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Antiosteoporotic Effects of Acer palmatum Extract on Osteoclastogenesis and Osteoblastogenesis
Kenji Kuriya,Masahiro Nishio,Shohei Wada,Hirotaka Katsuzaki,Masayuki Nishise,Hiroyuki Okamoto,Hayato Umekawa 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.4
Osteoporosis is a systemic skeletal disease that causes bone weakness and fragility. Consuming bone-beneficial nutrients through diet can prevent and treat osteoporosis. Acer palmatum (Japanese maple) leaves are used to make tea, but there have been few reports of their health benefits, especially regarding bone homeostasis. In this study, we evaluated the effects of A. palmatum hot water extract (APE) on osteoclastogenesis and osteoblastogenesis in cultured cells. APE suppressed the number of tartrate-resistant acid phosphatase-positive multinucleated osteoclasts in RANKL induced RAW264.7 cells. Furthermore, APE facilitated Alkaline phosphatase activity and calcium deposition during osteoblast differentiation in MC3T3–E1 cells. High-performance liquid chromatography analysis was performed to investigate the effective components of APE, and four flavonoids orientin, isoorientin, vitexin, and isovitexin were identified with the LC-MS analysis. Treatment with fractionated APE suppressed osteoclastogenesis and facilitated osteoblastogenesis in cultured cells. These findings suggest that APE contains antiosteoporotic compounds; thus, APE might have health promoting effects that help prevent osteoporosis by inhibiting osteoclastogenesis and facilitating osteoblastogenesis.
Tomihiko Edura,Hiromasa Takahashi,Masashi Nakata,Ken Tsutsui,Kenji Itaka,고이누마히데오미,Jun Mizuno,Yasuo Wada 한국물리학회 2006 Current Applied Physics Vol.6 No.1
Organic thin lm transistors (O-TFTs) are attracting attentions recently for their possible application to exible eld eect tran-sistor (FET) devices and even for candidate devices in post-silicon information systems. However, the organic thin lms usuallygrow in a polycrystalline state, and the electrical properties are very dicult to set at an appropriate value because orientationand size of the polycrystalline grains are almost uncontrollable. Thus, it should be necessary to clarify the conduction characteristicsorganic thin lms. This paper reports on a nano-scale electrode array, which provides a method to characterize single organic semi-conductor grain, as well as to determine the single grain boundary eect on the electrical conduction. The fabrication method of thenano-scale electrode array and evaluation results are described. Single grain and single grain boundary in MBE grown pentacenethin lm were detected and were measured for the rst time using FET structures. The resistance of single grain was estimatedof the resistance of single grain pentacene thin lm and single pentacene grain boundary.
Yo Kubota,Satoshi Tanabe,Mizutomo Azuma,Kazue Horio,Yoshiki Fujiyama,Takafumi Soeno,Yasuaki Furue,Takuya Wada,Akinori Watanabe,Kenji Ishido,Chikatoshi Katada,Keishi Yamashita,Wasaburo Koizumi,Chika Ku 대한위암학회 2021 Journal of gastric cancer Vol.21 No.4
Purpose: Promoter DNA methylation of various genes has been associated with metachronous gastric cancer (MGC). The cancer-specific methylation gene, cysteine dioxygenase type 1 (CDO1), has been implicated in the occurrence of residual gastric cancer. We evaluated whether DNA methylation of CDO1 could be a predictive biomarker of MGC using specimens of MGC developing on scars after endoscopic submucosal dissection (ESD). Materials and Methods: CDO1 methylation values (TaqMeth values) were compared between 33 patients with early gastric cancer (EGC) with no confirmed metachronous lesions at >3 years after ESD (non-MGC: nMGC group) and 11 patients with MGC developing on scars after ESD (MGCSE groups: EGC at the first ESD [MGCSE-1 group], EGC at the second ESD for treating MGC developing on scars after ESD [MGCSE-2 group]). Each EGC specimen was measured at five locations (at tumor [T] and the 4-point tumor-adjacent noncancerous mucosa [TAM]). Results: In the nMGC group, the TaqMeth values for T were significantly higher than that for TAM (P=0.0006). In the MGCSE groups, TAM (MGCSE-1) exhibited significantly higher TaqMeth values than TAM (nMGC) (P<0.0001) and TAM (MGCSE-2) (P=0.0041), suggesting that TAM (MGCSE-1) exhibited CDO1 hypermethylation similar to T (P=0.3638). The area under the curve for discriminating the highest TaqMeth value of TAM (MGCSE-1) from that of TAM (nMGC) was 0.81, and using the cut-off value of 43.4, CDO1 hypermethylation effectively enriched the MGCSE groups (P<0.0001). Conclusions: CDO1 hypermethylation has been implicated in the occurrence of MGC, suggesting its potential as a promising MGC predictor.