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Phan, Ngan Thi,Trinh, Lan Thi,Rho, Mi-Young,Park, Tae-Sung,Kim, Ok-Rye,Zhao, Jun,Kim, Hyoung-Moon,Sim, Sung-Chur Elsevier 2019 Scientia horticulturae Vol.243 No.-
<P><B>Abstract</B></P> <P>Advances in sequencing technology have facilitated allele mining with high resolution for quantitative traits in crop species. In this study, a genome-wide association study (GWAS) was conducted to detect quantitative trait loci (QTL) for fruit traits in tomato. We developed a core collection of 192 tomato accessions representing contemporary breeding lines, vintage varieties, and wild species. Phenotypic variations in this collection were evaluated for six traits including fruit shape, fruit color, pericarp thickness, fruit weight, fruit height, and fruit width over two years in field trials. Genotyping by sequencing (GBS) detected a total of 140,072 SNPs in the core collection and 8,550 SNPs were selected based on missing data rate (<20%) and minor allele frequency (≥5%) for GWAS. The 192 accessions were divided into seven clusters and the resulting membership coefficient matrix was used to account for population structure. We identified two loci for fruit color, seven loci for fruit shape, 11 loci for pericarp thickness, 13 loci for fruit weight, seven loci for fruit height, and 10 loci for fruit width at <I>P</I> < 0.0001 using the compressed mixed linear model. These loci explained 7.11–37.64% of total phenotypic variance. We also found that nine loci on seven chromosomes showed significant associations with multiple traits, suggesting pleiotropic effects of QTL. A total of 41 loci associated with the six fruit traits in our study will be a useful resource for marker-assisted selection to improve fruit traits in tomato.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A core collection of 192 tomato accessions was developed for GWAS. </LI> <LI> Phenotypic evaluations were conducted for the six fruit traits over two years in field trials. </LI> <LI> Genotyping by sequencing generated the quality filtered 8,550 SNPs. </LI> <LI> A total of 41 SNP loci were significantly associated with the six fruit traits. </LI> </UL> </P>
생리적 신호를 이용한 통증 인식을 위한 딥 러닝 네트워크
( Kim Ngan Phan ),이귀상 ( Guee-sang Lee ),양형정 ( Hyung-jeong Yang ),김수형 ( Soo-hyung Kim ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.2
Pain is an unpleasant experience for the patient. The recognition and assessment of pain help tailor the treatment to the patient, and they are also challenging in the medical. In this paper, we propose an approach for pain recognition through a deep neural network applied to pre-processed physiological. The proposed approach applies the idea of shortcut connections to concatenate the spatial information of a convolutional neural network and the temporal information of a recurrent neural network. In addition, our proposed approach applies the attention mechanism and achieves competitive performance on the BioVid Heat Pain dataset.
Trieu Ngan Hoang Kim,Phan Xuan Thi,Tran Linh Thanh,Pham Huy Minh,Huynh Dai Quang,Nguyen Tuan Manh,Mai Anh Tuan,Du Quan Quoc Minh,Nguyen Bach Xuan,Pham Thao Thi Ngoc 대한중환자의학회 2023 Acute and Critical Care Vol.38 No.3
Background: Hemostatic dysfunction during extracorporeal membrane oxygenation (ECMO) due to blood-circuit interaction and the consequences of shear stress imposed by flow rates lead to rapid coagulation cascade and thrombus formation in the ECMO system and blood vessels. We aimed to identify the incidence and risk factors for cannula-associated arterial thrombosis (CaAT) post-decannulation. Methods: A retrospective study of patients undergoing arterial cannula removal following ECMO was performed. We evaluated the incidence of CaAT and compared the characteristics, ECMO machine parameters, cannula sizes, number of blood products transfused during ECMO, and daily hemostasis parameters in patients with and without CaAT. Multivariate analysis identified the risk factors for CaAT. Results: Forty-seven patients requiring venoarterial ECMO (VA-ECMO) or hybrid methods were recruited for thrombosis screening. The median Sequential Organ Failure Assessment score was 11 (interquartile range, 8–13). CaAT occurred in 29 patients (61.7%), with thrombosis in the superficial femoral artery accounting for 51.7% of cases. The rate of limb ischemia complications in the CaAT group was 17.2%. Multivariate analysis determined that the ECMO flow rate–body surface area (BSA) ratio (100 ml/min/m2) was an independent factor for CaAT, with an odds ratio of 0.79 (95% confidence interval, 0.66–0.95, P=0.014). Conclusions: We found that the incidence of CaAT was 61.7% following successful decannulation from VA-ECMO or hybrid modes, and the ECMO flow rate–BSA ratio was an independent risk factor for CaAT. We suggest screening for arterial thrombosis following VA-ECMO, and further research is needed to determine the risks and benefits of such screening.
