정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Breeding of Tetraploid in Platycodon grandiflorum (Jacq.)A. DC. by Colchicine treatment

Kim,Ik-Hwan,Kim,Hag-Hyun,Hong,Eui-Yon,Yun,Jong-Sun,Yun,Tae,Hwang,Ju-Kwang,Lee,Cheol-Hee 한국자원식물학회 2003 Plant Resources Vol.6 No.3

Present studies were carried out to produce tetraploid plants by colchicine treatment using seeds, seedlings and shoot tips of Platycodon grandiflorum in Campanulaceae. The most successful colchicine treatment for tetraploid production in P. grandiflorum was soaking treatment using 0.01 and 0.5% colchicine solution for 1 hour and 12 hours, respectively. Morphological characteristics of both diploid and tetraploid were similar, but tetraploid plants had more leaves. Compared to diploid, tetraploid had the larger stomata, but less number of stomata. Fresh weight of tetraploids was 20∼40% heavier than that of diploid.

간문부 담관암 환자에서 경피경관 양측성 금속 배액관의 효과

김금래,김주형,박원규,장재천,조재호,김태년,김준화,장병익 영남대학교 의과대학 2005 Journal of Yeungnam Medical Science Vol.22 No.2

Background: The purpose of this study was to determine the effectiveness of percutaneously place self-expanding metallic stent for the relief of biliary obstruction in patients with hilar cholangiocarcinoma. Materials and Methods: From November 2001 to December 2004, 48 patients with hilar cholangiocarcinoma were prospectively studied. After percutaneous placement of bilateral self-expanding, uncovered metallic stents, follow-up evaluation was carried out until July 2005. Results: There were 4 cased of Bismuth type Ⅱ,21 cases of Bismuth typeⅢa 8 cases of Bismuth type Ⅲb and 15 cases of Bismuth type Ⅳ. Stent placement was technically successful in all patients All patients had satisfactory biliary drainage, resulting in one week drainage rate of 72.8% and final drainage of 91.9% There were 12 cases (21.3%) of abdominal pain requiring analgesics and 1 case (7.1%) of cholangitis; both were successfully managed with conservative treatments. Late complications occurred in four patient (8.3%), including two patients with cholangitis, one patient with liver abscess, and one patient with biloma; all were appropriately managed by percutaneous drainage. The average length and median durations of stent patency and median survival time were 303 days (range, 60~815) and 338 days (range, 60 ~1175), respectively. Conclusion: Placement of a percutaneous metallic stent is an effective and safe method of palliation of patients with hilar cholangiocarcinoma.

Breeding of Tetraploid in Codonopsis lanceolata (Sieb. et Zucc.) Trautvetter by Colchicine Treatment

Kim,Ik-Hwan,Kim,Hag-Hyun,Hong,Eui-Yon,Yun,Jong-Sun,Yun,Tae,Hwang,Ju-Kwang,Lee,Cheol-Hee 한국자원식물학회 2003 Plant Resources Vol.6 No.3

Present studies were carried out to produce tetraploid plants by colchicine treatment using seeds, seedlings and shoot tips of Codonopsis lanceolata. Three tetraploid plants of C. lanceolata were produced from seeds which absorbed 0.1 % colchicine solution for 12 hours, and 0.5% colchicine solution for 1 and 6 hours from seedlings, respectively. But tetraploid was not produced from shoot tips treated by colchicine solution. Compared to diploid, tetraploid plants had larger stomata, but less number of stomata. Fresh weight of tetraploid plants was 1.4∼3.6 times heavier than diploid plants.

QT연장 증후군 환자에서 Head-Up Tilt Test에 의해 유발된 Torsades De Pointes 1례

전익수,차태준,김길수,김동완,김규종,김찬욱,김성만,주승재,이재우 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

겉보기 열용량법을 이용한 합금의 레이저 융용풀에서의 열 및 유동해석

김우승,심복철,임익태 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1

An apparent capacity method is employed to solve numerically transient and steady state laser melting emblem of alloy. Momentum equations are solved in the liquid and mushy zones by using the SOLA-VOF algorithm. Using a laser with a top-hat profile, a wide range of studies are performed for steel. The streamline plots show the existence of rotating cell in the molten pool. It is found that the shapes of pool, the distributions of surface velocity and surface temperature are quite different from the case without convection effect in the mushy zone.

폐쇄성 황달로 내원한 담관내 증식을 동반한 간세포암 1예

김승범,김태년,이호찬,박재현,은종렬,장병익,이헌주,윤성수,배영경 영남대학교 의과대학 2008 Journal of Yeungnam Medical Science Vol.25 No.2

The incidence of hepatocellular carcinoma presenting as obstructive jaundice is 0.7 -9% The mechanisms of obstructive jaundice include bile duct invasion by tumor, tumor thrombi, blood clots, direct bile duct compression by tumor, and intraductal tumor growth. We report a rare case of hepatocellular carcinoma with intraductal growth A 46-year-o1d woman was admitted due to colicky right upper abdominal pain and jaundice for 4 days Computed tomography showed dilatation of the left intrahepatic duct, and endoscopic retrograde cholangiography showed a filhng defect in the left main intrahepatic duct. We performed a left lobectomy with a Roux-en-Y hepaticojejunostomy. The tumor was diagnosed as a hepatocellular carcinoma with intraductal growth.

