정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Cu/Kieselguhr 觸媒에 依한 Acrylonitrile의 水和反應에 關한 硏究

尹奇俊,姜喆象 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.2

Catalytic hydration of acrylonitrle over Cu/kieselguhr catalysts was studied at 343K. The catalysts with varying Cu loadings were prepared by the precipitation method using NaOH and K_2CO_3 solutions as the precipitants. The active surface areas were measured by O_2 chemisorption at 77K in order to determine the areal reaction rate constants. Some effects of the precipitant and the Cu loading were investigated. The results were as follows : (1) Only acrylamide was produced over the catalysts prepared using NaOH, whereas ethylene cyanohydrin was also produced over the catalyst prepared using K_2CO_3. (2) The reaction rate for the production of acrylamide was first order with respect to the concentration of acrylonitrile. (3) The areal reaction rate constant. for the catalysts prepared using NaOH decreased significantly with decreasing Cu loading. The constant at 343K for the catalyst having 50% Cu loading was 2.83 x 10 wxp(-6)l/㎡. min.

인터넷 비지니스와 전개방향

윤문길,최기철 한국항공대학교 경영연구소 1997 경영연구 Vol.4 No.1

The wide spread af Internet has motivated the introduction af various application on the communication network, and activated the network usage. The Internet represents in miniature a model for the new communications industry of the Zlst Century. By examining the structure of the marketplace which the Internet model represents, companies am make sense of sometimes apparently confliction trends now taking place in the telecoms, IT and broadcasting/publishing sectors. In this paper, new business opportunities on the Internet are surveyed and analyzed for increasing the revenue of telecoms. Discussing with the future trend of Internet business, some strategic schemes for telecoms are suggested to cope with the new business environment evolving on the cyber space.

인터넷 통신에서 자바 바이트코드를 이용한 애플릿 보안

윤찬호,석경휴,나기창,배철수,나상동 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.1

Java applets are downloaded from web server through internet and executed in Java Virtual Machine of clients' browser. Before execution of java applets, JVM checks bytecode program with bytecode verifier and performs runtime tests with interpreter. However, these tests will not protect against undesirable runtime behavior of java applets, such as denial of service attack, email forging attack, URL spoofing attack, or annoying sound attack. In order to protect malicious applets, a technique used in this paper is java bytecode modification. This technique is used to restrict applet behavior or insert code appropriate to profiling or other monitoring efforts. Java byte modification is divided into two general forms, class-level modification involving subclassing non-final classes and method-level modification used when control over objects from final classes or interface. This paper showed that malicious applets are controlled by java bytecode modification using proxy server. This implementation does not require any changes in the web sever, JVM or web browser.

전원지역 초등학교계속구강건강관리 사업 모형의 개발에 관한 연구

윤신종,박기철,신승철,김광영 단국대학교 치과대학 예방치과 1998 예방치과 세미나집 Vol.- No.12

The purpose of this study was to develop of a model for School based Oral health program in Korea. Study model of school based dental program was established at Mockcheon Grade school, in 1989 and followed the program for 6 years. 324 school children have been participated in the program. Dental students and dental hygienist's students of Dankook University School of Dentistry have been providing al dental services under the supervision of a public health dentist. Primary preventive care such as sealants, fluoride mouthrinse fluoride topical applications, toothbrusing instruction, oral prophylaxis, were provided to all of the participendents by the students under the supervision of public health dentists. Data for DMF rate, DMFT rate and DMFT index were collected annually. The amounts of money and time consumptions for this program were also monitored. The results obtained for this study were as followings ; 1. The combined school based oral health care program utilized in Mockcheon primary school resulted a reduction of 33.5% in caries incidence after 6 years of implemention. 2. The school based oral health care program tested in this program reduced an average of 53% of dental treatment cost for school children ofter 6 years of implemention. 3. It is therefore suggested that the school based oral health care program is an effective means of public health project for school children in Korea.

