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Song Soobin,Kim Doo-Young,Oh Seon Min,Woo So-Yeun,Kim Il-joo,Kim Mun-Ock,Park Ji-Yoon,Kim Namho,Kim Hae-Young,Lee Juhee,Kim Sang Yoon,Hwang Bang Yeon,Ryu Hyung Won,Oh Sei-Ryang 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
YPL-001 is a drug substance of Pseudolysimachion rotundum var. subintegrum and has been reported to be a potent COPD inhibitor. For the first time, this study demonstrated a correlation among the iridoid constituents, antioxidants, and MUC5AC inhibition activities in P. rotundum during different growth stages (5 to 11 weeks). Single-factor extraction was used to optimize the plant extraction conditions to maximize the major iridoid constituents (70% ethanol, 40 °C, 1 h); isolated metabolites 1–6 were identified using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). The contents of each metabolite and antioxidant/MUC5AC inhibition effects were markedly changed according to the growth stages, especially for catalposide (2, 5.97 → 10.99 mg/g, 1.8-fold) and isovanillyl catapol (5, 4.42 → 20.00 mg/g, 4.5-fold), which were the predominant substances in August. Our results indicated that YPL-001 could potentially contribute to enhancing the P. rotundum value in accumulated iridoids at the growth stage and the biological effect aspects to develop industrial medicinal crops.
( Sangmin Lee ),( Soobin Joo ),( Jihyun Chae ),( Heeseong Hwang ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-
According to the IPCC (IPCC Special Report, 2018), atmospheric warming should be <2°C to avoid the most severe consequences associated with climate change. The obligation to reduce carbon by the 2050 Carbon Neutrality Declaration, added worldwide, is urgent. The Korean government is making efforts to achieve carbon neutrality by converting to eco-friendly energy and using various carbon capture methods. Among the current CO<sub>2</sub> sequestration methods, a mineral carbonation process requires less area than ocean storage or deep saline aquifer. However, mineral carbonation needs immense energy for mining and crushing ore to provide stable metal sources and alkaline solutions for fixing CO<sub>2</sub>. On the other hand, concentrated seawater has various cations like Mg<sup>2+</sup>, Ca<sup>2+</sup>, and Na<sup>+</sup>, and it is not necessary for the pretreatment of ore or industry waste like waste concrete, slag, and asbestos. In this study, the concentrated seawater is electrolyzed by membrane electrolysis at low voltage to generate a strong alkali solution and hydrogen gas. The mineral carbonation reactor was supplied by the alkali byproduct of the electrolyzed seawater and a high concentration of alkaline earth metals. To find out operation conditions for optimum mineral carbonation, the types of electrode materials, the strength of applied current density, and the flow rate of an electrolyte were investigated. The pH behavior and CO<sub>2</sub> concentration were continuously monitored by a CO<sub>2</sub> sensor and the amount of CO<sub>2</sub> reduction was calculated by integrating the time-CO<sub>2</sub> graph. In addition, precipitated metal carbonates which are formed by Mg<sup>2+</sup>, Ca<sup>2+</sup>, and Na<sup>+</sup> were analyzed by FE-SEM and EDAX for their crystal structure and morphology. An unexpected result is that precipitation occurred while electrolyzing the concentrated seawater without a CO<sub>2</sub> supply. This might be presumed to be Mg(OH)<sub>2</sub> according to FE-SEM and EDAX results. Thus, an additional step is necessary to solve the consumption of magnesium and alkalinity before mineral carbonation. This method can provide an economical carbon sequestration method that can overcome the drawbacks of classical mineral carbonation. This study proved the potential of CO<sub>2</sub> reduction and valuable precipitated metal carbonates like MgCO<sub>3</sub>, CaCO<sub>3</sub>, and NaHCO<sub>3</sub> by accelerated mineral carbonation.