남성 건강검진 수진자에서 간기능 장애 및 비알코올성 지방간과 대사 증후군과의 관련성

최태성,유재영,김진석,장은철,박주언,김병익 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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초음파 기법을 활용한 콘크리트 구조물의 내부 균열 검출

김태식,신동익,진교홍,진치섭 釜山大學校生産技術硏究所 2002 生産技術硏究所論文集 Vol.61 No.-

최근, 콘크리트 구조물(터널, 고가교 등)에서의 박리 및 낙하사고 등으로 콘크리트 구조물에 대한 유지관리시스템의 중요성이 재인식되었다. 콘크리트 구조물의 유지관리 및 보수시 조사·분석해야 할 가장 중요한 결함 요인은 콘크리트의 균열이다. 콘크리트의 균열은 내부에 발생하지만 구조적으로 문제가 없는 경우도 상당수 있으므로 종합적으로 분석하여 상태를 평가해야 하며 균열 상태는 폭, 깊이, 방향, 형상의 측면에서 조사 분석해야 한다. 이중 균열 깊이가 구조물의 안전거동에 미치는 영향이 큰 경우에는 콘크리트에 발생된 균열 깊이를 정확히 측정하여 정도에 따른 적절한 대책을 수립해야 한다. 본 연구에서는 콘크리트에 이미 발생된 균열의 초음파 탐상검사 방법으로 측정된 결과를 이해하기 쉽도록 3차원으로 화상처리 하는데 목적이 있다. 이를 위해, 서로 다른 균열 형상의 12가지 시험편을 제작하고 초음파 탐상검사 방법으로 균열 깊이를 측정한 후 균열 형상을 화상처리 할 수 있는 프로그램을 작성하였다. Cracks of concrete structure must be analyzed and estimated synthetically in order to have a maintenance and to insure the safety and the durability of structure. Concrete cracks have to be surveyed with respect to depth, width, shape and direction, but crack depth and shape among these items are not measured easily. Occasionally, it needs to measure the crack depth and shape of concrete structure for the purpose of evaulating the safe capacity and the necessity of repair. Therefore, experiments were carried with three-dimensional(3D) Ultra-Sonic Technique to detection and analysis crack shape in concrete and this report is performed to veritf the applicability and the accuracy of Ultra-Sonic Technique in non-destructive testing methods. Moreover, the result shows that the measurement of crack in concrete is related to the shape and angle of inclination of notch.

브랑쿠시의 美的 哲學과 抽象性 考察 : 새(鳥)시리즈, 물고기, 포가니 양, 티르구 지우앙상블을 중심으로 Birds series, The Fish, Pogany series, Tirgu-Jiu ensemble

金翊泰 효성여자대학교 산업미술연구소 1995 산업미술 Vol.5 No.-

Brancusi is widely accepted as the most important and original sculptor of this century, and his work dramaically shows the new responsiveness to form and materials that was central to the modern aesthetic. We can outline Brancusi's work and personality like this' "Metaphysical Background," "East-West", "Sculptor, Peasant and Philosopher in Paris", "From Material to Form", "Spatial Dynamism", "Role and Formation of the Pedestal". This various and complex notion represents Brancusi's abstruseness of primitivism, brilliancy of ancient arts, holiness of medieval thimes, sophistication of modern times. Brancusi, in particular, was as reponsive to the folk traditions of his homeland as he was to the demands of his own pioneering aesthetic. For a time after 1913 the sculptor was certainly influenced by the forms of african carving : but throughout his life he also maintained and developed a wide repertory of forms that were derived from Romanian folk art and architecture, as well as from other Slavonic, Egyptian, Buddhist, and Cycladic sculptural traditions. Althouth he lived in Paris rather than Romanian for a variety of cultural and economic reasons, until the lat 1940s he always maintained his connections with his country of origin, and created his greatest work there. Among Brancusi's works, bird series including "The Cock", are characterized by their abstraction, simplicity, and sophistication. Biomorphism, Constructivism (bases upon geometry), and Ready-made trends are clearly represent those Brancusi's works. Whther Brancusi's "Bird series" are derived from the shapes of living forms or not, they still have the tightness, the tension, and the refinememt obtained by Brancusi's consistent working. In the "Pogany series", Brancusi's philisophical knowledge, deflected geometry, and primitive ideas were emphasized. The ensemble of "Endless Column", "The Gate of the Kiss", and "The Table of the Silence" can be classified as enviroment sculpture. Geometrical precision and philosophical insight increased the value of Tirgu-giu ensemble. The spatial dynamism, the freedom and disire for openness, the meaning of a life and communionwere mysteriously mixed to represent the culmination of Brancusi's art. Brancusi's philosophical intelligence and artistic talent have contibuted to the beauty of his sculpture. Brancusi's creativeness and modern civilization made it possible Brancusi's works look elegant and sophisticated. In addition, Brancusi took advantage of bases to reinforce : they are sculpture itself. The releationship between the subject and base is like the relationship between the leaves-flower-stem and rotos of a plant. In general, it is said that Brancusi created his work on the basis of his intuition. His intuition, however, had been slowly developed by great effort, patience, manytrials and errors, at last, made people believe that he had kept ingenuity, creativeness, and intuitions. Brancusi influenced a great many modernist sculptors including Wilhelm Lehmbruck, Barbara Hepworth, Henry Moore, and David Smith, etc. Considering Brancusi's creativeness, philosophy, modernity, effrot, and evolutionary development, Brancusi's influence is not likely to die but fade away.