급성백혈병의 화학요법에서 조혈간세포 보충요법

이규보,배선근,손상균,이재태,이건수,이경혜,서장수 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

1. 목적 급성백혈병의 화학요법에 있어서 관해유도 요법시에 보다 더 강력한 항암화학요법을 시행하고 골수억제의 회복을 위하여 말초혈액에서 채취한 조혈모세포의 투여로 그 효과를 증대시키고자 시도하였다. 2. 방법 관해유도 화학요법후에 골수억제시기로부터 회복단계로서 백혈구감소증이 호전도면서 단핵세포가 증가될 때에 말초혈액에서 조혈간세포(stem cell)로 인정되고 있는 CD34+세포의 함유량이 1% 이상되는 시기를 찾아내고 그 때부터 평균 4차례의 단핵구를 분리채집을 하여 -74。C에 냉동보관하였다가 제2차 화학요법후에 해동시켜서 정맥주입하였다. 3. 결과 대상 급성백혈병환자는 6명에 23회의 조혈간세포를 함유한 단핵구 채집을 시행하였고 유효한 단핵구의 채집은 4례에서 가능하였고 2례에서는 유효한 채집이 못되었다. 채집효율은 39.0-74.5%로서 평균 49.8%였다. 채집 후에 혈액학적 변화는 혈색소의 약간 감소 (평균 1.34g/dl)와 혈소판의 감소 (평균20.25%)를 나타내었다. 해동 단핵구를 투여할시에 일과성인 불쾌감, 기침, 흉부압박감, 호흡곤란 등이 있었다. 4. 결론 자가골수이식에서 자기말초혈액조혈간세포이식으로 관심이 이행되는 현시점에 자가조혈간세포를 채집하여 수혈하는 기술이 확립되는 기초를 이루었다고 본다. 이번 대상들은 재발된 금성백혈병들에 시행하였으나, 향후에는 초발시에 제일차 관해유도 화학요법 과정에 시도해야할 것으로 생각한다. Object: Peripheral blood stem cells(PBSC) were collected after remission induction chemotherapy and reinfused after intensified chemotherapy in order to increase the chemotherapeutic efficacy. Method: Collection of mononuclear cells (MNC) was started when CD34+ cells above 1% and WBC above 1,000/ul with mononuclear cell percentage above 30%, the collection procedures were done 2-6 time in each patient of total 6 cases. The collected MNCs were stored in - 750C and reinfused after thawing in the water bath at 370C Results: Twenty three collection procedures from the 6 cases of acute leukemia had made effective MNC collection in 4 cases and mean collection efficiency was 49.8%(from 39.0% to 74.5%). Hematological changes after the procedure were mean reduction of hemoglobin 1.34g/dl and mean 20.25% of decreased platelet count. There were noticed transient symptoms of discomfort, coughing, chest tightness and dyspnea in association with the infusion of stored cells. Conclusion: The basic process for the peripheral blood stem cell transplantation (PBSCT) was accomplished with this supportive care for the consolidation chemotherapy of acute leukemia. Effective PBSCT would be warrented with more qualified process and high does chemotherapy. (Korean J Blood Transfus 6(2) : 41~47,1995)

Gene pyramiding effect of two major bakanae disease resistance gene using qBK1 and qBKWD

Sais-Beul Lee,Tae-Heon Kim,Su-Min Jo,Jun-Hyun Cho,Ji-Yoon Lee,Jong-Hee Lee2,Dongjin Shin,You-Chun Song,Myung-Kyu Oh,Dong-Soo Park 한국작물학회 2017 한국작물학회 학술발표대회 논문집 Vol.2017 No.-

부신피질 자극호르몬 단독결핍 1례

박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.

림프종 환자에서의 갈륨, TI-201 그리고 Tc-99m MIBI 섭취의 비교

천경아,조인호,원규장,이경희,이형우,현명수,이재태,이규보 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2

Purpose; Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

Multi-media and multi-pathway aggregate exposure assessment for polycyclic aromatic hydrocarbons to the inhabitant in Tae-an county after Hebei-spirit oil spill

Kim Chan-Kook(김찬국),Woo-Chul Jeong,Jonil Hur,Pan-Soo Park,Tae-Woo Lee,Hwi-Soo Seol,Jung-hyeon Park,Jong-Heop Lee,Jong-Ho Kim,Byeong-Kyu Kwak,Jong-Hyeon Lee 대한직업환경의학회 2010 대한직업환경의학회 학술대회 논문집 Vol.45 No.-