Quang, Tran Hong,Ngan, Nguyen Thi Thanh,Minh, Chau Van,Kiem, Phan Van,Nhiem, Nguyen Xuan,Tai, Bui Huu,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Song, Seok-Bean,Kim, Young-Ho Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited $TNF{\alpha}$-induced NF-${\kappa}B$ transcriptional activity in HepG2 cells in a dose-dependent manner, with $IC_{50}$ values ranging from 6.2 to 9.1 ${\mu}M$. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with $EC_{50}$ values ranging from 4.1-$12.7{\mu}M$. Compounds 4 and 5 exhibited $PPAR{\alpha}$, $PPAR{\gamma}$, and $PPAR{\beta}({\delta})$ transactivational activities in a dose-dependent manner, with $EC_{50}$ values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 ${\mu}M$, respectively.
α-Glucosidase Inhibitors from the Roots of Sophora flavescens
Quang, Tran Hong,Ngan, Nguyen Thi Thanh,Minh, Chau Van,Kiem, Phan Van,Tai, Bui Huu,Thao, Nguyen Phuong,Kwon, Se-Uk,Lee, Young-Mi,Kang, Hee-Kyoung,Kim, Young-Ho Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.5
Anti-inflammatory Triterpenoid Saponins from the Stem Bark of <i>Kalopanax pictus</i>
Quang, Tran H.,Ngan, Nguyen T. T.,Minh, Chau V.,Kiem, Phan V.,Nhiem, Nguyen X.,Tai, Bui H.,Thao, Nguyen P.,Tung, Nguyen H.,Song, Seok B.,Kim, Young H. American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.9
<P>Five new compounds, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (<B>1</B>), 4,23,29-trihydroxy-3,4-<I>seco</I>-olean-12-en-3-oate-28-oic acid (<B>2</B>), 3β,6β,23-trihydroxyolean-12-en-28-oic acid 28-<I>O</I>-β-<SMALL>d</SMALL>-glucopyranoside (<B>3</B>), 3-<I>O</I>-[2,3-di<I>-O</I>-acetyl-α-<SMALL>l</SMALL>-arabinopyranosyl]hederagenin 28-<I>O</I>-α-<SMALL>l</SMALL>-rhamnopyranosyl-(1→4)-β-<SMALL>d</SMALL>-glucopyranosyl-(1→6)-β-<SMALL>d</SMALL>-glucopyranoside (<B>4</B>), and 3-<I>O</I>-[3,4-di-<I>O</I>-acetyl-α-<SMALL>l</SMALL>-arabinopyranosyl]hederagenin 28-<I>O</I>-α-<SMALL>l</SMALL>-rhamnopyranosyl-(1→4)-β-<SMALL>d</SMALL>-glucopyranosyl-(1→6)-β-<SMALL>d</SMALL>-glucopyranoside (<B>5</B>), as well as 10 known compounds (<B>6</B>–<B>15</B>), were isolated from the stem bark of <I>Kalopanax pictus</I>. Compounds <B>1</B>–<B>5</B> and <B>7</B>–<B>14</B> inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC<SUB>50</SUB> values ranging from 0.6<B></B>to 16.4 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed on the basis of decreases in COX-2 and iNOS gene expression in HepG2 cells. The structure–activity relationship of the compounds with respect to anti-inflammatory activity is also discussed.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-9/np200382s/production/images/medium/np-2011-00382s_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np200382s'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np200382s'>ACS Electronic Supporting Info</A></P>
Dinh Tram Anh PHAN,Thi Thuy Ngan NGUYEN,Thi Khanh Nhi NGUYEN,Tran Thien An NGUYEN,Van Si Dan PHAN,Ngoc Phuong Thao HO,Kim Xuan DO,Trong Luan NGUYEN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.5
The outbreak of the COVID-19 pandemic has had a significant impact on the Vietnamese economy. In the midst of a complex disease that compelled people to limit their interaction, customers’ shopping habits shifted from “offline” to “online” transactions. Mobile payments have also grown in popularity. The goal of this study is to figure out what factors influence the use of mobile payments by hotel clients in Can Tho after COVID-19. The research team also examines how those factors influence customers’ willingness to use mobile payment and makes recommendations to better the current situation. Primary data was collected from 227 persons using online surveys and processed with SPSS software for this study. To analyze the correlation relationship between the elements determining the intention to use, the Cronbach alpha, EFA, Correlation, and Regression methods used to assess the scale are applied. Perceived Trustworthiness, Perceived Usefulness, and Perceived Ease of Use all have positive effects on customers’ propensity to use, according to the findings. Perceived Security, on the other hand, has no bearing. The findings of this study have significant theoretical and practical implications for the development of mobile payment services in Can Tho, particularly following the implementation of COVID-19.
