TV의 매체적 속성과 프로그램의 연관성 연구 : TV코미디 프로그램의 공감각적 특성을 중심으로 Focusing on Synesthetic Characteristics of TV Comedy Programs

하효숙,양지윤,홍예진 서강대학교 언론문화연구소 2002 언론문화연구 Vol.18 No.-

EphA2 Receptor Signaling Mediates Inflammatory Responses in Lipopolysaccharide-Induced Lung Injury

( Ji Young Hong ),( Mi Hwa Shin ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Background: Eph receptors and ephrin ligands have several functions including angiogenesis, cell migration, axon guidance, fluid homeostasis, oncogenesis, inflammation and injury repair. The EphA2 receptor potentially mediates the regulation of vascular permeability and inflammation in response to lung injury. Methods: Mice were divided into 3 experimental groups to study the role of EphA2 signaling in the lipopolysaccharide (LPS) -induced lung injury model i.e., IgG+phosphate-buffered saline (PBS) group (IgG instillation before PBS exposure), IgG+LPS group (IgG instillation before LPS exposure) and EphA2 monoclonal antibody (mAb)+LPS group (EphA2 mAb pretreatment before LPS exposure). Results: EphA2 and ephrinA1 were upregulated in LPS-induced lung injury. The lung injury score of the EphA2 mAb+LPS group was lower than that of the IgG+LPS group (4.30±2.93 vs. 11.45±1.20, respectively; p=0.004). Cell counts (EphA2 mAb+LPS: 11.33×104±8.84×104 vs. IgG+LPS: 208.0×104±122.6×104; p=0.018) and total protein concentrations (EphA2 mAb+LPS: 0.52±0.41 mg/mL vs. IgG+LPS: 1.38±1.08 mg/mL; p=0.192) were decreased in EphA2 mAb+LPS group, as compared to the IgG+LPS group. In addition, EphA2 antagonism reduced the expression of phospho-p85, phosphoinositide 3-kinase 110γ, phospho-Akt, nuclear factor κB, and proinflammatory cytokines. Conclusion: This results of the study indicated a role for EphA2-ephrinA1 signaling in the pathogenesis of LPS-induced lung injury. Furthermore, EphA2 antagonism inhibits the phosphoinositide 3-kinase-Akt pathway and attenuates inflammation.

Unsaturated fatty acids protect trophoblast cells from saturated fatty acid-induced autophagy defects

Hong, Ye-ji,Ahn, Hyo-Ju,Shin, Jongdae,Lee, Joon H.,Kim, Jin-Hoi,Park, Hwan-Woo,Lee, Sung Ki Elsevier 2018 Journal of reproductive immunology Vol.125 No.-

<P><B>Abstract</B></P> <P>Dysregulated serum fatty acids are associated with a lipotoxic placental environment, which contributes to increased pregnancy complications via altered trophoblast invasion. However, the role of saturated and unsaturated fatty acids in trophoblastic autophagy has yet to be explored. Here, we demonstrated that prolonged exposure of saturated fatty acids interferes with the invasiveness of human extravillous trophoblasts. Saturated fatty acids (but not unsaturated fatty acids) inhibited the fusion of autophagosomes and lysosomes, resulting in the formation of intracellular protein aggregates. Furthermore, when the trophoblast cells were exposed to saturated fatty acids, unsaturated fatty acids counteracted the effects of saturated fatty acids by increasing degradation of autophagic vacuoles. Saturated fatty acids reduced the levels of the matrix metalloproteinases (MMP)-2 and MMP-9, while unsaturated fatty acids maintained their levels. In conclusion, saturated fatty acids induced decreased trophoblast invasion, of which autophagy dysfunction plays a major role.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SFAs induce insoluble protein aggregation in trophoblasts. </LI> <LI> SFAs impair autophagosome-lysosome fusion in trophoblasts. </LI> <LI> UFAs attenuate SFA-induced protein aggregate formation. </LI> <LI> UFAs restore the invasive capabilities of trophoblasts. </LI> </UL> </P>

EphA2 Receptor Signaling Mediates Inflammatory Responses in Lipopolysaccharide-Induced Lung Injury

