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Validity and Reliability of Metacognitive Rating Scale for Nursing Students
( Lee¸ Kyunghee ),( Heo¸ Youngjin ),( Han¸ Mihwa ),( Kim¸ Mijung ),( Choi¸ Hyunseok ) 한국정신간호학회 2021 정신간호학회지 Vol.30 No.3
Purpose: The aim of this study was to determine the reliability and validity of the metacognition rating scale (MCRS), which is a revised version of the existing metacognition questionnaire (MCQ) with anger and anxiety added. Methods: A survey was conducted on 591 nursing students at colleges in North and South Gyeongsang Provinces, South Korea. The collected data were processed for the reliability and validity of the MCRS through Cronbach’s α and confirmatory factor analysis using SPSS 26.0. Results: Cronbach’s α for the reliability of MCRS was calculated at .88, .86, .77, .74, and .66 for five subfactors. Among the five subfactors, the first, second, third, and fifth factors showed high correlation in each of six items. Factor 4 was highly correlated in 5 out of 6 questions. Conclusion: The data confirm that the MCQ revised to include anger and anxiety is both reliable and valid for nursing students. Therefore, this scale can be used to identify the maladaptive metacognition of nursing students in stressful situations.
지역사회에서 형성된 사회적 지지와 근로자의 사회심리적 스트레스간의 관련성
임화영,김형수,최영환,장성훈,이건세,정최경희,오원기,최재욱,정춘화 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4
Objective: This study was performed to examine the relationship between community-based social support and psychosocial distress in workers. Methods: The study subjects were 596 workers recruited from 11 companies in Chungju city. A structured questionnaire was used to assess sociodemographics, health-related behaviors, job characteristics, job stress, work-based social support, community-based social support and level of psychosocial distress. Results: Hierarchical multiple regression analysis showed that workers with no chronic disease, exercise and sufficient sleep had a higher score of psychosocial distress than those with chronic disease, no exercise, and not enough sleep. Coworker's work-based social support and community-based social support were negatively associated with psychosocial distress. The R square value of total independent variables on psychosocial distress was 0.409, and that of community-based social support on psychosocial distress was 0.052. Conclusion: This study showed that community-based social support served as a protective factor against psychosocial distress in some workers. We recommend the establishment of a worksite stress reduction program in occupational level as well as community-based social support.
Kim, Hyunsoo,Kim, Han-Jong,Lee, Kyunghee,Kim, Jin-Man,Kim, Hee Sun,Kim, Jae-Ryong,Ha, Chae-Myeong,Choi, Young-Keun,Lee, Sun Joo,Kim, Joon-Young,Harris, Robert A,Jeong, Daewon,Lee, In-Kyu Blackwell Publishing Ltd 2012 Journal of cellular and molecular medicine Vol.16 No.2
<P><B>Abstract</B></P><P>Vascular calcification is prevalent in patients with chronic kidney disease and leads to increased cardiovascular morbidity and mortality. Although several reports have implicated mitochondrial dysfunction in cardiovascular disease and chronic kidney disease, little is known about the potential role of mitochondrial dysfunction in the process of vascular calcification. This study investigated the effect of α-lipoic acid (ALA), a naturally occurring antioxidant that improves mitochondrial function, on vascular calcification <I>in vitro</I> and <I>in vivo</I>. Calcifying vascular smooth muscle cells (VSMCs) treated with inorganic phosphate (Pi) exhibited mitochondrial dysfunction, as demonstrated by decreased mitochondrial membrane potential and ATP