참치 뼈를 이용한 Hydroxyapatite 세라믹 복합체의 합성 및 생체 친화성(제3보) : 인공체액에서의 Hydroxyapatite 세라믹 복합체간의 결합의 전자현미경 관찰 SEM Photographs of Bonding Properties between Hydroxyapatite Ceramics Composites in the Simulated Body Fluid

김세권,최진삼,이창국,변희국,전유진,이응호,박인용 대전산업대학교 반도체기술연구소 1999 半導體技術硏究所報 Vol.1 No.-

참치 뼈에서 추출한 hydroxyapatite를 출발물질로 여러 가지 세라믹 복합체를 제조하여 인공체액에서의 hydroxyapatite 복합체간의 화학결합을 조사하였다. hydroxyapatite 복합체들은 인공체액에서 4주 후부터 화학 결합성질을 나타내었다. 결합강도는 bioglass가 가장 강하게 나타났으며, 조성에 따른 의존성은 관찰할 수 없었다. 인공체액에서 복합체들은 이들의 경계면에서 불균일 핵생성 및 성장에 의해 화학적 결합으로 이루어졌다. Chemical bonding was investigated in the simulated body fluid of several selected hydroxyapatite-containing composites. The hydroxyapatite-containing composites chemically bonded with each other in the simulated body fluid after 4 weeks. Bioglass was strongly bonded in the simulated body fluid, but bonding strength was not depended on composition. Their composite bodies were chemically bonded by heterogeneous nucleation and growth at the interfaces of the specimens in the simulated body fluid.

구순구개열환자에서 자가입자망상골을 이용한 이차성 치조골이식에 관한 임상적 연구

김종렬,진성준,조영철,표세정,변준호 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.2

Purpose : This study is conducted to evaluate the clinical success of secondary alveolar bone grafting using autogenous iliac particulate cancellous bone marrow in cleft maxilla. Materials and methods : We evaluated 107 cleft patients who had been admitted to the Dept. of Oral and Maxillofacial Surgery of Pusan National University Hospital from January 1, 1991 to January 31, 1999 and had been performed secondary alveola bone grafting with autogenous particulated cancellous bone marrow from iliac crest. Results : 1. Men were 70 and women were 37, which shows 65.4% and 34.6% and the proportion of males to females was 1.9: 1. Unilateral cases were 89(83.2%) and bilateral cases were 18(16.8%). 2, Age of bone grafting is widely distributed from 7 to 29, and the average was 13.2. 3. Success rate was 97.8% in unilateral cases, 94.4% in bilateral cases. Overall success rate was 96.7%. 4. We evaluated the bone graft contour by the percentage of bone attachment level adjacent to the alveolar cleft and the menial side showed 82.4% and the distal 87.7%. 5. The amount of notching the alveolar ridge at the grafted site through the ratio of notching length up to the most apical base to the length of proximal segment anatomic root was 0.19.

질소 및 셀레늄 분위기 열처리가 나노 입자 Cu(In, Ga) Se₂ 광흡수층의 치밀화에 미치는 영향

김기현(Kim, Ki-Hyun),안세진(Ahn, Se-Jin),전영갑(Chun, Young-Gab),박병옥(Park, Byun-Ok),윤경훈(Yoon, Kyung-Hoon) 한국신재생에너지학회 2005 한국신재생에너지학회 학술대회논문집 Vol.2005 No.06

나노 입자 분무 기법을 이용한 Cu(In,;Ga)Se₂ (CIGS) 광흡수층 제조 기법은 고진공 장치를 사용하지 않는다는 점에서 대면적 저가형 CIGS 태양전지 양산에 적합한 차세대 기술로 인식되고 있다. 그러나 일반적으로 스프레이 된 상태의 CIGS충 자체는 태양전지 제조에 적합하지 않은데 이는 스프레이 막의 다공성 구조 때문이다. 본 연구에서는 나노입자 분무 기법을 이용하여 증착한 CIGS 광흡수층막을 질소 또는 셀레늄 분위기에서 열처리함으로써 태양전지 제조에 적합한 치밀한 구조의 CIGS 광흡수충을 제조하고자 하였다. 실험 결과, 질소 분위기 500?C의 온도에서 1시간 열처리하여도 CIGS 나노 입자의 성장은 거의 일어나지 않는 것으로 나타났다. 반면 셀레늄 분위기 500?C의 온도에서 30분 열처리시 입자 크기가 1{mu}m이상인 치밀한 광흡수층을 얻을 수 있었다. 본 결과는 CIGS 나노 입자의 입자 성장 반응에서 열에너지 단독에 의한 표면 에너지 감소 효과는 미미하며 셀레늄 증기의 역할이 더욱 크다는 것을 의미하는 것이다.

