정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

강원도 화천군 수달(Lutra lutra) 서식지의 식생 구조

서형수 ( Hyung Soo Seo ),신영섭 ( Young Seob Shin ),이경은 ( Kyung Eun Lee ),김윤미 ( Yoon Mi Kim ),전미나 ( Mina Jeon ),남택우 ( Taek Woo Nam ),한성용 ( Sung Yong Han ),정연숙 ( Yeonsook Choung ) 한국하천호수학회 2014 생태와 환경 Vol.47 No.special

In order to determine whether vegetation would be one of the factors for the selection of otter home range, vegetation structure and other potential factors were studied in Hwacheon, Korea. Thirteen sites, otter’s activity found and not found, were investigated in North Han River and connected tributary streams of Hwacheon-gun. Three types of vegetation were classified by cluster analysis, which is short grass, tall grass and shrub type. Vegetation zone of each channel is composed of either one type, or mosaic of tall grass and shrub type. Short grass type is common in Lake Paro and upper North Han-river where water level is highly variable throughout a year. Therefore, annual species such as Persicaria nodosa, Fimbristylis dichotomam and Chenopodium ficifolium are the most dominant. Shrub type is common at the downstream sites of Jichon stream and along mainstream of North Han River down Lake Paro. A shrub species, Salix koreensis, is the most common. Tall grass type is dominant occupying the most vegetation zone of the tributary channels. Phragmites japonica is absolutely dominant. Due to its dense cover, a few plant species are co-existed. Otter activity was found in all three vegetation types and no marked activity was found at some sites of tall grass type. There is no difference in species composition and physiognomy between tall grass sites with and without otter activity, while it shows significant difference in fish availability between two groups. Overall we found that home range of otters in the region is along the mainstream and downstream of tributary streams with high fish availability in all vegetation types and in various human activity levels.

신장이식 환자에서 HCMV 항원혈증 검사의 임상적 유용성

김탁,성흥섭,박관태,김송철,김성한,최상호,김양수,우준희,박수길,한덕종,이상오 대한감염학회 2009 감염과 화학요법 Vol.41 No.2

Background : This study was performed to determine the cut-off value and the predictability of symptomatic human cytomegalovirus (HCMV) infection according to the peak value of HCMV antigenemia assay in kidney transplant recipients. Materials and Methods : We reviewed the results of HCMV antigenemia assay (Chemicon, CA, USA) in patients who received kidney transplantation at our institution from May 2003 through May 2008, and investigated the existence and the type of HCMV infection by the medical record review. Patients who underwent the test only once during the episode or those who received ganciclovir for more than 48hrs before the test were excluded. The receiver-operator characteristic curve was drawn and the point showing maximum likelihood ratio (LR) was chosen as the cut-off value of symptomatic HCMV infection. Results : A total of 689 episodes were screened and 134 episodes were enrolled. Thirty-three (24.6%) episodes were symptomatic HCMV infection, 23 (17.2%) episodes were associated with HCMV syndrome, and 10 (7.5%) episodes were tissue-invasive diseases. The maximum LR was 7.5 (95% confidence interval, 4.014.2) and the cut-off value was 29.5 cells/200,000 WBC. The sensitivity, specificity, Positive predictive value, and negative predictive value were 66.7%, 91.1%, 71.0%, and 89.3%, respectively. Conclusions : The cut-off value of symptomatic HCMV infection by the peak value of HCMV antigenemia assay in our study was similar with previous results, although the sensitivity was relatively low.

用寒遠寒과 用熱遠熱에 대한 考察 : 六元正紀大論에서

채영진,신창환,임현택,여성원,한성규,이재원,정헌영,금경수 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

Five elements motion and six kinds of natural factors influence not only human disease but also difference of medicine effect. Because the climate of summer is very hot, that is easy to increase the properties of hot medicines, a doctor must be careful to use it in summer. Also the climate of winter is very cold, that is easy to increase the properties of cold medicines, a doctor must be careful to use it in winter. But in the certain conditions to use diaphoretics or purgatives, in spite of that regulation a doctor can use them.

인터넷/인트라넷의 사회·경제적 이용에 관한 연구 : 일본의 사례를 중심으로 the case of Japan

한성수 明知大學校 附設 日本問題硏究所 1999 日本硏究 Vol.7 No.-

아웃리거 구조 시스템의 최적 설계 인자분석에 관한 연구

한경민,박성수 부산대학교 생산기술연구소 2001 生産技術硏究所論文集 Vol.60 No.-

건물의 고층화에 따라 구조 시스템의 개발이 요구되었으며, 경제성을 위해 최적설계가 발달하게 되었다. 본 연구에서는 고층건물의 구조 시스템의 한 종류인 아웃리거 시스템을 중심으로 유전자 알고리즘을 사용하여 설계 최적인자에 대한 분석을 수행하였다. Nowaday, the high-rised building system is more and more important for economic efficiency, therefore, the optimized design for them is required in those fields. In this research, Design factors, which are used for high-rised building system, are analysed and reviewed for optimized design.