Hong, Ji Young,Shin, Mi Hwa,Chung, Kyung Soo,Kim, Eun Young,Jung, Ji Ye,Kang, Young Ae,Kim, Young Sam,Kim, Se Kyu,Chang, Joon,Park, Moo Suk The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Background: Eph receptors and ephrin ligands have several functions including angiogenesis, cell migration, axon guidance, fluid homeostasis, oncogenesis, inflammation and injury repair. The EphA2 receptor potentially mediates the regulation of vascular permeability and inflammation in response to lung injury. Methods: Mice were divided into 3 experimental groups to study the role of EphA2 signaling in the lipopolysaccharide (LPS)-induced lung injury model i.e., IgG+phosphate-buffered saline (PBS) group (IgG instillation before PBS exposure), IgG+LPS group (IgG instillation before LPS exposure) and EphA2 monoclonal antibody (mAb)+LPS group (EphA2 mAb pretreatment before LPS exposure). Results: EphA2 and ephrinA1 were upregulated in LPS-induced lung injury. The lung injury score of the EphA2 mAb+LPS group was lower than that of the IgG+LPS group ($4.30{\pm}2.93$ vs. $11.45{\pm}1.20$, respectively; p=0.004). Cell counts (EphA2 mAb+LPS: $11.33{\times}10^4{\pm}8.84{\times}10^4$ vs. IgG+LPS: $208.0{\times}10^4{\pm}122.6{\times}10^4$; p=0.018) and total protein concentrations (EphA2 mAb+LPS: $0.52{\pm}0.41mg/mL$ vs. IgG+LPS: $1.38{\pm}1.08mg/mL$; p=0.192) were decreased in EphA2 mAb+LPS group, as compared to the IgG+LPS group. In addition, EphA2 antagonism reduced the expression of phospho-p85, phosphoinositide 3-kinase $110{\gamma}$, phospho-Akt, nuclear factor ${\kappa}B$, and proinflammatory cytokines. Conclusion: This results of the study indicated a role for EphA2-ephrinA1 signaling in the pathogenesis of LPS-induced lung injury. Furthermore, EphA2 antagonism inhibits the phosphoinositide 3-kinase-Akt pathway and attenuates inflammation.

Impending Cardiac Tamponade and Hemorrhagic Pleural Effusion as Initial Presentations of Incomplete Kawasaki Disease: A Case Report

( Ye Ji Kim ),( Kyung Min Kim ),( Jae Young Lee ),( Ji Hong Yoon ),( Dae Chul Jeong ),( Woo Young Park ),( Gi Beom Kim ) 대한류마티스학회 2020 대한류마티스학회지 Vol.27 No.1

Kawasaki disease (KD) is an acute febrile illness that is characterized by systemic inflammation usually involving medium-sized arteries and multiple organs during the acute febrile phase, leading to associated clinical findings. The diagnosis is based on the principal clinical findings including fever, extremity changes, rash, conjunctivitis, oral changes, and cervical lymphadenopathy. However, KD diagnosis is sometimes overlooked or delayed because other systemic organ manifestations may predominate in acute phase of KD. As a cardiovascular manifestation, an acute pericarditis usually shows a small pericardial effusion, but large pericardial effusion showing clinical signs of cardiac tamponade is very rare. Here, we described a case of incomplete KD presenting with impending cardiac tamponade, and recurrent fever and pleural effusion. (J Rheum Dis 2020;27:68-72)

Free Paper Presentation : OS-38 ; Increased Prevalence of COPD Among Korean Population: An Analysis of KNHANES II and V

