Astragalin Inhibits Allergic Inflammation and Airway Thickening in Ovalbumin-Challenged Mice

Kim, Yun-Ho,Choi, Yean-Jung,Kang, Min-Kyung,Park, Sin-Hye,Antika, Lucia Dwi,Lee, Eun-Jung,Kim, Dong Yeon,Kang, Young-Hee American Chemical Society 2017 Journal of agricultural and food chemistry Vol.65 No.4

<P>Lung inflammation and oxidative stress are the major contributors to the development of obstructive pulmonary diseases. Macrophages are involved in pulmonary inflammation and alveolar damage in emphysema. Astragalin is an anti-inflammatory flavonoid present in persimmon leaves and green tea seeds. This study elucidated that astragalin inhibited inflammatory cell infiltration induced by 20 mu M H2O2 and blocked airway thickening and alveolar emphysema induced by 20 pig of ovalbumin (OVA) in mice. OVA induced mouse pulmonary MCP-1, and H2O2 enhanced the expression of MCP-1/ICAM-1/ccv integrin in bronchial airway epithelial BEAS-2B cells. Such induction was inhibited by supplying 10-20 mg/kg of astragalin to OVA-challenged mice and 1-20 mu M astragalin to oxidant-stimulated cells. Oral administration of 20 mg/kg of astragalin reduced the induction of F4/80/CD68/CD11b in airways of mice challenged with OVA. Additionally, emphysema tissue damage was observed in OVA-exposed alveoli. Mast cell recruitment in the airway subepithelium was blocked by supplementing astragalin to OVA-challenged mice. Orally treating 20 mg/kg of astragalin reduced alpha-SMA. induction in inflammation-occurring airways and appeared to reverse airway thickening and constriction induced by an OVA episode. These results revealed that astragalin may improve airway thickening and alveolar destruction with blockade of allergic inflammation in airways. Therefore, astragalin may be a therapeutic agent antagonizing asthma and obstructive pulmonary diseases.</P>

Host–guest sensing by calixarenes on the surfaces

Kim, Hyun Jung,Lee, Min Hee,Mutihac, Lucia,Vicens, Jacques,Kim, Jong Seung The Royal Society of Chemistry 2012 Chemical Society reviews Vol.41 No.3

<P>The present <I>critical review</I> reports on recent developments of optical nanoparticles based on the association of gold, silver, silica and quantum dots and calixarenes. These hybrid organic–inorganic compounds characterized by a thick organic layer self-assembled on the surface of a core of mineral surface atoms take advantage of the supramolecular recognition of luminescent calixarenes to fabricate nanodevices of nanoparticle size, capable of detecting metal cations, polyaromatic hydrocarbons and pesticides. Also presented is an explanation of the involvement of such nanoparticles in biochemical systems. This <I>critical review</I> provides an overview of their preparation, the manner in which they are characterized, and their use (108 references).</P> <P>Graphic Abstract</P><P>Host–guest interaction leading to the formation of a complex between calixarene functionalized nanoparticles and different substrates has been highlighted. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cs15169j'> </P>

Crosslinked Solid Polymer Electrolytes Based on Renewable Natural Gallic Acid for Lithium Ion Batteries Using Thiol-ene Click Reaction

Lucia Kim,Jimin Shim,Jong-Chan Lee 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

The effect of neutral-surface iron oxide nanoparticles on cellular uptake and signaling pathways

Kim, Eunjoo,Kim, Joon Mee,Kim, Lucia,Choi, Suk Jin,Park, In Suh,Han, Jee Young,Chu, Young Chae,Choi, Eun Sook,Na, Kun,Hong, Soon-Sun Dove Medical Press 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-

