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C57BL6 마우스에서 복합생약제인 황금궁의 육모 효과
허진주(Jin Joo Hue),리란(Lan Li),유설혜(Sul Hye Lyu),백인정(In Jeoung Baek),연정민(Jung Min Yon),남상윤(Sang Yoon Nam),윤영원(Young Won Yun),황석연(Seock Yeon Hwang),홍진태(Jin Tae Hong),이범준(Beom Jun Lee) 대한약학회 2005 약학회지 Vol.49 No.6
Hwanggumgung (HGG) is a hair-care product which is composed of several plant extracts used in oriental medicine. This study was carried out to investigate effect of HGG on hair regrowth in a shaving model of C57BL6 mice. Five-week-old mice were acclimated for 1 week under 23±3℃, 50±10% relative humidity, and 12h of a light/dark cycle before beginning experiment. There were four experimental groups including distilled water (D.W., control), 10% ethanol (EtOH, vehicle control), a positive control of 3% minoxidil (MXD), and HGG for female and male mice, respectively. Six-weeks old mice were trimmed by electric clippers so as not to damage the skin. The next day, mice without visible scraches were selected, randomized and separated in groups of 11 mice. The test compounds were topically treated with 0.15㎖ per mouse per day for 21 days. The hair regrowth was photographically and histologically determined during the experimental period of 21 days. Enzyme activities of γ-glutamyl transpeptidase and alkaline phosphatase were also determined using a rate assay method. There were no clinical signs in all experimental groups. The topical application of 3% MXD and HGG in female mice promoted hair regrowth earlier and faster than the control groups. In male mice, the topical application of 3% MXD and HGG also accelerated hair growth compared with the controls. Ten percent ethanol also promoted hair growth faster than D.W group. The histology of hair growth in experimental groups was strongly associated with the hair regrowth. 3% MXD and HGG promoted elongation of hair follicles compared with the controls in both female and male mice. Activities of alkaline phosphatase and γ-glutamyl transpeptidase, enzymes related to hair growth, significantly increased after treatments of 3% MXD and HGG for 2 weeks in both female and male mice (p<0.05). These results suggest that HGG has hair growth promoting activities and it can be for treatment for alopecia.
Effect of the SOOP Shampoo on Hair Growth Promotion in An Alopecia Model of C57BL/6 Mice
Lan Li, Jin-Joo Hue, Yea-Eun lee, Sul-Hye Lyu, In-Jeoung Baek, Jung-Min Yon,Sang Yoon Nam, Young Won Yun, Byeongwoo Ahn,Beom Jun Lee 충북대학교 동물의학연구소 2005 Journal of Biomedical and Translational Research Vol.6 No.2
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김금옥 ( Jin Jin-yu ),이하용 ( Ha-yong Lee ),양해술 ( Hae-sool Yang ),강배근 ( Bae-kenn Kang ),강상원 ( Sang-won Kang ),전대석 ( Dae-suk Jeon ),이주일 ( Joo-li Lee ) 한국정보처리학회 2008 한국정보처리학회 학술대회논문집 Vol.15 No.2
오늘날 전자정부는 초고속 정보통신망과 네트워크, 인터넷 기반기술을 이용한 정부간, 정부와 시민, 기업간 다양한 분야에 원활한 행정서비스를 제공하고 있다. 지금까지 일반 패키지 소프트웨어나 임베디드 소프트웨어 등에 관한 품질평가기술 개발 연구는 다양하게 진행해 왔지만 전자정부 소프트웨어에 대한 연구는 활발하지 못한 실정이다. 본 연구에서는 ISO/IEC 12119와 ISO/IEC 9126 및 ISO/IEC 14598을 기반으로 전자정부 소프트웨어의 품질요구사항을 체계화하고 전자정부 소프트웨어 품질평가를 위한 메트릭을 시험모듈 형식으로 구축하고 이를 적용하기 위한 시험표를 구축하였다.
Chang, Jae-Jin,Jeon, Su-Yeon,Song, Ji-Ye,Kim, Jin-Hee,Li, Lan,Park, Dae-Hun,Lee, Yun-Lyul,Park, Jeong-Joo,Woo, Dong-Wook,Kim, Gi-Jin,Lee, Min-Jae The Korean Society of Toxicogenomics and Toxicopro 2008 Molecular & cellular toxicology Vol.4 No.4
The X-linked inhibitor of apoptosis (XIAP) is a member of a novel family of inhibitors of apoptosis and has several BIR domains (BIR1, BIR2, and BIR3) and a carboxy-terminal RING zinc-finger. Since suppressionof apoptosis is fundamentally important for carcinogenesis and tumor growth, we investigated the expression and function of XIAP in DEN-induced carcinogenesis using rat model. Wistar rats were injected intraperitoneally with DEN at a dose of 50 mg/kg in twice a week for 12 weeks (Group II) and 16 weeks (Group III) followed by the recovery periods, respectively. The evaluation of DEN-induced carcinogenesis carried out the blood, RT-PCR, histopathological and western blot analysis. The level of blood chemistry including GOT/GPT, albumin, and total bilirubin were significantly exchanged comparing to control and Group I/Group II. The expression of albumin and collagen mRNA were significantly exchanged (P<0.05) in both groups. In addition, AFP mRNA expression decreased more after recovery periods than Group II. XIAP was expressed constitutively in normal rat liver as well as DEN-induced Groups I and Group II. In addition, XIAP expression increased more in Group I with 4 weeks recovery periods than Group I. However, XIAP expression shown to increase in Group lI, otherwise, it was decreased in Group II with 10 weeks repair periods. Taken together, these results suggest the alteration of XIAP expression could be involved in hepatocellular carcinogenesis.
