여름에 비정형 폐렴으로 발현한 쯔쯔가무시병 1예

박상돈,정문현,이혜명,김미경,강재승 대한감염학회 2008 감염과 화학요법 Vol.40 No.4

Scrub typhus usually occurs in October and November in Korea. Its typical clinical manifestations are fever, rash, eschar, and lymphadenopathies. Pneumonitis may occur, however it occurs as a complication at the late phase of scrub typhus, when it is inappropriately treated. We encountered a case of pneumonitis that was an initial manifestation of scrub typhus which was confirmed by rickettsial culture, Positive seroconversion, and polymerase chain reaction. The case was a 16-year-old high school adolescent who presented with fever and headache that lasted for 1 day in July, 2007, He denied of any outdoor activities. A chest radiograph showed patchy infiltrates in the left lower lung, which improved with the administration of cefotaxime and azithromycin for empirical treatment of community-acquired pneumonia. Blood taken on the second febrile day showed a positive culture for Orientia tsutsugamushi and was also positive for O. tsutsugamushi DNA polymerase chain reaction. Immunofluorescent antibody (IFA) test for O. tsutsugamushi showed that the initial antibody was negative, but convalescent serum tested positive with an antibody titer of 1:80. IFA for Coxiella burnetii showed false positive results; the initial IgM and IgG liters were 1:128 and 1:256, respectively, and the IgM and IgG titers in convalescent serum were 1:128 and 1:128, respectively.

추간판 내 스테로이드 주입에 의한추간판의 조직학적 변화

고현윤,신용범,박재흥,설미영 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.2

Hi-Lite^(R)를 이용한 상악 변색치의 표백술

박현식,정진호,김수미 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1

In a culture in which appearance is of paramount importance, patient's desire, and often need(for social, psychological, and sometimes professional reasons), reduction of discoloration caused by aging or stains. More than a century of experience has shown bleaching to be a effective treatment for the conditions of fluorosis, tetracycline staining, acquired external and internal discotorations. darkening that can result from defective endodontic therapy, and similar less-frequently seen problem. While bleaching used alone is often the sole treatment of choice, it also can be utilized effectively in conjunction with composite resin bonding and veneering, porcelain laminate veneers, and other treatment modalities to brighten a whole smile. The versatility of the system, along with the increasing interest of the public and the increasing technical ability of dentists to lighten stained or discolored teeth, has made bleaching an increasingly common part of conservative and general dental practice. However, although the clinician must be mindful of the patient's desires for a favorable cosmetic result, materials and techniques must be carefully selected. This article Presents a systematic approach for evaluation and treatment of patient with anterior discoloration. Clinical cases illustrated the spectrum of clinical techniques, including the use of Hi-Lite vital bleaching.

일개 병원 간호사의 암환자 통증관리에 대한 지식과 태도 : A Survey from Korean Cancer Pain Management Project

박현애,고명자,이현숙,김영미,김문숙 성인간호학회 2003 성인간호학회지 Vol.15 No.2

This study was conducted to examine the nurses’ knowledge about and attitude toward cancer pain management. Method: Study subjects of this retrospective cross-sectional survey study were 343 nurses sampled conveniently in a tertiary teaching hospital in Seoul. Seven measurement tools were used to collect data on demographic data, knowledge about and attitude toward cancer pain management, barrier to cancer pain management, knowledge about and concerns for the opioid use, and professional education of cancer pain management. Result: Nurses showed knowledge deficient when their knowledge on the cancer pain management and the opiod use was evaluated using two case scenarios and the 15-item questionnaire respectively. Ninety-five percent of the nurses believe that cancer pain management it a major problem. However, inadequate staff knowledge of pain management was rated as the single most important barrier to adequate pain management by 20.4% of nurses. Only 10.9% and 23.2% of the nurses replied that nursing school’s education and professional education in cancer pain management respectively, were adequate. Conclusion: This study confirms the existence of knowledge deficits and attitudinal barriers among Korean nurses that can impede cancer pain management. This study suggests a need for professional education for nurses on cancer pain management.