<P>In recent years, iron oxide nanoparticles (IONPs) have been applied widely to biomedical fields. However, the relationship between the physicochemical properties of IONPs and their biological behavior is not fully understood yet. We prepared 3-methacryloxypropyltrimethoxysilane (MPS)-coated IONPs, which have a neutral hydrophobic surface, and compared their biological behavior to that of Resovist (ferucarbotran), a commercialized IONP formulation modified with carboxymethyl dextran. The rate of MPS-IONP uptake by human aortic endothelial cells (HAoECs) was higher than ferucarbotran uptake, indicating that the neutral hydrophobic nature of MPS-IONPs allowed them to be absorbed more readily through the plasma membrane. However, the signaling pathways activated by MPS-IONPs and ferucarbotran were comparable, suggesting that surface charge is not a key factor for inducing changes in HAoECs. In vivo fate analysis showed that MPS-IONPs accumulated for longer periods in tissues than hydrophilic ferucarbotran. These findings could enlarge our understanding of NP behavior for advanced applications in the biomedical field.</P>

The ethnic difference of the prevalence of SfaN polymorphism in the nonsyndromic cleft palate

Kim, Myung-Hee,Nahm, Dong-Seok,Horatiu Rotaru,Lucia Hurubeanu,Choi, Je-Yong,Chae, Chang-Hoon,Kim, Seong-Gon 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.3

비증후군성 구순구개열은 가장 빈도가 높은 선천성 기형 중의 하나로 특히 한국이나 일본과 같은 극동 지방에서 높은 발생율을 보이고 동유럽에서는 드물게 보고되고 있다. 이러한 인종에 따른 차이는 이 질환에 유전적인 배경이 있음을 의미한다. 본 연구의 목적은 한국인의 비증후군성 구개열과 연관이 있다고 알려진 SfaN1 단일 염기 다형성증의 발현빈도가 한국인 구개열 가족과 루마니아 구순구개열 가족 사이에 통계적으로 유의할만한 차이가 있는지를 알아보기 위하여 시행하였다. 한국인 26가족과 루마니아 18가족을 대상으로 하였다. 전체 인원수는 한국인의 경우 78명이었고 루마니아의 경우 41명이었다. 유전자 서열분석에 사용된 샘플은 각 참여자의 혈액이나 타액을 채취하여 분석하였다. SfaN1 단일 염기 다형 성증은 TCF-β3 유전자의 5번 인트론에서 관찰된다 (A18141G). 결과를 보면 한국인과 루마니아인의 비증후군성 구개열 가족 사이에는 통계적으로 유의할만한 차이가 인지되었다. 전체 샘플 중에서 AA allele는 한국인에서는 18명 (23.1%)이었으나 루마니아는 27명 (65.9%)이었다. AS allele는 한국인에서는 27명 (34.6%)이었으나 루마니아에서는 13명 (31.7%)이었다. GG allele는 한국인에서는 33명 (42.3%)이었으나 루마니아에서는 1명 (2.4%)이었다. 두 집단 사이의 차이는 통계적으로 유의하였다 (p<0.001). 결론적으로 한국인과 루마니아인의 비증후군성 구개열 가족 사이에 SfaN1 단일 염기 다형성증의 발현빈도는 한국인에서 통계적으로 유의할만하게 높게 나타났으며, 이는 한국에서 루마니아보다 비증후군성 구개열의 빈도가 높게 나타나는 현상을 부분적으로 설명하여 주는 것으로 사료된다. Nonsyndromic cleft lip and/or palate (NSCLP) is one of the most common congenital deformities and its prevalence in Far East Asia, such as within Korean and Japanese populations, is relatively high. However, in the eastern part of Europe, clefts are relatively rare situations. These ethnic differences infer a genetic background of the disease. The objective of this study was to compare the frequency of single nucleotide polymorphism (SNP) in TGF-β3 between Korean and Romanian cleft families. Korean cleft families samples were collected from twenty-six families (n=78) and Romanian cleft families samples were collected from eighteen families (n=41). For sequencing, the blood or saliva of the subjects was sampled. A single nucleotide plolymorphism was observed in the intron 5 of TGF-β3 (A18141G). The frequency of each allele was significantly different between the Korean and Romanian samples. The AA allele was present in 18 out of 78 Korean samples (23.1%) and in 27 out of 41 Romanian samples (65.9%). The AG was present in 27 (34.6%) out of 78 Koreans and in 13 (31.7%) out of 41 Romanians. The GG was found in 33 (42.3%) Koreans and in 1 (2.4%) Romanian. The difference between the groups was significant (p<0.001). In conclusion, the frequency of observed SNP was significantly different between the two countries. SNP in TGF-β3 in the Korean population seemed to have a higher possibility of occurrence for nonsyndromic cleft palate than the Romanian population.