소양호에서의 종속영양세균의 종구성 및 Alkaline phosphatase 분비 세균에 관한 연구

이동훈,안태석,조규송 江原大學校 附設 環境硏究所 1990 環境硏究 Vol.7 No.-

The total and heterotrophic bacterial distributions, compositions and alkaline pho-sphatese activities were analyzed in Lake Soyang from Sep. 1987 to Aug. 1988. The heterotrophic bacteria was small porition, 0.07-2.63% of total bacterial number which ranged from 3.2×10^(5) to 3.2×10^(6) cells/ml. The composition of bacterial commumity was less diverse insummer and at the fish farm site and Pe-ridinium blooming site. Pseudomonas and Flavo bacterium were the dominant genera in all sites. The highest proportion and activity of alkaline phsophatase was appeared in Flavobacterium, while Pseudomonas was the most predominant group.

SEM용 전자 검출기의 설계 및 제작

이상욱,전종업,박기태,박규열 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

The nature of the signals collected by an SEM(Scanning Electron Microscope) in order to form images are all dependent on the detector used to collect them, and the quality of an acquired image is strongly influenced by detector performance. Therefore, the development of detector with high performance is very important in pulling up the resolution of SEM This study presents the secondary electron detector for use in scanning electron microscope, electric circuit and I/V conversion circuit for driving that detector.

中國大陸의 社會主義 現代化政策에 대한 연구 : The Reform and Open-door Policy in the Mainland China and Modernization of China 中國大陸의 改革.開放政策과 中國의 現代化

李奎泰 관동대학교 1996 關大論文集 Vol.24 No.2

The purpose of this paper is to research the modernization of socialism in the Mainland China. This paper studies its problems and its influence on the modernization of Chinese society, by analyzing the theory of modernization of socialism, the reform and the open-door policy of chinese Communist Party. In conclusion, this paper estimates the historical of socialism has, comparing this Mainland China's model of the modernization proceeding within the framework of socialism with different models of the other Chinese societies such as Taiwan and Hong-Kong.

유리섬유강화 복합절연재료의 열화특성에 관한 연구

이규철,유근민,김경석,박홍태 울산대학교 1996 공학연구논문집 Vol.27 No.2

본 연구에서는 주위 환경 열화에 따른 복합절연재료의 절연특성과 수명을 향상시키기 위해 고온에서 흡습량을 변화시켰을 때와 탈습량을 변화시켰을 때 흡십시료와 탈습시료의 전기적 특성 및 기계적 특성을 조사하였다. 유리섬유 각층의 흡습상수는 각각 1층에서 0.0117, 2층에서 0.0123, 3층에서 0.0152를 나타냈다. 전기적 특성 및 기계적 특성은 복합재료의 흡습에 따라 크게 떨어졌다. 70℃에서 습기가 완전히 건조되어도 흡습전의 전기적 및 기계적 특성을 얻기가 어려운 것으로 나타났다. 수분에 의해 발생한 복합절연재료내에 존재하는 많은 결함들은 에폭시 메트릭스와 필라사이에 존재하였다. The electrical and mechanical properties of moisture absorbed and moisture desorbed specimens were investigated to improve the insulating characteristics and the reliability of composite materials against environment aging. Moisture absorption constants with the layers of glass fiber showed 0.0117 in 1 layer, 0,0123 in 2 layer and 0.0152 in 3 layer, respectively. Although moisture was removed at 70℃, it was impossible to obtain the initial electrical and mechanical properties. Many defects induced by moisture were observed at the interface between epoxy matrix and filler in composite materials.

SIMOS EPROM의 고찰과 8080A를 이용한 EPROM Writer

이기돈,박규태 연세대학교 산업기술연구소 1980 논문집 Vol.12 No.2

The structure of a new nonvolatile charge-storage device is reviewed. The stackedgate injection Mos(SIMOS) device is an n-channel MOS transistor with a control gate stacked on the floating gate. This paper describes the SIMOS device. The characterics concerning charge accumulation and charge removal are also described. The characteristics of EPROM S6834,2708 and 2716 are investigated. EPROM Writer for S6834,2708 and 2716 using 8080A is constructed by the TTL Latch. Decoder, tri-state Buffer and program pulse driver circuits. Programming for EPROM is performed with system software. The experimental results gave a good agreement with the calculated values.