Body Mass Index (BMI), and to compare the eating behavior of students in the normal range (19<I≤24) and those in risk groups (BMI≤19, 24<I≤27, BMI>). Method : 1176 elementary school students, 850 middle school students and 672 high school City, were the participants The instrument for this study was a structured questionnaire that included demographic data as well as dietary habits, and the eating behavior instrument developed by Stunkard &essick(1985) and revised by Kim &im (1997). Result : 1) As students moved up in grade level their dietary habits became more irregular and the degree that students chewed food was reduced 2) As students moved up in grade level, a greater number of the students did not eat breakfast. The reasons given were that there were not enough time before classes started(40.4%) and a lack of appetite in the morning(10.6%) in high school students. 3) As for supper, from 67.8 to 81.9% of subjects reported having regular supper. However the rest of the subjects did not eat supper because of anorexia and fear of weight gain. 4) The results identified risk groups according to their BMI showed that for elementary school students, 55.9% were in the low weight group, 5.5% in the overweight group, and 0.9% in the obese group. For middle and high school students, 40.6% and 35.5% respectively were in the low weight group, 7.4% and 6.3% in the overweight group, and 4.1% and 2.5% the obese group. 5) Comparisons of the eating behavior of students in the normal weight group with that of those in the three risk groups showed that there were significant differences in 'hunger' and 'cognitive restraint of eating' in elementary school students, and significant differences in 'cognitive restraint of eating' in middle and high school students. Conclusion : The results of this study show that management of diet in school health sholud be addressed from both the aspect of lack of nutrition and that of excess nutrition. In other words, good diet is as important for students in the low weight group as it is f3r those in the overweight and obese groups. The estatblishment of good dietary habits and eating behavior in students, by nurses and dieticians should be done by providing repeated diet education and involvement in diet counseling.

食用油脂類에 對한 免疫生物學的 硏究

朴炳哲,文宰奎,朴榮吉,金杏順,安年衡,金度勳,金正勳,安榮根,李相根,鮮于演 圓光大學校 1990 論文集 Vol.24 No.2

食用油脂는 健康維持에 必須的인 營養素이다. 그러나 食用油脂는 脂肪을 構成하는 脂肪酸의 種類와 攝取하는 量에 따라 健康을 保衛하는 必須的인 食品의 成分이 되기도 하고 有害한 影響을 끼칠 수도 있어서 脂質代謝와 關連된 疾病 뿐만아니라 老化를 促進하고, 乳房癌, 大腸癌等의 癌發生과도 關連된 것으로 밝혀져 있다. 本 硏究는 우리生活環境에서 食用으로 接할 수 있는 10種의 油脂에 對한 免疫生物學的인 活性에서 究明한 結果 對照群인 참기름食餌群에 比해 올리브유食用群은 全般的으로 體液性 및 細胞性免疫을 有意性있게 增加시켰으나, 大食細胞의 活性과 末梢循環白血球數는 有意性없는 減少를 보였고, 動物性 油脂인 牛脂食餌群과 植物性 油脂인 옥수수기름食餌群, 들기름食餌群, 米糠油食餌群, 大豆油食餌群, 菜種油食餌群 및 고추씨기름食餌群에서는 全般的으로 體液性 및 細胞性免疫, 大食細胞의 活性 및 末梢循環白血球數를 有意性있게 減少시켰다. This study was performed to investigate the effects of edible oils and fats on the immunobiological responses in ICR male mice. Ten groups of experimental diets, such as sesame oil diet, beef tallow diet, lard oil diet, olive oil diet, corn oil diet, perilla oil diet, rice polishing oil diet, soybeen oil diet, rape seed oil diet, and red pepper seed oil diet were fed adlibitum to the ICR male mice for 27 days. The results of this study were summarized as followings. 1. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes in sesame oil group were increased. However, the increasing rate of body weight and the weight retios of spleen and thymus to body were generally decreased. 2. Hemagglutination titer(HA) and rosette forming cell(RFC) of the beef tallow group and the lard group were significantly lower than the sesame oil group(P<0.01), but the lard group significantly increased Arthus reaction and delayed type hypersensitivity(DTH)(P<0.01). 3. Arthus reaction, DTH, and RFC of the olive oil group were significantly higher than the sesame oil group(P<0.01). 4. DTH of the corn oil group was significantly higher than the sesame oil group(P<0.01) whereas phagochyte activity was significantly lower(P<0.01). But no statistically significant differences were found between the two groups in the humoral immune response. 5. HA, PFC, DTH, RFC, phagocyte activity, and number of leukocytes of the perilla oil group and the rice polishing oil group were significantly lower than the sesame oil group(P<0.01). 6. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes of the soybeen oil group, the rape seed oil group, and the red pepper oil group were significantly lower than the sesame oil group(P<0.01).

