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Hong, Soon Auck,Jang, Si-Hyong,Oh, Mee-Hye,Kim, Sung Joon,Kang, Jin-Hyung,Hong, Sook-Hee Elsevier 2018 Pathology, research and practice Vol.214 No.3
<P>EGFR tyrosine kinase inhibitor (EGFR TKI) is approved as first-line treatment for advanced-stage EGFR mutant lung adenocarcinoma (LADC). Yes-associated protein 1 (YAP1), a main effector of the Hippo pathway, is associated with adverse prognosis and disruption of EGFR TKI modulation of non-small cell lung cancer. In this study, we demonstrated a prognostic role of YAP1 in EGFR mutant LADC and efficacy of EGFR TKI therapy. A total of 63 patients, including 41 with paired lung cancer specimens before and after EGFR TKI therapy and 22 with non-paired lung cancer specimens prior to EGFR TKI, were enrolled for examination. Expression of YAP1 protein was evaluated using immunohistochemistry. Fifteen paired cases (36.6%) with high nuclear YAP1 expression were detected in the pre-EGFR TKI LADC group and 21 paired cases (52.5%) after treatment with EGFR TKI. Nuclear YAP1 expression was significantly upregulated after EGFR TKI therapy (P=.002). Fifteen paired cases with high nuclear YAP1 expression before EGFR TKI LADCs showed poorer overall survival (OS) (P=.023) and progression-free survival (PFS) (P=.041). Among the 63 patients under study, those with high nuclear YAP1 expression before EGFR TKI showed shorter OS (P=.038) and PFS (P<.001). High nuclear YAP1 expression in cases with acquired EGFR exon 20 T790 M mutant LADCs showed poorer OS (P<.001). We demonstrated that YAP1 burden before clinical application of EGFR TKI plays a crucial role in prognosis of EGFR mutant LADC treated using EGFR TKI.</P>
박선균 ( Sun-kyun Park ),홍순억 ( Soon-auck Hong ) 국군의무사령부 2013 대한군진의학학술지 Vol.44 No.1
Objective : This study was performed to investigate the prevalence of hypertension and diabetes in naval ship repairing shop. Method : The study was conducted from March, 2012 to July, 2012, and total study participants were 1,260 male workers. To compare with general population in Korea, data from the Korean National Health and Nutrition Survey in 2010 were used and analysed together. Results : Among subjects with age ≥ 30 years, the age-standardized prevalences of prehypertension, hypertension, prediabetes, and diabetes were 52.9 % (95 % C.I. 50.1-55.7), 25.1 % (95 % C.I. 22.6-27.5), 23.9 % (95 % C.I. 21.5-26.3), and 6.7 % (95 % C.I. 5.3-8.1), respectively. Generally, age-specific prevalences of hypertensive and diabetic states were increasing as age increased except for prehypertension. Conclusion : The results show that the prevalence of prehypertension is more than a half in the subjects. The republic of Korea Navy should concentrate to improve awareness and control of prehypertension.
Der Sheng Sun,Hye Sung Won,Soon Auck Hong,Ji Hyung Hong,Heejoon Jo,Heejin Lee,Okran Kim,Myung Ah Lee,Yoon Ho Ko 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2
Background/Aims: Hyaluronic acid (HA) regulates cell adhesion, migration and proliferation in various cancers. The clinical implications of HA in resected head and neck squamous cell carcinoma have not been elucidated. We investigated the clinical significance and prognostic value of the expression of tumoral and stromal HA and its related proteins in oropharyngeal and oral cavity cancer. Methods: Resected tissues from oropharyngeal or oral cavity cancer patients undergoing surgery were analysed in tissue microarrays divided into stroma and cancer panels. The expression levels of HA, HA synthases and hyaluronidases were also assessed by immunohistochemistry. Results: A total of 160 resected oropharyngeal or oral cavity cancer tissues were analysed. Stromal HA expression was observed more frequently in human papilloma virus (HPV)-negative tumors, but other clinicopathological characteristics did not differ. In patients with HPV-negative oral cavity cancers, high stromal HA expression was associated with significantly shorter recurrence-free survival and overall survival compared with low stromal HA expression. The expression of HA in both tumors and stroma was significantly correlated with poorer outcomes than other combinations in patients with HPV-negative oral cavity cancers. However, these prognostic roles of HA were not observed in patients with HPV-negative oropharyngeal cancers. In the HPV-stratified multivariate analysis, high stromal HA expression remained an independent indicator of poor prognosis in terms of recurrence-free survival. Conclusions: High stromal HA and expression of HA in both tumors and stroma were correlated with poor prognosis in HPV-negative oral cavity cancer, but not in HPV-negative oropharyngeal cancers.