Chlorantraniliprole 저항성 초파리 계통 확립과 저항성 특성 구명
김아영,권덕호,정인홍,특안판,트란비느안,이시혁,고영호,Kim, A-Young,Kwon, Deok Ho,Jeong, In Hong,Thuc, Ahn Phan,Tran, Vi Ngan,Lee, Si Hyeock,Koh, Young Ho 한국응용곤충학회 2016 한국응용곤충학회지 Vol.55 No.4
Chlorantraniliprole은 곤충 근육의 $Ca^{2+}$ 농도를 조절하는 Ryanodine 수용기(RyR)에 작용 하는 diamide계통의 작물보호제이다. 최근에 보고된 chlorantraniliprole 저항성 배추좀나방 계통은 RyR에 돌연변이를 가지고 있다. 본 연구에서는 초파리를 모델 곤충으로 저농도와 고농도의 chlorantraniliprole로 도태된 두 종류의 저항성 계통을 확보하였다. 두 종류의 저항성 계통은 접촉독성과 섭식독성 평가법을 활용하여 저항성 지수를 산출하였다. 접촉 독성 평가에서 두 종류의 저항성 계통은 대조군과 비교하여 95% 신뢰구간에서 저항성 발달에 차이가 없었지만, 섭식 독성 평가의 경우에서는 고농도 저항성 계통과 저농도 저항성 계통에서 대조군 대비 각각 2.1배와 8.1배의 통계적으로 유의한 저항성 증가가 나타났다. 작용점 유전자인 RyR 발현량 비교 결과, 두 종류의 저항성 계통에서 RyR의 발현량이 유의하게 감소하였고, 주요 약제 관련 효소인 Acetylcholinesterase와 Glutathione-S-transferase 활성은 조직 특이적으로 증가하는 것을 확인하였다. 이러한 결과들은 초파리에서 chlorantraniliprole에 대한 섭식독성 저항성의 발달에는 주요 해독 관련 효소의 과활성도 관여할 것 임을 보여주고 있다. Ryanodine receptors (RyRs) regulate the contractions of insect muscles by altering intracellular $Ca^{2+}$ concentration and are the targets of chlorantraniliprole. Recently, a chlorantraniliprole-resistant strain was reported in the diamondback moth Plutella xylostella by obtaining point mutations on the RyRs. In the present study, we established two resistant strains from Drosophila melanogaster, which were treated with low or high concentrations of chlorantraniliprole, and their resistance levels were determined on the basis of contact and ingestion toxicities. Compared with the control strain, the two resistant strains did not show any significant differences in contact toxicity. However, they showed significantly increased resistance ratios in ingestion toxicity than that by the control strain. The low and high concentration resistant strains exhibited 2.1- and 8.1-fold increased resistance ratios, respectively, compared with that by the control strain. Moreover, we found that the resistant strains had altered expression levels of RyRs and more enhanced Acetylcholinesterase and Glutathione-S-transferase activities than that by the non-selected strain. These results suggested that the resistance development of chlorantraniliprole in the two strains might be mediated by the activation of detoxification pathways in D. melanogaster.