다중센서 환경에서 공중표적 데이타의 연계

정진영,우영운,고봉홍,김재희,홍인표,조동래 연세대학교 산업기술연구소 1994 논문집 Vol.26 No.2

In the system using one sensor, to describe accurate situation or conclude from information of one source in difficult. Moreover, sensor noise degrades the belief of decision. Multisensor information system, however, can increase the belief of date by imploying more than one source of information simultaneously. Another advantage of the system is that it can accomplish its task with other sources of information when one source malfunctions. In this paper, we implemented data association methods to identity moving flight targets using distance, probability theory, Dempster-Shafter theory for the low level process in the information fusion system. Data association is to classify information from various sources into data groups depending for the same flight object. Times and errors of these data association methods are analyzed.

Neuroleptic Malignant Syndrome에 합병되어 나타난 급성 신부전증 1예

채영래,백인호,송정중 大韓神經精神醫學會 1990 신경정신의학 Vol.29 No.4

Neuroleptic malignant syndrome(NMS) is an uncommon but fatal idiosyncratic reaction to neuroleptics. It comprises fever, muscular rigidity, altered consciousness and autonomic dysfunction. The most common serious complications of NMS is rhabdomyolysis, which produces acute myoglobinuric renal failure. The authors experienced a schizophrenic male patient with acute renal failure as a sequela of NMS. The patient was 27-year-old man who had received haloperidol for 9 years. Emergency hemodialysis, hydration and diuretics promoted recovery of impaired renal function. The patient survived the acute episode of NMS without any sequela and resumed his treatment with neuroleptics.

Interleukin-5 저해 활성 chalcone 화합물의 유효 입체 구조

이기철,김민석,P. Thanigaimalai,Vinay K. Sharma,박경래,김영수,정상헌 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-

Interleukin(IL)-5 appears to be one of the main proinflammatory mediators among the growing number of cytokines and chemokines that induce eosinophilic inflammation. Previously, our group synthesized a number of chalcone derivatives to determine their inhibitory activity against IL-5. However, the structure-activity relationship (SAR) of these chalcones was somewhat unclear, robably due to presence of three free rotatable bonds. To further, explore the SAR of these chalcones, we synthesized eight 2-(benzylidene)-2,3-dihydroinden-1-ones and 2- benzylidene)-3,4-dihydronaphthalen-1(2H)-ones 6 and evaluated for their inhibitory activity against IL-5. These rigidified chalcones 6 exhibited very weak inhibitory activity against IL-5 compared to chalcones 2. The structures of 6 closely resemble to the stretched conformations of chalcone 2, not effective conformation for the inhibition on IL-5 function.

Significant improvement in cell adhesion and wear resistance of biomedical β-type titanium alloy through ultrasonic nanocrystal surface modification

Kheradmandfard, Mehdi,Kashani-Bozorg, Seyed Farshid,Lee, Jung Seung,Kim, Chang-Lae,Hanzaki, Abbas Zarei,Pyun, Young-Sik,Cho, Seung-Woo,Amanov, Auezhan,Kim, Dae-Eun Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.762 No.-

<P><B>Abstract</B></P> <P>A novel β-type Ti–29Nb–13Ta–4.6Zr (TNTZ) alloy with a low Young's modulus, high bio-corrosion resistance, and excellent biocompatibility has been recently introduced for implant applications. Here, ultrasonic nanocrystal surface modification (UNSM) treatment was applied to TNTZ alloy to improve its wear resistance and biofunctionality. Application of UNSM to a TNTZ alloy resulted in the generation of a nanostructured surface layer. The wear resistance of the UNSM-treated specimen was observed to be more than 7 times higher than that of the untreated one. Cell culture tests indicated that MC3T3 cells adhered and spread more readily on the UNSM-treated specimen than on the untreated one. MTT assays after 1 and 4 days in culture also indicated enhancement of cell proliferation on the UNSM-treated specimen than that of the untreated one. Live/dead assay revealed no significant cytotoxicity in either substrate. The significant improvement of cell adhesion, spreading, and proliferation on the UNSM-treated TNTZ alloy specimen were attributed to both grain refinement and micro-patterned surface effects. These results demonstrate that UNSM-treatment not only improves the wear resistance of TNTZ alloy, but also enhances its biocompatibility, which makes it a strong candidate for applications in medical implants.</P> <P><B>Highlights</B></P> <P> <UL> <LI> UNSM treatment was applied to a β titanium alloy to generate nanostructured surface. </LI> <LI> The wear resistance of the UNSM-treated specimen was significantly improved. </LI> <LI> Treated specimens showed significant improvement of cell adhesion and proliferation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Study of complex electrodeposited thin film with multi-layer graphene-coated metal nanoparticles

