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RISS 인기검색어
- 검색키워드
- 저자 : ( Kyung Joo Um ) (검색결과 49 건)
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嚴柱鉉,金鍾聲,兪台沂,李柱炅 최신의학사 1967 最新醫學 Vol.10 No.6
One 19-year-old male was admitted to P.N.U. Hospital on March 19, 1966, because of severe recurrent, colicky abdominal pain, chillness, nausea, vomitting, headache, sweating, extreme weakness and dizziness for two days'duration, and brownish dark urine on one occation after 24 hours of administration of the Secobarbital 400mg (4 cap.). Another 21-year-old male was admitted to this hospital, on March 21,. 1966, because of unconsciousness after ingestion of the secobarbital 1, 700mg (17 cap.).. After recovery from this state on the second days of admission, he has complained the . chillness, diffuse, colicky abdominal pain, myalgia, and headache, and also discharged dark urine in the evening. The diagnosis of the acute hemolytic anemia was established by means of the abovesymtoms, physical examinations and laboratory findings of which, the peripheral blood showed hemoglobinemia in the serum, increased bilirubin titer, mostly indirect, and spherocytosis; hemoglobin in the urine. After initial. response to therapy with blood transfusion (5 Pt.), and to control of fluid and electrolytes, the clinical and laboratory findings were much improved within the two week's of admission. The prednisolone has been administered 80 mg a day at first on the 3rd days of admission,- and then decreased the dose until 20 mg once a day for all the 5 days. Both the patients were discharged on the 14th day of admission and all have good condition until one year after then.
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李天馥,嚴慶一,鮮于洋一,申恩珠 東亞大學校附設基礎科學硏究所 1988 基礎科學硏究論文集 Vol.5 No.1
Many enzymes are known to be associated with the recognition of specific lesions and incision of the DNA strand in their vicinity(Clarson and Mitchell, 1983), and several enzymes concerned with excision and polymerization have also been identified(Collins & Johnson, 1984; Collins et al., 1984; Downes et al., 1985; Mattern et al., 1982). In a number of studies, controversial results have been obtained on whether DNA polymerase α is(Cleaver, 1984; Collins et al., 1982; Dresler and Frattini, 1986: Dresler and Kimbro, 1987; Johnson et al., 1987; Snyder and Reagan, 1981, 1982) or is not(Giulotto and Mondello, 1981; Hardt et al., 1981; Seki et al., 1980) important in DNA repair, while DNA polymerase β has been postulated to have a role in the repair of DNA(Cleaver, 1983; Dresler and Lieberman, 1983; Miller and Chinault, 1982; Spadari et al., 1982). Many conclusions concerning the functions at these enzymes can be obtained using enzyme inhibitors. Among them, the commonly used inhibitors have been aphidicolin(APC), an inhibitor of DNA polymerase α(Smith and Paterson, 1983; Th'ng and Walker, 1985), and 2',3'-dideoxythymidine(ddThd) or 2',2'-dideoxythymidine 5'-triphosphate(ddTTP), an inhibitor of DNA polymerase β(Dresler and Kimbro, 1987; Th'ng and walker, 1985; Yamada et al., 1985). On the other hands, the studies using APC and ddTTP yielded results that suggest the participation of both polymerases in DNA repair depending on the agent used and the dosage applied(Cleaver, 1983; Dresler and Liberman, 1983; Yamada et al., 1985). Therefore, the same approach, using three differenc assays for DNA repair and two inhibitors, has been undertaken in this study with the view to give insight into the role of specific enzymes in the repair process. The purpose of this study is to elucidate the involvement of DNA polymerase α or β in DNA repair synthesis induced by EMS, an alkylating agent, or BLM, an antibiotics and X-ray mimetic agent, in CHO cells.
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Um, Jae-Young,Ok, Yoon-Young,Joo, Jong-Cheon,Kim, Kyung-Yo,Kim, Na-Hyung,Hong, Seung-Heon,Kim, Hyung-Min Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.2
Glutathione S-transferase polymorphisms (GST) were examined in 98 cases with cerebrovascular disease (CVD) to test the hypothesis that GST polymorphisms confer a risk to an individual to develop CVD. Tobacco smoke is a major cause of both cancer and vascular disease. We therefore were stratified the subjects with CVD for smoking status, and then examined whether polymorphisms in this detoxification enzyme gene, GST, influence risk of CVD. Neither GSTM1 nor GSTT1 genotypes in the CVD group was significantly different from the control group (n=230), even in smokers. We attempted the combined analyses for GSTM1 and GSTT1 genotypes in CVD for smoking status. No significant association observed between the combined genotypes and CVD. We also classified the subjects and control group into four types according to Sasang Constitutional Medicine, Korean Traditional Oriental Medicine, and investigated the association among GST genotypes, CVD, and Sasang constitutional classification. Our observations do not confirm the effect of the GSTM1 and GSTT1 genotypes as a risk factor for CVD, even in smokers. Furthermore, we first attempted to evaluate the efficacy of Sasang Constitutional Medicine, and to find an association with CVD.
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Um, Jae-Young,Kim, Jong-Kwan,Joo, Jong-Cheon,Kim, Kyung-Yo,Hong, Seung-Heon,Kim, Hyung-Min Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.2
Sasang Constitutional Medicine is a major branch of Korean Traditional Oriental Medicine. The differences of disease susceptibility to be shown in Sasang constitution may be due to genetic factors. Therefore, we examined interrelationship among cerebral infarction (CI), apolipoprotein E (apoE) gene polymorphism, and Sasang constitutional classification. ApoE is a key protein modulating the highly atherogenic apoB containing lipoproteins and is a candidate gene for the development of coronary artery disease (CAD). The ${\varepsilon}2\;and/or\;{\varepsilon}4$ alleles were the first to be implicated in premature CAD, which resulted in this polymorphism being extensively studied. We investigated the association between apoE genotype and CI by case-control study in a Korean population. We also classified CI patients and control group into groups according to Sasang Constitutional Medicine. 196 CI patients and 379 controls without CI were examined. ApoE genotype was determined by 8% polyacrylamide gel separation after DNA amplification. A significant difference in the apoE genotype distribution was observed in the CI patients compared with that in controls ($X^{2}$=14.920, df=4, P=0.005). Also, the frequency of Taeumin constitution in patients with CI was significantly higher than that in controls (58.0% vs. 36.9%; P<0.001). However, the Taeumin constitution did not enhance the relative risk for CI in the subjects with apoE ${\varepsilon}2\;and/or\;{\varepsilon}4$ alleles. No differences in the apoE genotypes frequencies were observed in the Taeumin compared with that in the other constitutions. In addition, we investigated whether the DD genotype of angiotensin converting enzyme (ACE) gene, a candidate gene for CI, was associated with CI, Taeumin constitution, and apoE polymorphism. As a result, the frequency of Taeumin constitution was significantly higher in CI patients with both apoE ${\varepsilon}3/{\varepsilon}4$ and ACE ID/DD genotypes than in the remaining Sasang constitutions (14.5% vs. 8.3% and 0%) ($X^{2}$=13.521, df=6, P=0.035). In summary, we concluded that the apoE polymorphism is a major risk factor for CI in Koreans and the ACE ID/DD genotype enhanced the relative risk for CI in the subjects with apoE ${\varepsilon}3/{\varepsilon}4$ genotype and Taeumin constitution.
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DNA 상해와 회복기작에 미치는 환경성 돌연변이원의 영향
엄경일,채기수,이주혜,정정남,이천복 한국유전학회 1986 Genes & Genomics Vol.8 No.4
The effects of aphidicolin, an inhibitor of DNA polymerase α, on ethyl methanesulfonate (EMS)- or bleomycin (BLM)-induced DNA repair were investigated in Chinese hamster ovary (CHO) cells. The amount of unscheduled DNA synthesis induced by EMS or BLM was increased according to dose increment and decreased with incubation time after treatment, and the damage almost seemed to be recovered during 4 hour incubation. The EMS-induced DNA single-strand breaks showed dose dependent increment and were increased according to EMS containing time. BLM also showed dose dependent increment on DNA single-strand breaks. On the other hand, it was shown that aphidicolin inhibited excision repair induced by EMS, and thus, the post-treatment with aphidicolin induced the higher degree of unscheduled DNA synthesis and the more accumulation of DNA single-strand breaks than the cells post-incubated without aphidicolin. However, aphidicolin did not inhibit excision repair induced by BLM, and thus, the cells post-incubated with or without aphidicolin for 1 hour had the same value in the amount of unscheduled DNA synthesis and of DNA single-strand breaks. These results suggested that the participation of DNA polymerase α in DNA repair induced by EMS or BLM was dependent on different types of damage.
