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Kim, Seongseop,Park, Dae‐,Hun,Kim, Tai Hoon,Hwang, Moogak,Shim, Jaegal Blackwell Publishing Ltd 2009 The FEBS journal Vol.276 No.17
<P>Pyrimidine biosynthesis enzymes function in many cellular processes and are closely associated with pyrimidine antagonists used in cancer chemotherapy. These enzymes are well characterized from bacteria to mammals, but not in a simple metazoan. To study the pyrimidine biosynthesis pathway in <I>Caenorhabditis elegans</I>, we screened for mutants exhibiting resistance to the anticancer drug 5‐fluorouracil (5‐FU). In several strains, mutations were identified in ZK783.2, the worm homolog of human uridine phosphorylase (UP). UP is a member of the pyrimidine biosynthesis family of enzymes and is a key regulator of uridine homeostasis. <I>C.?elegans</I> UP homologous protein (UPP‐1) exhibited both uridine and thymidine phosphorylase activity <I>in vitro</I>. Knockdown of other pyrimidine biosynthesis enzyme homologs, such as uridine monophosphate kinase and uridine monophosphate synthetase, also resulted in 5‐FU resistance. Uridine monophosphate kinase and uridine monophosphate synthetase proteins are redundant, and show different, tissue‐specific expression patterns in <I>C.?elegans.</I> Whereas pyrimidine biosynthesis pathways are highly conserved between worms and humans, no human thymidine phosphorylase homolog has been identified in <I>C.?elegans.</I> UPP‐1 functions as a key regulator of the pyrimidine salvage pathway in <I>C.?elegans</I>, as mutation of <I>upp‐1</I> results in strong 5‐FU resistance.</P>
An economic impact analysis of the Korean exhibition industry
Kim, Samuel Seongseop,Chon, Kaye John WileySons, Ltd. 2009 The international journal of tourism research Vol.11 No.3
<P>This study estimates the multiplier effect of the exhibition industry. In order to calculate the exhibition industry's total expenditure, consideration is made of three major sources of expenditure including hosts, exhibitors and foreign attendees. According to the summary of the economic impact analysis, the total exhibition receipts of US$645.7 million produced US$1.2 billion in output; 21 692 full-time equivalent jobs, US$260 million in personal income for residents, US$577.4 million in value-added, US$54.2 million in indirect tax and US$104.3 million in imports. Copyright © 2008 John Wiley & Sons, Ltd.</P>
Kim, Samuel Seongseop,Kim, Miju,Park, Jungwoong,Guo, Yingzhi Routledge 2008 Asia Pacific Journal of Tourism Research Vol.13 No.3
<P> Geotourism is one among many types of ecotourism or nature tourism. Cave tourism within geotourism has gained popularity in Korea. The study's objectives include cave tourists' characteristics, segmenting them according to motivation factors, and finally identifying who they are. The sample population for this research consisted of tourists who have visited the Hwansun Cave in Samchuk City. Among a total of 547 questionnaires distributed, 537 questionnaires were used for further data analyses. On the basis of cluster analysis using the motivation factors, cluster 1 was named an “escape-seeking group”, cluster 2 was termed a “knowledge- and novelty-seeking group”, cluster 3 was called a “novelty-seeking group” and cluster 4 was termed a “socialization group”. Differences in socio-demographic variables, beliefs about cave tourism resources, preferred cave tourism products, satisfaction with this tour, willingness to participate in another cave tour and belief in the value of cave tourism resources were found among the four clusters. The study's findings were expected to be helpful in understanding who they are.</P>
Kim, Seongseop,Park, Dae-Hun,Shim, Jaegal Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.4
<P>5-Fluorouracil (5-FU), a pyrimidine antagonist, has a long history in cancer treatment. The targeted pyrimidine biosynthesis pathway includes dihydropyrimidine dehydrogenase (DPD), which converts 5-FU to an inactive metabolite, and thymidylate synthase (TS), which is a major target of 5-FU. Using Caenorhabditis elegans as a model system to study the functional and resistance mechanisms of anti-cancer drugs, we examined these two genes in order to determine the extent of molecular conservation between C. elegans and humans. Overexpression of the worm DPD and TS homologs (DPYD-1 and Y110A7A.4, respectively) suppressed germ cell death following 5-FU exposure. In addition, DPYD-1 depletion by RNAi resulted in 5-FU sensitivity, while treatment with Y110A7A.4 RNAi and 5-FU resulted in similar patterns of embryonic death. Thus, the pathway of 5-FU function appears to be highly conserved between C. elegans and humans at the molecular level.</P>
Seongseop Kim,심재갈 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.1
Pyrimidine antagonists including 5-Fluorouracil (5- FU) have been used in chemotherapy for cancer patients for over 40 years. 5-FU, especially, is a mainstay treatment for colorectal cancer. It is a pro-drug that is converted to the active drug via the nucleic acid biosynthetic pathway. The metabolites of 5-FU inhibit normal RNA and DNA function, and induce apoptosis of cancer cells. One of the major obstacles to successful chemotherapy is the resistance of cancer cells to anti-cancer drugs. Therefore, it is important to elucidate resistance mechanisms to improve the efficacy of chemotherapy. We have used C. elegans as a model system to investigate the mechanism of resistance to 5- FU, which induces germ cell death and inhibits larval development in C. elegans. We screened 5-FU resistant mutants no longer arrested as larvae by 5-FU. We obtained 18 mutants out of 72,000 F1 individuals screened, and mapped them into three complementation groups. We propose that C. elegans could be a useful model system for studying mechanisms of resistance to anti-cancer drugs.
Kim, Youngmi,Kim, Samuel Seongseop,Agrusa, Jerome Routledge 2008 Asia Pacific Journal of Tourism Research Vol.13 No.4
<P> The purpose of this study is to evaluate the factors that made the Hampyeong Butterfly Festival a success and to identify its impacts on the host community. Hitherto, most studies have focused on a festival's economic impact or the level of visitor satisfaction, which was mainly regarded as the overall satisfaction of festival participants. However, this study examines the festival's operational procedures to clarify the successful factors. In addition, this study indicates some problems the festival has experienced, as well as offering solutions through assessing the economic, socio-cultural and environmental impacts.</P>
산업용 IoT 디바이스의 배터리 수명 예측을 위한 모니터링 기술 연구
김성섭(Seongseop Kim),이승우(Seungwoo Lee),권영민(Youngmin Kwon) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.10
산업용 일차 리튬전지의 수명 예측 및 잔량 예측 기술 개발을 위해 본 논문에서는 일차 리튬전지 기반 IoT 디바이스의 상태 데이터 모니터링 기법을 제안한다. 전압, 전류, 동작 정보 등을 수집하는 모니터링 구조 설계와 함께 배터리 특성을 분석하기 위하여 계측 장비 기반의 배터리 특성 분석을 진행하였으며, 일차전지의 방전 전 급격한 상태 변화 특성을 확인할 수 있었다. 추후 연구로는 제안하는 산업용 IoT 디바이스의 배터리 모니터링 및 수집 구조를 통해 얻은 데이터를 학습에 활용하여 일차 전지의 수명 예측 및 잔량 예측기술을 진행할 예정이다.