Young-Lae Cho,Jung-woo Lee,Chan Park,Young-il Song,Su-Jeong Suh 한국탄소학회 2017 Carbon Letters Vol.21 No.-

We have demonstrated the production of thin films containing multilayer graphene-coated copper nanoparticles (MGCNs) by a commercial electrodeposition method. The MGCNs were produced by electrical wire explosion, an easily applied technique for creating hybrid metal nanoparticles. The nanoparticles had average diameters of 10–120 nm and quasi-spherical morphologies. We made a complex-electrodeposited copper thin film (CETF) with a thickness of 4.8 μm by adding 300 ppm MGCNs to the electrolyte solution and performing electrodeposition. We measured the electric properties and performed corrosion testing of the CETF. Raman spectroscopy was used to measure the bonding characteristics and estimate the number of layers in the graphene films. The resistivity of the bare-electrodeposited copper thin film (BETF) was 2.092 × 10–6 Ω·cm, and the resistivity of the CETF after the addition of 300 ppm MGCNs was decreased by 2% to ~2.049 × 10–6 Ω·cm. The corrosion resistance of the BETF was 9.306 Ω, while that of the CETF was increased to 20.04 Ω. Therefore, the CETF with MGCNs can be used in interconnection circuits for printed circuit boards or semiconductor devices on the basis of its low resistivity and high corrosion resistance.

Quantitative evaluation of patient-specific quality assurance using online dosimetry system

Jung, Jae-Yong,Shin, Young-Ju,Sohn, Seung-Chang,Min, Jung-Whan,Kim, Yon-Lae,Kim, Dong-Su,Choe, Bo-Young,Suh, Tae-Suk 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.

<P>In this study, we investigated the clinical performance of an online dosimetry system (Mobius FX system, MFX) by 1) dosimetric plan verification using gamma passing rates and dose volume metrics and 2) error-detection capability evaluation by deliberately introduced machine error. Eighteen volumetric modulated arc therapy (VMAT) plans were studied. To evaluate the clinical performance of the MFX, we used gamma analysis and dose volume histogram (DVH) analysis. In addition, to evaluate the error-detection capability, we used gamma analysis and DVH analysis utilizing three types of deliberately introduced errors (Type 1: gantry angle-independent multi-leaf collimator (MLC) error, Type 2: gantry angle-dependent MLC error, and Type 3: gantry angle error). A dosimetric verification comparison of physical dosimetry system (Delt4(PT)) and online dosimetry system (MFX), gamma passing rates of the two dosimetry systems showed very good agreement with treatment planning system (TPS) calculation. For the average dose difference between the TPS calculation and the MFX measurement, most of the dose metrics showed good agreement within a tolerance of 3%. For the error-detection comparison of Delta4(PT) and MFX, the gamma passing rates of the two dosimetry systems did not meet the 90% acceptance criterion with the magnitude of error exceeding 2 mm and 1.5 au broken vertical bar, respectively, for error plans of Types 1, 2, and 3. For delivery with all error types, the average dose difference of PTV due to error magnitude showed good agreement between calculated TPS and measured MFX within 1%. Overall, the results of the online dosimetry system showed very good agreement with those of the physical dosimetry system. Our results suggest that a log file-based online dosimetry system is a very suitable verification tool for accurate and efficient clinical routines for patient-specific quality assurance (QA).</P>

Persistent Sick Sinus Syndrome in Scrub Typhus

Jung, Lae-Young,Yoon, Ji-Young,Song, Soo-Kyeong,Lee, Chang-Seop Allen Press, etc 2017 The American journal of tropical medicine and hygi Vol.96 No.5

Pulmonary sarcomatoid carcinoma accompanying duodenal involvement.