production, the disruption of mitochondrial structural integrity and concurrently increased production of reactive oxygen species. These Pi-induced functional and structural mitochondrial defects were accompanied by mitochondria-dependent apoptotic events, including release of cytochrome <I>c</I> from the mitochondria into the cytosol, subsequent activation of caspase-9 and -3, and chromosomal DNA fragmentation. Intriguingly, ALA blocked the Pi-induced VSMC apoptosis and calcification by recovery of mitochondrial function and intracellular redox status. Moreover, ALA inhibited Pi-induced down-regulation of cell survival signals through the binding of growth arrest-specific gene 6 (Gas6) to its cognate receptor Axl and subsequent Akt activation, resulting in increased survival and decreased apoptosis. Finally, ALA significantly ameliorated vitamin D<SUB>3</SUB>-induced aortic calcification and mitochondrial damage in mice. Collectively, the findings suggest ALA attenuates vascular calcification by inhibiting VSMC apoptosis through two distinct mechanisms; preservation of mitochondrial function <I>via</I> its antioxidant potential and restoration of the Gas6/Axl/Akt survival pathway.</P>
Lee, Kyunghee,Kim, Hyunsoo,Kim, Jin-Man,Kim, Jae-Ryong,Kim, Keuk-Jun,Kim, Yong-Jin,Park, Se-Il,Jeong, Jae-Ho,Moon, Young-mi,Lim, Hyun-Sook,Bae, Dong-Won,Kwon, Joseph,Ko, Chang-Yong,Kim, Han-Sung,Shin, Blackwell Publishing Ltd 2011 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.15 No.10
<P>Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery of diverse damaged tissues. This study investigated the effects of systemic transplantation of human ASCs (hASCs) on bone repair. We found that hASCs secrete various bone cell-activating factors, including hepatocyte growth factor and extracellular matrix proteins. Systemic transplantation of hASCs into ovariectomized mice induced an increased number of both osteoblasts and osteoclasts in bone tissue and thereby prevented bone loss. We also observed that conditioned medium from hASCs is capable of stimulating proliferation and differentiation of osteoblasts <I>via</I> Smad/extracellular signal-regulated kinase (ERK)/JNK (c-jun NH<SUB>2</SUB>-terminal kinase) activation as well as survival and differentiation of osteoclasts <I>via</I> ERK/JNK/p38 activation <I>in vitro</I>. Overall, our findings suggest that paracrine factors secreted from hASCs improve bone repair and that hASCs can be a valuable tool for use in osteoporosis therapy.</P>
Distinctive and selective route of PI3K/PKCα-PKCδ/RhoA-Rac1 signaling in osteoclastic cell migration
Kim, Jin-Man,Kim, Mi Yeong,Lee, Kyunghee,Jeong, Daewon Elsevier 2016 Molecular and cellular endocrinology Vol.437 No.-
<P><B>Abstract</B></P> <P>Cell migration during specialized stages of osteoclast precursors, mononuclear preosteoclasts, and multinucleated mature osteoclasts remain uncertain. M-CSF- and osteopontin-induced osteoclastic cell migration was inhibited by function-blocking monoclonal antibodies specific to the integrin αv and β3 subunits, suggesting that integrin αvβ3 mediates migratory signaling induced by M-CSF and osteopontin. M-CSF and osteopontin stimulation was shown to regulate two branched signaling processes, PI3K/PKCα/RhoA axis and PI3K/PKCδ/Rac1 axis. Interestingly, inactivation of RhoA or Rac1 blocked preosteoclast and mature osteoclast migration but not osteoclast precursor migration in a transwell-based cell migration assay. Moreover, the inhibitory effect on preosteoclast and mature osteoclast migration induced by Rac1 inactivation was more effective than that by RhoA inactivation. Collectively, our findings suggest that osteoclast precursor migration depends on PI3K/PKCα-PKCδ signaling mediated via integrin αvβ3 bypassing RhoA and Rac1, whereas preosteoclast and mature osteoclast migration relies on PI3K/PKCα-PKCδ/RhoA-Rac1 axis signaling mediated via integrin αvβ3 with increased dependency on PKCδ/Rac1 signaling route as differentiation progresses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Osteoclast precursor migration depends on PI3K/PKC signaling bypassing RhoA and Rac1. </LI> <LI> Preosteoclast and mature osteoclast migration relies on PI3K/PKC/RhoA-Rac1 signaling. </LI> <LI> Mature osteoclast migration is predominantly dependent on PI3K/PKCδ/Rac1 signaling. </LI> </UL> </P>
Kim, Ju Young,Lee, Ra Ham,Kim, Tae Min,Kim, Dong-Wook,Jeon, Young-Joo,Huh, Sung-Ho,Oh, Se-Yeong,Kyba, Michael,Kataoka, Hiroshi,Choi, Kyunghee,Ornitz, David M.,Chae, Jung-Il,Park, Changwon American Society of Hematology 2014 Blood Vol.124 No.19
<P>In this study, we report that OVOL2, a C<SUB>2</SUB>H<SUB>2</SUB> zinc finger protein, is a novel binding protein of ER71, which is a critical transcription factor for blood and vessel development. OVOL2 directly interacted with ER71, but not with ETS1 or ETS2, in the nucleus. ER71-mediated activation of the <I>Flk1</I> promoter was further enhanced by OVOL2, although OVOL2 alone failed to activate it. Consistently, coexpression of ER71 and OVOL2 in differentiating embryonic stem cells led to a significant augmentation of FLK1<SUP>+</SUP>, endothelial, and hematopoietic cells. Such cooperative effects were impaired by the short hairpin RNA-mediated inhibition of <I>Ovol2</I>. Collectively, we show that ER71 directly interacts with OVOL2 and that such interaction is critical for FLK1<SUP>+</SUP> cell generation and their differentiation into downstream cell lineages.</P>
KyungHee Kim(김경희),Seoung-ho Ryu(유승호) 한국콘텐츠학회 2016 한국콘텐츠학회논문지 Vol.16 No.6
웰빙(well-being)은 이제 전 세계적으로 국가의 중요 정책이 되고 있다. 대표적 국제기구들 중 하나인 OECD는 GDP가 더 이상 국민들의 행복을 반영하지 못한다는 사실을 인지하고 그 대체지수로서 더 나은 삶 지표(Better Life Index)를 고안하여 세계 각국에 권고하고 있다. 그 지표들 중 하나인 일과 삶의 균형(work-life balance)은 부양가족을 지닌 근로자들의 행복을 위한 매우 중요한 지표들로 간주하여 11개의 지표 중 하나로 선정되었다. 그러나 한국의 경우 일과 삶의 균형 지표는 다른 지표과 비교했을 때 공동체 지표와 함께 최하위권에 머물고 있다. 본 논문에서는 한국인의 일과 삶의 균형에서 당면한 문제와 이를 해소하기 위한 정책적 방안들을 탐구하고자 한다. 연구 과제는 첫째, 일과 삶의 균형의 개념은 무엇인가, 둘째, 한국 근로자들이 처해있는 한국사회 고유의 특성과 일과 삶 균형에 관련된 정책은 어떠한가, 셋째, 기존의 관련 정책을 한국 사회의 특성에 맞춰 어떻게 변화 또는 발전시켜야 하는가이다. 논의의 결과는 다음과 같다. 우선 정부 차원에서의 문화적 접근이 부족했다. 즉 적극적 캠페인을 통해 전통적 성 역할에 대한 인식을 전환시키려는 실질적인 노력이 없었다. 회사 차원에서는 권위적인 조직 문화를 역이용하여 근로자들의 일과 삶의 균형에 적극 활용할 필요가 있다. 다시 말해 근로시간의 준수, 출산 및 육아휴직의 사용을 회사차원에서 적극적으로 권고하는 것을 제도화 할 필요가 있다. 일하는 여성이 직장인과 엄마 역할 사이에서 갈등하는 상황을 남편 및 가족의 이해와 지지로 극복할 수 있도록 도와주는 가족지원책이 필요한 것이다. Along with the mood of ‘Beyond GDP’, it is necessary to explore how these subjective concepts such as happiness and well-being are quantified to be compared among many countries. The concept of ‘Work-life balance (WLB)’ is likely to be located on the boundary between the subjective and objective areas. Thus, this article aims to examine the policies related to WLB and how to change or develop those policies considering the concept of WLB and the circumstantial particularity of Korea. There are several suggestions on certain developments in the existing policies interfering WLB at three levels. First the government needs to conduct campaigns to transform traditional gender roles through active advertisement. Second, the company needs to use the long-lasting ‘hierarchical organisation culture’ for employee’s work-life balance for regulating working hours and exhausting paid holidays and maternity or paternity leave. Finally, families should understand and support their wives’ current circumstances facing the struggle between a mother and economic worker.