서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

상처받은 주체의 치유, '몸'과 '세계'의 이중억압을 넘어서 : 『달력공장 공장장님 보세요』를 중심으로 본 김혜순의 시 세계

김석환,박상수 明知大學校 人文科學硏究所 2004 인문과학연구논총 Vol.26 No.-

This study seeks to investigate the interplay between 'body' and 'object' in the poetry of Kim, Hye-Soon. In Kim's poems, the body is the source of interminable existential crises and also the basis for suffering. Futthermore, the outer world that the body occupies proves to be no less an aggressive threat to the subject. In an attempt to effectively overcome this 'double oppression,' Kim foregrounds both the inner and the outer sphere affecting the body. However, in terms of the inner sphere, the wounded subject fails to overcome the limits sets by the reality principle. Likewise, in terms of te outer sphere, the attempt at the pluralization of the subject is also doomed to failure, insofar as the process f convergence back to a singular self ultimately comes into play. In the end, the yoke of multiple oppression can only be surmounted by re-establishing the relationship between the wounded subject and the external savior.

혈우병 환자에 동반된 자발성 후복막강 출혈

김광일,김동호,우상민,이석주,김홍성,조인성,윤환중,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Spontaneous retroperitoneal hemorrhage due to hemophilia A with impaired coagulopathy is very rare. Spontaneous retroperitoneal hemorrhage has been recorded as having originated from many retroperitoneal organs and blood vessels, and it may be due to local and/or systemic factors. In the majority of the patients, kidney and adrenal gland were the major site of hemorrhage. The systemic causes of spontaneous retroperitoneal hemorrhage are anticoagulation therapy and chronic hemodialysis. During the course of these treatments, hemorrhagic complications may occur at many site, including the retroperitoneal space. Blood dyscrasias including leukemia, polycythemia, sickle cell trait and hemophilia have been reported associated with spontaneous retroperitoneal hemorrhage. We report a case of spontaneous retroperitoneal hemorrhage occurred in a gemophilia A patient with brief review of literature

고삼투압성 비케톤성 상태의 예후인자

안성훈,김양원,김미란,진헌철,안지영,이상래,류석용,김홍용,김성준,이병권,김경환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: A hyperosmolar nonketotic state has been known to have a high mortality, and even now, despite this high mortality, only a few studies of this disease have been performed. We studied the prognostic factors for the hyperosmolar nonketotic state. Methods: We retrospectively studied the cases of 40 patients who were in a hypersomolar nonketotic state when admitted to Sanggye Paik Hospital during the 6-year Period from 1995 through 2000. We divided the hyperosmolar nonketotic patients into two groups, the complete recovery group and the incomplete recovery group, and compared the clinical features, the laboratory findings, and the precipitating factors between two groups. Results: 1) A total of 40 patients were studied: 24 in the complete recovery group and 16 patients in the incomplete recovery group. The mortality rate was 32.5%. 2) No significant statistical difference existed among the clinical features of the two groups, except for the sex(p<0.01). 3) Among the laboratory findings of both groups, analysis revealed that the effective osmolarity was significantly higher among those in the incomplete recovery group(p<0.01). Serum sodium concentration was also significantly higher among those in the incomplete recovery group(p<0.01). Serum creatinine was also significantly higher among those in the incomplete recovery group(p<0.05). Serum bicarbonate concentration, on the other hand, was significantly lower among those in that group(p<0.05).4) Infection was identified as the most common precipitating factor(62.5%). Among the precipitating factors of the two groups, there were significant statistical difference in pneumonia, UTI, and inappropriate glucose control. 5) A significant statistical difference existed among the initial level of consciousness of both groups(p<0.05). 6) The only significant independent factor responsible for prognosis of nonketotic hyperosmolar state patients was the sex. Conclusion: The sex was only significant independent prognostic factor of nonketotic hyperosmolar state patients.

Testosterone에 의한 승홍의 신독성 유발에 의한 연구

김회영,허근,김석환,최종원 東亞大學校 附設 生活科學硏究所 1993 생활과학연구 논문집 Vol.1 No.-

Mercuric chloride, inorganic compound, is one of the most important drugs that has been used in the field of argriculture, antisyphilitica and anticeptics, but it is not used clinically at present. We have studied the effect of testosterone on the mercuric chlorideinduced nephrotoxicity. Renal lipid peroxide concentration of male rat treated with mercuric chloride was significantly increased in comparison with that of the female rat, it showed similar effects on testosterone pretreatment. Changes in renal catalase and glutathione peroxidase activities were not siginificantly different in testosterone-treated groups. But, renal xanthine oxidase and aldehyde oxidase activities of testrosterone-treated group given mercuric chloride significantly increased in comparison with that of the testosterone-treated alone. Animals treated with testosterone prior to mercuric chloride showed more severe damage on histological observations than those treated with testosterone only. Consequently, we suggest that the mercuric chloride-induced nephrotoxicity might be renal lipid peroxide generating enzyme system by testosterone.