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키워드 네트워크 분석을 활용한 부모 교육 연구동향 분석
이경주(Kyung-Joo Lee),조영애(Young-Ae Cho),엄형준(Hyung-Jun Um) 한국부부가족상담연구학회 2022 부부가족상담연구 Vol.3 No.2
본 연구는 빅데이터를 활용한 키워드 네트워크 분석을 통해 부모 교육의 연구동향을 살펴보는 데 목적이 있다. 이를 위해 2012년-2021년에 발표된 부모 교육과 관련된 KCI 등재(후보) 학술지 논문 452편 중에서 교육정책 관련 논문과 중복 기재된 연구 26편을 제외한 총 426편의 자료를 분석 대상으로 선정하였고, 키워드 827개를 추출했다. Textom과 UCINET 6을 활용하여 단어 출현 빈도를 분석하고 네트워크를 시각화하였다. 연구결과는 다음과 같다. 전체 네트워크의 연결중심성 분석과 매개 중심성을 바탕으로 키워드 네트워크에서 분석된 키워드들은 프로그램, 어머니, 부모, 개발 등이 상위에 있었으며, 이 키워드들을 중심으로 대부분 서로 연결되어 있어, 부모 교육과 연구 변인들은 연관성이 높은 것으로 나타났다. 마지막으로 구조적 등위성 분석을 위한 CONCOR 분석 결과 관심 대상, 대상자의 경험요인, 프로그램 개발과 효과 검증 변인, 관련 변인으로 4개의 하위집단으로 형성되었다. 본 연구결과를 바탕으로 하여 후속 연구에 대한 제언과 시사점을 논하였다. The purpose of this study is to examine the research trends of parent education through keyword network analysis using big data. To this end, a total of 426 articles in KCI-listed (candidate) academic journals related to parental education published in 2012-2021 were selected for analysis, and 827 keywords were extracted. Using Textom and UCINET 6, the frequency of word appearance was analyzed and the network was visualized. Based on the results of this study, suggestions and implications for subsequent studies were discussed.
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Hyun Joo Kim,Hyuktae Kwon,Seung-Won Oh,Cheol Min Lee,Hee-Kyung Joh,Youngju Kim,Yoo-Jin Um,Sang Hyun Ahn 대한가정의학회 2015 Korean Journal of Family Medicine Vol.36 No.5
Background: Postmenopausal osteoporosis is a common disease which can cause various morbidity and economic burden. Lactation is known to cause a decline in bone mineral density (BMD), but there are controversies on whether decreased BMD is fully recovered after lactation and whether lactation duration has an influence on postmenopausal BMD. This study was conducted to see whether breastfeeding is associated with postmenopausal bone loss using a highly representative sample of Korean population. Methods: Retrospective cross sectional study was done using data collected from Korea National Health and Nutrition Examination Survey V. The study outcome was BMD measured with dual-energy X-ray absorptiometry and divided into 2 groups: normal or low BMD (T score<-1), and breastfeeding duration was categorized into 4 groups (never, 1st, 2nd, and 3rd tertile). Logistic regression analysis was done to examine the association between lactation duration and BMD. Results: Among 1,694 postmenopausal women (mean age, 63.5±9.1), 85.71% were in low BMD group. Compared to never breastfeeding group, postmenopausal women with longer than 79 months of breastfeeding duration are more likely to have low BMD (adjusted risk ratio [ARR]=1.24; 95% confidence interval, 1.17 to 1.32). As the duration of breastfeeding increases, ARR and risk difference for low BMD also increases (P for trend=0.008). Conclusion: The study results showed that total breastfeeding duration was associated with postmenopausal low BMD. All women planning on breastfeeding should be aware of its risks and should take adequate dietary calcium and vitamin D before, during, and after breastfeeding.
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Dietary Fat Intake and the Risk of Metabolic Syndrome in Korean Adults
Yoo-Jin Um,Seung-Won Oh,Cheol-Min Lee,Hyuk-Tae Kwon,Hee-Kyung Joh,Young-Ju Kim,Hyun-Joo Kim,Sang-Hyun Ahn 대한가정의학회 2015 Korean Journal of Family Medicine Vol.36 No.5
Background: The effect of dietary fat intake on the risk of cardiovascular disease remains unclear. We investigated the association between dietary fat and specific types of fat intake and the risk of metabolic syndrome. Methods: The study population included 1,662 healthy adults who were 50.2 years of age and had no known hypertension, diabetes, hyperlipidemia, or metabolic syndrome at the initial visit. Dietary intake was obtained from a 1-day food record. During 20.7 months of follow-up, we documented 147 cases of metabolic syndrome confirmed by self-report, anthropometric data, and blood test results. The intakes of total fat, vegetable fat, animal fat, saturated fatty acid (SFA), polyunsaturated fatty acid (PUFA), monounsaturated fatty acid (MUFA), and cholesterol level divided by quintile. Multivariate analyses included age, sex, body mass index, smoking status, alcohol intake, physical activity, total calorie, and protein intake. Results: Vegetable fat intake was inversely associated with metabolic syndrome risk (odds ratio for the highest vs. the lowest quintile, 0.33; 95% confidence interval, 0.14 to 0.76). Total fat, animal fat, SFA, PUFA, MUFA, and cholesterol intakes showed no association with metabolic syndrome. Vegetable fat intake was inversely associated with the risk of hypertriglyceridemia among the components of metabolic syndrome. Conclusion: These data support an inverse association between vegetable fat and the risk of metabolic syndrome.
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