경주지역 여고생의 초경과 체성장간의 관계

김준섭,권오구,박진석,오종수,박정현,박제식,안세한,이용환,서정호,신태섭,최영배,김덕수,이관,박수경 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

본 연구는 경주지역 1개 고등학교 3학년 여고생을 대상으로 초경 시작 전인 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레 수치와 초경 연령을 파악하여 여성의 초경이 빠를수록 체성장 속도의 변화가 있을 것이라는 가설을 기초로 두 요인간의 관련성을 파악하고자 시행되었다. 경주시 1개 여자고등학교 3학년생 총 317명에 대해 ㅊ경 나이, 초경시 심리 상태, 초경이 시작되었을 때의 상담 여부와 상담하였던 사람, 부모 신장과 초경전후의 식사 규칙성, 다이어트 경험, 수면시간, 스트레스, 음주/흡연 여부, 질병력 등에 대한 설문 조사를 시행하였고, 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레에 대한 정보는 건강기록부에서 확보하였다. 상기 대상자 중 건강기록부가 분실된 39명, 초경나이에 대해 응답하지 않았던 29명 및 결석 등으로 조사를 하지 못하였던 42명을 제외한 조사 대상자는 206명으로 선정하였다. 대상자들의 초경연령 평균값(Mean±SD)은 13.0±1.11이었고, 초등학교 4학년부터 고등학교 2학년까지의 초경 이후 신장 성장률은 감소하였으며, 초경연령이 빠른 군이 초등학교 때는 신장에 있어서 우위를 차지하나 고등학교에 오면서 신장은 비슷한 수준이 되었다. 초경후 1-2년 사이에 체중과 흉위의 증가율은 감소하였고, 초경연령이 빠른 군이 초등학교와 고등학교 사이에 체중과 흉위에서 모두 우위를 차지하였다. 본 연구의 결과는, 흔히 이차 성징의 시작 시점 혹은 사춘기의 시작 시점으로 보고있는 초경 연령이 청소년기의 성장과 밀접한 관련성이 있고, 특히 체중과 흉위의 성장 속도와 밀접한 관련성이 있음을 시사한다. To understand the onset of menarche in relation to changes in physical growth that take place during female adolescence, especially the changes in height and weight velocity. The 207 senior in one women high school of Kyongju were investigated in April 3 to 8, 2001. We collected the information, relation in the age at menarche, height & weight of parents, regularity of eating, and obesity diet, duration of sleeping, sickness & stress near age at menarche, by self-recording. The status of height, weight & chest circumference between the 4th grade of primary school and the junior of high school was collected by individual Health Record. The results were followed; The average age at menarche was 12.95±1.11 years old and the most frequent age of menarche is 13 years. After menarche, the velocity of height, weight and chest circumference were decreased. The most rapid group of menarche hold dominant position in height during elementary school. As time passed, they dont hold dominant position in height. The most rapid group of menarche get an advantage in the weight and the girth of chest after elementary school. The height of subjects is directly proportional to the height of their parents. These results suggest that the starting age at menestuation can be closely associated with physical growth and development.

태안해안국립공원 학암포 지역의 조류 현황

강화연(Hwa-Yeon Kang),서슬기(Seul-Gi Seo),박세영(Se-Yeong Park),이지용(Ji-Yong Lee),권영수(Young-Soo Kwon) 국립공원연구원 2015 국립공원연구지 Vol.6 No.4

서해안 육상지역을 통과하는 조류의 이동생태를 파악하기 위해, 2014년 7월부터 2015년 6월까지 태안해안국립공원 학암포 지역의 조류상을 조사하였다. 조사 결과 관찰된 조류는 총 14목 30과 88종 23,230개체이며, 평균 조사일당 159.7개체가 관찰되었다. 전체 우점종은 괭이갈매기 Larus crassirostris 21.1%, 되새 Fringilla montifringilla 18.5%, 박새 Parus major 12.7%, 붉은머리오목눈이 Paradoxornis webbianus 8.2%, 노랑턱멧새 Emberiza elegans 5.8% 순이었다. 이동시기인 5월과 10월에는 각각 56종, 조사일당 평균 310.5개체로 가장 많은 종과 개체수가 기록되었다. 종과 개체수가 가장 적은 시기는 여름철인 8월로, 기록된 종 수는 24종이며 조사일당 평균 95개체가 관찰되었다. 종풍부도(R ) 지수는 가장 많은 종이 관찰된 5월에 가장 높았으나, 종다양도(H )와 종균등도(E )는 오히려 이동시기에 낮은 편으로 나타났으며, 이는 일부 상위 우점종의 개체수가 월등히 증가했기 때문인 것으로 판단된다. 환경부, 문화재청, IUCN 등이 지정한 멸종위기 및 법정보호종은 총 9종이 관찰되었다. From July 2014 to Jun 2015, bird survey was conducted in Hakampo, Taeanhaean National Park. A total of 23,230 and 159.7 per day of birds representing 14 orders, 30 families, 88 species were observed. The most abundant species were the Black-tailed Gull Larus crassirostris (21.1%), the Brambling Fringilla montifringilla (18.5%), the Great Tit Parus major (12.7%), the Vinous-throated Parrotbill Paradoxornis webbianus (8.2%), Yellow-throated Bunting Emberiza elegans (5.8%). The number of species and individual was the highest in May and October, respectively, as 56 species and 310.5 individual per day were recorded. According to Korean Ministry of Environment, Cultural Herigage Adinistration of Korea and IUCN Red List, a total of 9 protected species were recorded during the survey.