간경변증 환자의 정신과적 특성 및 아임상적 간성뇌병증 진단을 위한 연구 : 인지기능 및 유발전위를 중심으로 Cognitive Functions and Evoked Potentials

유승호,이소영,김진세,변관수,정인과 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 본 연구는 명백한 간성뇌병증이 없는 간경변증 환자에서 불안, 우울기분 및 삶의 질 등 정신과적 특징과 신경심리학적인 결손의 양상을 밝히기 위해서 고안되었다. 그리고 아임상적 간성뇌병증의 평가에서 체성감각 유발전위 검사의 역할을 연구하고자 하였다. 방 법 : 간경변증으로 진단된 41명의 환자군과 정상 대조군 31명을 대상으로 하였다. 이들에서 우울기분 및 불안을 평가하기 위해 Beck Depression Inventory와 State & Trait Anxiety Inventory를 시행하였고 삶의 질의 평가를 위해 Health-related Quality of Life Questionnaire를 시행하였다. 또한 어휘검사, 숫자외우기 검사, 토막짜기 검사, 숫자기호 바꿔쓰기 검사 및 선로잇기 검사 A와 B 등 간단하지만 포괄적인 인지기능검사를 시행하였다. 또한 41명의 환자군 중에서 인지기능검사 결과에 의거하여 분류된 13명의 아임상적 간성뇌병증군(SHE군)과 11명의 아임상적 간성뇌병증이 아닌 간경변증 환자군(non-SHE군) 그리고 8명의 정상 대조군에서 체성감각 유발전위를 측정하였다. 결 과 : 간경변증 환자는 정상인에 비해서 우울기분과 특성불안이 유의하게 증가하였다. 또한 건강과 관련된 일상생활의 삶의 질의 수준이 정상인보다 저하되었고, 특히 주의력과 각성이 요구되는 행동에서 수행이 저하되었다. 또한, 간경변증 환자는 숫자기호 바꿔쓰기 검사와 선로잇기 검사에서 정상 대조군보다 저하된 수행을 나타내었다. 또한 이러한 인지기능검사를 통해서 진단한 아임상적 간성뇌병증군에서 6개월 추적조사를 하였을 때, 명백한 간성뇌병증의 빈도가 아임상적 간성뇌병증이 아닌 군보다 유의하게 높았다. 체성감각 유발전위 소견은 N65 잠복기와 N20-N65 IPL의 경우 SHE군, non-SHE군 및 정상 대조군 사이의 유의한 차이가 있었다. 특히 N65는 SHE군만이 정상 대조군과 유의한 차이가 있었고 N95는 숫자기호 바꿔쓰기 검사 및 선로잇기 검사 A와 유의한 상관관계가 있었다. 결 론 : 간경변증 환자에게 우울 및 불안 등 정서적인 어려움에 대한 실제적인 관리 및 삶의 질을 높일 수 있는 치료적 접근이 고려되어야 하겠다. 또한 숫자기호 바꿔쓰기 검사와 선로잇기 검사가 아임상적 간성뇌병증의 조기 진단에 민감하고 유용한 도구로 생각되어 간경변증 환자에서 정례적으로 적용시키는 것이 간경변증 환자의 관리에 도움을 줄 수 있을 것으로 생각된다. 마지막으로, 본 연구에서의 체성감각 유발전위 소견은 간경변증 환자에서 아임상적 간성뇌병증 환자의 진단 및 연구에 중요한 의미를 지닌다고 생각된다. Objectives : This study was designed to elucidate the psychiatric characteristics and nature of the neuropsychological deficits associated with subclinical hepatic encephalopathy(SHE) in patients with non-alcoholic liver cirrhosis. And also the authors prospectively studied the role of somatosensory evoked potentials(SEP) in the assessment of SHE. Methods : Beck Depression Inventory(BDI) for measuring depression, State Trait Anxiety Inventory(STAI) for measuring anxiety, and Health-related Quality of Questionnaire(HQLQ) for measuring quality of life were administered the 41 non-encephalopathic liver cirrhosis patients(NELC) group and 31 carefully matched normal controls. And a prospective study to compare the performance of NELC group and normal controls on a short but comprehensive cognitive tests was conducted. After several cognitive, NELC group was divided into two groups, SHE group and non-SHE group by results of digit symbol substitution test(DSST) and/or trail making test(TMT) A and B. And then median nerve evoked cortical responses in 13 SHE patients group, 11 non-SHE patients group, and 8 normal controls were recorded for latencies of N13, P16, N20, P25, N30, P45, N65, and P95. And also responses for N13-N20 interpeak latency(IPL) and N20-N65 IPL were recorded. Results : There were significant differences between the NELC group and normal controls on BDI, trait anxiety scales in STAI, and almost all HQLQ except for the cognitive function, social interaction and life satisfaction(p<0.05). The NELC group exhibited poor performance in DSST, TMT A and TMT B compared with normal controls(p<0.05). As 17 NELC patients had abnormal cognitive test results, 41.5% of cirrhotic patients had SHE. In SEP assessment, NELC group with SHE and without SHE had higher N20-N65 IPL and only NELC group with SHE had higher N65 latency compared with normal controls(p<0.05). Conclusion : This study suggests that the patients with liver cirrhosis exhibit relatively selective deficits in complex attentional and fine motor skills, with preservation of general intellectual ability, memory, language and visuospatial perception. DSST, TMT A and TMT B seem to be useful screening tests for the detection of SHE. And also it is expected that late components and N20-N65 IPLs of SEP are helpful in the assessment of SHE.