녹차가루와 녹차물 추출액의 첨가수준에 따른 제주보리빵의 기호성 및 품질특성

김우실,이미정,박영선 제주한라대학 2000 論文集 Vol.24 No.-

At the production of 「Jejuborybbang」, the separate characteristic is duly reviewed by each addition of green tea powder in the ratio of 0%, 2.5%, 5%, 10% and water extract of green tea in of 50%, 70%, 100% as well. A unique difference in color and property has been come out in addition of green tea powder by chemical analysis and sensory evaluation, but not so much noticeable with the comparison of control in addition of water extract green tea. The conclusion is that it is most preferable to use control at making of 「Jejuborybbang」, but also preferable to add the ratio of 50%, 70%, 100% of water extract of green tea and 2.5% of green tea powder each into the making of 「Jejuborybbang」.

신경망을 이용한 협력적 추천 시스템의 성능 향상

김종수,도영아,류정우,김명원 한국뇌학회 2001 한국뇌학회지 Vol.1 No.2

개인화 기술은 과다한 정보를 줄이기 위한 여과 기술로서 최근 인터넷 사용자들과 정보 제공자들로부터 관심의 대상이 되고 있다. 그 중 가장 많이 사용되고 있는 개인화 기술은 협력적 추천으로서, 이 방법은 사용자에게 어떤 항목(상품)을 추천해주는 데 있어서 그 사용자의 다른 항목들에 대한 선호도나 추천 항목에 대한 다른 사용자들의 선호도를 이용하여 추천해준다. 협력적 추천 방법 중 보편적으로 많이 사용되는 최근접 이웃 방법은 유사한 사용자들의 행위에 기반하여 항목들을 추천해 준다. 그러나 이 방법은 사용자들간의 단순한 유사도를 계산함으로써 성능이 떨어지는 문제점이 있다. 데이터마이닝 기법을 적용하여 사용자 선호도 데이터로부터 추천 규칙을 생성하여 추천을 해주는 연관규칙 방법 또한 사용자나 항목간의 내용적, 분류적인 공통성 또는 개념에 의한 연관성을 고려하지 못하고, 단지 단순하고 표면적인 연관성만을 고려하는 문제점을 가지고 있다. 본 논문에서는 추천의 정확도를 향상시키기 위한 신경망 추천 모델을 제안한다. 신경망으로는 다층 퍼셉트론을 사용하여 우선 학습변수들과 입력차원의 변화에 따른 신경망에 기반한 협력적 추천의 성능에 대해 조사하고, 순수한 협력적 추천에서의 문제점인 희소성(sparsity)문제를 해결하기 위해 내용기반 추천과 협력적 추천을 병합한 모델을 신경망에서 보인다. 마지막으로 다른 협력적 추천 방법과의 비교를 통하여 본 신경망 추천 방법의 장점과 성능의 우수함을 보인다. Personalization is a filtering technique to reduce information overload and it recently draws attention upon internet users and information providers. The collaborative recommendation is one of the widely used personalization methods. It recommends a user an article based on other users preferences for the target article or the preferences for other articles of the target user. The nearest neighbor method is one of the common collaborative recommendation methods, which recommends articles based on the behavior of the similar users. However, it suffers from poor performance mainly because it fails in properly computing similarity between users. The rule method extracts recommendation rules from the users preference data using data mining technique. It also suffers from simple and superficial association between users or articles without utilizing conceptual level of association such as commonality in contents and category. In this paper we propose neural networks model to improve the accuracy of recommendations. We investigate various aspects of collaborative recommendation based on multi-layer perceptrons by varying parameters and the dimension of input data. We also combine the collaborative recommendation and the content-based recommendation within a neural network model to solve sparsity problem in pure collaborative recommendation. We finally demonstrate through experiments that the neural network based collaborative recommendation outperforms the existing methods.