Campylobacter pylori 위장내 분리위치에 따른 병원성

한왕수,한상진,김정목,조양자 대한감염학회 1989 감염 Vol.21 No.1

Compylobacter pylori may cause gastritis and has been proposed as an etiologic factor in the development of peptic ulcer. However, it is unknown where is primary colonization sites of C. pylori. Isolation sites of C. pylori in stomach and duodenum and pathology in antrum were evaluated in 90 subjects endoscoped at Hanyang University Hospital in Seoul, Korea. C. pylori detected in biopsied specimens of 40 (74%) of 54 C. pylori-positive patients at antrum only, and 13 (24%) of the same patients at antrum and body, but did not detected in duodenal biopsied specimens. Antral pathology results were chiefly found in active chronic gastritis. These findings strongly suggest that antrum is a primary colonization sites of C. pylori and the agent may be spread within stomach from the antrum.

國民學校 兒童들의 運動傷害 調査 : focussed on 4 districts in Kangweon province 江原道內 4個地域을 中心으로

韓相俊,金龍洙,吳壽一,朴南煥,洪寬伊,兪玉在 江原大學校附設 體育科學硏究所 1983 江原大學校附設體育科學硏究所論文集 Vol.- No.8

To suggest the basic data for a precautionary measures against sports injuries and safety educaion in Elementary school boys and girls, 1,149 boys and 1,111 girls(Total 2,260 answerers) who are 4th, 5th, 6th grade of Elementary school residing 4 districts((city, farm, fishing, and mining village) in Gang-weon province were answered on the questionair which is contents, 21 numbers of questions from Oct. 3, 1982. to Nov.3, 1982. The conclusions from gained results by analyzed data are as follows: 1. The most favorite sports Boys, Baseball and soccer Girls: Running and lope jumping Especially, boys residing in city area answered that the most favorite sports is baseball, and boys residing in the other districts answered that it is soccer. 2. The time required for carry out sports. About 85% of tatal answerer carry out sports 30min. to 1 hour per day. 3. Causes of sports injuries. Taking no notice of boys and girls carelessness and insufficiency of practice on the skill is the most. The next order, foul and a dangerous place in boys and fitness difficency in girls. 4. Situation injuries. When fall down a body toward the front was the most. During mining and collision against the other body were next order. 5. Injuried places and the weather. Out-door ground was most, the weather when injuried was clear. On the other hand, over 80% of total answere injuried season were summer and fall. 6. Sports events which caused sports injuries. Boys: Mainly soccer and baseball Girls: Running and lope jumping 7. Injuried part of the body was represented following order: ①The knee ②The ankle ③Hand and the charecteristic special features of injuries were sprain and laceration in addition, its symptom was acute form of decease. 8. treatment after injuried Boys and girls care at their home but 3.9% among total answeres who were injuried, and duration of curing was and day to 30 days. 9. A trend of experience on sports injury. 84% among total answerers in boys, and 75% among total answerers in girls. Thus it shows the experience ratis are more in boys than in girls.

초정밀 공작기계용 스핀들의 설계제작 및 특성 평가

한복수,박성환,명태식,권경우 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

Precision machining widely bases on the technology connected with machine tools, machining and others. The prototype was designed in the base of the analysis of the precision air bearing spindle which have greate influence upon the machining accuracy of the precision machine. The contents in this study are as follows. 1) Design and manufacture of the spindle system, 2) Performance test of the system. The spindle system is made of aero-static, which has the excellent rotation accuracy was designed and manufactured. As a result of the test (static vibration, dynamic vibration, spindle rotation), the air spindle system was stability. We think that this system can apply to the ultra-precision machine tools.

쇠고기의 품질차별화 전략을 위한 속성가격분석

한성일,이상영,박민수,정호근 한국농업정책학회, 한국축산경영학회 2001 농업경영정책연구 Vol.28 No.1

This article applies Hedonic price theory to estimate the attribute prices of beef. Result shows that the difference between attribute prices is dependent upon breed, quality attributes, quantity attributes in order. This indicates that current wholesale pricing reflects the grading standards very well. Also, under current beef grading system, the attribute prices clearly reflect changes in the attribute level of beef. For each farmer, quality differentiation strategy is to make a decision on which attribute level is possibly improved given breeding technology. Thus, to produce higher value-added, farmers should be able to consider their management skills from every angles prior to quality differentiation.