건선 병변부 및 병변주위부 피부의 Cytokines 유전자 발현

윤기성,김도원,정상립,김문규,김정철 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

It has been proposed that cytokines may be involved in mediating the characteristic pathological changes in psoriasis, including epidermal hyperplasia, compromised keratinocyte differentiation, and dermal and epidermal infiltration by polymorphonuclear leukocytes and mononuclear cells. The purpose of this study os to assess the pattern of cytokine gene expression in psoriatic skin lesion. To investigate the cytokine expression pattern, we examined the transcripts of cytokine genes using reverse transcription and polymerase chain reaction (RT-PCR) method with 13 cytokine-specific primers. The Results were as follow; 1. Only the TGF-β gene was expressed in the normal skin. 2. IL-1α, IL-1β, IL-8, and TGF-β were detected in both lesional and perilesional psoriatic skin. The lesions showed more prominent expression. 3. IL-10 and GM-CSF were weakly detectable in three lesional psoriatic skin respectively, and IL-2R in two lesional psoriatic skin. 4. IL-2,IL-4,IL-5,IL-6 TNF-α, IFN-γ were not detectable on both lesional and perilesional psoriatic skin. Therefore, distinct differences in the cytokines gene expression were noted between normal and psoriatic skin. The patterns of cytokines gene expression in perilesional skin were similiar to those of lesional psoriatic skin.

새로운 환자표본자료 표본 추출 및 대표성 검증

윤철영,안재준,이경민,최용석,김리현,하대우,유기봉 건강보험심사평가원 2021 HIRA RESEARCH Vol.1 No.2

혈뇨의 감별진단을 위한 이형적혈구의 형태학적 연구

윤철종,박정오,문희주,윤기은 韓國電子顯微鏡學會 1999 Applied microscopy Vol.29 No.3

전체 성인의 약 4%에서 정도 차이는 있지만 혈뇨가 있다고 볼 때 그 원인을 구명하는 일이 중요하다. 그 원인이 사구체성 신염인지 기타 그 외의 비사구체성 원인에 따른 질환인지를 쉽게 감별하는 일이 중요하다. 본 연구자들은 혈뇨를 동반한 소아과 환자중에서 신 생검 조직검사까지 한 5명의 환자에서 혈뇨를 표본 제작하여 먼저 위상차현미경적 표본제작법을 통하여 적혈구를 감별하였고 방법을 달리하여 주사형 전자현미경으로 요침사를 관찰하여 형태학적 고찰을 통하여 이형적혈구를 보다 명확한 3차원구조를 관찰할 수 있었다. 침생검을 통해 얻은 조직학적 소견으로는 사구체의 기저막을 통과한 혈구들의 요로를 통하여 배출과정을 광학현미경 및 투과형 전자현미경으로 확인할 수 있었다. 본 연구에서 육안적 혈뇨의 색은 유출되는 적혈구의 양과 상관관계가 있으며 용혈된 정도가 심한 경우에 콜라색 혈뇨가 있음을 알 수 있었다. 이들 결과에서 본 연구자들은 사구체성 질환을 동반한 유극적혈구 및 환형 적혈구 등과 같은 변형된 적혈구를 주사형 전자현미경으로 명확한 관찰을 함으로 사구체성 질환으로 인한 혈뇨의 감별에 주사형 전자현미경이 가장 유용한 검사 방법이라고 생각된다. Examination of the morphology of red blood cells in the urine has been shown to be a promising adjunct in determining whether hematuria represents glomerular or nonglomerular bleeding. This is due to distortion of RBCs as they pass across the basement membrane of the glomerular capillaries. It is concluded that is method can greatly help the clinician in distinguishing between glomerular and non glomerular bleeding in patients with hematuria and channeling such patients toward the most appropriate investigations. We have experimented dysmorphic red blood cells that 5 patients of the hematuria are distorted with irregular outlines and often have small blebs extruding from the red cell membrane. Tried urinary sediments were seen with phase contrast microscope and confirmed scanning electron microscope. There are seen acanthocytes, anulocytes, ghost cells and sphero-echinocytes in dysmorphic erythrocytes. Clinical diagnosis was referred from the result of the biopsy-proven. Scanning electron microscopic findings of the hematuria are good diagnostic tool that disclose in distorted red blood cells from patients with glomerular disorders.