Overexpression of Transforming Growth Factor-beta1 in the Valvular Fibrosis of Chronic Rheumatic Heart Disease

Lucia Kim,김도균,신동환,양우익,정익모,박한기,장병철 대한의학회 2008 Journal of Korean medical science Vol.23 No.1

For the purpose of determining the pathogenic role of transforming growth factor- 1 (TGF- 1) in the mechanism of chronic rheumatic heart disease, we evaluated the expression of TGF- 1, proliferation of myofibroblasts, and changes in extracellular matrix components including collagen and proteoglycan in 30 rheumatic mitral valves and in 15 control valves. High TGF- 1 expression was identified in 21 cases (70%) of rheumatic mitral valves, whereas only 3 cases (20%) of the control group showed high TGF- 1 expression (p<0.001). Additionally, increased proliferation of myofibroblasts was observed in the rheumatic valves. High TGF- 1 expression positively correlated with the proliferation of myofibroblasts (p=0.004), valvular fibrosis (p< 0.001), inflammatory cell infiltration (p=0.004), neovascularization (p=0.007), and calcification (p<0.001) in the valvular leaflets. The ratio of proteoglycan to collagen deposition inversely correlated with TGF- 1 expression in mitral valves (p=0.040). In conclusion, an ongoing inflammatory process, the expression of TGF- 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease.

Critical Review on IT Governance Literature for IT Services and Related Research Fields

Sojung Lucia Kim(김소정) 중앙대학교 한국전자무역연구소 2015 전자무역연구 Vol.13 No.4

연구목적: 본 연구는 IT 거버넌스 연구의 핵심 연구 동향을 파악하고, 바람직한 IT 의사결정을 보장하기 위한 활동으로 정의된 IT의 본질을 이해하기 위해, IT 거버넌스 문헌 연구 및 관련 연구에 대한 문헌 연구를 수행한다. 논문구성/논리: IT 거버넌스에 대한 8개의 정의 및 7개의 문헌 연구를 도출하고 메타 분석을 수행함으로써 기존의 IT 연구동향에 대해 파악하였다. 또한 기존 문헌 연구에서는 다뤄지지 않았던 최근의 IT 거버넌스 연구의 문헌 연구를 추가로 수행함으로써 주요 연구 동향 및 향후 연구 방향을도출한다. 결과: 기존의 문헌 연구에 따르면 IT 거버넌스는 구조/프로세스, 상황/제도 관점으로 이해될 수 있다. 그러나 최근 논문에 대한 추가 문헌 연구 결과, 우리는 4개의 핵심 영역으로 구분할 수 있다고 주장한다. 성과, 의사결정에 영향을 주는 상황요인, 의사결정에 따른 성과, 그리고 IT 통제 메커니즘이다. 독창성/가치: 효과적인 전자무역 활동을 지원하기 위한, 핵심에 집중한 보다 발전적인 IT 거버넌스 연구를 위한 초석을 제공한다. Purpose: We perform a critical review on IT governance literature in order to elicit which are the IT governance research streams as well as to state why they are useful for ensuring desirable behavior for IT activities. Composition/Logic: We list eight definitions of IT governance and seven IT governance literature review papers and conduct meta analysis. We find key literature and main research streams in the previous literature review. We conduct a new literature review focusing on recent studies on IT governance. Findings: IT governance has been viewed under two dimensions which are structural/process and contingency/institution perspectives. We added newly studied research to the list of IT governance and found the main research streams may fall into 4 main issues which are performance, locus of decision making influenced by contingency factor, locus of decision making to lead performance, and IT control mechanism Originality/Value: This study may shed light on the ongoing and developed governance research, especially for E-trade and related area.