Jung, Lae Young,Jeon, So Yeon,Kim, So Ri,Chung, Myoung Ja,Lee, Yong Chul American Lung Association 2012 American journal of respiratory and critical care Vol.185 No.8

추출방법에 따른 한약재의 인체신경모세포 SK-N-SH 보호 효과

Jung Min Kwon(권정민),Yeon Gyu Moon(문연규),Young Suk Kim(김영숙),Ji Young Jung(정지영),Yeong Lae Ha(하영래),Jae Kyung Yang(양재경) 한국생명과학회 2011 생명과학회지 Vol.21 No.8

한약재의 추출방법에 따른 인체신경모세포 SK-N-SH에 대한 보호 효과를 연구하였다. 당귀, 건지황, 작약 및 천궁을 시료로 사용하였고, 열수추출(환류냉각, 5 시간), 증숙추출(100℃ 및 120℃, 90분 후 열수추출) 방법과 에탄 올추출(환류냉각, 5 시간)방법을 비교하였다. 추출물을 농도별로 SK-N-SH 세포에 2 시간 처리한 후 H₂O₂로 250 μM로 2 시간 산화스트레스를 유발한 다음 세포독성 및 apoptosis와 caspase-3의 발현 정도를 측정하였다. 모든 약재의 열수추출물이 다른 추출물보다 세포 증식을 촉진하였고, apoptosis를 억제하였다. 한약재 열수추출물 1 ㎍/㎕ 농도까지는 세포증식을 촉진하였지만, 그 이상의 농도에서는 오히려 감소시켰다. 열수추출물은 다른 추출물보다 총페놀성 화합물이 많이 함유되어 있었고, 항산화능이 높았다. 또한, 이와 같은 효과는 당귀의 열수추출물이 다른 약재 열수추출물보다 우수하였다. 본 연구결과는 약재의 열수추출법이 인체신경모세포인 SK-N-SH의 증식과 세포사멸 억제를 위해 가장 우수한 방법이었고, 당귀 열수추출물이 가장 우수한 효과를 지니고 있어 기억력 보호나 상실억제제로 활용할 수 있을 것이다. Extraction methods of medicinal plants were evaluated for growth enhancing effects of human neuroblastoma SK-N-SH cells. Hot-water extraction (reflux for 5 hr), hot-water extraction post treatment (100℃ or 120℃, 90 min) and ethanol extraction (reflux for 5 hr) methods were applied to Angelica gigas, Rhemania glutinosa, Paeonia lactiflora and Cnidium officinale samples to extract their constituents. Cells were treated for 2 hr with various concentrations of extracts (0, 0.5, 1, 2, 4 ㎍/㎕ media) prior to H₂O₂ (250 μM) treatment for 2 hr to provide oxidative stress. Cell viability, caspase-3 expression and apoptosis were measured for cells treated with sample extracts. Hot-water extract exhibited a stronger growth enhancing and apoptosis protecting ability than other extracts. These activities were shown at less than 1 ㎍/㎕ concentration, and not greater than 2 ㎍/㎕ concentration. Hot-water extract contained more polyphenolic compounds than other extracts coming along with stronger antioxidant activity. The efficacy of antioxidant activity was stronger in the hot-water extract of Angelica gigas than other hot-water extracts of medicinal plants. These results suggest that hot-water extraction is an appropriate method to extract materials for growth enhancing and apoptosis protection of SK-N-SH cells, and hot-water extracts of Angelica gigas might be useful materials for protection from aging brain cells.

Masked Hydronephrosis

( Lae Young Jung ),( Kyung Pyo Kang ),( Won Kim ),( Sung Kwang Park ),( Sik Lee ) 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.2