유산소 운동이 비만여성의 심폐기능 및 혈청지질에 미치는 영향

이기철,박상갑,윤미숙 부산외국어대학교 정보과학연구소 2000 情報科學論集 Vol.2 No.-

The purpose of this study was to investigate the changes of body composition, circulorespiratory functions, serum lipids after 12weeks walking exercise. Subjects were composed of ten middle-aged women. VO2max was determined for each subjects by administering a treadmill exercise test. Subjects were trained during 12weeks(80m/min, 5 frequencies /week, 1 hour). The result of this study are as follows ; 1.Weight and %fat were decreased to 4.2kg and 6.5%, respectively, after 12weeks walking exercise. 2.Circulorespiratory function was improved because of increasing in VO2max, VO2max/kg after 12weeks walking exercise. 3.Total cholesterol, Low density lipoprotein cholesterol and Triglyceride were decreased to 39.3mg/㎗, 25.6mg/㎗ and 36.5mg/㎗ respectively after 12weeks walking exercise. 4.Atherogenic Index was decreased to 1.45 after 12weeks walking exercise. In conclusion, 60min walking training was shown to maintain aerobic capacity which decrease according to aging and positive influence on preventing and improving in low HDL and hear disease to be cause by the lack of exercise.

TRANSPALATAL LINGUAL ARCH에 의한 골내 응력 분포에 관한 광탄성적 연구

고기영,태기출,국윤아,김상철 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

본 연구는 TMA wire로 제작된 transpalatal lingual arch에 의한 골내 응력 분포를 파악하기 위하여 양측성 및 편측성 확장을 가하여 이때 발생하는 치아주위조직 응력 분포 양상을 광탄성 응력해석법으로 관찰하여 다음과 같은 결과를 얻었다. 1. 양측성 확장시 수평 변형만 적용했을 때 탄선끝이 각진 경우 둥근 탄선끝을 적용한 경우보다 응력이 치근단으로 집중되며 회전중심을 의미하는 흑색선이 변화하는 양태를 보였고 수직변형량이 증가되면서 전체적인 응력차수의 증가와 흑색선의 하방 이동 양상을 보였다. 2. 편측성 확장을 위해 수평 변형과 함께 확장측에만 수직 변형을 적용하였을 때 확장력이 확장측으로 편중되는 응력분포를 관찰할 수 있었다. 수직 변형량의 증가시 확장측 구치는 정출하는 응력을 보였고 수평변형량의 증가시 고정측치아도 경사지려는 응력분포가 관찰하였다. 3. 편측 구치의 회전을 개선하기 위해 철사끝을 비대칭적으로 toe-in한 경우 변형량이 적은 구치의 치근단 원심측에 응력분포를 관찰할 수 있었다. 4. 악궁 확장시 철사의 길이를 줄일수록 무늬차수가 증가하는 응력 분포를 보였다. The purpose of this study was to investigate the stress distribution and intensity derived from the transpalatal lingual arch in the investing bone composed of photoelastic material(PL-3). The transpalatal lingual arch wire was deflected in the horizontal and vertical direction to give the various conditions. The two-dimensional photoelastic stress analysis was performed, and the stress distrebution was recored by photography. The results were as follows: 1. In bilateral expansion, as horizontal deflection was singly applied, the stress was more concentrated on the root apex in square free end than round. In square free end, as vertical deflection was increased gradually, the black line meaning center of rotation moved inferiorly together with the increment of whole fringes. 2. In application of vertical deflection on anchorage side for unilateral expansion, the stress distribution that expansive force leaned to expansion side was observed. As vertical deflection increased, the extruding stress was observed on molar of expansion side. And as horizontal deflection increased, the tipping stress on the molar of anchorage side was observed. 3. In unilateral rotation with the asymmetric toe-in, the fringe appeared on the distal aspect of root apex.