도라지(Platycodi Radix)Saponin이 Aldehyde Oxidase活性에 미치는 影響

金碩煥 東亞大學校附設基礎科學硏究所 1984 基礎科學硏究論文集 Vol.1 No.1

實驗動物을 使用하여 aldehyde oxidase를 精製하고 이 精製酵素에 對하여 tyrosine의 中間代謝物인 dopamine 이 미치는 影響과 dopamine과 도라지saponin 分劃을 동시에 添加하였을때의 作用을 觀察로한 成積은 다음과 같다. 1. Aldehyde oxidase活性測定에 있어서 基質인 N-methylnicotinamide의 最適濃度는 5×10? M이었다. 2. Dopamine은 本 酵素에 경쟁적 억제작용을 나타내었다. 3. Dopamine과 도라지 saponin分劃을 同時에 添加 하였을때 本 酵素活性을 20% 정도 상승시켰다. The purpose of this study was to investigate the effect of dopamine and Platycodi Radix Saponin on the hepatic aldehyde oxidase activity in rabbit liver, in virtro test. 1. Aldehyde oxidase was measured optimum substrate concentration at 3×10? M and incubation time for 10 minutes. 2. Aldehyde oxidase were inhibited by dopamine. 3. It was observed that relationship between dopamine and substrate were competitive inhibition on aldehyde oxidase. 4. Platycodi Radix butanol fraction increased the enzyme activity.

Isoniazide 투여에 의한 Catecholamine의 생체내 변동에 미치는 Pyridoxal의 영향

김석환,최종원,김동훈 慶星大學校 環境問題硏究所 1991 環境硏報 Vol.1 No.1

Isoniazide is used in the treated of TB,the treatment of vitamine B?? is required in order to prevent their associated side effect, especially peripheral neuritis and severe exrcitation. The present work was undertaken to investigate the drug interaction between INAH and pyridoxal. When effect of pyridoxamine and pyridoxine on the hepatic mitochondrial MAO activity was investigated in vivo and in vitro test, its was slightly increased. But pyridoxal was significantly increased the activity of mitochondrial MAO compared to control. pyridoxal pretreatment in INAH-treated rats led to increased hepatic MAO activity and decreased catecholamine level in serum and urine. It was also observed that VMA level in the urine was insreased significantly the pretreatment with pyridoxal compared with INAH-treated group. Consequently, it was observed that the action of detoxification by the pretreatment of pyridoxal was due to the increasment of hepatic mitochondrial MAO activity and VMA excretion.

RS 및 GIS를 이용한 지형변화분석

김용인, 이승기, 조의환, 최석근 충북대학교 건설기술연구소 2009 충북대학교 건설기술연구소 논문집 Vol.28 No.2

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Orotic acid 투여가 흰쥐의 혈청, 肝臟 및 腎臟 지질 농도에 미치는 영향

김석환,車載英,조영수 東亞大學校附設遺傳工學硏究所 1997 遺傳工學硏究 Vol.- No.4

Orotic acid 의 과잉 섭취는 지질대사의 이상으로 인한 간 장해를 야기시키는 것이 알려져있다. 특히 지방간 생성에 대하여 관심을 가지게 되어서 본 연구는 orotic acid에 의한 혈청, 腎臟및 肝臟의4 지질 농도에 미치는 영향에 대하여 검토하였다. 시판 분말 chow 식이에 orpotic acid 1% 첨가, 무첨가한 식이를 21일간 90g전후의 성장기 Spragud-Dawley 系 웅성 쥐에 급여하였다. 그 결과 orotic acid 1% 첨가 식이에서 혈청 cholesterol, triglyceride및 phospholipid 농도는 각각 5% 수준에서 유의하게 저하하였다. 肝臟의 triglyceride농도는 5% 수준에서 유의하게 저하하였다, Orotic acid 첨가 식이에서 肝臟중량은 증가한 반면 腎臟중량은 저하하였다. Orotic acid 1% 첨가한 군에서 肝臟및 腎臟의 phospholipid 조성에의 영향은 인정되지 않았으나, 腎臟의 lysophosphatidylcholine은 높은 증가율을 보였다. 肝臟 phospholipid와 비교하여 腎臟에서는 sphingomyeline phospphatidylethanolamin은 유의하게 높은 분포를 나타냈다. 腎臟 phospholipid의 지방산 조성중에서 linoleic acid(18:2)가 상승하고 arachidonic acid (20:4)가 감소하였다. It was generally known that over-ingestion of dietary orotic acid caused hepatic disorder by the lesion of fatty acid and cholesterol synthesis in rats. The present study was carried out to investigate the effects of dietary orotic acid on the lipid composition of serum. liver and kidney of rats. For the experiments rats were fed with commercialized chow powder diet in the presence or absence of 1% orotic acid. The prepared diets were fed to male rats (Sprague-Dawley strain. 90∼100g of body weight) for 21 days. According to the results, orotic acid treated group showed that each concentration of serum cholesterol, triglyceride and phospholipid was significantly decreased (p<0.05). The centration of liver triglyceride was significantly decreased (p<0.05). In the presence of 1% orotic acid, the weight of liver increased while that kidney decreased. The treatment of orotic acid seemed to have no effects on the phospholipid composition in liver and kidney, except the kidney lysophosphatidylcholine. In the comparison of the phospholipid composition between liver and kidney, the levels of sphingomyeline and phosphtidylethanolamine in the kidney were higher than those in the liver. Among the composition of fatty acid in kidney, the concentration of linoleic acid (18:2) was increased, and the concentration of arachidonic acid(20:4) was decreased with the addition of the orotic acid.