Ambidextrous Governance, Balance Tuning, and Outsourced ISD Performance: A Three Dimensional Response Surface Analysis

Sojung Lucia Kim(김소정),Seonyoung Shim(심선영) 연세대학교 경영연구소 2020 연세경영연구 Vol.57 No.2

정보시스템개발 아웃소싱 성과에 있어 계약적 거버넌스와 관계적 거버넌스는 기본적 두 거버넌스 방법론으로, 두 가지 거버넌스를 동시에 사용하는 양손잡이 거버넌스도 많이 채택되고 있다. 양손잡이 거버넌스의 경우 둘 간의 적절한 균형점을 찾는 것이 필수적으로 요구된다. 선행연구에서도 강조되었듯 두 거버넌스 간 조율을 통해 최적의 거버넌스 형태를 찾기 위한 과학적 분석이 필요하다. 우리는 두 거버넌스를 모두 채택하는 양손잡이 전략하에서 균형과 불균형 거버넌스를 개념화하고 이러한 거버넌스 형태가 정보시스템개발 성과에 미치는 영향을 다항회귀모델(polynomial regression)과 반응표면분석(response surface analysis)을 통하여 고찰하였다. 발주사와 수주사가 서로 쌍을 이룬 107건의 데이터를 수집, 분석하여 다음의 결과를 얻었다. (1) 두 거버넌스 간 균형은 정보시스템개발 성과에 긍정적이다. (2) 두 거버넌스 간 불균형은 정보시스템개발 성과에 부정적이다. (3) 두 거버넌스 간 최적의 균형점은 계약적 거버넌스에서 관계적 거버넌스로 점점 이동하며 발견된다. 이상의 결론을 바탕으로 3차원 반응표면분석을 기반의 본 연구는 그 간의 IT거버넌스 및 정보시스템개발관리 연구에 새로운 함의를 제공한다. Two basic modes of IT governance—contractual and relational, the combination of which shapes ambidextrous governance—are equally important in information systems development (ISD) outsourcing performance; thus, managing an appropriate balance between them is necessary. Past literature also argues that the governance mode should be adjusted through a systematic process; therefore, tuning for an optimal balance is critical. We set up an ambidexterity process model and conceptualize balanced and imbalanced governance. We then test the association between ambidextrous governance and ISD performance using polynomial regression and response surface methodology. Data from both client and vendor—107 dyadic matched outsourced ISD projects—show that (1) balance between the two modes is beneficial to ISD performance, (2) imbalance between the two modes is hazardous to ISD performance, and (3) the optimal balance point is found by gradually moving from contract-weighted to relation-weighted governance through a systematic process. We contribute to the research on extant IT governance and ISD project control literature by adopting three-dimensional response surface methodology and analyzing the ambidextrous nature of governance from the perspective of this novel approach.

우리나라 MRI 이용의 사회경제적 특성

김루시아 ( Lucia Kim ),문옥륜 ( Ok Ryun Moon ) 한국보건행정학회 1992 보건행정학회지 Vol.2 No.2

지식정보 구축 대가의 개발 : 국가직무표준(National Competency Standards)과의 통합 방안을 중심으로

김소정(Sojung Lucia Kim),서용원(Yong Won Seo),손영호(Young-ho Son) 한국IT서비스학회 2017 한국IT서비스학회지 Vol.16 No.3

The reference guide for the cost of establishing the digital documents has been used as a basis for establishing the budget for the construction of the knowledge information resource. However, due to the abolition of the nominal unit price notification in terms of IT projects, it is necessary to conduct research to convert the standard of the current labor force grade standard to the national incompetency standard (NCS). In this study, we investigate and revise the system and contents of the current knowledge information cost estimation model. In specific, i) we conducted gap analysis of cost estimation model and existing NCS model. As the contents conforming for the construction of the knowledge information resource were not adoptable, we define the description of the construction of the knowledge information resource and to identify the core elements of NCS prior to the improvement of the cost model. ⅱ) then we proposed improve the cost model considering integration with newly proposed NCS model for knowledge information construction job. In order to ensure the validity of the application of NCS development and cost estimation model, the experts reviewed relevant contents and made plans for improvement by using experts from supply and demand groups of various fields of national knowledge informatization projects.