Dimethomorph의 제형에 따른 고추 역병 방제 효과

박정용,류연주,류나현,이용세 대구대학교 생명과학연구소 2004 생명과학연구 Vol.3 No.1

Dimethomorph(DMM) is an effective Oomycete fungicide useful for the control of late blight of potato and pepper by preventative sprays. Efficacy of five formulations, suspension concentrate (DM150), wettable powder (DM250) and three different dispersible concentrates (DM630, DM631, DM632), were investigated in their biological activity against phytophthora blight of red-pepper in vitro and in vivo. Their in vitro biological activities against mycelial growth, zoosporangial formation and zoosporangial germination of Phytophthora capsici were similar. The incidence of late blight on red pepper plants was progressively increased from June 11 to August 8 in untreated plants. However, in the case of DMM treated plants diseased plants, were increased after July 11. When compared with that on July 11, the incidence of late blight on July 18 in the treated plants except in DM630 were increased drastically. This increase were thought to be the result of flooding with more than 80 mm rainfall at July 15. The incidence of late blight on July 29 in the treated plants were increased compared with that on July 18. These also thought to be the result of flooding with more than 100 mm rainfall on July 23. All of the tested DMM formulations showed similar high control value against the late phytophthora blight on red pepper plants in the field test until July 11. However, after flooding the test field, DM630 showed the greatest disease control efficacy. DM250 showed relatively poor disease control efficacy in the test. Therefore more studies on the DM630 formulation are needed.

물류시스템 최적화를 위한 설비배치에 관한 연구

박세준,이영해,허선,이문환,유지용 한국경영과학회 1998 한국경영과학회 학술대회논문집 Vol.- No.2

We consider a facility layout problem for optimized material flow system design in the automated production system design. Existing facility layout algorithm have a weak point that arranged facilities have irregular shape or don't preserve their own shape and size. The proposed algorithm give a layout which is minimize total material handling cost and maximize space utility under preserving each facilities own shape and size.

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

정신분열병과 Neuregulin 1 유전자의 연합연구

박동연,이유상,조은영,조승희,장용이,전현옥,장수연,윤세창,김종원,홍경수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregutin 1 (NRGI) was identified in this locus as a positional and functional candidate gene for Schizo-phrenia, through several independent studies with European and Chinese populations. The purpose of this study is to determine whether NRGl is associated with schizophrenia in Korean population. Methods : Three SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177) and two microsatellites markers (478B14-848,420M9-1395) located at the 5' end of NRGI were genotyped for 242 unrelated schizophrenia patients and the same num-ber of normal controls. Genetic association was tested by χ²-test (df=1). Not only for the whole patients group but also for asubgroup of patients with auditory hallucination. This subtype showed stronger linkage with chromosome 8p12 in the prior study of the authors with multiplex families. Results : G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with auditory hallucination compared to the control group (p=0.03, 0R=1.76). We also found that 3 SNPs haplotype TTC (p=0.04, 0R=0.58) and five markers haplotype TTC53 (p=0.01,0R=0.49) were associated with schziophrenia with a protective effect. Three SNPs haplotype CGT which is a part of the at-risk haplotype of the Icelandic schizophrenia families was found in excess in the patients group but no significant association was observed. Conclusion : NRGI might either play a mle in the predisposition to schizophrenia or be in linkage disequilibrium with a causal locus of this illness.

道路交通事故에 대한 刑事制裁

朴光燮,金容世 忠南大學校 法學硏究所 1994 法學硏究 Vol.5 No.1

뇌열환자에서 임상증상과 영상소견과의 관계 : Correlation of Clinical Outcome with Imaging Findings

박세혁,조용준,이규호,오세문 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12

Schizencephaly is an infrequent congenital disorder of neuronal migration characterized by gray matter-lined clefts that extend through the entire cerebral hemisphere, from the ependymal lining of the lateral ventricle to the pial covering of the cortex. We have studied seven patients with schizencephaly rstrospectively to correlate clinical outcome with the type, size, and location of the clefts and to find associated brain anomalies. Three patients had bilateral clefts(one with two open lip clefts and the other two with a left open lip cleft and a right closed lip cleft), another two patients had left unilateral open lip clefts, and the rest two patients had right closed lip clefts. Clinically these patients presented motor dysfunction such as hemiparesis, seizures, and variable developmental delay. Patients with bilateral clefts, paticularly open lip type had worse motor and developmental impairment than those with unilateral clefts. Patient with unilateral medium open lip cleft had worse motor and intellectual impairment than those with unilateral closed lip clefts or small open lip cleft. All patients with f개ntal lobe involvement had motor dysfunction. Absence of septum pellucidum, gray matter heterotopia, polymicrogyria, and hypoplasia of optic nerves were also frequently found to be associated with schizencephaly. Three patients with skull changes such as enlargement of the hemicranium of erosion of the inner table of the skull were shunted but only one patient improved in the imaging study We conclude that the severity of patient's symptoms is related to the amount type and location of the involved brain.

賂物의 職務關聯性

朴光燮,金容世 忠南大學校 法學硏究所 1995 法學硏究 Vol.6 No.1

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.