( Ji Young Hong ),( Song Yee Kim ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Moo Suk Park ),( Se Kyu Kim ),( Joon Chang ),( Young Sam Kim ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: COPD is a serious public health problem. Understanding the longitudinal trend of prevalence is important in characterizing the burden of COPD and planning health service planning. Method: We analyzed the prevalence of airflow obstruction between 2001 and 2011 using data from Korean National Health and Nutritional Examination Survey (KNHANES II and V). Airway obstruction was defined by FEV1/FVC < 0.7. The participants aged over 40 years recording less than 0.7 of FEV1/FVC was defined to have COPD. To compare the prevalence of COPD after age and gender standardization, we used the data from the Population and Housing Census, which was conducted by Statistics Korea in 2010. Statistical analyses were performed using SAS version 9.2. Result: Data were acquired from 5,318 subjects, who aged =40 years and underwent spirometry adequately (2001: n=2,217; 2011: n=3,101). The prevalence of COPD increased from 2001 to 2011 (2001: 13.0%, 2011: 13.2%). The prevalence of COPD increased in men, but not in women (2001: men 20.5%, women 6.5%; 2011: men 22.2%, women 6.4%). Interestingly, the prevalence of COPD decreased after age and gender standardization (2001: total 15%, men 22.3%, women 8.3%; 2011: total 12.6%, men 19.6%, women 6.4%).The proportion of ever-smokers increased from 2001 to 2011 (2001: men 79.8%, women 5.2%; 2011: men 82.9%, women 6.3%). On the contrary, the proportion of current smokers decreased from 2001 to 2011 (2001: men 54.1%, women 4.5%; 2011: men 36.7%, women 3.7%). Conclusions: From 2001 to 2011, the prevalence of COPD in Korea has been increased, but it declined after age and gender standardization. This result suggests the burden of COPD increased mainly due to aging of population despite the progressive anti-smoking prevention policies.

Utility of Routine Culture for Tuberculosis from Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in a Tuberculosis Endemic Country

Hong, Ji-Young,Jung, Ji-Ye,Kang, Young-Ae,Park, Byung-Hoon,Jung, Won-Jai,Lee, Su-Hwan,Kim, Song-Yee,Lee, Sang-Kook,Chung, Kyung-Soo,Park, Seon-Cheol,Kim, Eun-Young,Lim, Ju-Eun,Kim, Se-Kyu,Chang, Joon The Korean Academy of Tuberculosis and Respiratory 2011 Tuberculosis and Respiratory Diseases Vol.71 No.6

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a technique developed to allow mediastinal staging of lung cancer and also to evaluate intrathoracic lymphadenopathy. In a tuberculosis-endemic area, tuberculosis should be considered as an etiology of mediastinal lymphadenopathy. The aim of this study was to investigate the utility of the routine culture for tuberculosis from specimens of EBUS-TBNA. Methods: We prospectively performed routine culture for tuberculosis from aspiration or core biopsy specimens got from 86 patients who had undergone EBUS-TBNA due to mediastinal lymphadenopathy between March 2010 and March 2011. Results: A total of 135 lymph node aspiration and 118 core biopsy specimens were included in this analysis. We confirmed the malignancy in 62 (72.9%), tuberculosis in 7 (8.1%), sarcoidosis in 7 (8.1%), asperogillosis in 2 (2.3%) and pneumoconiosis in 2 (2.3%) patients. One lung cancer patient had pulmonary tuberculosis coincidentally and 5 patients had unknown lymphadenopathy. The number of positive culture for Mycobacterium tuberculsosis by EBUS-TBNA is 2 (1.5%) from 135 lymph node aspiration specimens and 2 (1.7%) from 118 core biopsy specimens. Out of eight patients confirmed with tuberculosis, only one patient had positive mycobacterial culture of aspiration specimen from EBUS-TBNA without histopathologic diagnosis. Conclusion: These results propose that routine culture for tuberculosis from EBUS-TBNA may not provide additional information for the diagnosis of coincident tuberculous lymphadenitis. However, if there is any possibility of tuberculous lymphadenopathy or pulmonary tuberculosis, it should be considered to perform EBUS-TBNA in patients who have negative sputum AFB smears or no sputum production.

The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-033 : Mycobacterial Diseases ; Increased Serum CA 19-9 Levels in Pulmonary Nontuberculous Mycobacterial Disease