당뇨병성 케톤산증으로 발현된 갈색세포종 1예

( Se Jin Byun ),( Ki Hyun Park ),( Yoon Jung Lee ),( Ji Hoon Kim ) 대한내과학회 2012 대한내과학회 추계학술발표논문집 Vol.2012 No.1

Small biopsy from area of Hutchinson’s sign : useful for the diagnosis of subungual melanoma in situ

( Se Jin Oh ),( Young Hwan Choi ),( Hyun Jeong Byun ),( Seung Hwan Oh ),( Se-won Park ),( Ji-hye Park ),( Jong Hee Lee ),( Joo-heung Lee ),( Jun-mo Yang ),( Dong-youn Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Although nail matrix biopsy is recommended to diagnose subungual melanoma (SUM), it is technically demanding and has potential for complication including permanent nail dystrophy. Small biopsy from area of Hutchinson’s sign (HS), an important clinical clue for the diagnosis of SUM, is thought to provide adequate samples and less invasive than nail matrix biopsy. Objectives: We investigated the diagnostic value of small biopsy of HS in SUM in situ patients. Methods: We retrospectively evaluated 9 patients who were diagnosed as SUM in situ and underwent punch biopsy at HS area. Clinical features as well as histopathological findings at HS area were analyzed. Results: All patients had finger lesions and the most common area was the thumb (40%). HS was mostly seen in the hyponychium (90%), and only one case was seen in the proximal nail fold (10%). Histopathologically, all cases showed irregularly scattered atypical melanocytes. The size of the nucleus varied from small to large, and Focal pagetoid spread was observed in 6 cases. A confluent pattern of atypical melanocytes was observed in 4 cases. Three dermatologists reviewed the slides, and 8 out of 10 cases had no difficulty in diagnosing melanoma. The remaining two cases showed subtle changes which were not sufficient for the diagnosis for SUM in situ. Conclusion: When approaching longitudinal melanonychia, we suggest that small biopsy at HS area is less invasive and useful procedure that can be selectively performed first.

Flavonoids from <i>Machilus japonica</i> Stems and Their Inhibitory Effects on LDL Oxidation

Joo, Se-Jin,Park, Hee-Jung,Park, Ji-Hae,Cho, Jin-Gyeong,Kang, Ji-Hyun,Jeong, Tae-Sook,Kang, Hee Cheol,Lee, Dae-Young,Kim, Hack-Soo,Byun, Sang-Yo,Baek, Nam-In MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.9

<P>Stems of <I>Machilus japonica</I> were extracted with 80% aqueous methanol (MeOH) and the concentrated extract was successively extracted with ethyl acetate (EtOAc), normal butanol (<I>n</I>-BuOH), and water. Six flavonoids were isolated from the EtOAc fraction: (+)-taxifolin, afzelin, (−)-epicatechin, 5,3'-di-<I>O</I>-methyl-(−)-epicatechin, 5,7,3'-tri-<I>O</I>-methyl-(−)-epicatechin, and 5,7-di-<I>O</I>-methyl-3',4'-methylenedioxyflavan-3-ol. The chemical structures were identified using spectroscopic data including NMR, mass spectrometry and infrared spectroscopy. This is the first report of isolation of these six compounds from <I>M. japonica</I>. The compounds were evaluated for their diphenyl picryl hydrazinyl scavenging activity and inhibitory effects on low-density lipoprotein oxidation. Compounds <B>1</B> and <B>3</B>–<B>6</B> exhibited DPPH antioxidant activity equivalent with that of ascorbic acid, with half maximal inhibitory concentration (IC<SUB>50</SUB>) values of 0.16, 0.21, 0.17, 0.15 and 0.07 mM, respectively. The activity of compound <B>1</B> was similar to the positive control butylated hydroxytoluene, which had an IC<SUB>50</SUB> value of 1.9 µM, while compounds <B>3</B> and <B>5</B> showed little activity. Compounds <B>1</B>, <B>3</B>, and <B>5</B> exhibited LDL antioxidant activity with IC<SUB>50</SUB> values of 2.8, 7.1, and 4.6 µM, respectively.</P>

