일 대학병원에 입원한 노년기 양극성 장애 환자의 인구학적 및 임상적 특징

조숙현(Sook Hyun Cho),정한용(Han Yong Jung),권영준(Young Jun Kwon),이소영(So Young Lee),김양래(Yang Rae Kim),김윤정(Yun Jung Kim) 대한노인정신의학회 2006 노인정신의학 Vol.10 No.2

Objectives : As the elderly population is continuing to increase, psychiatric diseases of the elderly are becoming an important social issue. This study looks into the demographical and clinical features of the elderly patients diagnosed with bipolar disorder in a University hospital. Methods : The study subjects include patients admissioned in the closed wards of Soonchunhyang Seoul hospital and Cheonan hospital from March, 2000 to February, 2005 who met the DSM-IV-TR criteria for bipolar disorder at the time of discharge. A total of 146 patients (76 men, 70 women) medical records were studied retrospectively. Subjects older than the age of 50 at time of admission were grouped as the old age group, whereas those who were younger than 50 as the young age group. Also among the old age group, those who had the first onset of episode under the age of 50 were grouped as the early onset group, whereas those who had the first onset after the age 50 were grouped as the late onset group. Results : The number of bipolar disorder patients in the young age group and old age group were 73 and 73 respectively. The number of early onset group and late onset group were 46 and 23 respectively. The old age group had a relatively higher incidence of bipolar II disorder than the young age group. Also in the old age group there was a higher incidence of hypomanic or depressive episode rather than manic episode compared to the young age group. And in the old age group psychotic symptoms were less common and the mean admission length shorter than the young age group. Additionally in the old age group treatment with Lithium monotherapy or with no mood stabilizers at all were relatively common. Among the old age group, late onset group had a higher rate of bipolar II disorder than the early onset group. Conclusion : This study shows differences in the demographical and clinical features among different age groups. But additional research would be required to determine whether the bipolar disorders in the elderly or late onset group are actually a different type of disorder from those of the young.

Complete genome sequence of Sphingobium sp. strain PAMC 28499 reveals a potential for degrading pectin with comparative genomics approach

So‑Ra Han,Sung‑Min Jang,Young Min Chi,Byeollee Kim,정상희,Yung Mi Lee,Jun Uetake,Jun Hyuck Lee,Hyun Park,오태진 한국유전학회 2020 Genes & Genomics Vol.42 No.9

Background Spingobium sp. PAMC 28499 is isolated from the glaciers of Uganda. Uganda is a unique region where hot areas and glaciers coexist, with a variety of living creatures surviving, but the survey on them is very poor. The genetic character and complete genome information of Sphingobium strains help with environmental studies and the development of better to enzyme industry. Objective In this study, complete genome sequence of Spingobium sp. PAMC 28499 and comparative analysis of Spingobium species strains isolated from variety of the region. Methods Genome sequencingwas performed using PacBio sequel single-molecule real-time (SMRT) sequencing technology. The predicted gene sequences were functionally annotated and gene prediction was carried out using the program NCBI nonredundant database. And using dbCAN2 and KEGG data base were degradation pathway predicted and protein prediction about carbohydrate active enzymes (CAZymes). Results The genome sequence has 64.5% GC content, 4432 coding protein coding genes, 61 tRNAs, and 12 rRNA operons. Its genome encodes a simple set of metabolic pathways relevant to pectin and its predicted degradation protein an unusual distribution of CAZymes with extracellular esterases and pectate lyases. CAZyme annotation analyses revealed 165 genes related to carbohydrate active, and especially we have found GH1, GH2, GH3, GH38, GH35, GH51, GH51, GH53, GH106, GH146, CE12, PL1 and PL11 such as known pectin degradation genes from Sphingobium yanoikuiae. These results confrmed that this Sphingobium sp. strain PAMC 28499 have similar patterns to RG I pectin-degrading pathway. Conclusion In this study, isolated and sequenced the complete genome of Spingobium sp. PAMC 28499. Also, this strain has comparative genome analysis. Through the complete genome we can predict how this strain can store and produce energy in extreme environment. It can also provide bioengineered data by fnding new genes that degradation the pectin