현행 고등학교 중국어 교과서에 게재된 사진의 문화적 고찰

朴現圭,陳秀美,柳知惠,金善兒 한국중국문화학회 2001 中國學論叢 Vol.12 No.-

自從1992年8月, 韓中兩國建交以后, 在外交·商務·文化交流1留學·旅游等各個方面都得到了蓬勃的發展. 爲了順應這一國際潮流, 最重要駒就是語言能力. 因此, 敎育部的敎育課程也增大了對中國語敎育的關心, 事實上在高中敎育中, 將中國語選爲第二外國語的比率呈逐漸增加的縕勢. 在外國語敎育中, 作爲基本的敎材的作用不僅在外國語敎育方面, 而且還注重于對使用相應語言的國家和民族的文化進行理解. 因此, 最近爲了在中國語敎育課程中也强化有關中國文化敎育的重要性, 在敎材課文中直接載入中國文化以及韓中兩國文化之뇌較等內容, 而且在敎材中還附加照片和揷鬪資料, 幷行視覺敎育 通過這-方法, 學生在首次接觸中國語敎材時, 通過封面和封面內的照片, 以及本文中的據獨照片, 可以更加准確地把握何霜中國的形象和文化.本論文正是着眼于這-點, 選擇第雌騙驗育課程中被選定的一般高中現行中國語敎材共5冊, 以其中所登載的照片爲對象進行分析. 同時分析內容還包括, 讀些照片對于學生來說, 在了解中國文化方面如何有效地傳達知識, 在增進理解方面會起到多大作用, 幷旦對這里所存在的間題進行討論, 探求合理的改善方案. 書本是內容的充實也固然重要, 但外部的設計以及附加照片 1 揷圖等視覺效果也不容忽視, 具有同等的重要性. 一般的書籍如此, 而作爲敎材來講, 在增進學習效果方面, 這種視覺效果更重要. 本論文雖然以對現行中國語敎材中所收錄駒部分照片爲進行了分析, 但在誤計彧圖片部分也可作與沈相同約結論. 2002年敎育課程的轉換時機卽將來臨, 中國語敎材也重新進拒了改編. 希望今盾被改編的中國語敎材將對本論文中所提及的問題進行改善, 對書中的每一張照片都進行愼重的選擇, 從而可使學習中國語的學生更加准確多方面地了解中國文化. 爲了對這些間題進行改善, 筆者認爲敎育當局應該投入更多的關心, 幷在制度上予以充分的協助.

한국인 혈관성 치매환자에서 아포지단백 E ε4 대립유전자형의 발현빈도

강현욱,박미영 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: The clinical significance of the apolipoprotein E (Apo E) ε4 allele in vascular dementia (VaD) has been a subject of debate. VaD is the most common subtype of dementia in Korean population. Apo E allele frequencies were evaluated in Korean patients with VaD diagnosed by the Erkinjuntti criteria of subcortical vascular dementia and mini-mental-state examination(MMSE) in this study Methods: Forty patients participated in the study. 20 patients with VaD and 20 controls with no risk factors for stroke who had absolutely normal brain MRI findings The Apo E genotype was determined by the polymerase chain reaction (PCR) and allele specific hybridization using the Apo E typing test kit Results: The Apo E ε4 allele frequency in the VaD group was 20% and was not significantly different from those of normal controls (15%) The severity of dementia assessed by K-MMSE was not different between the VaD patients with Apo E ε4 allele and the VaD patients without Apo E ε4 allele Conclusions: These results did not show neither increased frequency of Apo E ε4 allele in Korean VaD patients, nor any differences in trends compared to control subjects.

당뇨환자에서 비케톤성 고혈당에 동반하여 나타난 전신성 무도병 1예

신현란,김지훈,박미영 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2

Even thoght the nonketotic hyperglycemia is a metabolic disorder, it complicates hemichorea-hemiballism rarely. Moreover, generalized chorea-ballism associated with nonketotic hyperglycemia in diabetes mellitus is very rare, so has not been reported in Korean literature. Although the precise pathophysiologic mechanisms of these disorders are still poorly understood, deficiency of gamma aminobutyric acid (GABA) in nonketotic hyperglycemia or reduced GABAnergic inhibition by striatal lesion may increase inhibitory output to subthalamic nucleus. These result loss of pallidal inhibition and produce contralateral hemichorea-hemiballism. The striatal lesions, such as transient ischemia with reactive astrocytosis or small amount of petechial hemorrhage, are related with changes of magnetic resonance image (MRI) findings presumably. We report a diabetic old woman who developed generalized chorea-ballismus as a very rare complication of nonketotic hyperglycemia. Her brain MRI showed high signal intensity in left lentiform nucleus and right pallidum on T1 weighted images and low signal intensity in bilateral putamen on T2 weighted images with highly enhanced corresponding lesions on T1 weighted enhancement images.