Large Duct Pancreatic Ductal Adenocarcinoma: A Morphological Variant of Pancreatic Ductal Adenocarcinoma With Distinct CT and MRI Characteristics

Choi Se Jin,Kim Sung Joo,Kim Dong Wook,Lee Seung Soo,Hong Seung-Mo,Kim Kyung Won,Kim Jin Hee,Kim Hyoung Jung,Byun Jae Ho 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.12

Objective: To investigate the imaging characteristics of large duct pancreatic ductal adenocarcinoma (LD-PDAC) on computed tomography (CT) and magnetic resonance imaging (MRI). Materials and Methods: Thirty-five patients with LD-PDAC (63.2 ± 9.7 years) were retrospectively evaluated. Tumor morphology on CT and MRI (predominantly solid mass vs. solid mass with prominent cysts vs. predominantly cystic mass) was evaluated. Additionally, the visibility, quantity, shape (oval vs. branching vs. irregular), and MRI signal intensity of neoplastic cysts within the LD-PDAC were investigated. The radiological diagnoses rendered for LD-PDAC in radiology reports were reviewed. Results: LD-PDAC was more commonly observed as a solid mass with prominent cysts (45.7% [16/35] on CT and 37.1% [13/35] on MRI) or a predominantly cystic mass (20.0% [7/35] on CT and 40.0% [14/35] on MRI) and less commonly as a predominantly solid mass on CT (34.3% [12/35]) and MRI (22.9% [8/35]). The tumor morphology on imaging was significantly associated with the size of the cancer gland on histopathological examination (P = 0.020 [CT] and 0.013 [MRI]). Neoplastic cysts were visible in 88.6% (31/35) and 91.4% (32/35) of the LD-PDAC cases on CT and MRI, respectively. The cysts appeared as branching (51.6% [16/35] on CT and 59.4% [19/35] on MRI) or oval shapes (45.2% [14/35] on CT and 31.2% [10/35] on MRI) with fluid-like MRI signal intensity. In the radiology reports, 10 LD-PDAC cases (28.6%) were misinterpreted as diseases other than typical PDAC, particularly intraductal papillary mucinous neoplasms. Conclusion: LD-PDAC frequently appears as a solid mass with prominent cysts or as a predominantly cystic mass on CT and MRI. Radiologists should be familiar with the imaging features of LD-PDAC to avoid misdiagnosis.

융기성 피부섬유육종의 폐전이

정세진 ( Se Jin Jung ),변민광 ( Min Kwang Byun ),정우영 ( Woo Young Chung ),박무석 ( Moo Suk Park ),강신명 ( Shin Myung Kang ),김혜령 ( Hae Ryoung Kim ),신동환 ( Dong Hwan Shin ),김세규 ( Se Kyu Kim ),장준 ( Joon Chang ),김성규 ( 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.6

Dermatofibrosarcoma protuberans (DFPS) is a locally aggressive skin tumor with a very low incidence in the general population. This tumor has a remarkable tendency to recur, However, a metastasis is rare. We report a case of DFPS with a pulmonary metastasis in 28-year-old man. The pulmonary metastasis developed 5 years after a complete resection of the primary skin tumor. We reviewed the clinical manifestations and treatment of DFPS, and highlight the need for a long-term follow-up examination for metastases after a wide excision of these lesions. (Tuberc Respir Dis 2006; 61: 573-577)

급성 심부전으로 발현된 상장간막 동맥 혈전증 1예

변세진 ( Se Jin Byun ),강은규 ( Eun Kyu Kang ),박서화 ( Seo Hwa Park ),정현숙 ( Hyun Sook Jung ),윤성보 ( Seong Bo Yoon ),김영우 ( Yong Woo Kim ) 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.2

Acute thromboembolic occlusion of the superior mesenteric artery (SMA) is a life-threatening condition with high mortality, and the lack of accurate and readily available diagnostic clues often results in delay in diagnosis and treatment. We describe the case of a 68-year-old man suffering from SMA thromboembolism presenting as acute heart failure.