Fustin flavonoid attenuates β-amyloid (1–42)-induced learning impairment
Jin, Chun-Hui,Shin, Eun-Joo,Park, Jae-Bong,Jang, Choon-Gon,Li, Zhengyi,Kim, Min Soo,Koo, Kyo Hwan,Yoon, Hyoung-Jong,Park, Sang-Jae,Choi, Won-Cheol,Yamada, Kiyofumi,Nabeshima, Toshitaka,Kim, Hyoung-Chu Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.16
<P>Natural flavonoids ameliorate amyloid-β peptide (Aβ)-induced neurotoxicity. We examined whether the fustin flavonoid affects Aβ-induced learning impairment in mice. Repeated treatment with fustin significantly attenuated Aβ (1–42)-induced conditioned fear and passive avoidance behaviors. This effect was comparable to that of EGb761, a standard extract of ginkgo. Fustin treatment significantly prevented decreases in acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene expression induced by Aβ (1–42). Fustin also consistently suppressed increases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1–42). In addition, fustin significantly attenuated Aβ (1–42)-induced selective decreases in muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity (as determined by [<SUP>3</SUP>H]pirenzepine binding) by modulating extracellular signal-regulated kinase 1/2 (ERK 1/2) and cAMP response-element binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression. These effects of fustin were reversed by treatment with dicyclomine, a muscarinic M1 receptor antagonist, and SL327, a selective ERK inhibitor, but not by chelerythrine, a pan-protein kinase C (PKC) inhibitor. Taken together, our results suggest that fustin attenuates Aβ (1–42)-impaired learning, and that the ERK/CREB/BDNF pathway is important for the M1 receptor-mediated cognition-enhancing effects of fustin. © 2009 Wiley-Liss, Inc.</P>
Association of estrogen receptor 1 intron 1 C/T polymorphism in Korean vitiligo patients
Jin, Sheng-Yu,Park, Hyun-Ho,Li, Guang-Zhe,Lee, Hee Jae,Hong, Mee-Suk,Park, Hae-Jeong,Park, Hun-Kuk,Seo, Jung-Chul,Yim, Sung-Vin,Chung, Joo-Ho,Lee, Mu-Hyoung KYUNG HEE UNIVERSITY MEDICAL CENTER 2005 고황의학상 수상논문집 Vol.21-22 No.-
Background: Vitiligo is a common disease characterized by cutaneous white maculae due to loss of melanocytes. It is a polygenic disease, however, the exact pathogenesis of vitiligo is not yet known. The estrogen receptor (ESR) 1 gene was selected as a candidate gene because some researchers treated vitiligo successfully with the steroid-thyroid hormone mixture containing estrogen. Furthermore ESR was expressed in the melanocytes which have an important role in the pigmentation. The polymorphisms of ESR1 gene in vitiligo patients was not reported yet. Objective: To determine whether polymorphisms of ESR1 gene were associated with susceptibility to vitiligo patients in Korean population. Methods: We conducted case-control association study of vitiligo patients (120) and healthy controls (254). Genotypes of ESR1 gene (intron 1 C/T, exon 4 C/G, and exon 8 A/G) were determined by polymerase chain reaction followed by restriction enzyme digestion. Results: Intron 1 T/C allele frequency was significantly different between patients and controls (P=0.034). Intron 1 T/C genotype distribution (P=0.021) and allele frequency (P = 0.013) were different between female vitiligo patients and female controls. Intron 1 T/C allele frequency showed significantly difference between generalized type of vitiligo patients and controls (P=0.044). Genotype distributions and allele frequencies of exon 4 C/G and exon 8 A/G polymorphisms were not different between patients and controls. Conclusion: The present study suggests that ESR1 may be a possible risk factor for female or generalized type of vitiligo patients.
Li, Mei Hong,Kothandan, Gugan,Cho, Seung-Joo,Huong, Pham Thi Thu,Nan, Yong Hai,Lee, Kun-Yeong,Shin, Song-Yub,Yea, Sung-Su,Jeon, Young-Jin The Korean Society of Pharmacology 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.6
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-${\kappa}B$/Rel in RAW 264.7 cells. Immunohisto-chemical staining of iNOS and Western blot analysis showed magnolol to inhibit iNOS gene expression. Reporter gene assay and electrophoretic mobility shift assay showed that magnolol inhibited NF-${\kappa}B$/Rel transcriptional activation and DNA binding, respectively. Since p38 is important in the regulation of iNOS gene expression, we investigated the possibility that magnolol to target p38 for its anti-inflammatory effects. A molecular modeling study proposed a binding position for magnolol that targets the ATP binding site of p38 kinase (3GC7). Direct interaction of magnolol and p38 was further confirmed by pull down assay using magnolol conjugated to Sepharose 4B beads. The specific p38 inhibitor SB203580 abrogated the LPS-induced NF-${\kappa}B$/Rel activation, whereas the selective MEK-1 inhibitor PD98059 did not affect the NF-${\kappa}B$/Rel. Collectively, the results of the series of experiments indicate that magnolol inhibits iNOS gene expression by blocking NF-${\kappa}B$/Rel and p38 kinase signaling.