불안 증상을 동반한 신체화 환자의 인지적 특성

나영석,정한용,권영준,이소영,박준호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.6

Objectives : Assuming that somatization closely interacts with anxiety symptoms, one might speculate that anxiety symptoms will produce the significant differences in development, course and treatment of somatization and the cause of these differences will be elucidated in the cognitive aspect. This study was performed to examine the cognitive characteristics in terms of the somatosensory amplification and the symptom interaction in patients with somatization accompanied by anxiety symptoms. Methods : The following measures were administered to subjects who had a T-score of >60 on somatization subscale of Symptom Checklist-90-Revision (SCL-90-R) : 1) Minnessota Multiphasic Personality Inventory-Korean Version (MMPI-K), 2) Somato-sensory Amplification Scale (SSAS), 3) Symptom Interpretation Questionnaire (SIQ). There was a comparison of differences in the somatosensory amplification and the symptom interpretation between the anxiety group and the non-anxiety group divided by T-score of >60 on the psychasthenia subscale of MMSE-K. Multiple regression analysis was performed to determine the effect of the differences in the somatosensory amplification and the symptom interpretation on age, sex, marital status and level of education between those two groups. Results : There was a greater amplification of sensation in the anxiety group than the non-anxiety group. The former showed a higher level of physical, psychological and catastrophic interpretation than non-anxiety group except with regard to environ-mental interpretation. Somatization was affected by somatosensory amplification and physical interpretation in both groups, as well as psychological interpretation in the anxiety group. Conelusion : Regarding the cognitive aspect, the somatosensory amplification and symptom interpretation were more severely distorted in patients accompanied by anxiety symptoms. These results suggest that a therapeutic approach based on the cognitive charactehstics is essential for the effective management of somatizer.

실신으로 발현된 기립성빈맥증후군 : 단일 기관 예비 연구

이동준,김종국,허소영 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background and Objectives : Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia without prominent hypotension in the upright position. Most of the patients experience symptoms of orthostatic intolerance such as lightheadedness, dizziness, palpitation, nausea, or headache. There were limited POTS cases presenting as syncope thus, we analyzed syncope patients who showed orthostatic tachycardia in tilt table test. Methods : A single center retrospective analysis was done for patients with POTS who developed syncope. We reviewed their clinical records and results of autonomic function tests (sympathetic skin response, heart rate variability test to hyperventilation, heart rate variability test to Valsalva maneuver, 15:30 ratio and blood pressure and heart rate response to tilt table test). Results : There were 13 patients of POTS with syncope. Mean age of onset was 22.3 (14-38) years old. Men were eight and women were five. In autonomic function tests, mean orthostatic heart rate increments were 35.2 beats per minutes (bpm). Mean maximal heart rate within 10 minutes and the time for maximal heart rate were 99.9 (87-128) bpm and 7 minutes, respectively. Mean systolic blood pressure was not changed significantly during tilt table tests but, mean diastolic blood pressure was increased as much as 14.4 (±8.0) mmHg compared with supine position. Conclusions : POTS patients who manifested assyncopal attack showed similar patterns in clinical characteristics and autonomic function tests compared with ordinary POTS reported previously. These suggest that syncope can be one of the leading features of POTS. This preliminary study suggests that structured and controlled studies about POTS and syncope are needed.

한의과대학 부속 한방병원 한방응급실 내원환자에 대한 임상적 분석

소형진,류재환,김영철,이범준 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objectives : By recording basic data of patients visiting the emergency room of the oriental medicine center, we can understand their characteristics and gain better insight about them. Methods : We performed a retrospective study of 2,674 patients who visited the emergency room of Kyunghee Oriental Medical Center, from June 1, 2006 to May 31, 2007. Results : 1. Of 2,674 total patients, the male to female ratio was 0.94:1 and the 6th decade of life was the peak age group. 2. The majorit of patients visited our emergency room between 06:00 and 24:00(midnight). 3. Most patients visited on a Saturday or Sunday. 4. By monthly distribution, the patients incrcased slightly during June, July, August and October. 5. The majority of patients visited the emergency room within 24 hours of onset. 6. The patients were categorized as follows : neurological diseases 71.15%, musculoskeletal diseases 16.02%, internal medical discase 9.04% psychiatric and related disease 3.79%. 7. The average transit time waS about 1 hour 30 minutes. 8. Admission rate was 48% and the rate of admission to the intensive care unit (ICU) was 5% of total visiting patients. Conclusion : Assuming that this research will continue adding patien's data continuously, this work will help us to understand the features of patients who visiting the emergency room of the oriental medical center.