폐결핵치료 중인 환자에서 Rifampicin에 의해 유발된 위막성 대장염 2예

김봉진,권균홍,임창섭,김자영,홍정범,옥미선,배용목,김지연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Pseudomembranous colitis (PMC) is a disease caused by Clostridium difficile proliferation. The causative drugs are clindamycin, third-generation cephalosporins, flouroquinolone and so on. Rifampicin has been reported as a cause of PMC in the 1980s, and the frequency of PMC is increasing because rifampicin is a first line drug for anti-tuberculosis therapy. Two patients were recently admitted to our hospital due to watery diarrhea for 1 month and they were diagnosed with PMC by sigmoidoscopy. Their onset age were 74, 72 years old and latent period of symptoms were 60, 129 days, respectively. In one case, the patient displayed coexisting hypertension and diabetes. The clinical symptoms improved after discontinuing the rifampicin and then administering oral metronidazole. We report here on two cases presumed to be rifampicin-induced PMC.

시멘틱 웹 환경에서의 온톨로지 기반의 정보검색

정은경,김영민,변영철,이상준,박경린 濟州大學校 基礎科學硏究所 2003 基礎科學硏究 Vol.16 No.2

온톨로지는 시멘틱 웹을 구현하기 위한 이론이다. 온톨로지는 웹자원의 효과적인 검색, 통합, 재사용을 위한 새로운 기술이고 사람과 이질의 응용 시스템 간에 지식을 공유하고 재사용하기 위한 방법을 제공한다. 온톨로지의 역할은 특별한 개념을 명세화하는 것이다. 도메인과 일반적인 온톨로지는 정보와 지식 시스템을 분석하고 디자인하는 측면에서 공유, 통합, 재사용될 수 있다. 본 연구는 제주도의 숙박과 관광정보를 위한 온톨로지를 디자인하는데 목적이 있다. 그리고 제안된 온톨로지 기반으로 인터넷 웹 검색 시스템을 만드는데 목적이 있다. 본 연구에 의해 클라이언트가 사용하는 표현은 다르지만 뜻이 같은 동의어에 의해 같은 결과를 얻을 수 있다는 것을 알게 되었다. Ontologies are formal theories that are suitable for implementing the semantic web. Which is a new technology that attempts to achieve effective retrieval, integration, and reuse of web resources. Ontologies provide a way of sharing and reusing the knowledge among the people and the heterogeneous application systems. The role of ontologies is that of making explicit specified conceptualizations. In this context, domain and generic ontologies can be shared, reused, and integrated in the analysis and design stage of information and knowledge systems. This study aims to design an ontology for juju lodges and tour, and build an Internet web retrieval system based on the proposed ontologies. This study found that we can take the same result for synonym that cilent use.

거푸집 일체형 외단열 갱폼시스템의 전단내력실험

김호수,정희범,김소연,박영석,원종덕 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.34 No.1

The shear capacity is evaluated for the structural safety security of integrated gang form system for outer insulation. Therefore, this study presents the composition types of outer insulation system and evaluates the shear capacity for the several design cases. Through the results, we find out the influencing factors that affect the shear capacity.

비임균성의 요도염에서 Azithromycin과 Doxycycline의 치료효과 비교

김정수,김재홍,노영석 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.2

Currently, there is no single-dose therapy that is effective in the treatment of nongonococcal urethritis. Azithromycin is a new azalide antibiotic and has activity in vitro against Chlamydia trachomatis, and its novel pharmacokinetics suggest that single dose may be effective in the treatment of non-gonococcal urethritis. The aim of this study is to find out the efficacy and safty of Azithromycin in the treatment of males with uncomplicated non-gonoccocal urethritis. 32 patients were given a single 100mg oral dose of Azithromycin and 30 patients were treated with doxycyclin 100mg bid for 7 days. Follow-ups after one and two weeks to examine for cure and adverse events were made. The result showed that 27 out of 32 patients treated with Azithromycin were cleared of urethritis and 24 out of 30 patients treated with doxycycline were cleared of urethritis. Single dose azithromycin shows a similar effectiveness as a 7-day regimen of doxycycline and the patient's compliance has also improved.

154kV용 활선 안전 경보기 개발에 관한 연구

정민규,조현광,우종수,안창회,서영석,김응태,박창기,오세득 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

In this report we developed a high voltage alarm for the safety of workers who check and repair the 154kV power line. This high voltage alarm we developed is attached on workers' helmet and alarms automatically in order to let workers know when workers work over the safety distance near 154kV power line. Until now the exact safety distance hasn't been regulated and high voltage alarm we've been using was for the range of 6∼22.9kV power line. We fabricated this high voltage alarm on the basis of electric density and actual measurement of power line. The experimental result was that high voltage alarm at 66kV power line alarmed near 90cm, at 154kV power line alarmed near 160cm from the line. Accordingly, we developed the new high voltage alarm which is operated in the range of 66∼154kV power line.