( Ji Young Hong ),( Song Yee Kim ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Moo Suk Park ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Young Ae Kang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: CA 19-9 is a useful marker for the diagnosis of gastrointestinal cancer including pancreatic cancer. However, there are several previous studies about CA 19-9 elevation in benign lung diseases like emphysema, fibrosis and bronchiectasis. This study investigated the clinical signifi cance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial (PNTM) disease, compared with pulmonary TB. Method: Serum CA 19-9 in patients with PNTM (n=59) and pulmonary TB (n=36) were measured. Multivariate logistic regression analysis was performed to evaluate the factors related to CA 19-9 elevation in PNTM disease. The sequential changes in serum CA 19-9 before and after treatment were compared between pulmonary TB and PNTM disease. Results: The median CA 19-9 level was higher in patients with PNTM disease than pulmonary TB (PNTM: 13.80, TB: 5.85, P<0.001). However, after adjusting for age, sex, radiologic severity and previous TB history, the CA 19-9 levels between two groupswere not different (PNTM: 28.35, TB: 12.68, P =0.471). Among 59 patients with PNTM disease, serum CA 19-9 levels were elevated in 11(18.6%). M.abscessus species (OR 10.37, 95% CI: 1.96, 54.93; P=0.006) and extensive pulmonary lesions more than three lobes (OR 6.37, 95% CI: 1.02, 39.60, P=0.047) were signifi cantly associated with an elevated CA 19-9 levels. While the CA 19-9 levels showed a tendency to decrease during successful treatment of PNTM disease, but not in pulmonary TB. Conclusions: Serum CA 19-9 level was increased in substantial proportions of the patients with PNTM disease and it may be useful in the monitoring of therapeutic responses of PNTM disease.

Identification of Two New Races of Podosphaera xanthii Causing Powdery Mildew in Melon in South Korea

Hong, Ye-Ji,Hossain, Mohammad Rashed,Kim, Hoy-Taek,Park, Jong-In,Nou, Ill-Sup The Korean Society of Plant Pathology 2018 Plant Pathology Journal Vol.34 No.3

Powdery mildew caused by the obligate biotrophic fungus Podosphaera xanthii poses a serious threat to melon (Cucumis melo L.) production worldwide. Frequent occurrences of the disease in different regions of South Korea hints at the potential existence of several races which need to be identified. The races of five isolates collected from different powdery mildew affected regions were identified based on the pathogenicity tests of these isolates on eight known differential melon cultigens namely, SCNU1154, PMR 45, WMR 29, PMR 5, MR-1, PI124112, Edisto 47 and PI414723. None of the isolates have shown same disease responses to those of the known races tested in this study and in previous reports on these identical differential melon cultigens. This indicates that the tested uncharacterized isolates are new races. Among the isolates, the isolates from Hadong, Buyeo, Yeongam and Gokseong have shown same pathogenicity indicating the possibility of these isolates being one new race, for which we propose the name 'race KN1'. The isolate of Janghueng have also shown unique disease response in the tested differential melon cultigens and hence, we identified it as another new race with a proposed name 'race KN2'. Report of these new races will be helpful in taking effective control measures in prevalent regions and for future breeding programs aimed at developing varieties that are resistant to these race(s).

The Immediate Effects of Dynamic Stretching and Static Stretching Using a Wedge Board on the Balance Ability and Jump Function of Healthy Adult

( Ye-ri Ji ),( Yoo-sun Hong ),( Dongyeop Lee ),( Ji-heon Hong ),( Jae-ho Yu ),( Jin-seop Kim ),( Seong-gil Kim ) 대한물리치료학회 2021 대한물리치료학회지 Vol.33 No.6

Purpose: This study aims to measure the improvement of balanced ability and rapid response of 30 healthy adults by performing dynamic stretching, static stretching, and sargent jump. Methods: The sample 30 peoples without any musculoskeletal disease who volunteered to be the subject of the study. We measured all subjects on following metrics to evaluate the function and stability under the normal condition, with dynamic stretching (DS) group, static stretching (SS) group: vertical jump height and reaching distance Anterior, Posteromedial, Posterolateral and NO (Normal eye open), NC (Normal eye close), PO (Pillow with eye open), and PC (Pillow with close eye) were evaluated. All measures were analyzed using independent t-test and One-way repeated Anova. Results: There was a significant increase in SJH (Sargent jump) in both groups (p<0.05). In Y-balance test, there was a significant increase in both groups except for the ANT (Anterior) direction, and there was a significant increase only in the SS group in the ANT (Anterior) direction (p< 0.05). There was no significant difference between the DS group and the SS group (p >0.05). There was no significant improvement in ST (Stability Index) and WDI (Weight Distribution Index) in both groups (p>0.05). Conclusion: Both DS and SS showed significant improvement in SJH and Y-balance tests, which are dynamic functions, but had no significant effect on static balance ability.