장기저장 미곡의 성분 변화 특성

소규호,김영수,홍재식,정준영,조재민 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.4

미곡의 장기저장에 따른 이화학적 특성의 변화를 조사하여 효율적인 저장방법을 구명하기 위한 기초적 자료를 제공하기 위해 4년간 조곡상태의 미곡 50가마니를 상온 창고에서 저장하면서 성분 변화를 조사하였다. 고내 온도의 변화는 계절에 따라 35℃ 정도였다. 미곡의 수분함량은 저장기간 동안 15% 이상으로 증가한 적이 없어 비교적 안전하였으나 곡온이 18℃이상 유지되는 매년 6월부터 9월까지의 4개월 동안은 고내 습도의 상승과 함께 미질 저하를 일으킬 수 있는 저장 위험 기간이었다. 저장기간 중의 환원당, amylose 함량, 조단백의 변화를 조사한 결과 각각 입고시 0.24%, 19.23%, 7.02%에서 4년간 저장후 각각 0.5%, 20.31%, 7.46%로 증가하는 경향이었다. 저장미의 amylogram 특성을 조사한 결과 저장 기간이 길어짐에 따라 최고 점도, 최종 점도 및 setback은 입고시 각각 449B.U, 610B.U, 161B.U에서 4년 후 493B.U, 715B.U, 222B.U로 높아졌다. 반면에 Breakdown은 입고시 125B.U에서 4년 후 76B.U로 낮아졌다. 저장미의 호화응집성(gel consistency)은 입고시 44.7mm에서 4년후 39.9mm로 감소하였으며 지방산도는 입고시 4.5KOH㎎/100g에서 4년 저장후 각각 24.4KOH㎎/100g로 증가하였다. 배아율과 배아활성은 각각 97%, 100%에서 4년 후 각각 0%, 0.4%로 감소하였다. 한편 미곡에 착생한 미생물상의 변화를 조사한 결과 저장기간이 길어짐에 따라 세균 착생립수는 감소하고 곰팡이의 착생립수는 다소 증가하는 경향이었다. In order to investigate the changes of rice qualities during 4 years storage of paddy stored in warehouse of normal temperature condition. Temperature in warehouse was changed more than 30℃ under the influence of average temperature outside of a warehouse. Water content of paddy was not increased over 15%. But, as average temperature in wasehouse was gone up 18℃ from June to September every years, it was supposed that these periods were to be deterioration of rice quality. On investigation of change in paddy components during the long term storage, reducing sugar, amylose, crude protein were increased 0.24%, 19.23%, 7.02% at enterance time to 0.5%, 20.31%, 7.46% 4 years later, respectively. Max. viscosity, final visocity and set back value by amylograph were increased 449B.U, 610B.U, 161B.U to 493B.U, 715B.U, 222B.U but breakdown was decreased 125B.U to 76B.U with the increase of storage period. Gel consistency of rice stored was decreased 44.7mm at enterance time to 39.9mm 4 years later. Fatty acid was increased remarkably 4.5KOH㎎/100g to 24.4KOH㎎/100g. Germination ratio and germ activity of paddy during long-term storage were decreased 97%, 100% to 0%, 0.4%, respectively. With the increase of storage period, contaminated paddy by molds increased and its by bacteria decreased.