Dimethyl-β-Cyclodextrin을 이용한 Omeprazole의 대체투여경로 개발

정미분,박승현,김하형,이광표 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

For the purpose of increaing the stability and bioavailability of omeprazole(OME), inclusion complexes of OME with demethyl-β-cycoldextrin(DMβCD) and hydroxypropyl-β-cyclodextrin(HPβCD) were prepared by freeze drying method. The interactions of OME with DMβCD and HPβCD in aqueous solutions and in solid states were investigated by solubility study. IR spectroscopy and DSC. The type of OME-DMβCD inclusion complex was found to be classified as Bs-type on phase solubility diagram, and the stoichiometric ratio of OME-DMβCD incousion complex was a 1:2 and stability constant was 359.46M^-1. The OME-HPβCD inclusion complex appeare to be AL type. The stoichiometric ratio was found to be 1:1, and stability constant was 34M^-1. Clear differences in a IR spectra and DSC curves were observed between the inclusion complex formation at pH 6.8. The mean dissolution time(MDT). which represents the degree of the rapidity of dissolution rate, was increased in the order of OME-DMβCD I.C(0.60) < OME-HPβCD I.C.(0.71) < OME-DMβCD P.M.(7.23) < OME-HPβCD P.M.(10.06). In order to compare simultaneously the intrinsic absorptivity of OME in the jejunum and nasal cavity of rats, the in situ nasal and jejunal perfusion method was employed as a new trial. The in situ recirculation study revealed that OME-CDs inclusion complexes rate proportionally increased the absorption of OME in nasal cavity(N) and the jejunum(J) of rats. The decreasing order of apparent OME permeability(Papp:cm/sec×10-5), corrected for surface area of absorption was as follows : 8.77±0.18(N, OME-DMβCD). > 5.97±0.17(N. OME-HPβCD) > 4.84±0.02(J. OME-DMβCD). 3.50±0.25(J. OME-HPβCD) at IPB pH 7.4. The present results suggest that OME-DMβCD inclusion complex may serve as a potential means for the nasal delivery of OME.

식이 섬유질의 첨가가 성인여자의 칼슘과 철분대사에 미치는 영향

이현옥,박미경 中央大學校 家庭文化硏究所 1995 가정문화논총 Vol.9 No.-

This study was carried out to investigate the effect of addition of dietary fiber in the daily diet on the calcium and iron metabolism in healthy young woman. The subjects were equally divided into control group(CG) and fiber group(FG) that consisted on six healthy, woman student of 19 to 24 years of age. The 12-day study was conducted on a 6-day equilibration period and 6-day experiment period(fiber intake:CG 9.4g, FG 21.1g). Except for fiber supplement the daily diet and nutrient intake of the subjects were approximately the recommended dietary allowances during both periods without significant differences. For experiment period there was no siginificant difference between CG(Ca:53%, Fe:29%) and FG(Ca:57%, Fe:44%) of fecal excretion rate of calcium, iron. The excretions of calcium, iron in the urine were not significantly different between groups. Mean calcium and iron level in serum was not significantly different between in FG and CG. This study shows that supplement of 12g fiber in the daily diet did not influence on calcium and iron excretion from fecal and urine and also on the serum calcium and iron level.

에폭시/TETA계의 경화 및 물성 연구

홍진후,박미영,김현경 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.2

The curing of diglycidyl ether of bisphenol A (DGEBA) with triethyl-enetetramine (TETA) under controlled thermal conditions was discussed. A real-time FT-IR ATR was employed to determine crosslinking reactions and degree of cure. Infrared 914cm^(-1) band was used to monitor the conversion of the reactions. To measure the thermal mechanical properties of the various systems, DMTA was employed. Results of ATR and DMTA data show that optimum TETA/DGEBA ratio was about 0.1. When the ratio was higer than 0.1. a phase separation was occurred with short pot life. It is demonstrated that real-time FT-IR ATR is powerful technique to better understand the formulation-process-property relationship of the Epoxy ITETA system.