하지수술에서 희석된 고비중 Bupivacaine의 효과

소금영,양인호,안태훈,이준영 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Background: Although lidocaine seems to be one of the most suitable spinal anesthesias for ambulatory surgery, the safety of lidocaine spinal anesthesia has been called into question by report of both permanent and transient neurologic toxicity. The purpose of this study is to investigate the possibility of adapting the longer acting spinal bupivacaine in short duration of lower extremity operation. Methods: Forty five patient were randomly assigned to three groups for spinal anesthesia, Group Ⅰ (15㎎ bupivacaine), 3㎖ of 0.5% spinal bupivacaine in 8% dextrose; Group Ⅱ (10㎎ bupivacaine), 2㎖ of the 0.5% spinal bupivacaine +1㎖ saline; Group Ⅲ (7.5㎎ bupivacaine), 1.5㎖ of the 0.5% spinal bupivacaine +1.5㎖ saline. Dural puncture were performed at the L3-L4 with 25 gauge needle in lateral position after which the patients were turned to the supine horizontal position. We checked peak sensory level and height, time to two segment regression and S2 sensory regression via pin-prick test and motor block level by modified Bromage scale. Results: There were significantly difference with regard to peak sensory level and height, time to two segment regression and S2 regression, and motor blockade level between Group Ⅰ, Ⅱ and Group Ⅲ. Conclusions: Dilute Bupivacaine in spinal anesthesia provided the combination of adequate depth of anesthesia and rapid recovery. We conclude that 0.5% bupivacaine 7.5㎎ with normal saline 1.5㎖ is effective in spinal anesthesia for short-duration lower extremity surgery.

멸치액젓의 휘발성 향기성분에 관한 연구

차용준,박지영,장성민,김훈,김소정 창원대학교 생활과학연구소 1998 생활과학연구 Vol.- No.2

Volatile flavor components in salt-fermented anchovy sauce were analyzed by simultaneous steam distillation-solvent extraction/gas chromatography/mass spectormetry. Ninety-eight compounds were detected in sample. These compounds were composed mainly of aldehydes(13). ketones(6), alcohols(16), aromatic compounds(21), N-containing compounds(7), esters(5), S-containing compounds(5) and miscellaneous compounds(25). Among these, 3-(methythio)propanal, 2-ethyl-3.5-dimethylpyrazine, dimethyl disulfide and dimethyl trisulfide having high odor values were supposed to be playing to be a major role in the overall aroma of salt-fermented anchovy sauce.

마이크로그로브 형태에 따른 평활근 세포 운동 측정

유소영,박찬영,정석,김동익,이병붕,허세호,한동철,장준근 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.2

Purpose: The spreading, orientation, and chemotaxis the gradient of a chemoattractant of smooth muscle cells (SMCs) were studied on the micro-grooved substrata by the light, fluorescence and scanning electron microscopy. Method: Vertical-walled grooves were produced in silicon wafers by the micromachining technique. All grooves were 4~20㎛ deep and 10~80㎛ wide, SMCs were cultured on each microgroove and examined under stereo-microscope. Result: Cell clusters were markedly oriented by all the grooved substrata examined. Tim-lapse images acquired from CCD (Charge Coupled Device) showed that the grooves directed the migration of SMCs. There was no prominent difference in the migration speed of SMCs according to the grooves. All the cytoskeletal fibers were reoragnized in the same direction with grooves. Especially the alignments of microtubule and intermediate filaments were distinguished in the SMCs on the micro grooves. Conclusion: These results could be applied to the analysis of vascular restenosis and the development of artificial blood vessels.

피혁슬러지 고형화시 시멘트 혼화제의 영향

주소영,박상찬,전태성,손종렬,김태영 대한위생학회 2003 대한환경위생공학회지 Vol.18 No.4

The cement-based system among S/S(Solidification/Stabilization) is widely used to treat hazardous wastes. In this study, tannery sludge was solidified to evaluate the stabilization effects of using admixtures in the cement-based S/S. Fly ash as substitute also used to increase the strength of the S/S of hazardous waste. The compressive strength measurement and leaching experiment of chromium metal of solidified mortar were carried out to compare and evaluate the physical and chemical characteristics of solidified hazardous waste sludge. From the result of this study, there was increased of compressive strength by using AEW-3(early-hardening AE water reducing agent), and leaching concentration of chromium became low enough to satisfy the regulatory criteria. The successful solidification for the organic contaminant and heavy metal in hazardous waste should enable to treat by cement-based system using early-hardening AE water reducing admixture and fly ash as substituted cement.